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Tytuł :
Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity.
Autorzy :
Xu L; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Zhao Q; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Luo J; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Ma W; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Jin Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Li C; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Hou Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Feng M; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Wang Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Chen J; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Zhao J; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Zheng Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China. Electronic address: .
Yu D; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111166. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*metabolism
Dimethylformamide/*toxicity
Environmental Pollutants/*toxicity
Hepatocytes/*drug effects
Lipid Metabolism/*drug effects
Metabolome/*drug effects
Proteome/*metabolism
Animals ; Cell Survival/drug effects ; Cells, Cultured ; Endoplasmic Reticulum Stress/drug effects ; Glutathione/metabolism ; Hepatocytes/metabolism ; Humans ; Lipidomics ; Metabolomics ; Primary Cell Culture ; Proteomics ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Toxicity Tests/methods
Czasopismo naukowe
Tytuł :
Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury.
Autorzy :
Kang J; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Zhang C; Department of Orthopedics, School of Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
Zhi Z; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Wang Y; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Liu J; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Wu F; Shanghai Clinical Research Center for Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xu G; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 627-638.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes/*transplantation
MicroRNAs/*genetics
Spinal Cord Injuries/*therapy
Stem Cells/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Cells, Cultured ; Culture Media, Conditioned/metabolism ; Culture Media, Conditioned/pharmacology ; Exosomes/genetics ; Exosomes/metabolism ; Gene Expression Regulation ; Humans ; Locomotion/physiology ; Male ; Neuroepithelial Cells/cytology ; Neuroepithelial Cells/metabolism ; Neurons/metabolism ; Neurons/pathology ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Macrophage-derived Wnt signaling increases endothelial permeability during skeletal muscle injury.
Autorzy :
Tusavitz S; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
Keoonela S; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
Kalkstein M; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
McCormick S; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
Gasser B; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
Arrigale M; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
Rafferty P; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA.
Carpenter AC; Health and Exercise Physiology, Ursinus College, 601 E. Main St, Collegeville, PA, 19426, USA. .
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Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2020 Dec; Vol. 69 (12), pp. 1235-1244. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Wnt Signaling Pathway*
Endothelium/*pathology
Macrophages/*pathology
Muscle, Skeletal/*injuries
Muscle, Skeletal/*pathology
Animals ; Antibodies, Blocking/pharmacology ; Cells, Cultured ; Endothelial Cells/pathology ; Humans ; Mice ; Mice, Knockout ; Permeability ; Regeneration ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors ; Wound Healing
Czasopismo naukowe
Tytuł :
Cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle.
Autorzy :
Takaishi K; Department of Dental Anesthesiology, Tokushima University Hospital, Tokushima, Japan.
Kinoshita H; Department of Anesthesiology, Tokushima University Hospital, Tokushima, Japan; Department of Anesthesiology, Aichi Medical University School of Medicine, Aichi, Japan. Electronic address: .
Feng GG; Department of Anesthesiology, Aichi Medical University School of Medicine, Aichi, Japan.
Azma T; Department of Anesthesiology & Pain Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Japan.
Kawahito S; Department of Anesthesiology, Tokushima University Hospital, Tokushima, Japan.
Kitahata H; Department of Dental Anesthesiology, Tokushima University Hospital, Tokushima, Japan.
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Dec; Vol. 144 (4), pp. 197-203. Date of Electronic Publication: 2020 Aug 23.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochalasin B/*pharmacology
Cytoskeleton/*metabolism
Glucose/*adverse effects
Hyperglycemia/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Oxidative Stress/*drug effects
Adult ; Aged ; Cells, Cultured ; Cromakalim/pharmacology ; Female ; Humans ; Hyperglycemia/physiopathology ; In Vitro Techniques ; Male ; Middle Aged ; Muscle Relaxation/drug effects ; NADPH Oxidases/metabolism ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.
Autorzy :
He SD; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Huang SG; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Zhu HJ; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Luo XG; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Liao KH; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Zhang JY; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Tan N; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Li DY; Traditional Chinese Medicine Department of Rheumatism, Huazhong University of Science and Techology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2020 Dec; Vol. 58 (1), pp. 146-151.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Arthritis, Rheumatoid/*drug therapy
Diterpenes, Kaurane/*pharmacology
Fibroblasts/*drug effects
Synoviocytes/*drug effects
Apoptosis/drug effects ; Autophagy/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Chloroquine/administration & dosage ; Chloroquine/pharmacology ; Diterpenes, Kaurane/administration & dosage ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Fibroblasts/cytology ; Humans ; Inhibitory Concentration 50 ; Synoviocytes/cytology ; Time Factors
Czasopismo naukowe
Tytuł :
Angiogenic protein synthesis after photobiomodulation therapy on SHED: a preliminary study.
Autorzy :
Oliveira Prado Bergamo MT; Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.
Vitor LLR; Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.
Lopes NM; Department of Biology Science, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, 17012-901, Brazil.
Lourenço Neto N; Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.
Dionísio TJ; Department of Biology Science, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, 17012-901, Brazil.
Oliveira RC; Department of Biology Science, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, 17012-901, Brazil.
Oliveira Rodini C; Department of Biology Science, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, 17012-901, Brazil.
Santos CF; Department of Biology Science, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, 17012-901, Brazil.
Machado MAAM; Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.
Oliveira TM; Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil. .
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Źródło :
Lasers in medical science [Lasers Med Sci] 2020 Dec; Vol. 35 (9), pp. 1909-1918. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Low-Level Light Therapy*
Angiogenic Proteins/*biosynthesis
Tooth, Deciduous/*radiation effects
Biomarkers/metabolism ; Cell Proliferation/radiation effects ; Cell Survival/radiation effects ; Cells, Cultured ; Child ; Child, Preschool ; Dental Pulp/cytology ; Humans ; Lasers, Semiconductor ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway.
Autorzy :
Marshall KE; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK.
Vadukul DM; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK.
Staras K; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK. .
Serpell LC; Sussex Neuroscience, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Dec; Vol. 77 (23), pp. 5031-5043. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Folding*/drug effects
Amyloid beta-Peptides/*chemistry
Amyloid beta-Peptides/*metabolism
Endosomes/*metabolism
Lysosomes/*metabolism
Peptide Fragments/*chemistry
Peptide Fragments/*metabolism
Amyloid beta-Peptides/toxicity ; Animals ; Cells, Cultured ; Dynamins/metabolism ; Endocytosis/drug effects ; Endosomes/ultrastructure ; Hydrogen-Ion Concentration ; Lysosomes/drug effects ; Lysosomes/ultrastructure ; Neurons/drug effects ; Neurons/pathology ; Ovalbumin/metabolism ; Peptide Fragments/toxicity ; Rats
Czasopismo naukowe
Tytuł :
Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents.
Autorzy :
Shen QK; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China.
Gong GH; Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, China.; Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China.
Li G; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China.
Jin M; Department of Central Laboratory, Yanbian University Hospital, Yanji, China.
Cao LH; College of Medical, Yanbian University, Yanji, China.
Quan ZS; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 85-95.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Amides/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Anti-Ulcer Agents/*pharmacology
Quinoxalines/*pharmacology
Stomach Ulcer/*drug therapy
Amides/chemical synthesis ; Amides/chemistry ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Ulcer Agents/chemical synthesis ; Anti-Ulcer Agents/chemistry ; Cell Survival/drug effects ; Cells, Cultured ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Dose-Response Relationship, Drug ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Molecular Structure ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/metabolism ; Quinoxalines/chemical synthesis ; Quinoxalines/chemistry ; RAW 264.7 Cells ; Rats ; Stomach Ulcer/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening.
Autorzy :
Yao D; Guangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen, China.; Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural small molecule Drugs, Engineering Laboratory of Shenzhen Natural small molecule Innovative Drugs, Shenzhen University Health Science Center, Shenzhen, China.
Zhang J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, China.
Wang J; Shenzhen Honghui Bio-Pharmaceutical Co. Ltd., Shenzhen, China.
Pan D; Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
He Z; Guangdong Key Laboratory for Genome Stability & Human Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen, China.; Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural small molecule Drugs, Engineering Laboratory of Shenzhen Natural small molecule Innovative Drugs, Shenzhen University Health Science Center, Shenzhen, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 713-725.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
ATPases Associated with Diverse Cellular Activities/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
DNA-Binding Proteins/*antagonists & inhibitors
ATPases Associated with Diverse Cellular Activities/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; DNA-Binding Proteins/metabolism ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis.
Autorzy :
Ma Y; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Song J; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Almassri HNS; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Zhang D; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Zhang T; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Cheng Y; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Wu X; Stomatological Hospital of Chongqing Medical University, Yubei District, Chongqing, China.; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 151-160.
Typ publikacji :
Journal Article
MeSH Terms :
Tissue Scaffolds*
Alveolar Bone Loss/*drug therapy
Bone Regeneration/*drug effects
Minocycline/*administration & dosage
Minocycline/*pharmacology
Animals ; Cells, Cultured ; Drug Liberation ; Osteoblasts/drug effects ; Osteogenesis/drug effects ; Polyglycolic Acid/chemistry ; Rats
Czasopismo naukowe
Tytuł :
The effect of photobiomodulation on human dental pulp-derived stem cells: systematic review.
Autorzy :
Kulkarni S; School of Dentistry and Oral Health, Griffith University, Corner Olsen Ave and Parklands Dr, Gold Coast, QLD, Australia.; School of Dentistry, University of Adelaide, Adelaide, SA, Australia.
Meer M; School of Dentistry and Oral Health, Griffith University, Corner Olsen Ave and Parklands Dr, Gold Coast, QLD, Australia.
George R; School of Dentistry and Oral Health, Griffith University, Corner Olsen Ave and Parklands Dr, Gold Coast, QLD, Australia. .
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Źródło :
Lasers in medical science [Lasers Med Sci] 2020 Dec; Vol. 35 (9), pp. 1889-1897. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Low-Level Light Therapy*
Dental Pulp/*cytology
Stem Cells/*cytology
Stem Cells/*radiation effects
Cell Differentiation ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Humans ; Outcome Assessment, Health Care ; Publication Bias ; Risk ; Tooth, Deciduous/cytology
Czasopismo naukowe
Tytuł :
Circular RNA cZNF292 silence alleviates OGD/R-induced injury through up-regulation of miR-22 in rat neural stem cells (NSCs).
Autorzy :
Cao Y; Neonatal Intensive Care Unit, Zhoukou Central Hospital, Zhoukou, China.
Liu H; Neonatal Intensive Care Unit, Zhoukou Central Hospital, Zhoukou, China.
Zhang J; Neonatal Intensive Care Unit, Zhoukou Central Hospital, Zhoukou, China.
Dong Y; Neonatal Intensive Care Unit, Zhoukou Central Hospital, Zhoukou, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 594-601.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Interference*
MicroRNAs/*genetics
Neural Stem Cells/*metabolism
RNA, Circular/*genetics
Reperfusion Injury/*prevention & control
Animals ; Apoptosis ; Cell Survival ; Cells, Cultured ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Glucose/metabolism ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Neural Stem Cells/pathology ; Oxygen/metabolism ; Protein Kinase C/metabolism ; Rats ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Signal Transduction ; Wnt3A Protein/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
The effect of β-cyclocitral treatment on the carotenoid content of transgenic Marsh grapefruit (Citrus paradisi Macf.) suspension-cultured cells.
Autorzy :
Zheng X; Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan, China.
Zhu K; Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan, China.
Ye J; Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan, China.
Price EJ; School of Biological Sciences, Royal Holloway, University of London, Egham Hill, Egham, Surrey, TW20 0EX, UK; Faculty of Sports Studies, Masaryk University, Brno, Czech Republic; RECETOX Centre, Masaryk University, Brno, Czech Republic.
Deng X; Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan, China. Electronic address: .
Fraser PD; School of Biological Sciences, Royal Holloway, University of London, Egham Hill, Egham, Surrey, TW20 0EX, UK. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2020 Dec; Vol. 180, pp. 112509. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji :
Journal Article
MeSH Terms :
Citrus*
Citrus paradisi*/genetics
Aldehydes ; Carotenoids ; Cells, Cultured ; Diterpenes ; Wetlands
Czasopismo naukowe
Tytuł :
Regulation of lipid droplets via the PLCβ2-PKCα-ADRP pathway in granulosa cells exposed to cadmium.
Autorzy :
Liu Q; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Liang Y; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Gao N; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Gao J; The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Wang Y; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Li X; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Qin J; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Xiang Q; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China; Guangzhou Biopharmaceutical R&D Center of Jinan University Co.,Ltd, Guangzhou, 510632, China.
Wu X; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, 510632, China.
Chen H; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China.
Huang Y; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China; Guangzhou Biopharmaceutical R&D Center of Jinan University Co.,Ltd, Guangzhou, 510632, China.
Zhang Q; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China; Guangzhou Biopharmaceutical R&D Center of Jinan University Co.,Ltd, Guangzhou, 510632, China. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 Dec; Vol. 267, pp. 115541. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cadmium*
Lipid Droplets*
Animals ; Cells, Cultured ; Female ; Granulosa Cells ; Perilipin-2 ; Phospholipase C beta ; Progesterone ; Protein Kinase C-alpha ; Rats
Czasopismo naukowe
Tytuł :
Inhibition of autophagy enhances cadmium-induced apoptosis in duck renal tubular epithelial cells.
Autorzy :
Wang C; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Nie G; School of Information Technology, Jiangxi University of Finance and Economics, No. 665 Yuping West Street, Economic and Technological Development District, Nanchang, 330032, Jiangxi, PR China.
Zhuang Y; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Hu R; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Wu H; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Xing C; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Li G; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Hu G; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Yang F; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China. Electronic address: .
Zhang C; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111188. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Ducks*
Apoptosis/*drug effects
Autophagosomes/*drug effects
Autophagy/*drug effects
Cadmium/*toxicity
Epithelial Cells/*drug effects
Kidney Tubules/*drug effects
Animals ; Autophagosomes/metabolism ; Autophagosomes/pathology ; Cells, Cultured ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Membrane Potential, Mitochondrial/drug effects
Czasopismo naukowe
Tytuł :
Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction.
Autorzy :
Jurek S; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.
Sandhu MA; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.; Department of Veterinary Biomedical Sciences, PMAS-Arid Agriculture University, Rawalpindi, Pakistan.
Trappe S; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.
Bermúdez-Peña MC; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.; Nursing Faculty, Autonomous University of Queretaro, Querétaro City, Mexico.
Kolisek M; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.; Division of Neurosciences, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Sponder G; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.
Aschenbach JR; Institute of Veterinary-Physiology, Freie Universität Berlin, Berlin, Germany.
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Źródło :
Adipocyte [Adipocyte] 2020 Dec; Vol. 9 (1), pp. 35-50.
Typ publikacji :
Journal Article
MeSH Terms :
Ascorbic Acid/*pharmacology
Fatty Acid-Binding Proteins/*genetics
Fatty Acid-Binding Proteins/*metabolism
Mesenchymal Stem Cells/*cytology
Animals ; Cattle ; Cell Differentiation ; Cell Transdifferentiation ; Cells, Cultured ; Culture Media/chemistry ; Gene Expression Regulation/drug effects ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase.
Autorzy :
Krasavin M; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Žalubovskis R; Latvian Institute of Organic Synthesis, Riga, Latvia.; Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia.
Grandāne A; Latvian Institute of Organic Synthesis, Riga, Latvia.
Domračeva I; Latvian Institute of Organic Synthesis, Riga, Latvia.
Zhmurov P; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Supuran CT; Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 506-510.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrases/*metabolism
Coumarins/*pharmacology
Enzyme Inhibitors/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Insulin negatively regulates dedifferentiation of mouse adipocytes in vitro.
Autorzy :
Zang L; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Kothan S; Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Yang Y; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Zeng X; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Ye L; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Pan J; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.; Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
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Źródło :
Adipocyte [Adipocyte] 2020 Dec; Vol. 9 (1), pp. 24-34.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes, White/*cytology
Insulin/*pharmacology
Leptin/*genetics
Receptors, Leptin/*genetics
Tumor Necrosis Factor-alpha/*genetics
Adipocytes, White/metabolism ; Animals ; Biomarkers/analysis ; Cell Dedifferentiation ; Cells, Cultured ; Culture Media/chemistry ; Gene Expression Regulation ; Gene Knockout Techniques ; Mice ; Point Mutation ; Primary Cell Culture ; Receptors, Leptin/metabolism
Czasopismo naukowe
Tytuł :
Immunohistochemical Study of SARS-CoV-2 Viral Entry Factors in the Cornea and Ocular Surface.
Autorzy :
Roehrich H; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN.
Yuan C; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN.; Lions Gift of Sight Eye Bank, St. Paul, MN.
Hou JH; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN.; Lions Gift of Sight Eye Bank, St. Paul, MN.
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Źródło :
Cornea [Cornea] 2020 Dec; Vol. 39 (12), pp. 1556-1562.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*physiology
Cell Adhesion Molecules/*metabolism
Conjunctiva/*metabolism
Epithelium, Corneal/*metabolism
Lectins, C-Type/*metabolism
Peptidyl-Dipeptidase A/*metabolism
Receptors, Cell Surface/*metabolism
Serine Endopeptidases/*metabolism
Adult ; Aged ; Aged, 80 and over ; Cells, Cultured ; Conjunctiva/cytology ; Coronavirus Infections/immunology ; Epithelial Cells/metabolism ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Limbus Corneae/cytology ; Male ; Microscopy, Fluorescence ; Middle Aged ; Pandemics ; Pneumonia, Viral/immunology ; Tissue Donors ; Viral Tropism/physiology ; Virus Internalization ; Young Adult
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Pinostilbene hydrate suppresses hepatic stellate cell activation via inhibition of miR-17-5p-mediated Wnt/β-catenin pathway.
Autorzy :
Zhou G; Department of Infectious Diseases, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Li C; Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, No.2 FuXue lane, Wenzhou 325000, China.
Zhan Y; Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, No.2 FuXue lane, Wenzhou 325000, China.
Zhang R; Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, No.2 FuXue lane, Wenzhou 325000, China.
Lv B; Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Geng W; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: .
Zheng J; Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, No.2 FuXue lane, Wenzhou 325000, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153321. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatic Stellate Cells/*drug effects
MicroRNAs/*metabolism
Stilbenes/*pharmacology
Wnt Signaling Pathway/*drug effects
Actins/genetics ; Actins/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Proliferation/drug effects ; Cells, Cultured ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Mice ; beta Catenin/metabolism
Czasopismo naukowe

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