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Wyświetlanie 1-20 z 20177
Tytuł:
Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression.
Autorzy:
You L; College of Physical Education and Health, Chongqing College of International Business and Economics, Chongqing, 401520, China.; College of Life Science, Yangtze University, Jingzhou, 434025, China.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03, Hradec Králové, Czech Republic.
Valko M; Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37, Bratislava, Slovakia.
Wu Q; College of Life Science, Yangtze University, Jingzhou, 434025, China. .; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03, Hradec Králové, Czech Republic. .
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03, Hradec Králové, Czech Republic. .; Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI), University of Granada, Granada, Spain. .
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Źródło:
Archives of toxicology [Arch Toxicol] 2023 Feb; Vol. 97 (2), pp. 393-404. Date of Electronic Publication: 2022 Nov 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Tumor Suppressor Protein p53*/metabolism
Cellular Senescence*
Humans ; Oxidative Stress ; Immunosuppression Therapy ; Hypoxia
Czasopismo naukowe
Szczegóły
Tytuł:
Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.
Autorzy:
Yu Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Ren Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Li Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Li Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Li Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Zhang Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Gui R; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Cui Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.
Qian L; Department of Endocrinology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Northwest University, Xi'an, Shaanxi, China.
Xiong Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, Shaanxi, China.; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Northwest University, Xi'an, Shaanxi, China.
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Źródło:
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Jan 09; Vol. 2023, pp. 4654083. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*/genetics
Autophagy*/physiology
Cellular Senescence*/genetics
Cellular Senescence*/physiology
Endothelial Cells*/metabolism
Endothelial Cells*/physiology
Animals ; Humans ; Mice ; Aging/genetics ; Aging/metabolism ; Calcium/metabolism ; Myosin Type I ; Myosins
Czasopismo naukowe
Szczegóły
Tytuł:
Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence.
Autorzy:
Li J; Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082, P. R. China.
Bi Z; Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082, P. R. China.
Wang L; Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082, P. R. China.
Xia Y; Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082, P. R. China.
Xie Y; Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082, P. R. China.
Liu Y; Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University, Changsha, Hunan, 410082, P. R. China.
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Źródło:
Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Jan 03; Vol. 24 (1), pp. e202200364. Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*
Precision Medicine*
Biomarkers ; Kinetics
Czasopismo naukowe
Szczegóły
Tytuł:
The Relationship of Birth Size and Postnatal Growth with Cellular Senescence in Adults: Data from the New Delhi Birth Cohort.
Autorzy:
Tarik M; Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.
Ramakrishnan L; Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India. lakshmy_.
Sinha S; Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India.
Sachdev HPS; Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India.
Tandon N; Department of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Roy A; Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
Bhargava SK; The New Delhi Birth Cohort, D-7, Gulmohar Park, New Delhi, India.
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Źródło:
Indian journal of pediatrics [Indian J Pediatr] 2023 Jan; Vol. 90 (1), pp. 49-55. Date of Electronic Publication: 2022 Jun 15.
Typ publikacji:
Journal Article
MeSH Terms:
Birth Weight*
Cellular Senescence*/genetics
Infant, Low Birth Weight*
Chronic Disease*/epidemiology
Adult ; Humans ; Infant, Newborn ; Birth Cohort ; Cohort Studies ; India/epidemiology ; Biomarkers ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p21/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
p21 induces a senescence program and skeletal muscle dysfunction.
Autorzy:
Englund DA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Jolliffe A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Aversa Z; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Sakamoto AE; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Zeidler JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA.
Warner GM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA.
McNinch C; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Chini EN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA; Paul F. Glenn Center for the Biology of Aging at Mayo Clinic, Rochester, MN, USA.
Baker DJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Paul F. Glenn Center for the Biology of Aging at Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA; Paul F. Glenn Center for the Biology of Aging at Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2023 Jan; Vol. 67, pp. 101652. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/physiology
Muscle, Skeletal*
Humans
Czasopismo naukowe
Szczegóły
Tytuł:
Mechanisms of RNA and Protein Quality Control and Their Roles in Cellular Senescence and Age-Related Diseases.
Autorzy:
Kang D; Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Republic of Korea.; Department of Molecular Medicine, College of Medicine, Inha University, Incheon 22212, Republic of Korea.
Baek Y; Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Republic of Korea.; Department of Molecular Medicine, College of Medicine, Inha University, Incheon 22212, Republic of Korea.; Program in Biomedical Science & Engineering, Inha University, Incheon 22212, Republic of Korea.
Lee JS; Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon 22212, Republic of Korea.; Department of Molecular Medicine, College of Medicine, Inha University, Incheon 22212, Republic of Korea.; Program in Biomedical Science & Engineering, Inha University, Incheon 22212, Republic of Korea.
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Źródło:
Cells [Cells] 2022 Dec 15; Vol. 11 (24). Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA*
Cellular Senescence*/genetics
Cell Cycle Checkpoints ; Homeostasis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components.
Autorzy:
Sharma R; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India. .
Diwan B; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India.
Sharma A; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, 500037, India.
Witkowski JM; Department of Pathophysiology, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk, Poland. .
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Źródło:
Biogerontology [Biogerontology] 2022 Dec; Vol. 23 (6), pp. 699-729. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/physiology
Immunosenescence*
Humans ; Aged ; Aging/physiology ; Diet ; Immunotherapy
Czasopismo naukowe
Szczegóły
Tytuł:
Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging.
Autorzy:
Chung YP; Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Weng TI; Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chan DC; Department of Geriatrics and Gerontology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yang RS; Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liu SH; Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan. .; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. .; Department of Pediatrics, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan. .
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Źródło:
Archives of toxicology [Arch Toxicol] 2023 Feb; Vol. 97 (2), pp. 547-559. Date of Electronic Publication: 2022 Nov 01.
Typ publikacji:
Journal Article
MeSH Terms:
Cartilage, Articular*/drug effects
Cartilage, Articular*/metabolism
Cellular Senescence*/drug effects
Chondrocytes*/drug effects
Trialkyltin Compounds*/toxicity
Animals ; Humans ; Mice ; Aging/metabolism ; Cells, Cultured ; NF-kappa B/metabolism ; RNA, Messenger/metabolism ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Gliovascular interface abnormality in mice with endothelial cell senescence.
Autorzy:
Kawauchi S; Comprehensive Education and Research Center, Kobe Pharmaceutical University, Kobe, Japan.
Mizoguchi T; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan.
Horibe S; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan.
Tanaka T; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan.
Sasaki N; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan.
Ikeda K; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.
Emoto N; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.
Hirata KI; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Rikitake Y; Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan.
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Źródło:
Glia [Glia] 2023 Feb; Vol. 71 (2), pp. 467-479. Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
Laminin*/metabolism
Matrix Metalloproteinase 2*/metabolism
Cellular Senescence*
Neuroglia*/metabolism
Animals ; Mice ; Aquaporin 4/genetics ; Aquaporin 4/metabolism ; Astrocytes/metabolism ; Mice, Transgenic
Czasopismo naukowe
Szczegóły
Tytuł:
Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain.
Autorzy:
Neumann P; Institute of Anatomy, Universität Leipzig, Leipzig, Germany.
Lenz DE; Institute of Anatomy, Universität Leipzig, Leipzig, Germany.
Streit WJ; Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida, USA.
Bechmann I; Institute of Anatomy, Universität Leipzig, Leipzig, Germany.
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Źródło:
Glia [Glia] 2023 Feb; Vol. 71 (2), pp. 377-390. Date of Electronic Publication: 2022 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Microglia*/metabolism
Cellular Senescence*
Humans ; Aged ; Brain/metabolism ; Aging/pathology ; Ferritins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a.
Autorzy:
Zheng Y; Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, China.
Wu S; Center of Reproductive Medicine, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China.
Ke H; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Peng S; Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, China.
Hu C; Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, China. Electronic address: .
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Źródło:
Experimental gerontology [Exp Gerontol] 2023 Feb; Vol. 172, pp. 112062. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/physiology
Mesenchymal Stem Cells*/physiology
Autophagy/physiology ; Bone Marrow Cells/metabolism ; Interleukin-6/metabolism ; Interleukin-8 ; Forkhead Transcription Factors
Czasopismo naukowe
Szczegóły
Tytuł:
Bone-targeted delivery of senolytics to eliminate senescent cells increases bone formation in senile osteoporosis.
Autorzy:
Xing X; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Laboratory Center of Stomatology, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Tang Q; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of stomatology, West China School of Public Health & West China Fourth Hospital, Chengdu, Sichuan 610041, China.
Zou J; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Laboratory Center of Stomatology, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Huang H; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Yang J; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Gao X; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Xu X; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Ma S; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Li M; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Liang C; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Tan L; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Liao L; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: .
Tian W; National Engineering Laboratory for Oral Regenerative Medicine & Engineering Research Center of Oral Translational Medicine, Ministry of Education & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: .
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Źródło:
Acta biomaterialia [Acta Biomater] 2023 Feb; Vol. 157, pp. 352-366. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Osteoporosis*/pathology
Mice ; Animals ; Osteogenesis ; Senotherapeutics ; Quercetin/pharmacology ; Liposomes ; Aging/pathology ; Bone and Bones/pathology
Czasopismo naukowe
Szczegóły
Tytuł:
β-Galactosidase-Activatable Nile Blue-Based NIR Senoprobe for the Real-Time Detection of Cellular Senescence.
Autorzy:
Lozano-Torres B; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camí de Vera S/N, Valencia 46022, Spain.; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, C/ Eduardo Primo Yúfera 3, Valencia 46012, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.
García-Fernández A; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camí de Vera S/N, Valencia 46022, Spain.; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, C/ Eduardo Primo Yúfera 3, Valencia 46012, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Av. Fernando Abril Martorell, 10, Torre A 7a̲ planta, Valencia 46026, Spain.
Domínguez M; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camí de Vera S/N, Valencia 46022, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.
Sancenón F; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camí de Vera S/N, Valencia 46022, Spain.; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, C/ Eduardo Primo Yúfera 3, Valencia 46012, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Av. Fernando Abril Martorell, 10, Torre A 7a̲ planta, Valencia 46026, Spain.
Blandez JF; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camí de Vera S/N, Valencia 46022, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Av. Fernando Abril Martorell, 10, Torre A 7a̲ planta, Valencia 46026, Spain.
Martínez-Máñez R; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camí de Vera S/N, Valencia 46022, Spain.; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, C/ Eduardo Primo Yúfera 3, Valencia 46012, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Av. Fernando Abril Martorell, 10, Torre A 7a̲ planta, Valencia 46026, Spain.
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Źródło:
Analytical chemistry [Anal Chem] 2023 Jan 17; Vol. 95 (2), pp. 1643-1651. Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Mice ; Animals ; Cell Cycle Checkpoints/physiology ; Cell Line ; beta-Galactosidase/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Autorzy:
Yun J; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Hansen S; NBE Therapeutics, Hochbergstrasse 60C, 4057, Basel, Switzerland.
Morris O; Exscientia Ltd., The Schrödinger Building Oxford Science Park, Oxford, OX4 4GE, UK.
Madden DT; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Libeu CP; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Kumar AJ; Fred Hutch/University of Washington, 1100 Fairview Ave. N., Seattle, WA, 98109, USA.
Wehrfritz C; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Nile AH; Calico Labs LLC., 1170 Veterans Blvd, South San Francisco, CA, 94080, USA.
Zhang Y; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Zhou L; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Liang Y; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Modrusan Z; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Chen MB; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Overall CC; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Garfield D; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Campisi J; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Schilling B; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Hannoush RN; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .
Jasper H; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Jan 11; Vol. 14 (1), pp. 156. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/genetics
Intestines*
Animals ; Cell Differentiation ; Aging ; Stem Cells/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis.
Autorzy:
Nagao H; Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA.
Jayavelu AK; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; Proteomics and Cancer Cell Signaling Group, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cai W; Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA.; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, 11568, USA.
Pan H; Bioinformatics and Biostatistics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA.
Dreyfuss JM; Bioinformatics and Biostatistics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA.
Batista TM; Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA.
Brandão BB; Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA.
Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.
Kahn CR; Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 02215, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Jan 04; Vol. 14 (1), pp. 57. Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/genetics
Cell Division*/genetics
Protein-Tyrosine Kinases*/metabolism
Receptor, Insulin*/genetics
Receptor, Insulin*/metabolism
Cellular Senescence*/genetics
Insulin/metabolism ; Ligands ; Phosphorylation ; Humans ; Animals ; Mice
Czasopismo naukowe
Szczegóły
Tytuł:
Prolonged Rather Than Early Childhood Parent-Child Separation Predicts Change in Molecular Markers of Cellular Aging: A Consideration of the Role of Adolescence.
Autorzy:
Wang S; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China.
Zhao X; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China.
Yu Y; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Tao F; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China.; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, 230032, Anhui, China.; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China.
Liu D; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China. .
Sun Y; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China. .; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, 230032, Anhui, China. .; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui Province, China. .
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Źródło:
Journal of youth and adolescence [J Youth Adolesc] 2023 Jan; Vol. 52 (1), pp. 165-176. Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:
Journal Article
MeSH Terms:
Telomere Shortening*
Cellular Senescence*/genetics
Humans ; Adolescent ; Child, Preschool ; Child ; Cohort Studies ; Biomarkers ; Parent-Child Relations
Czasopismo naukowe
Szczegóły
Tytuł:
N6-Methyladenosine Methylation of mRNA in Cell Senescence.
Autorzy:
Zhang L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Xia J; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China. .; Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. .
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Źródło:
Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Jan; Vol. 43 (1), pp. 27-36. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
RNA-Binding Proteins*/genetics
RNA-Binding Proteins*/metabolism
Cellular Senescence*/genetics
Methylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Inhibition of cellular senescence hallmarks by mitochondrial transplantation in senescence-induced ARPE-19 cells.
Autorzy:
Noh SE; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Lee SJ; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Lee TG; Nano-Safety Team, Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS), Daejeon, Republic of Korea.
Park KS; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Kim JH; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: .
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Źródło:
Neurobiology of aging [Neurobiol Aging] 2023 Jan; Vol. 121, pp. 157-165. Date of Electronic Publication: 2022 Nov 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/physiology
Macular Degeneration*/therapy
Humans ; Retinal Pigment Epithelium/metabolism ; Mitochondria/metabolism ; Oxidative Stress
Czasopismo naukowe
Szczegóły
Tytuł:
The heterogeneity of cellular senescence: insights at the single-cell level.
Autorzy:
Cohn RL; UConn Center on Aging, UConn Health, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.
Gasek NS; UConn Center on Aging, UConn Health, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.
Kuchel GA; UConn Center on Aging, UConn Health, Farmington, CT, USA.
Xu M; UConn Center on Aging, UConn Health, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA. Electronic address: .
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Źródło:
Trends in cell biology [Trends Cell Biol] 2023 Jan; Vol. 33 (1), pp. 9-17. Date of Electronic Publication: 2022 May 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*/genetics
Aging*/metabolism
Humans
Czasopismo naukowe
Szczegóły
Tytuł:
Role of autophagy in aging: The good, the bad, and the ugly.
Autorzy:
Tabibzadeh S; Frontiers in Bioscience Research Institute in Aging and Cancer, Irvine, California, USA.
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Źródło:
Aging cell [Aging Cell] 2023 Jan; Vol. 22 (1), pp. e13753. Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*/genetics
Neoplasms*/genetics
Humans ; Aging/genetics ; Signal Transduction ; Autophagy/genetics
Czasopismo naukowe
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