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Wyszukujesz frazę ""Cellular Senescence"" wg kryterium: Temat


Tytuł :
Muscle-specific programmed cell death 5 deletion attenuates cardiac aging.
Autorzy :
Naz A; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Zhang S; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
An L; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Song Z; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Zi Z; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Wu J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lai S; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Mazhar H; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Xu M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Chen Y; Department of Immunology, School of Basic Medical Sciences, Peking University; NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
Zou Y; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
He L; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Zhu H; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. Electronic address: .
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Źródło :
International journal of cardiology [Int J Cardiol] 2021 Dec 15; Vol. 345, pp. 98-104. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*/genetics
Cellular Senescence*
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Mice ; Mitophagy ; Myocytes, Cardiac ; Neoplasm Proteins
Czasopismo naukowe
Tytuł :
Mechanisms and Regulation of Cellular Senescence.
Autorzy :
Roger L; Structure and Instability of Genomes Laboratory, Muséum National d'Histoire Naturelle (MNHN), CNRS-UMR 7196/INSERM U1154, 43 Rue Cuvier, 75005 Paris, France.
Tomas F; Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier, CNRS UMR 5237, 1919 Route de Mende, 34293 Montpellier, France.
Gire V; Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier, CNRS UMR 5237, 1919 Route de Mende, 34293 Montpellier, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 06; Vol. 22 (23). Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Cellular Senescence*
DNA Damage*
Senescence-Associated Secretory Phenotype*
Inflammation/*pathology
Animals ; Humans ; Inflammation/etiology ; Signal Transduction
Czasopismo naukowe
Tytuł :
The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities.
Autorzy :
Bima A; Department of Clinical Biochemistry, Faculty of Medicine, King AbdulAziz University, Jeddah 21465, Saudi Arabia.
Eldakhakhny B; Department of Clinical Biochemistry, Faculty of Medicine, King AbdulAziz University, Jeddah 21465, Saudi Arabia.
Nuwaylati D; Department of Clinical Biochemistry, Faculty of Medicine, University of Jeddah, Jeddah 21959, Saudi Arabia.
Alnami A; Department of Clinical Biochemistry, Faculty of Medicine, King AbdulAziz University, Jeddah 21465, Saudi Arabia.
Ajabnoor M; Department of Clinical Biochemistry, Faculty of Medicine, King AbdulAziz University, Jeddah 21465, Saudi Arabia.
Elsamanoudy A; Department of Clinical Biochemistry, Faculty of Medicine, King AbdulAziz University, Jeddah 21465, Saudi Arabia.; Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
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Źródło :
Nutrients [Nutrients] 2021 Nov 17; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Atherosclerosis*/blood
Cellular Senescence*
Non-alcoholic Fatty Liver Disease*/blood
Obesity/*complications
Vitamin D/*blood
Vitamin D Deficiency/*complications
Comorbidity ; Humans ; Inflammation/etiology ; Liver/pathology ; Metabolic Syndrome/blood ; Metabolic Syndrome/etiology ; Morbidity ; Obesity/blood ; Obesity/physiopathology ; Risk Factors ; Vitamin D Deficiency/blood
Czasopismo naukowe
Tytuł :
A common signature of cellular senescence; does it exist?
Autorzy :
Sikora E; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. Electronic address: .
Bielak-Zmijewska A; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Mosieniak G; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Nov; Vol. 71, pp. 101458. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*/genetics
Cellular Senescence*
DNA Damage ; Fibroblasts ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
Senolytics and the compression of late-life mortality.
Autorzy :
Kowald A; UK National Innovation Centre for Ageing, The Catalyst, 3 Science Square, Newcastle University, Newcastle upon Tyne NE4 5TG, UK; Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany. Electronic address: .
Kirkwood TBL; UK National Innovation Centre for Ageing, The Catalyst, 3 Science Square, Newcastle University, Newcastle upon Tyne NE4 5TG, UK; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Nov; Vol. 155, pp. 111588. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Senotherapeutics*
Aging ; Animals ; Longevity ; Mice
Czasopismo naukowe
Tytuł :
An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.
Autorzy :
Giri S; Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 061-0293, Japan.
Takada A; Division of Biochemistry, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Paudel D; Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Yoshida K; Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Furukawa M; Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan.
Kuramitsu Y; Research Institute of Cancer Prevention, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Matsushita K; Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan.
Abiko Y; Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Furuichi Y; Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 061-0293, Japan. .
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Źródło :
Odontology [Odontology] 2022 Jan; Vol. 110 (1), pp. 44-53. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Hydrogen Peroxide*/pharmacology
Cells, Cultured ; Epithelial Cells ; Gingiva ; Humans
Czasopismo naukowe
Tytuł :
The Quest to Define and Target Cellular Senescence in Cancer.
Autorzy :
Wang B; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Gronignen, the Netherlands.
Demaria M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Gronignen, the Netherlands. .
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Źródło :
Cancer research [Cancer Res] 2021 Dec 15; Vol. 81 (24), pp. 6087-6089.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Immunomodulation*
Antineoplastic Agents/*therapeutic use
Neoplasms/*drug therapy
Neoplasms/*pathology
Humans ; Neoplasms/immunology
Czasopismo naukowe
Tytuł :
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Autorzy :
Gulluni F; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Prever L; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Li H; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Krafcikova P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Praha, Czech Republic.
Corrado I; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Lo WT; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Margaria JP; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Chen A; Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
De Santis MC; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Cnudde SJ; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Fogerty J; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Yuan A; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Massarotti A; Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, 'A. Avogadro', Largo Donegani 2, 28100 Novara, Italy.
Sarijalo NT; Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany.
Vadas O; Section des Sciences Pharmaceutiques, University of Geneva, 1211 Geneva, Switzerland.; Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland.
Williams RL; Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Thelen M; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.
Powell DR; Pharmaceutical Biology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Schueler M; Division of Nephrology and Internal Intensive Care Medicine, Charite University, Berlin, Germany.
Wiesener MS; Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany.
Balla T; Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
Baris HN; Division of Pediatric Endocrinology, Ruth Children's Hospital, Rambam Medical Center, Haifa 30196, Israel.; The Genetics Institute, Rambam Health Care Campus, Haifa, Israel.; Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 30196, Israel.
Tiosano D; Division of Pediatric Endocrinology, Ruth Children's Hospital, Rambam Medical Center, Haifa 30196, Israel.; Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 30196, Israel.
McDermott BM Jr; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Freie Universität Berlin, Faculty of Biology, Chemistry and Pharmacy, 14195 Berlin, Germany.
Perkins BD; Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Ghigo A; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Martini M; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Haucke V; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.; Freie Universität Berlin, Faculty of Biology, Chemistry and Pharmacy, 14195 Berlin, Germany.
Boura E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Praha, Czech Republic.
Merlo GR; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Buchner DA; Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Hirsch E; Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Dec 10; Vol. 374 (6573), pp. eabk0410. Date of Electronic Publication: 2021 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Cytokinesis*
Cataract/*pathology
Endosomal Sorting Complexes Required for Transport/*metabolism
Lens, Crystalline/*cytology
Phosphatidylinositol 3-Kinases/*metabolism
Phosphatidylinositols/*metabolism
Aging, Premature ; Animals ; Biological Evolution ; Calcium-Binding Proteins/metabolism ; Cataract/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line ; Humans ; Lens, Crystalline/growth & development ; Lens, Crystalline/metabolism ; Mice ; Mutation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Tubulin/metabolism ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Autorzy :
Zampetidis CP; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Galanos P; Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark. Electronic address: .
Angelopoulou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Zhu Y; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Polyzou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Karamitros T; Unit of Bioinformatics and Applied Genomics, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Lagopati N; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Mourkioti I; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Mirzazadeh R; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Polyzos A; Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Garnerone S; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Mizi A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Gusmao EG; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Sofiadis K; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Gál Z; Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Larsen DH; Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Pefani DE; Laboratories of Biology, Medical School, University of Patras, 26504 Rio, Greece.
Demaria M; University of Groningen (RUG), European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), 9713 AV Groningen, the Netherlands.
Tsirigos A; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
Crosetto N; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Maya-Mendoza A; DNA Replication and Cancer Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Papaspyropoulos A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Bartek J; Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden. Electronic address: .
Papantonis A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany. Electronic address: .
Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, M20 4GJ Manchester, UK; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Dec 02; Vol. 81 (23), pp. 4907-4923.e8. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Chromosome Inversion*
Epithelial-Mesenchymal Transition*
Oncogenes*
Recombination, Genetic*
Chromosomes/*ultrastructure
Neoplasms/*genetics
Animals ; Bronchi/metabolism ; CRISPR-Cas Systems ; Cell Cycle ; Cell Transformation, Neoplastic ; Circadian Rhythm ; Computational Biology ; Epithelial Cells/metabolism ; Flow Cytometry ; Genomics ; Humans ; Karyotyping ; Mice ; Mice, SCID ; Neoplasms/metabolism ; Phenotype ; Protein Binding ; Protein Domains ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł :
Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.
Autorzy :
Fletcher-Sananikone E; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
Kanji S; Department of Neurosurgery, University of Texas Health, San Antonio, Texas.
Tomimatsu N; Department of Neurosurgery, University of Texas Health, San Antonio, Texas.
Di Cristofaro LFM; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil.
Kollipara RK; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas.
Saha D; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
Floyd JR; Department of Neurosurgery, University of Texas Health, San Antonio, Texas.
Sung P; Department of Biochemistry and Structural Biology, University of Texas Health, San Antonio, Texas.
Hromas R; Department of Medicine, University of Texas Health, San Antonio, Texas.
Burns TC; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
Kittler R; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas.
Habib AA; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas.; Veterans Affairs North Texas Health Care System, Dallas, Texas.
Mukherjee B; Department of Neurosurgery, University of Texas Health, San Antonio, Texas.
Burma S; Department of Neurosurgery, University of Texas Health, San Antonio, Texas. .; Department of Biochemistry and Structural Biology, University of Texas Health, San Antonio, Texas.
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Źródło :
Cancer research [Cancer Res] 2021 Dec 01; Vol. 81 (23), pp. 5935-5947. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cellular Senescence*
Senescence-Associated Secretory Phenotype*
Tumor Microenvironment*
Brain/*pathology
Gamma Rays/*adverse effects
Glioblastoma/*pathology
Neoplasm Recurrence, Local/*pathology
Aniline Compounds/pharmacology ; Animals ; Antineoplastic Agents/pharmacology ; Astrocytes/drug effects ; Astrocytes/metabolism ; Astrocytes/pathology ; Brain/drug effects ; Brain/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/etiology ; Glioblastoma/metabolism ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/metabolism ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress.
Autorzy :
Cao JY; Department of Nephrology, Taizhou People's Hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.
Ling LL; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Ni WJ; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Guo HL; Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yang M; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
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Źródło :
Renal failure [Ren Fail] 2021 Dec; Vol. 43 (1), pp. 556-565.
Typ publikacji :
Journal Article
MeSH Terms :
Aldosterone/*pharmacology
Autophagosomes/*drug effects
Cellular Senescence/*drug effects
Kidney/*metabolism
Oxidative Stress/*drug effects
Aldosterone/administration & dosage ; Animals ; Cell Line ; Cells, Cultured ; Cellular Senescence/physiology ; Epithelial Cells/metabolism ; Humans ; Kidney/cytology ; Kidney/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides.
Autorzy :
Deryabin PI; Mechanisms of Cellular Senescence Group, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, Saint Petersburg, Russia.
Shatrova AN; Laboratory of Intracellular Membranes Dynamic, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, Saint Petersburg, Russia.
Borodkina AV; Mechanisms of Cellular Senescence Group, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064, Saint Petersburg, Russia. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Dec; Vol. 78 (23), pp. 7757-7776. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*
Apoptosis*
Cellular Senescence*
Cardiac Glycosides/*pharmacology
Cardiotonic Agents/*pharmacology
Mesenchymal Stem Cells/*cytology
Humans ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Anagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1).
Autorzy :
Zhao J; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
He X; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
Zuo M; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
Li X; Department of Cardiovascular Medicine, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, China.
Sun Z; Department of Cardiology, The Fourth People's Hospital of Shaanxi, Xi'an, Shaanxi, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 3968-3977.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Gene Expression Regulation*/drug effects
Interleukin-1beta/*toxicity
Muscle, Smooth, Vascular/*pathology
Myocytes, Smooth Muscle/*pathology
Pyrimidines/*pharmacology
Sirtuin 1/*genetics
Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cytokines/metabolism ; Gene Silencing/drug effects ; Humans ; Inflammation Mediators/metabolism ; Protective Agents/pharmacology ; Pyrimidines/chemistry ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
The role of mitochondria in cellular senescence.
Autorzy :
Ghosh-Choudhary SK; Aging Institute, University of Pittsburgh School of Medicine/UPMC, Pittsburgh, Pennsylvania, USA.
Liu J; Aging Institute, University of Pittsburgh School of Medicine/UPMC, Pittsburgh, Pennsylvania, USA.
Finkel T; Aging Institute, University of Pittsburgh School of Medicine/UPMC, Pittsburgh, Pennsylvania, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Dec; Vol. 35 (12), pp. e21991.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cellular Senescence*
Mitochondria/*physiology
Reactive Oxygen Species/*metabolism
Animals ; Humans
Czasopismo naukowe
Tytuł :
Cellular senescence links mitochondria-ER contacts and aging.
Autorzy :
Ziegler DV; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France. .; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. .
Martin N; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France. .
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France. .
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Źródło :
Communications biology [Commun Biol] 2021 Nov 24; Vol. 4 (1), pp. 1323. Date of Electronic Publication: 2021 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*
Cellular Senescence*
Endoplasmic Reticulum/*metabolism
Mitochondria/*metabolism
Mitochondrial Membranes/*metabolism
Animals ; Humans ; Mice ; Rats ; Secretome/metabolism
Czasopismo naukowe
Tytuł :
Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening.
Autorzy :
Turkiewicz S; Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Ditmer M; Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Sochal M; Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Białasiewicz P; Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Strzelecki D; Department of Affective and Psychotic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Gabryelska A; Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 21; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cellular Senescence/*genetics
Sleep Apnea, Obstructive/*genetics
Telomere/*genetics
Telomere Shortening/*genetics
Aging/genetics ; Cellular Senescence/physiology ; Humans ; Leukocytes/metabolism ; Oxidative Stress/genetics ; Sleep Apnea, Obstructive/pathology
Czasopismo naukowe
Tytuł :
In vitro expansion of human adipose-derived stem cells with delayed senescence through dual stage release of curcumin from mesoporous silica nanoparticles/electrospun nanofibers.
Autorzy :
Serati-Nouri H; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rasoulpoor S; Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Pourpirali R; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sadeghi-Soureh S; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Esmaeilizadeh N; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Dadashpour M; Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Roshangar L; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Zarghami N; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicine, Faculty of Medicine, Istanbul Aydin University, Istanbul, Turkey. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119947. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Drug Liberation*
Adipose Tissue/*cytology
Cell- and Tissue-Based Therapy/*methods
Curcumin/*administration & dosage
Mesenchymal Stem Cells/*drug effects
Nanofibers/*chemistry
Nanoparticles/*chemistry
Animals ; Cell Adhesion/drug effects ; Cell Proliferation ; Cells, Cultured ; Curcumin/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gelatin/chemistry ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/physiology ; Mice ; Polyesters/chemistry ; RNA, Messenger/biosynthesis ; Silicon Dioxide/chemistry ; Telomerase/biosynthesis
Czasopismo naukowe
Tytuł :
Ferroptosis Induction in Multiple Myeloma Cells Triggers DNA Methylation and Histone Modification Changes Associated with Cellular Senescence.
Autorzy :
Logie E; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
Van Puyvelde B; Laboratory of Pharmaceutical Biotechnology, Proteomics and Mass Spectrometry Department, Ghent University, 9000 Ghent, Belgium.
Cuypers B; Biomedical Informatics Network Antwerp (Biomina), Department of Computer Science, University of Antwerp, 2610 Antwerp, Belgium.
Schepers A; Center of Medical Genetics, University of Antwerp & Antwerp University Hospital, 2650 Edegem, Belgium.
Berghmans H; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
Verdonck J; Center for Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.
Laukens K; Biomedical Informatics Network Antwerp (Biomina), Department of Computer Science, University of Antwerp, 2610 Antwerp, Belgium.
Godderis L; Center for Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.; IDEWE, External Service for Prevention and Protection at Work, 3001 Heverlee, Belgium.
Dhaenens M; Laboratory of Pharmaceutical Biotechnology, Proteomics and Mass Spectrometry Department, Ghent University, 9000 Ghent, Belgium.
Deforce D; Laboratory of Pharmaceutical Biotechnology, Proteomics and Mass Spectrometry Department, Ghent University, 9000 Ghent, Belgium.
Vanden Berghe W; Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES) and Integrated Personalized and Precision Oncology Network (IPPON), Department of Biomedical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 12; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
DNA Methylation*
Ferroptosis*
DNA, Neoplasm/*metabolism
Histones/*metabolism
Multiple Myeloma/*metabolism
Neoplasm Proteins/*metabolism
Histone Code ; Humans ; Multiple Myeloma/pathology
Czasopismo naukowe
Tytuł :
Dermal Pericytes Exhibit Declined Ability to Promote Human Skin Regeneration with Ageing in 3D Organotypic Culture Models.
Autorzy :
Zhuang L; Epithelial Stem Cell Biology Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia.; Medical Research Council Cancer Unit, Hutchison/MRC Centre, University of Cambridge, Cambridge CB2 0XZ, UK.
Visalakshan RM; Epithelial Stem Cell Biology Laboratory, Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia.
Kaur P; Epithelial Stem Cell Biology Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia.; Epithelial Stem Cell Biology Laboratory, Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia.
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Źródło :
Cells [Cells] 2021 Nov 06; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Culture Techniques*
Cellular Senescence*
Regeneration*
Dermis/*pathology
Pericytes/*pathology
Epidermis/pathology ; Fibroblasts/pathology ; Homeostasis ; Humans ; Infant, Newborn ; Male ; Mesoderm/pathology ; Pericytes/ultrastructure
Czasopismo naukowe
Tytuł :
Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury.
Autorzy :
Lim S; School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea.
Kim TJ; Department of Neurology, Seoul National University Hospital, Seoul 03080, Korea.; Department of Critical Care Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Kim YJ; Department of Neurology, Seoul National University Hospital, Seoul 03080, Korea.
Kim C; School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea.
Ko SB; Department of Neurology, Seoul National University Hospital, Seoul 03080, Korea.; Department of Critical Care Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Kim BS; School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea.; Interdisciplinary Program for Bioengineering, Seoul National University, Seoul 08826, Korea.; Institute of Chemical Processes, Seoul National University, Seoul 08826, Korea.; Institute of Engineering Research, Seoul National University, Seoul 08826, Korea.; Bio-MAX Institute, Seoul National University, Seoul 08826, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 04; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Aniline Compounds/*pharmacology
Brain Ischemia/*drug therapy
Reperfusion Injury/*drug therapy
Senotherapeutics/*pharmacology
Sulfonamides/*pharmacology
Animals ; Antineoplastic Agents/pharmacology ; Brain Ischemia/etiology ; Brain Ischemia/pathology ; Infarction, Middle Cerebral Artery/complications ; Male ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/etiology ; Reperfusion Injury/pathology
Czasopismo naukowe

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