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Wyszukujesz frazę ""Cellular Senescence"" wg kryterium: Temat


Tytuł:
YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells.
Autorzy:
Yu Y; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.
Chu C; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.; Department of Pathology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Wang K; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.
Li Y; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.; Biomedical publications center, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
Mao Z; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.
Hu L; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.
Wang J; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.
Yu Y; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China.
Sun H; Department of Emergency, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, Jiangsu, China. .; The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing, 211166, Jiangsu, China. .
Chen F; Department of Forensic Medicine, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, China. .; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211166, Jiangsu, China. .; Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, 214023, Jiangsu, China. .
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Źródło:
Respiratory research [Respir Res] 2024 May 18; Vol. 25 (1), pp. 212. Date of Electronic Publication: 2024 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
YAP-Signaling Proteins*/metabolism
Mice, Inbred C57BL*
Pulmonary Fibrosis*/metabolism
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/pathology
Adaptor Proteins, Signal Transducing*/metabolism
Transcription Factors*/metabolism
Transcription Factors*/genetics
Paraquat*/toxicity
Animals ; Humans ; Mice ; Male ; Transcriptional Coactivator with PDZ-Binding Motif Proteins/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Trans-Activators/metabolism ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł:
Cell Senescence in Heterotopic Ossification.
Autorzy:
Pignolo RJ; Department of Medicine, Section of Geriatric Medicine & Gerontology, Mayo Clinic, Rochester, MN 55905, USA.; Divisions of Endocrinology and Hospital Internal Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Kaplan FS; Department of Orthopaedic Surgery, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.; The Center for Research in FOP and Related Disorders, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Wang H; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
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Źródło:
Biomolecules [Biomolecules] 2024 Apr 16; Vol. 14 (4). Date of Electronic Publication: 2024 Apr 16.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Ossification, Heterotopic*/genetics
Ossification, Heterotopic*/pathology
Ossification, Heterotopic*/metabolism
Cellular Senescence*/genetics
Myositis Ossificans*/genetics
Myositis Ossificans*/pathology
Myositis Ossificans*/metabolism
Humans ; Animals ; Activin Receptors, Type I/genetics ; Activin Receptors, Type I/metabolism
Czasopismo naukowe
Tytuł:
Cellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC.
Autorzy:
Zhou L; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China. .; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China. .
Zeng Y; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Department of Urology, Zhengzhou Key Laboratory for Molecular Biology of Urological Tumor Research, Henan Institute of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Liu Y; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Du K; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Luo Y; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Dai Y; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Department of Urology, Zhengzhou Key Laboratory for Molecular Biology of Urological Tumor Research, Henan Institute of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Pan W; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Zhang L; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China.
Zhang L; Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China. zhanglei_.
Tian F; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China. .
Gu C; Department of Urology, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China. .; Unit of Day Surgery Center, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan Province, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Apr 11; Vol. 24 (1), pp. 451. Date of Electronic Publication: 2024 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Renal Cell*/genetics
Cellular Senescence*/genetics
Kidney Neoplasms*
Metabolic Reprogramming*
Receptors, Prostaglandin E, EP4 Subtype*
Humans ; Sequence Analysis, RNA ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł:
Subcellular structure, heterogeneity, and plasticity of senescent cells.
Autorzy:
Bitencourt TC; Programa de Pós-Graduação Em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Vargas JE; Departamento de Biologia Celular, Universidade Do Paraná, Curitiba, Paraná, Brazil.
Silva AO; Faculdade Estácio RS, Porto Alegre, Rio Grande do Sul, Brazil.; Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Fraga LR; Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.; Programa de Pós-Graduação Em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Departamento de Ciências Morfológicas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Filippi-Chiela E; Programa de Pós-Graduação Em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.; Departamento de Ciências Morfológicas, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
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Źródło:
Aging cell [Aging Cell] 2024 Apr; Vol. 23 (4), pp. e14154. Date of Electronic Publication: 2024 Mar 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*/genetics
Telomere Shortening*
Humans ; Phenotype ; Cells, Cultured ; Oxidative Stress
Czasopismo naukowe
Tytuł:
A molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.
Autorzy:
Hamsanathan S; Aging Institute of UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Anthonymuthu T; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Prosser D; Department of Medicine, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Lokshin A; Department of Medicine, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Greenspan SL; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Resnick NM; Aging Institute of UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Perera S; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Okawa S; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Narasimhan G; Bioinformatics Research Group (BioRG), School of Computing and Information Sciences, Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA.
Gurkar AU; Aging Institute of UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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Źródło:
Aging cell [Aging Cell] 2024 Apr; Vol. 23 (4), pp. e14104. Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Secretome*
Humans ; Aging/genetics ; Aging/metabolism ; Metabolome ; Biomarkers/metabolism
Czasopismo naukowe
Tytuł:
The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation.
Autorzy:
Ibragimova M; Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Kussainova A; Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.; Department of Health Sciences, University of Genova, Via Pastore 1, 16132 Genoa, Italy.
Aripova A; Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Bersimbaev R; Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Bulgakova O; Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
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Źródło:
Cells [Cells] 2024 Mar 21; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Aging*
Cellular Senescence*/genetics
Humans ; Cells, Cultured ; Radiation, Ionizing
Czasopismo naukowe
Tytuł:
High Glucose Promotes and Aggravates the Senescence and Dysfunction of Vascular Endothelial Cells in Women with Hyperglycemia in Pregnancy.
Autorzy:
Zheng L; Department of Gynecology and Obstetrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Li M; Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200080, China.
Li H; Department of Gynecology and Obstetrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.; Department of Gynecology and Obstetrics, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai 201599, China.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 10; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Hyperglycemia*
Humans ; Female ; Pregnancy ; Human Umbilical Vein Endothelial Cells ; Aging ; Glucose/pharmacology
Czasopismo naukowe
Tytuł:
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
Autorzy:
Mahoney SA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Venkatasubramanian R; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Darrah MA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Ludwig KR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
VanDongen NS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Greenberg NT; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Longtine AG; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Hutton DA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Brunt VE; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Campisi J; Buck Institute for Research on Aging, Novato, California, USA.; Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Melov S; Buck Institute for Research on Aging, Novato, California, USA.
Seals DR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Rossman MJ; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Clayton ZS; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
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Źródło:
Aging cell [Aging Cell] 2024 Mar; Vol. 23 (3), pp. e14060. Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/genetics
Arteries*
Flavonols*
Mice ; Humans ; Animals ; Dietary Supplements ; Inflammation
Czasopismo naukowe
Tytuł:
Nucleobindin 2 inhibits senescence in gastric carcinoma.
Autorzy:
Ishibashi Y; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.; Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Itoh T; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.; Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Oguri Y; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Hashimura M; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Yokoi A; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Matsumoto T; Department of Pathology, Kitasato University School of Allied Health Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Harada Y; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.; Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Fukagawa N; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.; Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Hayashi M; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Ono M; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Kusano C; Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Saegusa M; Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2024 May 17; Vol. 14 (1), pp. 11261. Date of Electronic Publication: 2024 May 17.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/pathology
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Nucleobindins*/metabolism
Cellular Senescence*
Humans ; Female ; Male ; Cell Line, Tumor ; Middle Aged ; Aged ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Apoptosis ; Cell Movement ; Prognosis
Czasopismo naukowe
Tytuł:
Enhancing chronic wound healing with Thai indigenous rice variety, Kaab Dum: Exploring ER stress and senescence inhibition in HaCaT keratinocyte cell line.
Autorzy:
Payuhakrit W; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.; Pathobiology Information and Learning Center, Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Panpinyaporn P; Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Khumsri W; Interdisciplinary Program of Biomedical Sciences, Graduate School, Chulalongkorn University, Bangkok, Thailand.
Yusakul G; School of Pharmacy, Walailak University, Nakhon Si Thammarat, Thailand.
Praphasawat R; Department of Pathology, School of Medicine, University of Phayao, Phayao, Thailand.
Nuengchamnong N; Science Lab Centre, Faculty of Science, Naresuan University, Phitsanulok, Thailand.
Palipoch S; School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand.
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Źródło:
PloS one [PLoS One] 2024 May 15; Vol. 19 (5), pp. e0302662. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Oryza*/chemistry
Cellular Senescence*/drug effects
Wound Healing*/drug effects
Endoplasmic Reticulum Stress*/drug effects
Keratinocytes*/drug effects
Keratinocytes*/metabolism
Plant Extracts*/pharmacology
Humans ; Thailand ; Cell Line ; HaCaT Cells ; Oxidative Stress/drug effects ; Transforming Growth Factor beta/metabolism ; Cell Cycle Checkpoints/drug effects ; Southeast Asian People
Czasopismo naukowe
Tytuł:
Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway.
Autorzy:
Chen X; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Chen K; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Hu J; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Dong Y; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Zheng M; Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Jiang J; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Hu Q; Department of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. .
Zhang W; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. .
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Źródło:
Communications biology [Commun Biol] 2024 May 07; Vol. 7 (1), pp. 539. Date of Electronic Publication: 2024 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nucleus Pulposus*/metabolism
Nucleus Pulposus*/drug effects
Nucleus Pulposus*/pathology
Nucleus Pulposus*/cytology
Endoplasmic Reticulum Stress*/drug effects
Palmitic Acid*/metabolism
Palmitic Acid*/pharmacology
Cellular Senescence*/drug effects
Intervertebral Disc Degeneration*/metabolism
Intervertebral Disc Degeneration*/pathology
Lipid Droplets*/metabolism
Humans ; Male ; Female ; Adult ; Middle Aged
Czasopismo naukowe
Tytuł:
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression.
Autorzy:
Lozano-Vidal N; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Stanicek L; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.; Institute of Cardiovascular Regeneration, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Bink DI; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Juni RP; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Hooglugt A; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.; Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.
Kremer V; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Phelp P; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
van Bergen A; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
MacInnes AW; Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
Dimmeler S; Institute of Cardiovascular Regeneration, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Potsdamer Strasse 58, 10785, Berlin, Germany.
Boon RA; Department of Physiology, Amsterdam UMC, VU University, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands. .; Amsterdam Cardiovascular Sciences, Microcirculation, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. .; Institute of Cardiovascular Regeneration, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. .; German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Potsdamer Strasse 58, 10785, Berlin, Germany. .
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Źródło:
Communications biology [Commun Biol] 2024 May 07; Vol. 7 (1), pp. 541. Date of Electronic Publication: 2024 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mice, Knockout*
Semaphorins*/metabolism
Semaphorins*/genetics
Cellular Senescence*
Human Umbilical Vein Endothelial Cells*/metabolism
Animals ; Mice ; Humans ; Endothelial Cells/metabolism ; Aging/metabolism ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Mice, Inbred C57BL ; Membrane Glycoproteins/metabolism ; Membrane Glycoproteins/genetics ; Endothelium, Vascular/metabolism
Czasopismo naukowe
Tytuł:
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Autorzy:
Chen SJ; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, 430030, Wuhan, China.
Yu F; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
Feng X; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, 430030, Wuhan, China.
Li Q; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, 430030, Wuhan, China.
Jiang YH; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.
Zhao LQ; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.
Cheng PP; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, 430030, Wuhan, China.
Wang M; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, 430030, Wuhan, China.
Song LJ; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
Liang LM; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
He XL; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
Xiong L; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
Xiang F; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
Wang X; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China.; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China.
Ye H; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, 430030, Wuhan, China. .; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China. .
Ma WL; Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, China. .; Key Laboratory of Respiratory Diseases, National Health Commission of China, Wuhan, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Apr 26; Vol. 22 (1), pp. 245. Date of Electronic Publication: 2024 Apr 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bleomycin*
Cellular Senescence*
Circadian Rhythm*/genetics
Pulmonary Fibrosis*/pathology
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/genetics
Pulmonary Fibrosis*/metabolism
Animals ; Humans ; Male ; Mice ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Homeodomain Proteins/metabolism ; Homeodomain Proteins/genetics ; Mice, Inbred C57BL ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł:
CD4 T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets.
Autorzy:
Gao Y; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Lu Y; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Liang X; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Zhao M; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Yu X; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Fu H; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Yang W; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
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Źródło:
Cells [Cells] 2024 Apr 25; Vol. 13 (9). Date of Electronic Publication: 2024 Apr 25.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Neurodegenerative Diseases*/immunology
Neurodegenerative Diseases*/pathology
Neurodegenerative Diseases*/therapy
CD4-Positive T-Lymphocytes*/immunology
Cellular Senescence*/immunology
Humans ; Animals ; Aging/immunology ; Aging/pathology ; T-Cell Senescence
Czasopismo naukowe
Tytuł:
Microcephaly Gene Mcph1 Deficiency Induces p19ARF-Dependent Cell Cycle Arrest and Senescence.
Autorzy:
Jiang YN; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Gao Y; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Lai X; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Li X; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Liu G; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Ding M; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Wang Z; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Guo Z; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Qin Y; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Li X; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Sun L; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
Wang ZQ; State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Zhou ZW; Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 23; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/genetics
Mice, Knockout*
Microcephaly*/genetics
Microcephaly*/metabolism
Microcephaly*/pathology
Cell Cycle Checkpoints*/genetics
Cyclin-Dependent Kinase Inhibitor p16*/genetics
Cyclin-Dependent Kinase Inhibitor p16*/metabolism
Cyclin-Dependent Kinase Inhibitor p16*/deficiency
Animals ; Mice ; E2F1 Transcription Factor/genetics ; E2F1 Transcription Factor/metabolism ; Fibroblasts/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism
Czasopismo naukowe
Tytuł:
Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence.
Autorzy:
Wu D; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sun JK; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chow KH; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China.; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.; Nexus of Rare Neurodegenerative Diseases, The Chinese University of Hong Kong, Hong Kong SAR, China.
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Źródło:
PLoS biology [PLoS Biol] 2024 Apr 23; Vol. 22 (4), pp. e3002559. Date of Electronic Publication: 2024 Apr 23 (Print Publication: 2024).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Cellular Senescence*/genetics
Brain*/metabolism
Brain*/pathology
Aging*/physiology
Aging*/genetics
Cell Cycle*/genetics
Alzheimer Disease*/pathology
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Neurons*/metabolism
Neurons*/pathology
Animals ; Humans ; Mice ; Transcriptome/genetics ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Parkinson Disease/metabolism ; Gene Expression Profiling ; Male ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Mice, Inbred C57BL ; Aged
Czasopismo naukowe
Tytuł:
ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder.
Autorzy:
Przyklenk M; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Karmacharya S; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Bonasera D; Genetic Instability, Cell Death and Inflammation Laboratory, Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Pasanen-Zentz AL; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Kmoch S; Research Unit of Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Paulsson M; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Wagener R; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Liccardi G; Genetic Instability, Cell Death and Inflammation Laboratory, Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Schiavinato A; Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany. .; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. .; Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 23; Vol. 14 (1), pp. 9321. Date of Electronic Publication: 2024 Apr 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fibroblasts*/metabolism
Cellular Senescence*/genetics
Alopecia*/metabolism
Alopecia*/pathology
Alopecia*/genetics
Anodontia*
Growth Disorders*
Microfilament Proteins*
Humans ; Receptors, Cell Surface/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/deficiency ; Optic Atrophies, Hereditary/genetics ; Optic Atrophies, Hereditary/metabolism ; Actins/metabolism ; Progeria/genetics ; Progeria/pathology ; Progeria/metabolism
SCR Disease Name:
Growth retardation, Alopecia, Pseudoanodontia and Optic atrophy
Czasopismo naukowe
Tytuł:
Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age.
Autorzy:
Fullard N; Department of Biosciences, Durham University, Durham DH1 3LE, UK.
Wordsworth J; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Welsh C; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Maltman V; Department of Biosciences, Durham University, Durham DH1 3LE, UK.
Bascom C; Proctor & Gamble, Cincinnati, OH 45201, USA.
Tasseff R; Proctor & Gamble, Cincinnati, OH 45201, USA.
Isfort R; Proctor & Gamble, Cincinnati, OH 45201, USA.
Costello L; Department of Biosciences, Durham University, Durham DH1 3LE, UK.
Scanlan RL; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Przyborski S; Department of Biosciences, Durham University, Durham DH1 3LE, UK.
Shanley D; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
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Źródło:
Cells [Cells] 2024 Apr 09; Vol. 13 (8). Date of Electronic Publication: 2024 Apr 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Fibroblasts*/metabolism
Skin*/metabolism
Skin*/cytology
Collagen*/metabolism
Humans ; Adult ; Extracellular Matrix/metabolism ; Infant, Newborn ; Aging/metabolism ; Cell Proliferation ; Matrix Metalloproteinases/metabolism ; Cell Movement ; Cells, Cultured ; Middle Aged
Czasopismo naukowe
Tytuł:
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence.
Autorzy:
Wan R; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Long S; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Ma S; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Yan P; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Li Z; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Xu K; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Lian H; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Li W; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Duan Y; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Zhu M; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China.
Wang L; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China. .; College of Life Science, Henan Normal University, Xinxiang, Henan, China. .
Yu G; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Pingyuan Laboratory, Henan Normal University, Xinxiang, 453007, Henan, China. .; College of Life Science, Henan Normal University, Xinxiang, Henan, China. .
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Źródło:
Respiratory research [Respir Res] 2024 Apr 02; Vol. 25 (1), pp. 154. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Idiopathic Pulmonary Fibrosis*/drug therapy
Animals ; Mice ; Bleomycin/adverse effects ; Epithelial Cells/metabolism ; Lung/metabolism
Czasopismo naukowe
Tytuł:
Vitamin D 3 inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing.
Autorzy:
Sayegh S; Division of Medicine, University College London, London, UK.
Fantecelle CH; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Laphanuwat P; Division of Medicine, University College London, London, UK.
Subramanian P; Division of Medicine, University College London, London, UK.
Rustin MHA; Department of Dermatology, Royal Free Hospital, London, UK.
Gomes DCO; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Akbar AN; Division of Medicine, University College London, London, UK.
Chambers ES; Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
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Źródło:
Aging cell [Aging Cell] 2024 Apr; Vol. 23 (4), pp. e14093. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*/genetics
Cholecalciferol*/pharmacology
Cholecalciferol*/metabolism
Adult ; Humans ; Aged ; p38 Mitogen-Activated Protein Kinases/metabolism ; Aging ; Fibroblasts/metabolism ; Inflammation Mediators/metabolism ; Immunity
Czasopismo naukowe

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