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Wyświetlanie 1-8 z 8
Tytuł:
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.
Autorzy:
Kumar RJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Chao HX; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Simpson DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Feng W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cho MG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Roberts VR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sullivan AR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Shah SJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Wozny AS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Fagan-Solis K; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kumar S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Luthman A; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ramsden DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Purvis JE; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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Źródło:
NAR cancer [NAR Cancer] 2020 Dec; Vol. 2 (4), pp. zcaa038. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.
Autorzy:
Son S; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Stevens MM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chao HX; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Thoreen C; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA, USA.
Hosios AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Schweitzer LD; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA, USA.
Weng Y; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wood K; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA, USA.
Sabatini D; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA, USA.
Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.
Manalis S; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 21; Vol. 10 (1), pp. 12054. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji:
Published Erratum
Tytuł:
Bistable switches as integrators and actuators during cell cycle progression.
Autorzy:
Stallaert W; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Kedziora KM; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Chao HX; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Purvis JE; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
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Źródło:
FEBS letters [FEBS Lett] 2019 Oct; Vol. 593 (20), pp. 2805-2816. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
DNA Repair*/drug effects
Cell Cycle/*genetics
Cell Cycle Checkpoints/*genetics
Cyclin-Dependent Kinases/*genetics
E2F Transcription Factors/*genetics
Retinoblastoma Protein/*genetics
Animals ; Cell Cycle/drug effects ; Cell Cycle Checkpoints/drug effects ; Cyclin-Dependent Kinases/metabolism ; DNA Damage/drug effects ; DNA Replication/drug effects ; E2F Transcription Factors/metabolism ; Eukaryotic Cells/cytology ; Eukaryotic Cells/drug effects ; Eukaryotic Cells/metabolism ; Gene Expression Regulation ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Mitogens/pharmacology ; Retinoblastoma Protein/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Evidence that the human cell cycle is a series of uncoupled, memoryless phases.
Autorzy:
Chao HX; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum for Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Fakhreddin RI; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shimerov HK; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kedziora KM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kumar RJ; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Perez J; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Limas JC; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Grant GD; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cook JG; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Purvis JE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA jeremy_.; Curriculum for Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Źródło:
Molecular systems biology [Mol Syst Biol] 2019 Mar 18; Vol. 15 (3), pp. e8604. Date of Electronic Publication: 2019 Mar 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle/*physiology
Cyclin-Dependent Kinase 2/*antagonists & inhibitors
DNA Replication/*genetics
Cyclin D/genetics ; Cyclin D/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; DNA Damage ; Humans ; Oncogenes/genetics ; Temperature
Czasopismo naukowe
Tytuł:
The Cell Cycle Browser: An Interactive Tool for Visualizing, Simulating, and Perturbing Cell-Cycle Progression.
Autorzy:
Borland D; Renaissance Computing Institute, University of North Carolina, Chapel Hill, 100 Europa Drive, Suite 540, Chapel Hill, NC 27517, USA.
Yi H; Renaissance Computing Institute, University of North Carolina, Chapel Hill, 100 Europa Drive, Suite 540, Chapel Hill, NC 27517, USA.
Grant GD; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Kedziora KM; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Chao HX; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Haggerty RA; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Kumar J; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Wolff SC; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Cook JG; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Purvis JE; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA. Electronic address: jeremy_.
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Źródło:
Cell systems [Cell Syst] 2018 Aug 22; Vol. 7 (2), pp. 180-184.e4. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle*
Computer Simulation*
Models, Biological*
Software*
Cell Proliferation ; Cell Survival ; Flow Cytometry/methods ; Humans ; Image Processing, Computer-Assisted/methods
Czasopismo naukowe
Tytuł:
Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle.
Autorzy:
Chao HX; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Poovey CE; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Privette AA; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Grant GD; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Chao HY; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Cook JG; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA.
Purvis JE; Department of Genetics, University of North Carolina, Chapel Hill, Genetic Medicine Building 5061, CB#7264, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599-7264, USA. Electronic address: jeremy_.
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Źródło:
Cell systems [Cell Syst] 2017 Nov 22; Vol. 5 (5), pp. 445-459.e5. Date of Electronic Publication: 2017 Oct 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle Checkpoints/*genetics
DNA Damage/*genetics
Cell Line ; Cell Proliferation/genetics ; Humans
Czasopismo naukowe
Tytuł:
Cooperative nutrient accumulation sustains growth of mammalian cells.
Autorzy:
Son S
Stevens MM
Chao HX
Thoreen C; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA.
Hosios AM
Schweitzer LD; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA.
Weng Y; Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, MA.
Wood K; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA.
Sabatini D; Whitehead Institute for Biomedical Research Nine Cambridge Center, Cambridge, MA.
Vander Heiden MG; Dana-Farber Cancer Institute, Boston, MA.
Manalis S
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Źródło:
Scientific reports [Sci Rep] 2015 Dec 01; Vol. 5, pp. 17401. Date of Electronic Publication: 2015 Dec 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Proliferation/*drug effects
Culture Media/*chemistry
Culture Media/*pharmacology
Signal Transduction/*drug effects
Cell Culture Techniques ; Cell Line ; Humans
Czasopismo naukowe
Tytuł:
Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids.
Autorzy:
Yurtsev EA; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chao HX
Datta MS
Artemova T
Gore J
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Źródło:
Molecular systems biology [Mol Syst Biol] 2013 Aug 06; Vol. 9, pp. 683. Date of Electronic Publication: 2013 Aug 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Escherichia coli/*drug effects
Gene Transfer, Horizontal/*drug effects
Plasmids/*metabolism
Quorum Sensing/*genetics
beta-Lactam Resistance/*drug effects
Ampicillin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Bacterial Load/drug effects ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Models, Genetic ; Plasmids/agonists ; beta-Lactam Resistance/genetics ; beta-Lactamase Inhibitors ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
Czasopismo naukowe
    Wyświetlanie 1-8 z 8

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