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Wyświetlanie 1-17 z 17
Tytuł :
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Autorzy :
Che H; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang, China.
Wang Y; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li Y; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Lv J; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li H; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Liu Y; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, China.
Dong R; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, China.
Sun Y; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Xu X; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhao J; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Wang L; Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2020 Nov; Vol. 235 (11), pp. 7769-7779. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetic Cardiomyopathies/*metabolism
Fibroblasts/*pathology
Glucose/*toxicity
MicroRNAs/*metabolism
Smad7 Protein/*metabolism
Animals ; Cells, Cultured ; Diabetic Cardiomyopathies/pathology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibrosis ; Gene Expression Regulation ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
miR-150 regulates glucose utilization through targeting GLUT4 in insulin-resistant cardiomyocytes.
Autorzy :
Ju J; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Xiao D; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.; Department of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China.
Shen N; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.; Department of Pharmacy (Department of Clinical Medicine), ShaoXing Municipal Hospital, Shaoxing 312000, China.
Zhou T; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.; Department of Pharmacy, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Che H; Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Li X; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Zhang S; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Mokembo JN; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Jha NK; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Monayo SM; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Wang Z; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.
Zhang Y; Department of Pharmacology, Harbin Medical University (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin 150081, China.; Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin 150086, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Oct 19; Vol. 52 (10), pp. 1111-1119.
Typ publikacji :
Journal Article
MeSH Terms :
Glucose Transporter Type 4/*metabolism
Insulin Resistance/*genetics
MicroRNAs/*genetics
MicroRNAs/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Animals, Newborn ; Biological Transport/genetics ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Glucose/metabolism ; Glucose Transporter Type 4/genetics ; Heart/physiopathology ; Insulin/metabolism ; Male ; MicroRNAs/antagonists & inhibitors ; Myocardium/cytology ; Myocardium/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/ultrastructure ; Primary Cell Culture ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
The long non-coding RNA LOC285758 promotes invasion of acute myeloid leukemia cells by down-regulating miR-204-5p.
Autorzy :
Xue F; Laboratory Medicine, Jingmen No. 1 People's Hospital, China.
Che H; Laboratory Medicine, Jingmen No. 1 People's Hospital, China.
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Źródło :
FEBS open bio [FEBS Open Bio] 2020 May; Vol. 10 (5), pp. 734-743. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid, Acute/*genetics
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Apoptosis/genetics ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Survival/genetics ; China ; Gene Expression/genetics ; Gene Expression Regulation, Leukemic/genetics ; Humans ; Leukemia, Myeloid, Acute/metabolism ; MicroRNAs/metabolism ; Neoplasm Invasiveness/genetics ; RNA, Long Noncoding/metabolism
Czasopismo naukowe
Tytuł :
miR-101-3p/Rap1b signal pathway plays a key role in osteoclast differentiation after treatment with bisphosphonates.
Autorzy :
Li J; Department of Orthopaedics, Xuzhou Central Hospital, Clinical School of Xuzhou Medical University, Xuzhou, Jiangsu 221009, China.
Li Y; Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Wang S; Department of Orthopedics Surgery, Henan Province People's Hospital, Zhengzhou, Henan 450003, China.
Che H; Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Wu J; The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Ren Y; Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
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Źródło :
BMB reports [BMB Rep] 2019 Sep; Vol. 52 (9), pp. 572-576.
Typ publikacji :
Wiadomości
MeSH Terms :
Diphosphonates/*therapeutic use
MicroRNAs/*metabolism
Osteoclasts/*drug effects
Osteoclasts/*metabolism
rap GTP-Binding Proteins/*metabolism
Animals ; Cell Differentiation/drug effects ; Female ; Mice ; MicroRNAs/genetics ; Osteoporosis/metabolism ; Signal Transduction/drug effects ; rap GTP-Binding Proteins/genetics
Periodyk
Tytuł :
High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition.
Autorzy :
Li Q; Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Li Z; Department of Pharmacology (The State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjang 150081, P.R. China.
Lin Y; Department of Pharmacology (The State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjang 150081, P.R. China.
Che H; Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Hu Y; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Kang X; Department of Pharmacology (The State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjang 150081, P.R. China.
Zhang Y; Department of Pharmacology (The State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjang 150081, P.R. China.
Wang L; Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Zhang Y; Department of Pharmacology (The State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjang 150081, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2019 Apr; Vol. 19 (4), pp. 3190-3200. Date of Electronic Publication: 2019 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition/*genetics
Glucose/*metabolism
Liver Cirrhosis/*etiology
Liver Cirrhosis/*metabolism
MicroRNAs/*genetics
Neoplasm Proteins/*genetics
Animals ; Biomarkers ; Cells, Cultured ; Diabetes Mellitus, Experimental ; Disease Models, Animal ; Disease Progression ; Disease Susceptibility ; Gene Expression Regulation ; Glucose/adverse effects ; Hyperglycemia/complications ; Hyperglycemia/metabolism ; Liver Cirrhosis/pathology ; Male ; RNA Interference ; Rats
Czasopismo naukowe
Tytuł :
MicroRNA let-7c-5p Suppressed Lipopolysaccharide-Induced Dental Pulp Inflammation by Inhibiting Dentin Matrix Protein-1-Mediated Nuclear Factor kappa B (NF-κB) Pathway In Vitro and In Vivo.
Autorzy :
Yuan H; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Zhang H; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Hong L; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Zhao H; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Wang J; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Li H; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Che H; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
Zhang Z; Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2018 Sep 21; Vol. 24, pp. 6656-6665. Date of Electronic Publication: 2018 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Extracellular Matrix Proteins/*antagonists & inhibitors
Extracellular Matrix Proteins/*metabolism
MicroRNAs/*genetics
MicroRNAs/*metabolism
NF-kappa B/*metabolism
Phosphoproteins/*antagonists & inhibitors
Phosphoproteins/*metabolism
Animals ; Cell Differentiation/physiology ; Cell Survival/genetics ; Cells, Cultured ; Dental Pulp/drug effects ; Dental Pulp/metabolism ; Dentin/metabolism ; Extracellular Matrix Proteins/genetics ; Inflammation/genetics ; Inflammation/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; NF-kappa B/genetics ; Phosphoproteins/genetics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Effects of miR-23b on hypoxia-induced cardiomyocytes apoptosis.
Autorzy :
He W; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address: .
Che H; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Jin C; Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Ge S; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2017 Dec; Vol. 96, pp. 812-817. Date of Electronic Publication: 2017 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Hypoxia/*metabolism
MicroRNAs/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Caspase 3/metabolism ; Cell Proliferation/physiology ; Cells, Cultured ; Child ; Female ; Humans ; In Situ Nick-End Labeling/methods ; Male ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Up-Regulation/physiology ; bcl-2-Associated X Protein/metabolism ; bcl-Associated Death Protein/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-211 expression is down-regulated and associated with poor prognosis in human glioma.
Autorzy :
Zhang J; Department of Neurosurgery, Dalang Hospital, Dongguan, 523770, Guangdong, China.
Lv J; Department of Neurosurgery, Dalang Hospital, Dongguan, 523770, Guangdong, China.
Zhang F; Department of Neurosurgery, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.
Che H; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Medical University, Xi'an, 710077, Shaanxi, China.
Liao Q; Department of Neurosurgery, Dalang Hospital, Dongguan, 523770, Guangdong, China.
Huang W; Department of Neurosurgery, Dalang Hospital, Dongguan, 523770, Guangdong, China.
Li S; Department of Neurosurgery, People's Hospital, Dongguan, 523770, Guangdong, China. .
Li Y; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, Shaanxi, China. .
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Źródło :
Journal of neuro-oncology [J Neurooncol] 2017 Jul; Vol. 133 (3), pp. 553-559. Date of Electronic Publication: 2017 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Brain Neoplasms/*metabolism
Glioma/*metabolism
MicroRNAs/*metabolism
Biomarkers, Tumor/metabolism ; Brain/pathology ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic ; Glioma/pathology ; Glioma/therapy ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Prognosis ; Proportional Hazards Models ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion.
Autorzy :
Che H; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Yan Y; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Kang XH; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Guo F; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Yan ML; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Liu HL; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, China.
Hou X; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, China.
Liu T; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Zong DK; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Sun LL; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Bao YN; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Sun LH; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Yang BF; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Ai J; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150086, China. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2017 May; Vol. 54 (4), pp. 2595-2610. Date of Electronic Publication: 2016 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*metabolism
Hippocampus/*metabolism
Lysosomes/*metabolism
MicroRNAs/*metabolism
Animals ; Autophagy/genetics ; Base Sequence ; Brain Ischemia/pathology ; Chronic Disease ; Down-Regulation/genetics ; Hippocampus/ultrastructure ; Lysosomal-Associated Membrane Protein 2/metabolism ; Lysosomes/ultrastructure ; Male ; MicroRNAs/genetics ; Microtubule-Associated Proteins/metabolism ; Phagosomes/metabolism ; Phagosomes/ultrastructure ; Rats, Sprague-Dawley ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Sequestosome-1 Protein/metabolism ; Vacuoles/metabolism ; Vacuoles/ultrastructure
Czasopismo naukowe
Tytuł :
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
Autorzy :
Sun LH; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China. .
Yan ML; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Hu XL; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Peng LW; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Che H; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Bao YN; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Guo F; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Liu T; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Chen X; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Zhang R; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Ban T; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Wang N; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China.
Liu HL; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150081, China.
Hou X; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, 150081, China.
Ai J; Department of Pharmacology, Harbin Medical University, No.157 Baojian Road, Nangang District,Harbin, Heilongjiang Province, 15008, China. .
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Źródło :
Molecular neurodegeneration [Mol Neurodegener] 2015 Aug 11; Vol. 10, pp. 36. Date of Electronic Publication: 2015 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Voltage-Gated Sodium Channel Blockers*
Brain Ischemia/*metabolism
MicroRNAs/*pharmacology
NAV1.1 Voltage-Gated Sodium Channel/*metabolism
NAV1.2 Voltage-Gated Sodium Channel/*metabolism
Nerve Tissue Proteins/*metabolism
Protein Transport/*genetics
Animals ; Brain Ischemia/genetics ; Carotid Artery, Common ; Cerebral Cortex/metabolism ; Chronic Disease ; Gene Expression Regulation ; Gene Knockdown Techniques ; Genetic Vectors/pharmacology ; Hippocampus/metabolism ; Lentivirus/genetics ; Ligation ; Male ; MicroRNAs/genetics ; NAV1.1 Voltage-Gated Sodium Channel/genetics ; NAV1.2 Voltage-Gated Sodium Channel/genetics ; Nerve Tissue Proteins/genetics ; Oligonucleotides, Antisense/pharmacology ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Sodium/metabolism ; Voltage-Gated Sodium Channel beta-2 Subunit/biosynthesis ; Voltage-Gated Sodium Channel beta-2 Subunit/genetics
Czasopismo naukowe
Tytuł :
The changes of miRNA expression in rat hippocampus following chronic lead exposure.
Autorzy :
An J; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Cai T; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Che H; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Yu T; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Cao Z; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Liu X; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Zhao F; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Jing J; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Shen X; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Liu M; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Du K; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China.
Chen J; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China. Electronic address: .
Luo W; Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 West Changle Road, Xi'an 710032, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2014 Aug 17; Vol. 229 (1), pp. 158-66. Date of Electronic Publication: 2014 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hippocampus/*drug effects
Hippocampus/*metabolism
Lead/*toxicity
MicroRNAs/*biosynthesis
Animals ; Blotting, Western ; Body Weight/drug effects ; Computational Biology ; Drinking/drug effects ; Lead/blood ; Male ; Maze Learning/drug effects ; Microarray Analysis ; Nerve Regeneration/drug effects ; Neurodegenerative Diseases/chemically induced ; Neurodegenerative Diseases/genetics ; Rats ; Rats, Sprague-Dawley ; Synapses/drug effects
Czasopismo naukowe
Tytuł :
Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population.
Autorzy :
Huang GL; 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Chen ML; Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
Li YZ; Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
Lu Y; 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Pu XX; Department of Medical Oncology, Hunan Tumor Hospital, Changsha, China.
He YX; Department of Oncology, Central South University Xiangya Hospital, Changsha, China.
Tang SY; Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
Che H; Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
Zou Y; 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
Ding C; 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
He Z; 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
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Źródło :
Journal of human genetics [J Hum Genet] 2014 Mar; Vol. 59 (3), pp. 141-4. Date of Electronic Publication: 2014 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Genetic Predisposition to Disease*
Asian Continental Ancestry Group/*genetics
MicroRNAs/*genetics
Nasopharyngeal Neoplasms/*genetics
Polymorphism, Single Nucleotide/*genetics
Adult ; Carcinoma ; Case-Control Studies ; China ; Female ; Gene Frequency/genetics ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma ; Risk Factors
Czasopismo naukowe
Tytuł :
Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat.
Autorzy :
Che H; Department of Pharmacology, Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, Heilongjiang Province, China.
Sun LH
Guo F
Niu HF
Su XL
Bao YN
Fu ZD
Liu HL
Hou X
Yang BF
Ai J
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2014; Vol. 33 (1), pp. 11-22. Date of Electronic Publication: 2014 Jan 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
Aging/*genetics
Amyloid/*metabolism
Hippocampus/*metabolism
MicroRNAs/*genetics
Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Cognition ; Gene Expression Profiling ; Male ; MicroRNAs/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar
Czasopismo naukowe
Tytuł :
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells.
Autorzy :
Zhao S; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, People's Republic of China. />Liu H
Liu Y
Wu J
Wang C
Hou X
Chen X
Yang G
Zhao L
Che H
Bi Y
Wang H
Peng F
Ai J
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Źródło :
Cancer letters [Cancer Lett] 2013 Jun 10; Vol. 333 (2), pp. 253-60. Date of Electronic Publication: 2013 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glioma/*genetics
Glioma/*pathology
MicroRNAs/*genetics
Neoplastic Stem Cells/*pathology
Animals ; Base Sequence ; Cell Differentiation/genetics ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Deoxyglucose/pharmacology ; Female ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/pathology ; Glycolysis/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Neoplastic Stem Cells/drug effects ; Rats
Czasopismo naukowe
Tytuł :
MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.
Autorzy :
Ai J; Department of Pharmacology, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China, 150081. />Sun LH
Che H
Zhang R
Zhang TZ
Wu WC
Su XL
Chen X
Yang G
Li K
Wang N
Ban T
Bao YN
Guo F
Niu HF
Zhu YL
Zhu XY
Zhao SG
Yang BF
Pokaż więcej
Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Feb 27; Vol. 33 (9), pp. 3989-4001.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Carotid Artery Diseases/*complications
Dementia/*etiology
Gene Expression Regulation/*physiology
MicroRNAs/*therapeutic use
Neuroprotective Agents/*therapeutic use
Aged ; Aged, 80 and over ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/blood ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Analysis of Variance ; Animals ; Animals, Newborn ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Dementia/genetics ; Dementia/pathology ; Dementia/therapy ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Female ; Gene Expression Regulation/drug effects ; Hippocampus/cytology ; Hippocampus/metabolism ; Humans ; Immunoprecipitation ; Lipopolysaccharides/pharmacology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; MicroRNAs/biosynthesis ; MicroRNAs/blood ; Neurons/drug effects ; Neuroprotective Agents/metabolism ; Oligonucleotides, Antisense/pharmacology ; Peptide Fragments/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Transfection
Czasopismo naukowe
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