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Wyświetlanie 1-20 z 31
Tytuł:
Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus
Autorzy:
Cheema AK
Kaur P
Fadel A
Younes N
Zirie M
Rizk NM
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Temat:
type 2 diabetes mellitus pathway analysis regulators biomarkers disorders bioinformatics
Specialties of internal medicine
RC581-951
Źródło:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 13, Pp 2409-2431 (2020)
Opis pliku:
electronic resource
Relacje:
https://www.dovepress.com/integrated-datasets-of-proteomic-and-metabolomic-biomarkers-to-predict-peer-reviewed-article-DMSO; https://doaj.org/toc/1178-7007
Dostęp URL:
https://doaj.org/article/113f03c14d3041c29cee9687f2d39e47  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
HTLV-1-Associated Lymphoma Presented as Massive Lymphadenopathy
Autorzy:
Pei Ting Chen MD
David Onukogu MD
Gregory Gotlieb
Rashid Chaudhry MD
Vijay Jaswani MD
Karan Josan MD
Cheema Akhtar MD
Jen Chin Wang MD
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Temat:
Medicine (General)
R5-920
Pathology
RB1-214
Źródło:
Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2324-7096
Dostęp URL:
https://doaj.org/article/87c37ca114974f2e92ddef69b874c5c3  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Aggressive Diffuse Intermediate Size B-Cell Lymphoma With P53 Mutation Presented as Primary Bone Marrow Lymphoma
Autorzy:
Pei Ting Chen MD
Karan Jorsan MD
Boris Avezbakiyev MD
Cheema Akhtar MD
Jen Chin Wang MD
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Temat:
Medicine (General)
R5-920
Pathology
RB1-214
Źródło:
Journal of Investigative Medicine High Impact Case Reports, Vol 8 (2020)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2324-7096
Dostęp URL:
https://doaj.org/article/b5e7010274854ab390bb3ca86086e505  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart.
Autorzy:
Sridharan V; Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Krager KJ; Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Pawar SA; Department of Radiation Oncology, Upstate Cancer Center, Upstate Medical University, Syracuse, NY 13210, USA.
Bansal S; Department of Radiation Oncology, Georgetown University, Washington, DC 20057, USA.
Li Y; Department of Radiation Oncology, Georgetown University, Washington, DC 20057, USA.
Cheema AK; Department of Radiation Oncology, Georgetown University, Washington, DC 20057, USA.
Boerma M; Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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Źródło:
Cancers [Cancers (Basel)] 2023 Jan 07; Vol. 15 (2). Date of Electronic Publication: 2023 Jan 07.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates.
Autorzy:
Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Girgis M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Jayatilake M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Serebrenik AA; Humanetics Corporation, Minneapolis, MN, 55435, USA.
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Kaytor MD; Humanetics Corporation, Minneapolis, MN, 55435, USA.
Singh VK; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine 'America's Medical School', Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 05; Vol. 12 (1), pp. 13475. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Acute Radiation Syndrome*/drug therapy
Metabolomics*/methods
Administration, Oral ; Animals ; Area Under Curve ; Metabolome ; Powders ; Primates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells.
Autorzy:
Hinzman CP; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Centre, Washington, DC, USA.
Singh B; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Centre, Washington, DC, USA.
Bansal S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Centre, Washington, DC, USA.
Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Centre, Washington, DC, USA.
Iliuk A; Tymora Analytical Operations, West Lafayette, IN, USA.
Girgis M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Centre, Washington, DC, USA.
Herremans KM; Department of Surgery, University of Florida, Gainesville, FL, USA.
Trevino JG; Division of Surgical Oncology, VCU Massey Cancer Centre, Richmond, VA, USA.
Singh VK; Department of Pharmacology and Molecular Therapeutics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Banerjee PP; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Centre, Washington, DC, USA.
Cheema AK; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Centre, Washington, DC, USA.; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Centre, Washington, DC, USA.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2022 Jun; Vol. 11 (6), pp. e12232.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Carcinoma, Pancreatic Ductal*/metabolism
Extracellular Vesicles*/metabolism
Pancreatic Neoplasms*/metabolism
Unfolded Protein Response*
Epithelial Cells/metabolism ; Humans ; Palmitic Acid/metabolism ; Pancreas/metabolism ; Tumor Microenvironment ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure.
Autorzy:
Hinzman CP; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Jayatilake M; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Bansal S; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Fish BL; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Li Y; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Zhang Y; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Bansal S; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Girgis M; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA.
Iliuk A; Tymora Analytical Operations, West Lafayette, IN, 47906, USA.
Xu X; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA, 92037, USA.
Fernandez JA; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA, 92037, USA.
Griffin JH; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA, 92037, USA.
Ballew EA; Department of Radiation Medicine, MedStar Georgetown University Hospital, Washington, DC, 20007, USA.
Unger K; Department of Radiation Medicine, MedStar Georgetown University Hospital, Washington, DC, 20007, USA.
Boerma M; Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AK, 72205, USA.
Medhora M; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Cheema AK; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, 20007, USA. amrita.cheema@georgetown.edu.; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20007, USA. amrita.cheema@georgetown.edu.
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Źródło:
Journal of translational medicine [J Transl Med] 2022 May 10; Vol. 20 (1), pp. 199. Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Extracellular Vesicles*/metabolism
Radiation Exposure*
Animals ; Biomarkers/metabolism ; Humans ; Mass Spectrometry ; Rats ; Ultracentrifugation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC.
Autorzy:
Rajagopal MU; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Bansal S; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Kaur P; Department of Botany, Khalsa College, Amritsar 143002, India.
Jain SK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, India.
Altadil T; Biomedical Research Group in Gynaecology, Vall Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Hinzman CP; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA.
Li Y; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Moulton J; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Singh B; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Bansal S; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Chauthe SK; Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 380054, India.
Singh R; Department of Botany, Khalsa College, Amritsar 143002, India.
Banerjee PP; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA.
Mapstone M; Department of Neurology, University of California, Irvine, CA 92697, USA.
Fiandaca MS; Department of Neurology, University of California, Irvine, CA 92697, USA.; Department of Neurological Surgery, University of California, Irvine, CA 92697, USA.
Federoff HJ; Department of Neurology, University of California, Irvine, CA 92697, USA.
Unger K; Radiation Medicine, Med-Star Georgetown University Hospital, Washington, DC 20057, USA.
Smith JP; Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.
Cheema AK; Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Dec 09; Vol. 13 (24). Date of Electronic Publication: 2021 Dec 09.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Marker-assisted pyramiding of lycopene-ε-cyclase, β-carotene hydroxylase1 and opaque2 genes for development of biofortified maize hybrids.
Autorzy:
Singh J; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Sharma S; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Kaur A; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Vikal Y; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India. .
Cheema AK; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Bains BK; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Kaur N; Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, India.
Gill GK; Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, India.
Malhotra PK; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Kumar A; Department of Plant Breeding and Genetics, Regional Research Station, Gurdaspur, India.
Sharma P; School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Muthusamy V; Division of Genetics, Indian Agricultural Research Institute, New Delhi, India.
Kaur A; Department of Food Science and Technology, Punjab Agricultural University, Ludhiana, India.
Chawla JS; Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, India.
Hossain F; Division of Genetics, Indian Agricultural Research Institute, New Delhi, India.
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 16; Vol. 11 (1), pp. 12642. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biofortification/*methods
Zea mays/*genetics
DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Edible Grain/genetics ; Edible Grain/metabolism ; Endosperm/metabolism ; Genes, Plant ; Genetic Markers ; Humans ; Intramolecular Lyases/genetics ; Intramolecular Lyases/metabolism ; Lysine/metabolism ; Plant Breeding/methods ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tryptophan/metabolism ; Vitamin A/metabolism ; Vitamin A Deficiency/prevention & control ; beta Carotene/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure.
Autorzy:
Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Girgis M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Wise SY; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Fatanmi OO; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Seed TM; Tech Micro Services, 4417 Maple Avenue, Bethesda, MD, 20814, USA.
Maniar M; Onconova Therapeutics, Inc, 375 Pheasant Run, Newtown, PA, USA.
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Singh VK; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 01; Vol. 11 (1), pp. 11449. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji:
Journal Article
MeSH Terms:
Metabolome*/drug effects
Metabolome*/radiation effects
Radiation Injuries, Experimental*/blood
Radiation Injuries, Experimental*/drug therapy
Gamma Rays/*adverse effects
Sulfonamides/*pharmacology
Animals ; Macaca mulatta ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transcriptome of rhesus macaque (Macaca mulatta) exposed to total-body irradiation.
Autorzy:
Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Singh J; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine 'America's Medical School', Uniformed Serices University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Varghese R; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Zhang Y; Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC, USA.
Fatanmi OO; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine 'America's Medical School', Uniformed Serices University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Singh VK; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine 'America's Medical School', Uniformed Serices University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, USA. .; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 18; Vol. 11 (1), pp. 6295. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gamma Rays*
Macaca mulatta/*genetics
Radiation Injuries, Experimental/*genetics
Radiation Injuries, Experimental/*mortality
Transcriptome/*radiation effects
Whole-Body Irradiation/*methods
Animals ; Biomarkers/analysis ; Female ; Follow-Up Studies ; Macaca mulatta/blood ; Male ; RNA, Messenger/blood ; RNA, Messenger/genetics ; Radiation Dosage ; Radiation Injuries, Experimental/blood ; Sex Factors ; Signal Transduction/genetics ; Signal Transduction/radiation effects ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure.
Autorzy:
Girgis M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Ma J; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Sanda M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Wise SY; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Fatanmi OO; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Kaytor MD; Humanetics Corporation, Edina, MN, 55435, USA.
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Singh VK; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 09; Vol. 10 (1), pp. 19343. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Radiation, Ionizing*
Acute Radiation Syndrome/*metabolism
Acute Radiation Syndrome/*prevention & control
Proteomics/*methods
Animals ; Chromatography, Liquid ; Female ; Genistein/pharmacology ; Macaca mulatta ; Male ; Metabolome/drug effects ; Metabolomics/methods ; Principal Component Analysis ; Radiation-Protective Agents/pharmacology ; Tandem Mass Spectrometry ; Time Factors ; Whole-Body Irradiation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dysregulated metabolic pathways in age-related macular degeneration.
Autorzy:
Zhang M; Department of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Jiang N; Department of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Chu Y; Department of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Postnikova O; Laboratory of Retinal Cell & Molecular Biology (HNW28), NIH/NEI, Bethesda, MD, 20814, USA.
Varghese R; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Horvath A; Department of Pharmacology and Physiology, Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC, 20037, USA.
Cheema AK; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, 20057, USA.; Department of Oncology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Golestaneh N; Department of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA. .; Department of Neurology, Georgetown University Medical Center, Washington, DC, 20057, USA. .; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, 20057, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Feb 12; Vol. 10 (1), pp. 2464. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolic Networks and Pathways*
Macular Degeneration/*metabolism
AMP-Activated Protein Kinase Kinases ; Female ; Glycogen/metabolism ; Humans ; Lipid Metabolism ; Macular Degeneration/genetics ; Male ; Metabolome ; Mitochondria/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Retinal Pigment Epithelium/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Author Correction: Plasma microRNA markers of upper limb recovery following human stroke.
Autorzy:
Edwardson MA; Georgetown University, Department of Neurology, Washington, DC, USA. .; Georgetown University and MedStar National Rehabilitation Hospital, Center for Brain Plasticity and Recovery, Department of Rehabilitation Medicine, Washington, DC, USA. .
Zhong X; Georgetown University, Department of Biostatistics, Bioinformatics, and Biomathematics, Washington, DC, USA.
Fiandaca MS; University of California Irvine, Department of Neurology, Irvine, CA, USA.; University of California Irvine, Department of Neurological Surgery, Irvine, CA, USA.; University of California Irvine, Department of Anatomy & Neurobiology, Irvine, CA, USA.
Federoff HJ; University of California Irvine, Department of Neurology, Irvine, CA, USA.; UC Irvine Health System, Irvine, CA, USA.
Cheema AK; Georgetown University, Department of Biochemistry, Washington, DC, USA.; Georgetown University, Department of Oncology, Washington, DC, USA.
Dromerick AW; Georgetown University, Department of Neurology, Washington, DC, USA.; Georgetown University and MedStar National Rehabilitation Hospital, Center for Brain Plasticity and Recovery, Department of Rehabilitation Medicine, Washington, DC, USA.; VA Medical Center, Washington, DC, USA.
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Źródło:
Scientific reports [Sci Rep] 2020 Feb 07; Vol. 10 (1), pp. 2484. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation.
Autorzy:
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Li Y; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Girgis M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Jayatilake M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Simas M; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA.; Armed Forces Radiobiology Research Institute, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA.
Wise SY; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA.; Armed Forces Radiobiology Research Institute, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA.
Olabisi AO; Armed Forces Radiobiology Research Institute, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA.
Seed TM; Tech Micro Services, Bethesda, MD, USA.
Singh VK; Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA. .; Armed Forces Radiobiology Research Institute, Uniformed Serices University of the Health Sciences, Bethesda, MD, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 30; Vol. 9 (1), pp. 15701. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Amifostine/*pharmacology
Bone Marrow/*drug effects
Jejunum/*drug effects
Lung/*drug effects
Animals ; Bone Marrow/metabolism ; Bone Marrow/radiation effects ; Gamma Rays/adverse effects ; Humans ; Jejunum/metabolism ; Jejunum/radiation effects ; Lung/metabolism ; Lung/radiation effects ; Metabolomics ; Mice ; Radiation Exposure/adverse effects ; Radiation-Protective Agents/pharmacology
Czasopismo naukowe
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Tytuł:
Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation.
Autorzy:
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20001, USA.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20001, USA.
Mehta KY; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20001, USA.
Rajagopal MU; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20001, USA.
Wise SY; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA.; Scientific Research Department, Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA.
Fatanmi OO; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA.; Scientific Research Department, Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA.
Singh VK; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Scientific Research Department, Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 09; Vol. 20 (13). Date of Electronic Publication: 2019 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Radiation, Ionizing*
Gamma Rays/*adverse effects
Animals ; Biomarkers/metabolism ; Carnitine/analogs & derivatives ; Carnitine/metabolism ; Female ; Gene Expression/drug effects ; In Vitro Techniques ; Kidney/drug effects ; Kidney/metabolism ; Lipidomics ; Macaca mulatta ; Male ; Metabolomics/methods ; Primates
Czasopismo naukowe
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Tytuł:
Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice.
Autorzy:
Hinzman CP; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, D.C, 20057, USA.
Baulch JE; Department of Radiation Oncology, University of California, Irvine, CA, 92697, USA.
Mehta KY; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, D.C, 20057, USA.
Girgis M; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, D.C, 20057, USA.
Bansal S; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, D.C, 20057, USA.
Gill K; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, D.C, 20057, USA.
Li Y; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, D.C, 20057, USA.
Limoli CL; Department of Radiation Oncology, University of California, Irvine, CA, 92697, USA.
Cheema AK; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Georgetown University Medical Center, Washington, D.C, 20057, USA. .; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, D.C, 20057, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jul 01; Vol. 9 (1), pp. 9460. Date of Electronic Publication: 2019 Jul 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Radiation, Ionizing*
Extracellular Vesicles/*metabolism
Plasma/*radiation effects
Animals ; Biomarkers/metabolism ; Chromatography, High Pressure Liquid ; Cranial Irradiation/methods ; Enzyme-Linked Immunosorbent Assay ; Extracellular Vesicles/radiation effects ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Metabolome/radiation effects ; Mice ; Mice, Inbred C57BL ; Plasma/metabolism ; Proteome/analysis ; Proteome/metabolism ; Proteome/radiation effects ; Receptors, IgG/analysis ; Tandem Mass Spectrometry ; Triglycerides/analysis ; Triglycerides/metabolism
Czasopismo naukowe
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Tytuł:
Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model.
Autorzy:
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. amrita.cheema@georgetown.com.; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. amrita.cheema@georgetown.com.
Mehta KY; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. .
Santiago PT; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
Fatanmi OO; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
Kaytor MD; Humanetics Corporation, Edina, MN 55435, USA. .
Singh VK; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Mar 12; Vol. 20 (5). Date of Electronic Publication: 2019 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Genistein/*administration & dosage
Genistein/*pharmacokinetics
Metabolome/*drug effects
Nanoparticles/*administration & dosage
Suspensions/*administration & dosage
Suspensions/*pharmacokinetics
Acute Radiation Syndrome/drug therapy ; Acute Radiation Syndrome/metabolism ; Animals ; Chromatography, High Pressure Liquid/methods ; Female ; Genistein/adverse effects ; Macaca mulatta ; Male ; Metabolomics/methods ; Nanoparticles/adverse effects ; Nanoparticles/metabolism ; Primates ; Suspensions/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasma Derived Exosomal Biomarkers of Exposure to Ionizing Radiation in Nonhuman Primates.
Autorzy:
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. .; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. .
Hinzman CP; Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. .
Mehta KY; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. .
Hanlon BK; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
Garcia M; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
Fatanmi OO; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
Singh VK; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. .; Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20814, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Nov 01; Vol. 19 (11). Date of Electronic Publication: 2018 Nov 01.
Typ publikacji:
Journal Article
MeSH Terms:
Radiation, Ionizing*
Biomarkers/*blood
Exosomes/*metabolism
Animals ; Discriminant Analysis ; Female ; Least-Squares Analysis ; Lipid Metabolism/radiation effects ; Macaca mulatta ; Male ; Metabolomics
Czasopismo naukowe
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Tytuł:
Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls.
Autorzy:
Fiandaca MS; Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.; Department of Neurological Surgery, University of California Irvine, Irvine, CA United States of America.; Department of Anatomy & Neurobiology, University of California Irvine, Irvine, CA United States of America.
Mapstone M; Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.
Mahmoodi A; Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.
Gross T; Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.
Macciardi F; Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA United States of America.
Cheema AK; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America.; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, United States of America.
Merchant-Borna K; Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of America.
Bazarian J; Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of America.
Federoff HJ; Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.
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Źródło:
PloS one [PLoS One] 2018 Apr 20; Vol. 13 (4), pp. e0195318. Date of Electronic Publication: 2018 Apr 20 (Print Publication: 2018).
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Validation Study
MeSH Terms:
Metabolome*
Brain Concussion/*blood
Adolescent ; Adult ; Area Under Curve ; Athletes ; Athletic Injuries/blood ; Biomarkers/blood ; Brain Concussion/etiology ; Diagnosis, Differential ; Female ; Humans ; Linear Models ; Longitudinal Studies ; Male ; Metabolomics ; ROC Curve ; Retrospective Studies ; Support Vector Machine ; Tandem Mass Spectrometry ; Universities ; Young Adult
Czasopismo naukowe
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