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Wyszukujesz frazę ""Chemistry, Pharmaceutical"" wg kryterium: Temat


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Tytuł :
The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions.
Autorzy :
Dedroog S; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Boel E; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Kindts C; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Appeltans B; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Van den Mooter G; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Nov 20; Vol. 609, pp. 121201. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Pharmaceutical Preparations*
Drug Compounding ; Solubility ; Solvents
Czasopismo naukowe
Tytuł :
The Influence of Relative Humidity and Storage Conditions on the Physico-chemical Properties of Inhalation Grade Fine Lactose.
Autorzy :
Stankovic-Brandl M; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria.
Zellnitz S; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria.
Wirnsberger P; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria.
Kobler M; MEGGLE Excipients and Technology, Megglestraße 6-12, 83512, Wasserburg, Germany.
Paudel A; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria. .; Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13, 8010, Graz, Austria. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Nov 17; Vol. 23 (1), pp. 1. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Lactose*
Administration, Inhalation ; Aerosols ; Dry Powder Inhalers ; Humidity ; Particle Size ; Powders ; Surface Properties
Czasopismo naukowe
Tytuł :
Janus All-Cis 2,3,4,5,6-Pentafluorocyclohexyl Building Blocks Applied to Medicinal Chemistry and Bioactives Discovery Chemistry.
Autorzy :
Clark JL; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Neyyappadath RM; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Yu C; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Slawin AMZ; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Cordes DB; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
O'Hagan D; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Nov 17; Vol. 27 (64), pp. 16000-16005. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Aldehydes*
Chemistry, Pharmaceutical*
Catalysis ; Hydrogenation
Czasopismo naukowe
Tytuł :
Highlighting DEM's Potential to Gauge Mechanistic Attributes of MUPS Tablet and Capsule Formulations.
Autorzy :
Shekhar S; 3D Powders Group, School of Engineering, Deakin University, Waurn Ponds, Geelong, VIC, 3216, Australia.
Amini N; 3D Powders Group, School of Engineering, Deakin University, Waurn Ponds, Geelong, VIC, 3216, Australia.
Morton DAV; 3D Powders Group, School of Engineering, Deakin University, Waurn Ponds, Geelong, VIC, 3216, Australia.
Hapgood KP; 3D Powders Group, School of Engineering, Deakin University, Waurn Ponds, Geelong, VIC, 3216, Australia.
Russell A; Operations Science & Technology, AbbVie Deutschland GmbH & Co. KG, 67061, Ludwigshafen, Germany. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Nov 11; Vol. 22 (8), pp. 271. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Powders ; Tablets
Czasopismo naukowe
Tytuł :
Quick and Simultaneous Analysis of Dissolved Active Pharmaceutical Ingredients and Formulation Excipients from the Dissolution Test Utilizing UHPLC and Charged Aerosol Detector.
Autorzy :
Kimoto M; Formulation Research Institute, Otsuka Pharmaceutical Co., Ltd. 224-18 Hiraishi Ebisuno, Kawauchi-cho, Tokushima, 771-0182, Japan. .; Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan. .
Sakane T; Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan.
Katsumi H; Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan.
Yamamoto A; Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan.
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Nov 01; Vol. 22 (8), pp. 262. Date of Electronic Publication: 2021 Nov 01.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Excipients*
Aerosols ; Chromatography, High Pressure Liquid ; Delayed-Action Preparations ; Solubility ; Tablets
Czasopismo naukowe
Tytuł :
Optimized copolymeric microstructured platforms for smart controlled delivery of an anticoagulant drug: Preparation, in vitro assessment and crossover study in healthy adult human volunteers.
Autorzy :
Salama AH; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ahram Canadian University, 6(th) of October City, Cairo, Egypt; Pharmaceutical Technology Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: .
Abouelatta SM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ahram Canadian University, 6(th) of October City, Cairo, Egypt.
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Oct 25; Vol. 608, pp. 121084. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Anticoagulants*
Chemistry, Pharmaceutical*
Adult ; Area Under Curve ; Biological Availability ; Cross-Over Studies ; Healthy Volunteers ; Humans ; Tablets ; Therapeutic Equivalency
Czasopismo naukowe
Tytuł :
Amalgamation of Solid Dispersion and Melt Adsorption Technique: Improved In Vitro and In Vivo Performance of Ticagrelor Tablets.
Autorzy :
Yadav M; Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, At & Po: Tarsadi-394350, Dist: Surat, Gujrat, India.
Sarolia J; Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, At & Po: Tarsadi-394350, Dist: Surat, Gujrat, India.
Vyas B; Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, At & Po: Tarsadi-394350, Dist: Surat, Gujrat, India.
Lalan M; Babaria Institute of Pharmacy, BITS Edu Campus, Varnama, Vadodara, India.
Mangrulkar S; Priyadarshini J. L. College of Pharmacy, MIDC, Hingna Road, Nagpur, MS, India, 440016.
Shah P; Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, At & Po: Tarsadi-394350, Dist: Surat, Gujrat, India. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Oct 21; Vol. 22 (8), pp. 257. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Excipients*
Adsorption ; Animals ; Biological Availability ; Caco-2 Cells ; Calorimetry, Differential Scanning ; Humans ; Rats ; Solubility ; Tablets ; Ticagrelor
Czasopismo naukowe
Tytuł :
Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition.
Autorzy :
Savych VI; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Mykhalchuk VL; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Melnychuk PV; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Isakov AO; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Savchuk T; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Timoshenko VM; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska St. 5, 02094 Kyiv, Ukraine.
Siry SA; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska St. 5, 02094 Kyiv, Ukraine.
Pavlenko SO; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Kovalenko DV; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Hryshchuk OV; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Reznik VA; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Chalyk BA; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska St. 5, 02094 Kyiv, Ukraine.
Yarmolchuk VS; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
Rusanov EB; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska St. 5, 02094 Kyiv, Ukraine.
Mykhailiuk PK; Enamine Ltd.; Chervonotkatska 78, 02094 Kyiv, Ukraine, www.enamine.net.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Oct 01; Vol. 86 (19), pp. 13289-13309. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemistry, Pharmaceutical*
Pyrrolidines*
Alkenes ; Cycloaddition Reaction
Czasopismo naukowe
Tytuł :
Characterization of natural herbal medicines by thin-layer chromatography combined with laser ablation-assisted direct analysis in real-time mass spectrometry.
Autorzy :
Chen Y; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li L; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
Xu R; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li F; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Gu L; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liu H; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Wang Z; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yang L; The MOE Key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 27; Vol. 1654, pp. 462461. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*/methods
Chromatography, Thin Layer*
Mass Spectrometry*
Plants, Medicinal*/chemistry
Lasers
Czasopismo naukowe
Tytuł :
Potential of microchip electrophoresis in pharmaceutical analysis: Development of a universal method for frequently prescribed nonsteroidal anti-inflammatory drugs.
Autorzy :
Troška P; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, Ilkovičova 6, SK-84215 Bratislava, Slovakia.
Hradski J; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, Ilkovičova 6, SK-84215 Bratislava, Slovakia.
Chropeňová L; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, Ilkovičova 6, SK-84215 Bratislava, Slovakia.
Szucs R; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, Ilkovičova 6, SK-84215 Bratislava, Slovakia.
Masár M; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, Ilkovičova 6, SK-84215 Bratislava, Slovakia. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 27; Vol. 1654, pp. 462453. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal*/chemistry
Anti-Inflammatory Agents, Non-Steroidal*/isolation & purification
Chemistry, Pharmaceutical*/methods
Electrophoresis, Microchip*
Pharmaceutical Preparations*/chemistry
Electric Conductivity ; Isotachophoresis
Czasopismo naukowe
Tytuł :
Orthogonal pre-use and post-use efficiency testing for single-use anion exchange chromatography.
Autorzy :
Hester JF; 3M Separation and Purification Sciences Division, 3M Center 236-1C-14, St. Paul, MN 55144-1000, United States. Electronic address: .
Lu X; 3M Separation and Purification Sciences Division, 3M Center 236-1C-14, St. Paul, MN 55144-1000, United States.
Calhoun JD; 3M Separation and Purification Sciences Division, 3M Center 236-1C-14, St. Paul, MN 55144-1000, United States.
Hochstein RA; 3M Separation and Purification Sciences Division, 3M Center 236-1C-14, St. Paul, MN 55144-1000, United States.
Olson EJ; 3M Corporate Research Analytical Laboratory, 3M Center 201-BS-03, St. Paul, MN 55144-1000, United States.
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 27; Vol. 1654, pp. 462445. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*/methods
Chromatography, Ion Exchange*
Antibodies, Monoclonal ; Biological Products/standards ; Viruses/isolation & purification
Czasopismo naukowe
Tytuł :
Comprehensive characterization of the chemical constituents in Platycodon grandiflorum by an integrated liquid chromatography-mass spectrometry strategy.
Autorzy :
Huang W; School of Pharmacy, Fudan University, Shanghai 201203, PR China; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China.
Zhou H; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China.
Yuan M; Waters Corporation (China), Shanghai 201206, PR China.
Lan L; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China. Electronic address: .
Hou A; School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: .
Ji S; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 27; Vol. 1654, pp. 462477. Date of Electronic Publication: 2021 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*/methods
Chromatography, High Pressure Liquid*
Platycodon*/chemistry
Spectrometry, Mass, Electrospray Ionization*
Dietary Supplements/analysis ; Plants, Medicinal/chemistry
Czasopismo naukowe
Tytuł :
In situ fabrication of chiral covalent triazine frameworks membranes for enantiomer separation.
Autorzy :
Chen Y; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Xia L; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Lu Z; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Li G; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: .
Hu Y; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 27; Vol. 1654, pp. 462475. Date of Electronic Publication: 2021 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*/methods
Triazines*/chemistry
Chromatography, Liquid ; Membranes, Artificial ; Porosity ; Silicon Dioxide ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Electrostatic spray drying for monoclonal antibody formulation.
Autorzy :
Mutukuri TT; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
Maa YF; Pharmaceutical Development, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Gikanga B; Pharmaceutical Development, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Sakhnovsky R; Fluid Air, 2119 Fisher Drive, Naperville, IL 60563, USA.
Zhou QT; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Sep 25; Vol. 607, pp. 120942. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal*
Chemistry, Pharmaceutical*
Freeze Drying ; Particle Size ; Powders ; Spray Drying ; Static Electricity
Czasopismo naukowe
Tytuł :
PharmDE: A new expert system for drug-excipient compatibility evaluation.
Autorzy :
Wang N; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, China. Electronic address: .
Sun H; National Institute for Food and Drug Control, No. 2, Tiantan Xili Road, Beijing, 100050, China.
Dong J; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, China. Electronic address: .
Ouyang D; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, China. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Sep 25; Vol. 607, pp. 120962. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Excipients*
Artificial Intelligence ; Drug Stability ; Expert Systems
Czasopismo naukowe
Tytuł :
Fluidization characterization in the ConSigma 25 dryer via process data - A method of advanced quality assurance in continuous manufacturing.
Autorzy :
Rehrl J; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, Austria. Electronic address: .
Hörmann-Kincses T; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, Austria. Electronic address: .
Sibanc R; Bayer AG, Engineering & Technology, 51368 Leverkusen, Germany. Electronic address: .
Hsiao WK; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, Austria. Electronic address: .
Franke M; Bayer AG, Engineering & Technology, 51368 Leverkusen, Germany; Faculty of Science and Technology (TNW), University of Twente, Drienerlolaan 5, 7522 NB Enschede, the Netherlands(1). Electronic address: .
Khinast J; Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, 8010 Graz, Austria. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Sep 25; Vol. 607, pp. 121041. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Technology, Pharmaceutical*
Drug Compounding ; Particle Size ; Powders ; Temperature
Czasopismo naukowe
Tytuł :
Using multimodal chromatography for post-conjugation antibody-drug conjugate purification: A methodology from high throughput screening to in-silico process development.
Autorzy :
Keller WR; Purification Process Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, USA. Electronic address: .
Wendeler M; Purification Process Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, USA.
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 13; Vol. 1653, pp. 462378. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*/methods
Chromatography, Liquid*
Immunoconjugates*/isolation & purification
Computer Simulation ; Cysteine ; High-Throughput Screening Assays
Czasopismo naukowe
Tytuł :
Solvent-Assisted Hot Melt Extrusion of a Thermally Labile, High Melting Point Compound.
Autorzy :
Lagan C; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA.; School of Pharmacy, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland.
Huckle JE; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA. .
Katz JM; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA.
Khorsand B; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA.
Daurio D; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA.
Andrews GP; School of Pharmacy, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland.
Chung J; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA.
Alvarez-Nunez F; Drug Product Technologies, Amgen Inc., Thousand Oaks, California, 91320, USA.
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Sep 08; Vol. 22 (7), pp. 235. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Hot Melt Extrusion Technology*
Drug Compounding ; Hot Temperature ; Povidone ; Solubility ; Solvents
Czasopismo naukowe
Tytuł :
How to stop disproportionation of a hydrochloride salt of a very weakly basic compound in a non-clinical suspension formulation.
Autorzy :
Ojala K; Division of Pharmaceutical Chemistry and Technology, Industrial Pharmacy, University of Helsinki, P.O. Box 56, 00014 University of Helsinki, Finland; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland. Electronic address: .
Salmia J; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
Shevchenko A; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland; Particle Analytical ApS, Agern Alle 3, DK-2970 Hørsholm, Denmark.
Ylikotila J; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
Korjamo T; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
van Veen B; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
Koistinen P; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
Malmström C; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
Laakso S; Orion Pharma, Orionintie 1 A, 02200 Espoo, Finland.
Bansal I; Aurigene Discovery Technologies Limited, E-City, Phase-2, Bangalore 560100, Karnataka, India.
Samiulla DS; Aurigene Discovery Technologies Limited, E-City, Phase-2, Bangalore 560100, Karnataka, India.
Juppo A; Division of Pharmaceutical Chemistry and Technology, Industrial Pharmacy, University of Helsinki, P.O. Box 56, 00014 University of Helsinki, Finland.
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Sep 05; Vol. 606, pp. 120875. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Excipients*
Animals ; Hydrochloric Acid ; Rats ; Solubility ; Suspensions
Czasopismo naukowe
Tytuł :
Development of a stable lyophilized adeno-associated virus gene therapy formulation.
Autorzy :
Zhang YZ; Formulation and Drug Product Development, REGENXBIO Inc, Rockville, MD 20850, USA. Electronic address: .
DePaz RA; Formulation and Drug Product Development, REGENXBIO Inc, Rockville, MD 20850, USA.
Bee JS; Formulation and Drug Product Development, REGENXBIO Inc, Rockville, MD 20850, USA.
Marshall T; Process Development, REGENXBIO Inc., Rockville, MD 20850, USA.
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Sep 05; Vol. 606, pp. 120912. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Chemistry, Pharmaceutical*
Dependovirus*/genetics
Crystallization ; Drug Stability ; Freeze Drying ; Genetic Therapy ; Humans
Czasopismo naukowe

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