Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Chemistry & biology [Chem Biol] NLMUID: 9500160"" wg kryterium: JN


Tytuł :
Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.
Autorzy :
del Solar V; Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA.
Lizardo DY; Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA.
Li N; Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA.
Hurst JJ; Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA.
Brais CJ; Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA.
Atilla-Gokcumen GE; Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1662-70.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Apoptosis/*physiology
Sphingolipids/*metabolism
Staurosporine/*pharmacology
Cell Survival ; Colonic Neoplasms/drug therapy ; HCT116 Cells ; Humans ; Mass Spectrometry ; Molecular Structure ; Polymerase Chain Reaction ; Sphingolipids/analysis
Czasopismo naukowe
Tytuł :
Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.
Autorzy :
Vivoli M; Department of Biosciences, University of Exeter, Henry Wellcome Building, Stocker Road, Exeter EX4 4QD, UK.
Isupov MN; Department of Biosciences, University of Exeter, Henry Wellcome Building, Stocker Road, Exeter EX4 4QD, UK.
Nicholas R; Department of Biosciences, University of Exeter, Henry Wellcome Building, Stocker Road, Exeter EX4 4QD, UK.
Hill A; Department of Biosciences, University of Exeter, Henry Wellcome Building, Stocker Road, Exeter EX4 4QD, UK.
Scott AE; Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Kosma P; University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, 1190 Vienna, Austria.
Prior JL; Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Harmer NJ; Department of Biosciences, University of Exeter, Henry Wellcome Building, Stocker Road, Exeter EX4 4QD, UK. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1622-32.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Burkholderia pseudomallei/*enzymology
Phosphotransferases/*chemistry
Small Molecule Libraries/*pharmacology
Calorimetry, Differential Scanning ; Computer Simulation ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Heptoses/chemistry ; Models, Molecular ; Phosphotransferases/metabolism ; Protein Structure, Tertiary ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Autorzy :
Riemersma M; Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Froese DS; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
van Tol W; Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Engelke UF; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Kopec J; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
van Scherpenzeel M; Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Ashikov A; Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Krojer T; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
von Delft F; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
Tessari M; Institute for Molecules and Materials, Radboud University Nijmegen, 6525 ED Nijmegen, the Netherlands.
Buczkowska A; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawinskiego Street, 02-106 Warsaw, Poland.
Swiezewska E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawinskiego Street, 02-106 Warsaw, Poland.
Jae LT; Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Brummelkamp TR; Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Manya H; Molecular Glycobiology, Research Team for Mechanisms of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.
Endo T; Molecular Glycobiology, Research Team for Mechanisms of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.
van Bokhoven H; Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Yue WW; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. Electronic address: .
Lefeber DJ; Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1643-52. Date of Electronic Publication: 2015 Dec 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dystroglycans/*metabolism
Nucleotidyltransferases/*genetics
Nucleotidyltransferases/*metabolism
Cells, Cultured ; Choline-Phosphate Cytidylyltransferase/chemistry ; Crystallography, X-Ray ; Dystroglycans/chemistry ; Fibroblasts ; Gene Knockout Techniques ; Glycosylation ; Humans ; Nucleotidyltransferases/chemistry
Czasopismo naukowe
Tytuł :
Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.
Autorzy :
Moon TM; Department of Pharmacology, College of Medicine, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Tykocki NR; Department of Pharmacology, College of Medicine, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Sheehe JL; Department of Pharmacology, College of Medicine, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Osborne BW; Department of Pharmacology, College of Medicine, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Tegge W; Department of Chemical Biology, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Brayden JE; Department of Pharmacology, College of Medicine, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Dostmann WR; Department of Pharmacology, College of Medicine, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1653-61.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclic GMP*
Drug Design*
Peptide Library*
Cyclic GMP-Dependent Protein Kinase Type I/*metabolism
Peptides/*pharmacology
Animals ; Circular Dichroism ; Cyclic GMP-Dependent Protein Kinase Type I/isolation & purification ; Enzyme Activation/drug effects ; Enzyme Activators/chemical synthesis ; Enzyme Activators/pharmacology ; Microscopy, Confocal ; Muscle, Smooth, Vascular/drug effects ; Peptides/chemical synthesis ; Protein Isoforms/isolation & purification ; Rats
Czasopismo naukowe
Tytuł :
DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.
Autorzy :
Kawakami T; Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan. Electronic address: .
Ogawa K; Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.
Goshima N; Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.
Natsume T; Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1671-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Library*
Staining and Labeling*
Cytological Techniques/*methods
Fluorescent Dyes/*chemistry
Proteins/*chemistry
Cells/metabolism ; Models, Molecular
Czasopismo naukowe
Tytuł :
Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G.
Autorzy :
Zhao Z; McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.
Wang L; McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.
James T; McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.
Jung Y; College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406-840, Republic of Korea.
Kim I; College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406-840, Republic of Korea.
Tan R; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210093, PR China.
Hoffmann FM; McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.
Xu W; McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1608-21. Date of Electronic Publication: 2015 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Benzofurans/*pharmacology
Estrogen Receptor alpha/*drug effects
Estrogen Receptor beta/*drug effects
Benzofurans/chemistry ; Blotting, Western ; Breast Neoplasms/therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Molecular Docking Simulation ; Protein Stability/drug effects ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Halophilic Protein Adaptation Results from Synergistic Residue-Ion Interactions in the Folded and Unfolded States.
Autorzy :
Ortega G; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Vizcaya, Ed. 800, 48160 Derio, Spain.
Diercks T; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Vizcaya, Ed. 800, 48160 Derio, Spain.
Millet O; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Vizcaya, Ed. 800, 48160 Derio, Spain. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1597-607. Date of Electronic Publication: 2015 Nov 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptation, Biological*
Protein Folding*
Protein Stability*
Halobacteriales/*physiology
Proteins/*chemistry
Circular Dichroism ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Magnetic Resonance Spectroscopy
Czasopismo naukowe
Tytuł :
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
Autorzy :
Chekler EL; Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
Pellegrino JA; The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Lanz TA; Neuroscience and Pain Research Unit, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
Denny RA; Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
Flick AC; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Coe J; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Langille J; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Basak A; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Liu S; Structural Biology and Biophysics, Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Stock IA; Primary Pharmacology Group, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Sahasrabudhe P; Structural Biology and Biophysics, Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Bonin PD; Primary Pharmacology Group, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
Lee K; Rare Disease Research Unit, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
Pletcher MT; Rare Disease Research Unit, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
Jones LH; Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1588-96. Date of Electronic Publication: 2015 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
CREB-Binding Protein/*antagonists & inhibitors
Small Molecule Libraries/*chemistry
CREB-Binding Protein/genetics ; Fluorescence Resonance Energy Transfer ; Gene Expression Regulation/drug effects ; Humans ; Protein Structure, Tertiary ; RGS Proteins/genetics ; Small Molecule Libraries/pharmacology ; Transcriptome
Czasopismo naukowe
Tytuł :
Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.
Autorzy :
Srivastava S; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India; Academy of Scientific and Innovative Research, Rafi Marg, New Delhi 110001, India.
Chaudhary S; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India.
Thukral L; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India.
Shi C; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Gupta RD; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India.
Gupta R; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India; Academy of Scientific and Innovative Research, Rafi Marg, New Delhi 110001, India.
Priyadarshan K; CSIR-Center for Cellular and Molecular Biology, Hyderabad 500007, India.
Vats A; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India.
Haque AS; CSIR-Center for Cellular and Molecular Biology, Hyderabad 500007, India.
Sankaranarayanan R; CSIR-Center for Cellular and Molecular Biology, Hyderabad 500007, India.
Natarajan VT; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India; Academy of Scientific and Innovative Research, Rafi Marg, New Delhi 110001, India.
Sharma R; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India.
Aldrich CC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Gokhale RS; CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India; Academy of Scientific and Innovative Research, Rafi Marg, New Delhi 110001, India; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1577-87. Date of Electronic Publication: 2015 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipid Metabolism*
Dodecenoyl-CoA Isomerase/*metabolism
Fatty Acids, Unsaturated/*metabolism
Mycobacterium/*enzymology
Binding Sites ; Dodecenoyl-CoA Isomerase/chemistry ; Electrophoresis, Polyacrylamide Gel ; Host-Pathogen Interactions ; Lipids/chemistry ; Models, Molecular
Czasopismo naukowe
Tytuł :
Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps.
Autorzy :
Huang S; Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P.R. China.
Elsayed SS; Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
Lv M; Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P.R. China.
Tabudravu J; Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
Rateb ME; Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK; Pharmacognosy Department, School of Pharmacy, Beni-Suef University, Beni-Suef 32514, Egypt.
Gyampoh R; Department of Chemistry, University of Ghana, P.O. Box LG56, Legon-Accra, Ghana.
Kyeremeh K; Department of Chemistry, University of Ghana, P.O. Box LG56, Legon-Accra, Ghana.
Ebel R; Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
Jaspars M; Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
Deng Z; Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P.R. China.
Yu Y; Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P.R. China. Electronic address: .
Deng H; Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1633-42. Date of Electronic Publication: 2015 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbazoles/*chemistry
Biosynthetic Pathways ; Carbazoles/metabolism ; Chromatography, High Pressure Liquid ; Cloning, Molecular ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Hydroxylation ; Molecular Sequence Data ; Molecular Structure ; Prenylation ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.
Źródło :
Chemistry & biology [Chem Biol] 2015 Dec 17; Vol. 22 (12), pp. 1575-6.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Ascorbic Acid/*therapeutic use
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*genetics
Proto-Oncogene Proteins/*genetics
Proto-Oncogene Proteins B-raf/*genetics
ras Proteins/*genetics
Animals ; Female ; Humans
Czasopismo naukowe
Tytuł :
Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13.
Autorzy :
Urbach C; Department of Antibody Discovery and Protein Engineering, MedImmune, Granta Park, Cambridge CB21 6GH, UK. Electronic address: .
Gordon NC; Department of Antibody Discovery and Protein Engineering, MedImmune, Granta Park, Cambridge CB21 6GH, UK; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Strickland I; Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Lowne D; Department of Antibody Discovery and Protein Engineering, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Joberty-Candotti C; Department of Oncology, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
May R; Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Herath A; Non Clinical Biostatistics, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Hijnen D; Department of Dermatology, University Medical Center, 3508 GA Utrecht, the Netherlands.
Thijs JL; Department of Dermatology, University Medical Center, 3508 GA Utrecht, the Netherlands.
Bruijnzeel-Koomen CA; Department of Dermatology, University Medical Center, 3508 GA Utrecht, the Netherlands.
Minter RR; Department of Antibody Discovery and Protein Engineering, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Hollfelder F; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Jermutus L; Department of Antibody Discovery and Protein Engineering, MedImmune, Granta Park, Cambridge CB21 6GH, UK.
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1442-1452. Date of Electronic Publication: 2015 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-13/*metabolism
Matrix Metalloproteinases/*metabolism
Animals ; Catalytic Domain ; Cell Line ; Chemokine CCL2/metabolism ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Dermatitis, Atopic/therapy ; Electrophoresis, Polyacrylamide Gel ; Humans ; Interleukin-6/metabolism ; Kinetics ; Matrix Metalloproteinase 8/chemistry ; Matrix Metalloproteinase 8/genetics ; Matrix Metalloproteinase 8/metabolism ; Matrix Metalloproteinases/chemistry ; Mice ; Mice, Transgenic ; Protein Engineering ; Proteolysis ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/therapeutic use ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł :
Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus.
Autorzy :
Hu J; Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.
Liu J; Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.
Li L; Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.
Gagnon KT; Department of Biochemistry and Molecular Biology, Southern Illinois University, Carbondale, IL 62901, USA.
Corey DR; Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1505-1511. Date of Electronic Publication: 2015 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteins/*genetics
RNA, Double-Stranded/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Base Sequence ; C9orf72 Protein ; Cell Line ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Genetic Loci ; Humans ; Microsatellite Repeats ; Microscopy, Fluorescence ; Proteins/metabolism ; RNA Interference ; RNA, Double-Stranded/chemistry ; RNA, Small Interfering/metabolism ; Real-Time Polymerase Chain Reaction
SCR Disease Name :
Amyotrophic lateral sclerosis 1
Czasopismo naukowe
Tytuł :
Host-Microbe Protein Interactions during Bacterial Infection.
Autorzy :
Schweppe DK; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Harding C; Departments of Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Chavez JD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Wu X; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Ramage E; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Singh PK; Departments of Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Manoil C; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Bruce JE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA; Departments of Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington School of Medicine, 850 Republican Street, Brotman Building, Room 154, Seattle, WA 98109, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1521-1530. Date of Electronic Publication: 2015 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Host-Pathogen Interactions*
Acinetobacter Infections/*microbiology
Acinetobacter Infections/*physiopathology
Acinetobacter baumannii/*physiology
Animals ; Bacterial Outer Membrane Proteins/chemistry ; Bacterial Outer Membrane Proteins/metabolism ; Humans ; Mice ; Microscopy, Confocal ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Virulence Factors/chemistry ; Virulence Factors/metabolism
Czasopismo naukowe
Tytuł :
Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA.
Autorzy :
Finzel K; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Nguyen C; Departments of Molecular Biology and Biochemistry, Chemistry and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697-1450, USA.
Jackson DR; Departments of Molecular Biology and Biochemistry, Chemistry and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697-1450, USA.
Gupta A; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Tsai SC; Departments of Molecular Biology and Biochemistry, Chemistry and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697-1450, USA. Electronic address: .
Burkart MD; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1453-1460. Date of Electronic Publication: 2015 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Escherichia coli/*enzymology
Fatty Acid Synthase, Type II/*metabolism
Hydro-Lyases/*metabolism
Acyl Carrier Protein/chemistry ; Acyl Carrier Protein/genetics ; Acyl Carrier Protein/metabolism ; Binding Sites ; Cross-Linking Reagents/chemistry ; Fatty Acid Synthase, Type II/antagonists & inhibitors ; Fatty Acid Synthase, Type II/genetics ; Hydro-Lyases/antagonists & inhibitors ; Hydro-Lyases/genetics ; Molecular Dynamics Simulation ; Molecular Probes/chemistry ; Molecular Probes/metabolism ; Mutagenesis ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
Autorzy :
Chandramouly G; Department of Medical Genetics and Molecular Biochemistry, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
McDevitt S; Department of Medical Genetics and Molecular Biochemistry, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Sullivan K; Department of Microbiology and Immunology, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Kent T; Department of Medical Genetics and Molecular Biochemistry, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Luz A; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, New York, NY 10065, USA.
Glickman JF; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, New York, NY 10065, USA.
Andrake M; Institute for Cancer Research, Fox Chase Cancer Center, Temple Health, Philadelphia, PA 19111, USA.
Skorski T; Department of Microbiology and Immunology, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Pomerantz RT; Department of Medical Genetics and Molecular Biochemistry, Fels Institute for Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1491-1504. Date of Electronic Publication: 2015 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Rad52 DNA Repair and Recombination Protein/*antagonists & inhibitors
Small Molecule Libraries/*chemistry
Allosteric Regulation ; Apoptosis/drug effects ; BRCA1 Protein/deficiency ; BRCA2 Protein/deficiency ; Cell Line ; Cell Proliferation/drug effects ; DNA Damage/drug effects ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/metabolism ; Dihydroxyphenylalanine/analogs & derivatives ; Dihydroxyphenylalanine/chemistry ; Dihydroxyphenylalanine/metabolism ; Dihydroxyphenylalanine/toxicity ; Electrophoretic Mobility Shift Assay ; Humans ; Inhibitory Concentration 50 ; Microscopy, Fluorescence ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Binding ; RNA Interference ; RNA, Small Interfering/metabolism ; Rad52 DNA Repair and Recombination Protein/genetics ; Rad52 DNA Repair and Recombination Protein/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/toxicity
Czasopismo naukowe
Tytuł :
An L-RNA Aptamer that Binds and Inhibits RNase.
Autorzy :
Olea C Jr; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Weidmann J; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
Dawson PE; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Joyce GF; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1437-1441.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aptamers, Nucleotide/*metabolism
Ribonucleases/*metabolism
Aptamers, Nucleotide/chemistry ; Bacterial Proteins ; Base Sequence ; Binding Sites ; Binding, Competitive ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Nucleic Acid Conformation ; Protein Binding ; Protein Structure, Tertiary ; RNA/chemistry ; RNA/metabolism ; Ribonucleases/antagonists & inhibitors ; Ribonucleases/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Substrate Flexibility of a Mutated Acyltransferase Domain and Implications for Polyketide Biosynthesis.
Autorzy :
Bravo-Rodriguez K; Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
Klopries S; Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
Koopmans KRM; Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
Sundermann U; Dr. Fooke-Achterrath Laboratorien GmbH, Habichtweg 16, 41468 Neuss, Germany.
Yahiaoui S; Université de Caen Basse-Normandie, Centre d'Etudes et de Recherche sur le Médicament de Normandie, 14032 Caen, France.
Arens J; Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
Kushnir S; Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
Schulz F; Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany. Electronic address: .
Sanchez-Garcia E; Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1425-1430. Date of Electronic Publication: 2015 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acyltransferases/*metabolism
Polyketides/*metabolism
Acyltransferases/genetics ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Erythromycin/analogs & derivatives ; Erythromycin/biosynthesis ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Polyketide Synthases/chemistry ; Protein Structure, Tertiary ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel.
Autorzy :
Petronikolou N; Department of Biochemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA; Institute for Genomic Biology, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.
Nair SK; Department of Biochemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA; Center for Biophysics and Computational Biology and University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Roger Adams Lab Room 430, Urbana, IL 61801, USA; Institute for Genomic Biology, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemistry & biology [Chem Biol] 2015 Nov 19; Vol. 22 (11), pp. 1480-1490. Date of Electronic Publication: 2015 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Biofuels*
Bacterial Proteins/*metabolism
Methyltransferases/*metabolism
Mycobacterium marinum/*enzymology
Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Binding Sites ; Biocatalysis ; Catalytic Domain ; Crystallography, X-Ray ; Fatty Acids/metabolism ; Kinetics ; Methyltransferases/chemistry ; Methyltransferases/genetics ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; S-Adenosylhomocysteine/metabolism ; S-Adenosylmethionine/metabolism ; Sequence Alignment ; Substrate Specificity
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies