Differential responses to immune checkpoint inhibitor dictated by pre-existing differential immune profiles in squamous cell carcinomas caused by same initial oncogenic drivers.
Autorzy:
Chen SMY; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA.; Department of Pathology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Popolizio V; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Woolaver RA; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Ge H; UPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Krinsky AL; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. John J; UPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Danis E; Department of Pharmacology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Ke Y; Department of Pathology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Kramer Y; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA.; Department of Pathology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Bian L; Department of Pathology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Nicklawsky AG; Department of Pediatrics and Department of Biostatistics and Informatics, Cancer Center Biostatistics Core, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Gao D; Department of Pediatrics and Department of Biostatistics and Informatics, Cancer Center Biostatistics Core, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. Liu S; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Chen Z; UPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Wang XJ; Department of Pathology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, 80045, USA. . Wang JH; UPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA. .
Divergent outcomes of anti-PD-L1 treatment coupled with host-intrinsic differences in TCR repertoire and distinct T cell activation states in responding versus non-responding tumors.
Host-specific differences in top-expanded TCR clonotypes correlate with divergent outcomes of anti-PD-L1 treatment in responders versus non-responders.
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies
