- Tytuł:
-
Bone-targeted methotrexate-alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and
inflammation of collagen-induced arthritis in vivo. - Autorzy:
- Źródło:
- Drug delivery [Drug Deliv] 2018 Nov; Vol. 25 (1), pp. 187-197.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Alendronate/*pharmacology
Arthritis, Experimental/*drug therapy
Bone Resorption/*prevention & control
Bone and Bones/*drug effectsInflammation /*drug therapy
Methotrexate/*pharmacology
Osteogenesis/*drug effects
Animals ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/metabolism ; Arthritis, Rheumatoid/chemically induced ; Arthritis, Rheumatoid/drug therapy ; Bone Resorption/metabolism ; Bone and Bones/metabolism ; Collagen/pharmacology ; Cytokines/metabolism ; Drug Therapy, Combination/methods ; Female ;Inflammation /metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Muramidase/metabolism ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe