A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss.
Autorzy:
Chichura KS; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. Elfers CT; Seattle Children's Research Institute, 1900 Ninth Ave, Seattle, WA, 98101, USA. Salameh TS; Seattle Children's Research Institute, 1900 Ninth Ave, Seattle, WA, 98101, USA. Kamat V; Diabetes Research Institute and Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA, 98195, USA. ChepurnyOG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. McGivney A; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. Milliken BT; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. Holz GG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA.; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. Applebey SV; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Sweet IR; Diabetes Research Institute and Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA, 98195, USA. Roth CL; Seattle Children's Research Institute, 1900 Ninth Ave, Seattle, WA, 98101, USA. .; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, 98105, USA. . Doyle RP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY, 13244, USA. .; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. .; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 12; Vol. 13 (1), pp. 9554. Date of Electronic Publication: 2023 Jun 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK 2 R Cancer Theranostic Agents: A Preclinical Study.
Autorzy:
Nock BA; Molecular Radiopharmacy, INRASTES, NCSR 'Demokritos', 15341 Athens, Greece. Kanellopoulos P; Molecular Radiopharmacy, INRASTES, NCSR 'Demokritos', 15341 Athens, Greece. ChepurnyOG; Departments of Medicine and Pharmacology, State University of New York (SUNY), Upstate Medical University, Syracuse, NY 13210, USA and Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA. Rouchota M; BIOEMTECH, Lefkippos Attica Technology Park NCSR 'Demokritos', 15310 Athens, Greece. Loudos G; BIOEMTECH, Lefkippos Attica Technology Park NCSR 'Demokritos', 15310 Athens, Greece. Holz GG; Departments of Medicine and Pharmacology, State University of New York (SUNY), Upstate Medical University, Syracuse, NY 13210, USA and Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA. Krenning EP; Cyclotron Rotterdam BV, Erasmus MC, 3015 CE Rotterdam, The Netherlands. Maina T; Molecular Radiopharmacy, INRASTES, NCSR 'Demokritos', 15341 Athens, Greece.
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Źródło:
Pharmaceutics [Pharmaceutics] 2022 Mar 18; Vol. 14 (3). Date of Electronic Publication: 2022 Mar 18.
Cyclic AMP-dependent activation of ERK via GLP-1 receptor signalling requires the neuroendocrine cell-specific guanine nucleotide exchanger NCS-RapGEF2.
Autorzy:
Xu W; Section on Molecular Neuroscience, National Institute of Mental Health - Intramural Research Program, Bethesda, MD, USA. Dahlke SP; Section on Molecular Neuroscience, National Institute of Mental Health - Intramural Research Program, Bethesda, MD, USA. Emery AC; Section on Molecular Neuroscience, National Institute of Mental Health - Intramural Research Program, Bethesda, MD, USA. Sung M; Section on Molecular Neuroscience, National Institute of Mental Health - Intramural Research Program, Bethesda, MD, USA. ChepurnyOG; Department of Medicine, Upstate Medical University, State University of New York, Syracuse, NY, USA. Holz GG; Department of Medicine, Upstate Medical University, State University of New York, Syracuse, NY, USA. Eiden LE; Section on Molecular Neuroscience, National Institute of Mental Health - Intramural Research Program, Bethesda, MD, USA.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2021 May 06; Vol. 33 (7), pp. e12974. Date of Electronic Publication: 2021 May 06.
Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy.
Autorzy:
ChepurnyOG; Department of Medicine, State University of New York (SUNY), Upstate Medical University, Syracuse, New York, USA. Leech CA; Department of Medicine, State University of New York (SUNY), Upstate Medical University, Syracuse, New York, USA. Tomanik M; Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA. DiPoto MC; Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA. Li H; Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA. Han X; Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA. Meng Q; Department of Surgery, State University of New York (SUNY), Upstate Medical University, Syracuse, New York, USA. Cooney RN; Department of Surgery, State University of New York (SUNY), Upstate Medical University, Syracuse, New York, USA. Wu J; Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA. Holz GG; Department of Medicine, State University of New York (SUNY), Upstate Medical University, Syracuse, New York, USA.; Department of Pharmacology, State University of New York (SUNY), Upstate Medical University, Syracuse, New York, USA.
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 29; Vol. 6, pp. 28934. Date of Electronic Publication: 2016 Jun 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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