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    Wyświetlanie 1-12 z 12
    Tytuł:
    Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation.
    Autorzy:
    Lu PH; Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 970, Taiwan.
    Liao TH; Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.
    Chen YH; Department of Chemistry, Tamkang University, New Taipei City 251, Taiwan.
    Hsu YL; Department of Applied Chemistry, National Chia-Yi University, Chiayi City 600, Taiwan.
    Kuo CY; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.
    Chan CC; Department of Laboratory Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.
    Wang LK; Department of Life Sciences, Ministry of Science and Technology, Taipei 106, Taiwan.
    Chern CY; Department of Applied Chemistry, National Chia-Yi University, Chiayi City 600, Taiwan.
    Tsai FM; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2022 Jun 23; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 23.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Platelet Activation*
    Platelet Aggregation*
    Adenosine Diphosphate/pharmacology ; Blood Platelets ; Coumarins/pharmacology ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Glycoprotein GPIIb-IIIa Complex/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells.
    Autorzy:
    Tseng WC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Chen CY; Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
    Chern CY; Department of Applied Chemistry, National Chiayi University, Chiayi 600, Taiwan.
    Wang CA; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
    Lee WC; Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Chi YC; Cryo-EM Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
    Cheng SF; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Kuo YT; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Chiu YC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Tseng ST; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Lin PY; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Liou SJ; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
    Li YC; Department of Applied Chemistry, National Chiayi University, Chiayi 600, Taiwan.
    Chen CC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.; Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Apr 23; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 23.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    DNA Damage*
    Homologous Recombination*
    BRCA2 Protein/*deficiency
    Breast Neoplasms/*drug therapy
    Curcumin/*pharmacology
    Gene Expression Regulation, Neoplastic/*drug effects
    Rad52 DNA Repair and Recombination Protein/*antagonists & inhibitors
    Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; BRCA2 Protein/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; DNA Repair ; Female ; Humans ; Irinotecan/pharmacology ; Mice ; Mice, Nude ; Mutation ; Topoisomerase I Inhibitors/pharmacology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction.
    Autorzy:
    Chen LW; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
    Tsai MC; Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, Taipei, Taiwan.
    Chern CY; Department of Applied Chemistry, National Chiayi University, Chiayi City, Taiwan.
    Tsao TP; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.; Division of Cardiology, Cheng Hsin General Hospital, Taipei, Taiwan.
    Lin FY; Taipei Heart Research Institute and Department of Internal Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
    Chen SJ; Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
    Tsui PF; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
    Liu YW; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
    Lu HJ; Department of Applied Chemistry, National Chiayi University, Chiayi City, Taiwan.
    Wu WL; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    Lin WS; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
    Tsai CS; Division of Cardiovascular Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.; Department and Graduate Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan.; Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
    Lin CS; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
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    Źródło:
    British journal of pharmacology [Br J Pharmacol] 2020 Dec; Vol. 177 (23), pp. 5375-5392. Date of Electronic Publication: 2020 Jul 20.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Atherosclerosis*/drug therapy
    Atherosclerosis*/prevention & control
    Chalcone*/pharmacology
    Chalcones*/pharmacology
    ATP Binding Cassette Transporter 1/genetics ; Animals ; Cholesterol ; Inflammation/drug therapy ; Mice ; Mice, Knockout
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Chalcone Derivatives Enhance ATP-Binding Cassette Transporters A1 in Human THP-1 Macrophages.
    Autorzy:
    Teng IJ; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan. .
    Tsai MC; Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, Taipei 11490, Taiwan. .
    Shih SF; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. .
    Tsuei BF; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan. .
    Chang H; Department of Applied Chemistry, National Chiayi University, Chiayi City 60004, Taiwan. .
    Chuang YP; Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 11490, Taiwan. .
    Lin CS; Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. .
    Chern CY; Department of Applied Chemistry, National Chiayi University, Chiayi City 60004, Taiwan. .
    Chen SJ; Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2018 Jul 03; Vol. 23 (7). Date of Electronic Publication: 2018 Jul 03.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Up-Regulation*
    ATP Binding Cassette Transporter 1/*genetics
    Chalcones/*chemical synthesis
    Chalcones/*pharmacology
    Macrophages/*cytology
    Chalcones/chemistry ; Gene Expression Regulation/drug effects ; Humans ; Liver X Receptors/genetics ; Macrophages/drug effects ; MicroRNAs/genetics ; Molecular Structure ; Signal Transduction/drug effects ; THP-1 Cells
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo.
    Autorzy:
    Chen YH; Department of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, Taiwan. .
    Chang CY; Department of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, Taiwan. .
    Chang CF; Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan. .
    Chen PC; Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan. .
    Lee YT; Department of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, Taiwan. .
    Chern CY; Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan. .
    Tsai JN; School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan. .; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2015 Jul 09; Vol. 20 (7), pp. 12512-24. Date of Electronic Publication: 2015 Jul 09.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Developmental*
    Angiogenesis Inducing Agents/*pharmacology
    Chalcones/*pharmacology
    Neovascularization, Physiologic/*drug effects
    Vascular Endothelial Growth Factor A/*agonists
    Zebrafish Proteins/*agonists
    Angiogenesis Inducing Agents/chemical synthesis ; Animals ; Animals, Genetically Modified ; Chalcones/chemical synthesis ; Embryo, Nonmammalian ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Molecular Structure ; Morphogenesis/drug effects ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Synthesis of analogues of gingerol and shogaol, the active pungent principles from the rhizomes of Zingiber officinale and evaluation of their anti-platelet aggregation effects.
    Autorzy:
    Shih HC; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. .
    Chern CY; Department of Applied Chemistry, National Chiayi University, Chiayi 600, Taiwan. .
    Kuo PC; Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan. .
    Wu YC; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. .
    Chan YY; Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan. .
    Liao YR; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. .
    Teng CM; College of Medicine, Pharmacological Institute, National Taiwan University, Taipei 100, Taiwan. .
    Wu TS; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. .
    Pokaż więcej
    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2014 Mar 04; Vol. 15 (3), pp. 3926-51. Date of Electronic Publication: 2014 Mar 04.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Catechols/*pharmacology
    Fatty Alcohols/*pharmacology
    Zingiber officinale/*chemistry
    Platelet Aggregation Inhibitors/*pharmacology
    Rhizome/*chemistry
    Animals ; Catechols/chemical synthesis ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Fatty Alcohols/chemical synthesis ; Hydrogenation ; Models, Chemical ; Molecular Structure ; Oxidation-Reduction ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/chemical synthesis ; Platelet Count ; Rabbits
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model.
    Autorzy:
    Lee YT; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
    Fong TH; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
    Chen HM; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
    Chang CY; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
    Wang YH; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
    Chern CY; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
    Chen YH; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2014 Jan 07; Vol. 19 (1), pp. 641-50. Date of Electronic Publication: 2014 Jan 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Abnormalities, Drug-Induced/*pathology
    Chalcone/*analogs & derivatives
    Chalcone/*toxicity
    Muscle Fibers, Skeletal/*pathology
    Teratogens/*toxicity
    Animals ; Embryo, Nonmammalian/drug effects ; Embryonic Development/drug effects ; Muscle Fibers, Skeletal/drug effects ; Muscle, Skeletal/abnormalities ; Zebrafish
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model.
    Autorzy:
    Chen YH; Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. />Wang WH
    Wang YH
    Lin ZY
    Wen CC
    Chern CY
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2013 Feb 05; Vol. 18 (2), pp. 2052-60. Date of Electronic Publication: 2013 Feb 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anti-Inflammatory Agents/*pharmacology
    Chalcone/*analogs & derivatives
    Chalcone/*pharmacology
    Zebrafish/*metabolism
    Animal Fins/surgery ; Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Chalcone/chemical synthesis ; Chalcone/chemistry ; Larva/drug effects ; Larva/enzymology ; Models, Animal ; Neutrophil Infiltration/drug effects ; Peroxidase/metabolism ; Wound Healing/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-12 z 12

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