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Tytuł:
Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues.
Autorzy:
Pichlak M; Institute of Molecular and Industrial Biotechnology, Lodz University of Technology, Łódź, Poland.
Sobierajski T; Institute of Organic Chemistry, Lodz University of Technology, Łódź, Poland.
Błażewska KM; Institute of Organic Chemistry, Lodz University of Technology, Łódź, Poland.
Gendaszewska-Darmach E; Institute of Molecular and Industrial Biotechnology, Lodz University of Technology, Łódź, Poland.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2254012.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Lysine*
Proteolysis Targeting Chimera*
Arginine ; Ubiquitin-Protein Ligases ; Protein Processing, Post-Translational
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.
Autorzy:
Ahn G; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Riley NM; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Kamber RA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Wisnovsky S; Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Moncayo von Hase S; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Bassik MC; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Banik SM; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Bertozzi CR; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 20; Vol. 382 (6668), pp. eadf6249. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Lysosomes*/metabolism
Membrane Proteins*/metabolism
Proteolysis*
Receptor, IGF Type 2*/genetics
Receptor, IGF Type 2*/metabolism
Proteolysis Targeting Chimera*/metabolism
Humans ; HeLa Cells ; Cullin Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hybrid origin of a primate, the gray snub-nosed monkey.
Autorzy:
Wu H; State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
Wang Z; Key Laboratory for Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.
Zhang Y; State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
Frantz L; Palaeogenomics Group, Department of Veterinary Sciences, Ludwig Maximilian University of Munich, D-80539 Munich, Germany.; School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK.
Roos C; Gene Bank of Primates and Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Irwin DM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Zhang C; Beijing Key Laboratory of Captive Wildlife Technologies in Beijing Zoo, Beijing, China.
Liu X; Beijing Key Laboratory of Captive Wildlife Technologies in Beijing Zoo, Beijing, China.
Wu D; Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Huang S; Kunming Zoo, Kunming, China.
Gu T; State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
Liu J; Key Laboratory for Bio-resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.; State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystem, College of Ecology, Lanzhou University, Lanzhou 730000, China.
Yu L; State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jun 02; Vol. 380 (6648), pp. eabl4997. Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Presbytini*/anatomy & histology
Presbytini*/genetics
Hybridization, Genetic*
Biological Evolution*
Chimera*
Pigmentation*/genetics
Animals ; China ; Genome ; Genomics ; Reproductive Isolation ; Biological Variation, Population
SCR Organism:
Rhinopithecus roxellana
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Autorzy:
Mercer JAM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
DeCarlo SJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Sreekanth V; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nelson AT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Chen PJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Kokkonda P; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Tiwari PK; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Deb A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk4422. Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Proteolysis*
Ubiquitin-Protein Ligases*/chemistry
Degrons*/genetics
Zinc Fingers*/genetics
Directed Molecular Evolution*/methods
Cryoelectron Microscopy ; Thalidomide/chemistry ; Ubiquitination ; Proteolysis Targeting Chimera ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Utility of Next-Generation Sequencing-Based Chimerism Analysis for Early Relapse Prediction following Allogenic Hematopoietic Cell Transplantation.
Autorzy:
Lee H; Department of Laboratory Medicine, Chosun University Hospital, Gwangju 61453, Republic of Korea.
Chae SW; Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Cho SI; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Lee JS; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Kim MJ; Department of Genomic Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Seong MW; Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 28; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Chimerism*
Hematopoietic Stem Cell Transplantation*
Humans ; Transplantation Chimera ; Chronic Disease ; Recurrence ; High-Throughput Nucleotide Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The unusual genetics of invasive ants.
Autorzy:
Kronauer DJC; Laboratory of Social Evolution and Behavior, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, New York, NY, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. 33-34. Date of Electronic Publication: 2023 Apr 06.
Typ publikacji:
Journal Article
MeSH Terms:
Ants*/genetics
Ants*/growth & development
Introduced Species*
Chimera*
Reproduction*
Animals ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs.
Autorzy:
Minakawa K; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.
Ono S; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.
Watanabe M; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.
Sato Y; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Suzuki S; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.
Odawara S; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.
Kawabata K; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.
Ueda K; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan.; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Nollet KE; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Sano H; Department of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.
Ikezoe T; Department of Hematology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kikuta A; Department of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.
Ikeda K; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital, Fukushima, Japan. .; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 09; Vol. 12 (1), pp. 21328. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Transplantation Chimera*/genetics
Hematopoietic Stem Cell Transplantation*
Humans ; East Asian People ; Chimerism ; DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF Protein.
Autorzy:
Marini E; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Marino M; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Gionfriddo G; Candiolo Cancer Institute, FPO-IRCCS (Fondazione del Piemonte per l'Oncologia-Istituti di Ricovero e Cura a Carattere Scientifico), 10060 Candiolo, Italy.
Maione F; Candiolo Cancer Institute, FPO-IRCCS (Fondazione del Piemonte per l'Oncologia-Istituti di Ricovero e Cura a Carattere Scientifico), 10060 Candiolo, Italy.
Pandini M; Candiolo Cancer Institute, FPO-IRCCS (Fondazione del Piemonte per l'Oncologia-Istituti di Ricovero e Cura a Carattere Scientifico), 10060 Candiolo, Italy.
Oddo D; Candiolo Cancer Institute, FPO-IRCCS (Fondazione del Piemonte per l'Oncologia-Istituti di Ricovero e Cura a Carattere Scientifico), 10060 Candiolo, Italy.
Giorgis M; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Rolando B; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Blua F; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Gastaldi S; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Marchiò S; Candiolo Cancer Institute, FPO-IRCCS (Fondazione del Piemonte per l'Oncologia-Istituti di Ricovero e Cura a Carattere Scientifico), 10060 Candiolo, Italy.; Department of Oncology, University of Torino, 10060 Torino, Italy.
Kovachka S; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.; Centre National de la Recherche Scientifique, Institut de Chimie de Nice, Université Côte d'Azur, CEDEX 2, 06108 Nice, France.
Spyrakis F; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Gianquinto E; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
Di Nicolantonio F; Candiolo Cancer Institute, FPO-IRCCS (Fondazione del Piemonte per l'Oncologia-Istituti di Ricovero e Cura a Carattere Scientifico), 10060 Candiolo, Italy.
Bertinaria M; Department of Drug Science and Technology, University of Turin, 10125 Torino, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 03; Vol. 27 (23). Date of Electronic Publication: 2022 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins B-raf*
Proteolysis Targeting Chimera*
Humans ; Sulfonamides/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Cell Line, Tumor ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chimeras for the twenty-first century.
Autorzy:
Morata Tarifa C; Preclinical Department, Andalusian Network for Advanced Therapies, Fundación Progreso y Salud, Sevilla, Spain.
López Navas L; Preclinical Department, Andalusian Network for Advanced Therapies, Fundación Progreso y Salud, Sevilla, Spain.
Azkona G; Barcelona Biomedical Research Parc (PRBB), Barcelona, Spain.
Sánchez Pernaute R; Preclinical Department, Andalusian Network for Advanced Therapies, Fundación Progreso y Salud, Sevilla, Spain.
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Źródło:
Critical reviews in biotechnology [Crit Rev Biotechnol] 2020 May; Vol. 40 (3), pp. 283-291. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Chimera/*metabolism
Animals ; Bioethical Issues ; Chimera/classification ; Embryonic Stem Cells ; Humans ; Mice ; Models, Genetic ; Organogenesis ; Regenerative Medicine ; Transplantation Chimera
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning.
Autorzy:
Xie L; Department of Computer Science, Hunter College, The City University of New York, New York City, New York, United States of America.
Xie L; Department of Computer Science, Hunter College, The City University of New York, New York City, New York, United States of America.; Ph.D. Program in Computer Science, The Graduate Center, The City University of New York, New York City, New York, United States of America.; Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain & Mind Research Institute, Weill Cornell Medicine, Cornell University, New York City, New York, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2023 Aug 17; Vol. 19 (8), pp. e1010974. Date of Electronic Publication: 2023 Aug 17 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Ubiquitin-Protein Ligases*
Alzheimer Disease*
Humans ; Amino Acid Sequence ; Genome, Human ; Machine Learning ; Proteolysis Targeting Chimera
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice with humanized livers.
Autorzy:
Yoshida K; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Doi Y; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Iwazaki N; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Yasuhara H; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Ikenaga Y; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Shimizu H; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Nakada T; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Watanabe T; DMPK Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan.
Tateno C; Research and Development Department, PhoenixBio Co., Ltd., Hiroshima, Japan.
Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kotake Y; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Jan; Vol. 15 (1), pp. 79-91. Date of Electronic Publication: 2021 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Chimera*
Forecasting*
Metabolic Clearance Rate*
Liver/*metabolism
Animals ; Drug Elimination Routes ; Mice ; Models, Animal ; Pharmaceutical Preparations
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells.
Autorzy:
Ismail TM; Department of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Crick RG; Department of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Du M; Department of Clinical Infection, Microbiology and Immunity, University of Liverpool, Liverpool L69 7ZB, UK.
Shivkumar U; Department of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Carnell A; Department of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Barraclough R; Department of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Wang G; Department of Clinical Infection, Microbiology and Immunity, University of Liverpool, Liverpool L69 7ZB, UK.
Cheng Z; Medical School, Southeast University, Nanjing 230032, China.; Department of Gastroenterology, First Affiliated Hospital, Anhui Medical University, Hefei 210009, China.
Yu W; Medical School, Southeast University, Nanjing 230032, China.
Platt-Higgins A; Department of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Nixon G; Department of Chemistry, University of Liverpool, Liverpool L69 7ZB, UK.
Rudland PS; Department of Biochemistry and Systems Biology, University of Liverpool, Liverpool L69 7ZB, UK.
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Źródło:
Biomolecules [Biomolecules] 2023 Jul 10; Vol. 13 (7). Date of Electronic Publication: 2023 Jul 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
S100 Calcium-Binding Protein A4*/pharmacology
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/metabolism
Animals ; Humans ; Mice ; Rats ; Cell Line, Tumor ; Cell Movement ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Proteolysis Targeting Chimera/metabolism ; Proteolysis Targeting Chimera/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone.
Autorzy:
Li G; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.; College of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Meng X; College of Animal Science and Technology, Jilin Agricutural University, Changchun 130118, China.
Ren Z; School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Li E; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Yan F; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Liu J; School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Zhang Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Cui Z; College of Animal Science and Technology, Jilin Agricutural University, Changchun 130118, China.
Li Y; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Jin H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Cao Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Yi L; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Huang P; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Chi H; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Wang H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Sun W; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Wang T; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Gao Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Zhao Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Yang S; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Xia X; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.; College of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
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Źródło:
Viruses [Viruses] 2021 Jun 29; Vol. 13 (7). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chimera*
Encephalitis Virus, Japanese/*genetics
West Nile virus/*genetics
Animals ; Cell Line ; Cricetinae ; Encephalitis Virus, Japanese/pathogenicity ; Female ; Mice ; Mice, Inbred BALB C ; Virulence ; West Nile virus/pathogenicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chimerism Testing by Next Generation Sequencing for Detection of Engraftment and Early Disease Relapse in Allogeneic Hematopoietic Cell Transplantation and an Overview of NGS Chimerism Studies.
Autorzy:
Liacini A; Immunogenetics Laboratory, Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 N. Broad St., Office B242, Philadelphia, PA 19140, USA.
Tripathi G; Immunogenetics Laboratory, Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 N. Broad St., Office B242, Philadelphia, PA 19140, USA.
McCollick A; Immunogenetics Laboratory, Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 N. Broad St., Office B242, Philadelphia, PA 19140, USA.
Gravante C; Immunogenetics Laboratory, Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 N. Broad St., Office B242, Philadelphia, PA 19140, USA.
Abdelmessieh P; Fox Chase Cancer Center Medical Group, Temple Health, Philadelphia, PA 19140, USA.
Shestovska Y; Fox Chase Cancer Center Medical Group, Temple Health, Philadelphia, PA 19140, USA.
Mathew L; Immunogenetics Laboratory, Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 N. Broad St., Office B242, Philadelphia, PA 19140, USA.
Geier S; Immunogenetics Laboratory, Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 N. Broad St., Office B242, Philadelphia, PA 19140, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 23; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 23.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Chimerism*
Hematopoietic Stem Cell Transplantation*
Humans ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; High-Throughput Nucleotide Sequencing ; Neoplasm Recurrence, Local/genetics ; Chronic Disease ; Transplantation Chimera/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Microchimerism as Post-Transplant Marker of a Chronic Rejection Process.
Autorzy:
Sieńko J; Institute of Physical Culture Sciences, University of Szczecin, 70-453 Szczecin, Poland.
Kotowski M; Department of General Surgery and Transplantology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Czarnecka W; Scientific Circle at Department of Biochemical Sciences, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Podkówka A; Scientific Circle at Department of Biochemical Sciences, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Tejchman K; Department of General Surgery and Transplantology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Kotfis K; Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Zeair S; General and Transplant Surgery Ward with Sub-Departments of Pomeranian Regional Hospital in Szczecin, 71-455 Szczecin, Poland.
Czajkowski Z; Department of Intensive Care, Pomeranian Regional Hospital in Szczecin, 71-455 Szczecin, Poland.
Skonieczna-Żydecka K; Department of Biochemical Sciences, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 25; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Kidney Transplantation*/adverse effects
Humans ; Male ; Female ; Chimerism ; Transplantation Chimera ; Graft Rejection/genetics ; DNA/genetics ; Tissue Donors ; Urea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PROTACs: Emerging Targeted Protein Degradation Approaches for Advanced Druggable Strategies.
Autorzy:
Sincere NI; Laboratory Medicine Center, Lanzhou University Second Hospital, The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Anand K; Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa.
Ashique S; Department of Pharmaceutics, Bharat Institute of Technology (BIT), School of Pharmacy, Meerut 250103, India.
Yang J; Laboratory Medicine Center, Lanzhou University Second Hospital, The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
You C; Laboratory Medicine Center, Lanzhou University Second Hospital, The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 May 10; Vol. 28 (10). Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Proteasome Endopeptidase Complex*
Medicine*
Proteolysis ; Cytoplasm ; Head ; Proteolysis Targeting Chimera
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rethinking the oversight conditions of human-animal chimera research.
Autorzy:
Piotrowska M; Department of Philosophy, State University of New York at Albany, New York, New York, USA.
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Źródło:
Bioethics [Bioethics] 2021 Jan; Vol. 35 (1), pp. 98-104. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Animal Experimentation*
Chimera*
Animals ; Humans ; Morals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 7510

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