Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Autorzy:
Mercer JAM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. DeCarlo SJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Sreekanth V; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA. Nelson AT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Chen PJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Kokkonda P; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Tiwari PK; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA. Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Deb A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA. Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk4422. Date of Electronic Publication: 2024 Mar 15.
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