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Tytuł :
Genetic factors influencing the development of vincristine-induced neurotoxicity.
Autorzy :
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy.
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy.
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Źródło :
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2021 Feb; Vol. 17 (2), pp. 215-226. Date of Electronic Publication: 2020 Dec 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Addressing the Need of a Translational Approach in Peripheral Neuropathy Research: Morphology Meets Function.
Autorzy :
Monza L; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Fumagalli G; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Chiorazzi A; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Alberti P; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
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Źródło :
Brain sciences [Brain Sci] 2021 Jan 22; Vol. 11 (2). Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity.
Autorzy :
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Scali C; Global Medical and R&D Department, Kedrion S.p.A., Località Ai Conti, Castelvecchio Pascoli, 55051 Lucca, Italy.
Guarnieri C; Global Medical and R&D Department, Kedrion S.p.A., Località Ai Conti, Castelvecchio Pascoli, 55051 Lucca, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Alberti P; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Ballarini E; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Rodriguez-Menendez V; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Oggioni N; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.
Marmiroli P; Experimental Neurology Unit, School of Medicine and Surgery, and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20900 Monza, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 21; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
The relevance of multimodal assessment in experimental oxaliplatin-induced peripheral neurotoxicity.
Autorzy :
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Carozzi VA; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Oggioni N; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Rodriguez-Menendez V; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. Electronic address: .
Marmiroli P; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.
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Źródło :
Experimental neurology [Exp Neurol] 2020 Dec; Vol. 334, pp. 113458. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Autorzy :
Huang KM; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Leblanc AF; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Uddin ME; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Kim JY; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Chen M; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Eisenmann ED; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Gibson AA; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Li Y; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Hong KW; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
DiGiacomo D; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Xia SH; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Alberti P; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; NeuroMI, Milan Center for Neuroscience, Milan, Italy.
Chiorazzi A; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; NeuroMI, Milan Center for Neuroscience, Milan, Italy.
Housley SN; School of Biological Sciences and Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Cope TC; School of Biological Sciences and Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Sprowl JA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.
Wang J; Department of Cancer Biology and Genetics, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Loprinzi CL; Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota, USA.
Noonan A; Division of Medical Oncology, Department of Internal Medicine, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Lustberg MB; Division of Medical Oncology, Department of Internal Medicine, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Cavaletti G; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; NeuroMI, Milan Center for Neuroscience, Milan, Italy.
Pabla N; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Hu S; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Sparreboom A; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Sep 01; Vol. 130 (9), pp. 4601-4606.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxaliplatin*/adverse effects
Oxaliplatin*/pharmacokinetics
Oxaliplatin*/pharmacology
Neuroglia/*metabolism
Neurons/*metabolism
Neurotoxicity Syndromes/*metabolism
Organic Cation Transporter 2/*metabolism
Animals ; Female ; Male ; Mice ; Mice, Knockout ; Neuroglia/pathology ; Neurons/pathology ; Neurotoxicity Syndromes/genetics ; Neurotoxicity Syndromes/pathology ; Organic Cation Transporter 2/genetics ; Rats
Czasopismo naukowe
Tytuł :
Reply to a Comment Paper on the Published Paper by Canta, A. et al: "Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity"- Antioxidants 2020, 9 , 594.
Autorzy :
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Carozzi VA; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Rodriguez-Menendez V; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Oggioni N; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Näsström J; PledPharma AB, Grev Turegatan 11 C, 114 46 Stockholm, Sweden.
Marmiroli P; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
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Źródło :
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2020 Sep 01; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity.
Autorzy :
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Carozzi VA; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Rodriguez-Menendez V; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Oggioni N; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Näsström J; PledPharma AB, Grev Turegatan 11 C, 114 46 Stockholm, Sweden.
Marmiroli P; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
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Źródło :
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2020 Jul 07; Vol. 9 (7). Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity.
Autorzy :
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Alberti P; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Canta A; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Carozzi VA; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
Blennow K; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Zetterberg H; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy. .
Marmiroli P; Experimental Neurology Unit, School of Medicine and Surgery; NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, Monza, MB, Italy.
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Źródło :
Archives of toxicology [Arch Toxicol] 2020 Jul; Vol. 94 (7), pp. 2517-2522. Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Topiramate prevents oxaliplatin-related axonal hyperexcitability and oxaliplatin induced peripheral neurotoxicity.
Autorzy :
Alberti P; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy. Electronic address: .
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; PhD program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; Human Physiology Lab., School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; PhD program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Ballarini E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Rodriguez-Menendez V; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Oggioni N; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Sancini G; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; Human Physiology Lab., School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Marmiroli P; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; NeuroMI (Milan Center for Neuroscience), School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Mar 01; Vol. 164, pp. 107905. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*toxicity
Axons/*drug effects
Neuroprotective Agents/*pharmacology
Neurotoxicity Syndromes/*prevention & control
Oxaliplatin/*antagonists & inhibitors
Oxaliplatin/*toxicity
Peripheral Nervous System Diseases/*chemically induced
Peripheral Nervous System Diseases/*prevention & control
Topiramate/*pharmacology
Animals ; Female ; Neural Conduction/drug effects ; Pain Measurement ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Oxaliplatin-induced neuropathy occurs through impairment of haemoglobin proton buffering and is reversed by carbonic anhydrase inhibitors.
Autorzy :
Potenzieri A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy. Dr. Potenzieri is now with the NBT-Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.
Riva B; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy. Dr. Potenzieri is now with the NBT-Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.
Rigolio R; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Pozzi E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Ballarini E; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Genazzani AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy. Dr. Potenzieri is now with the NBT-Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy.
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Źródło :
Pain [Pain] 2020 Feb; Vol. 161 (2), pp. 405-415.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*toxicity
Carbonic Anhydrase Inhibitors/*pharmacology
Hemoglobins/*drug effects
Hydrogen-Ion Concentration/*drug effects
Neurons/*drug effects
Oxaliplatin/*toxicity
Peripheral Nervous System Diseases/*chemically induced
Acetazolamide/pharmacology ; Animals ; Buffers ; Ganglia, Spinal/cytology ; HEK293 Cells ; Hemoglobins/genetics ; Hemoglobins/metabolism ; Humans ; Hyperalgesia ; Mice ; Mice, Inbred BALB C ; Neurons/metabolism ; Primary Cell Culture ; Protons ; Topiramate/pharmacology ; Transient Receptor Potential Channels
Czasopismo naukowe
Tytuł :
An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection.
Autorzy :
Hucke A; Medizinische Klinik D, Experimentelle Nephrologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1/A14, 48149, Münster, Germany.
Rinschen MM; Department II of Internal Medicine, and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Bauer OB; Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität, Münster, Germany.
Sperling M; Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität, Münster, Germany.
Karst U; Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität, Münster, Germany.
Köppen C; Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität, Münster, Germany.
Sommer K; Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität, Münster, Germany.
Schröter R; Medizinische Klinik D, Experimentelle Nephrologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1/A14, 48149, Münster, Germany.
Ceresa C; Experimental Neurology Unit of the Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
Chiorazzi A; Experimental Neurology Unit of the Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
Canta A; Experimental Neurology Unit of the Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
Semperboni S; Experimental Neurology Unit of the Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
Marmiroli P; Experimental Neurology Unit of the Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
Cavaletti G; Experimental Neurology Unit of the Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
Schlatt S; Centrum für Reproduktionsmedizin und Andrologie, Universitätsklinikum Münster, Münster, Germany.
Schlatter E; Medizinische Klinik D, Experimentelle Nephrologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1/A14, 48149, Münster, Germany.
Pavenstädt H; Medizinische Klinik D, Experimentelle Nephrologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1/A14, 48149, Münster, Germany.
Heitplatz B; Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Münster, Germany.
Van Marck V; Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Münster, Germany.
Sparreboom A; Division of Pharmaceutics, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Barz V; Medizinische Klinik D, Experimentelle Nephrologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1/A14, 48149, Münster, Germany.
Knief A; Klinik für Phoniatrie und Pädaudiologie, Universitätsklinikum Münster, Münster, Germany.
Deuster D; Klinik für Phoniatrie und Pädaudiologie, Universitätsklinikum Münster, Münster, Germany.
Zehnhoff-Dinnesen AA; Klinik für Phoniatrie und Pädaudiologie, Universitätsklinikum Münster, Münster, Germany.
Ciarimboli G; Medizinische Klinik D, Experimentelle Nephrologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1/A14, 48149, Münster, Germany. .
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Źródło :
Archives of toxicology [Arch Toxicol] 2019 Oct; Vol. 93 (10), pp. 2835-2848. Date of Electronic Publication: 2019 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*toxicity
Cisplatin/*toxicity
Octamer Transcription Factor-1/*genetics
Organic Cation Transporter 2/*genetics
Animals ; Antineoplastic Agents/administration & dosage ; Cisplatin/administration & dosage ; Kidney Diseases/chemically induced ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Male ; Mice ; Mice, Knockout ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/genetics ; Octamer Transcription Factor-1/metabolism ; Organic Cation Transporter 2/metabolism ; Ototoxicity/etiology ; Ototoxicity/genetics ; Proteomics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer.
Autorzy :
Tesei A; Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRCCS), Meldola, Italy.
Cortesi M; Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRCCS), Meldola, Italy.
Pignatta S; Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRCCS), Meldola, Italy.
Arienti C; Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRCCS), Meldola, Italy.
Dondio GM; Aphad S.r.l., Milan, Italy.
Bigogno C; Aphad S.r.l., Milan, Italy.
Malacrida A; Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Miloso M; Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Chiorazzi A; Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Carozzi V; Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Rui M; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia, Italy.
Marra A; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia, Italy.
Rossi D; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia, Italy.
Collina S; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia, Italy.
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Źródło :
Frontiers in pharmacology [Front Pharmacol] 2019 May 14; Vol. 10, pp. 490. Date of Electronic Publication: 2019 May 14 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Ghrelin agonist HM01 attenuates chemotherapy-induced neurotoxicity in rodent models.
Autorzy :
Chiorazzi A; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Wozniak KM; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Rais R; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Wu Y; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Gadiano AJ; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Farah MH; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Liu Y; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neuromuscular Medicine and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Canta A; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Alberti P; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy; PhD Program in Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Rodriguez-Menendez V; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Meregalli C; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Fumagalli G; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy; PhD Program in Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Monza L; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy; PhD Program DIMET, University of Milano-Bicocca, 20900 Monza, Italy.
Pozzi E; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy; PhD Program in Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.
Vornov JJ; Medpace, Cincinnati, OH 45227, USA.
Polydefkis M; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neuromuscular Medicine and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Pietra C; Helsinn Healthcare SA, 6915 Lugano, Switzerland.
Slusher BS; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Medicine, Psychiatry and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: .
Cavaletti G; Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2018 Dec 05; Vol. 840, pp. 89-103. Date of Electronic Publication: 2018 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*adverse effects
Benzene Derivatives/*pharmacology
Ghrelin/*agonists
Nervous System/*drug effects
Neuroprotective Agents/*pharmacology
Animals ; Body Weight/drug effects ; Cisplatin/adverse effects ; Dose-Response Relationship, Drug ; Eating/drug effects ; Female ; Male ; Mice ; Neural Conduction/drug effects ; Piperidines ; Rats
Czasopismo naukowe

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