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Wyszukujesz frazę ""Chloride Channels"" wg kryterium: Temat


Tytuł :
Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel.
Autorzy :
Koster AK; Department of Chemistry, Stanford University, Stanford, CA 94305.; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Reese AL; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Kuryshev Y; Charles River Laboratories Cleveland, Inc., Cleveland, OH 44128.
Wen X; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
McKiernan KA; Department of Chemistry, Stanford University, Stanford, CA 94305.
Gray EE; Department of Chemistry, Stanford University, Stanford, CA 94305.
Wu C; Charles River Laboratories Cleveland, Inc., Cleveland, OH 44128.
Huguenard JR; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305; .
Maduke M; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305; .
Du Bois J; Department of Chemistry, Stanford University, Stanford, CA 94305; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32711-32721. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Chloride Channels/*antagonists & inhibitors
Chloride Channels/*chemistry
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
Animals ; Binding Sites ; CHO Cells ; Cell Line ; Chloride Channels/genetics ; Chloride Channels/metabolism ; Cricetulus ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Hippocampus/metabolism ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Docking Simulation ; Organ Culture Techniques ; Patch-Clamp Techniques ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Small Molecule Libraries/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Genome-wide identification and expression analysis of the CLC gene family in pomegranate (Punica granatum) reveals its roles in salt resistance.
Autorzy :
Liu C; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, China.; College of Forestry, Nanjing Forestry University, Nanjing, 210037, China.
Zhao Y; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, China.; College of Forestry, Nanjing Forestry University, Nanjing, 210037, China.
Zhao X; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, China.; College of Forestry, Nanjing Forestry University, Nanjing, 210037, China.
Dong J; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, China.; College of Forestry, Nanjing Forestry University, Nanjing, 210037, China.
Yuan Z; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, 210037, China. .; College of Forestry, Nanjing Forestry University, Nanjing, 210037, China. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2020 Dec 11; Vol. 20 (1), pp. 560. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article
MeSH Terms :
Multigene Family*
Chloride Channels/*genetics
Plant Proteins/*genetics
Pomegranate/*physiology
Salt Tolerance/*genetics
Salt-Tolerant Plants/*physiology
Amino Acid Sequence ; Chloride Channels/chemistry ; Chloride Channels/metabolism ; Gene Expression Profiling ; Genome, Plant ; Phylogeny ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Pomegranate/genetics ; Salt-Tolerant Plants/genetics ; Salt-Tolerant Plants/metabolism ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel.
Autorzy :
Kwon HC; Biophysics Graduate Program, University of California, Davis, California, United States of America.
Yu Y; BMCDB Graduate Program, University of California, Davis, California, United States of America.
Fairclough RH; Biophysics Graduate Program, University of California, Davis, California, United States of America.; BMCDB Graduate Program, University of California, Davis, California, United States of America.; Center for Neuroscience, University of California, Davis, California, United States of America.
Chen TY; Biophysics Graduate Program, University of California, Davis, California, United States of America.; BMCDB Graduate Program, University of California, Davis, California, United States of America.; Center for Neuroscience, University of California, Davis, California, United States of America.; Department of Neurology, University of California, Davis, California, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0240704. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ion Channel Gating*
Protons*
Chloride Channels/*metabolism
Chlorides/*metabolism
Chloride Channels/genetics ; Glutamic Acid/genetics ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Membrane Potentials ; Mutagenesis, Site-Directed ; Mutation ; Patch-Clamp Techniques ; Structural Homology, Protein
Czasopismo naukowe
Tytuł :
Chloride Intracellular Channel Protein 1 (CLIC1) Ιs Over-expressed in Muscle Invasive Urinary Bladder Cancer.
Autorzy :
Adelmann TG; Department of Microscopic Morphology/Histology, Angiogenesis Research Center Timisoara, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Camerota TC; Urology, IRCCS ICS Maugeri of Pavia, Pavia, Italy.
Ceausu AR; Department of Microscopic Morphology/Histology, Angiogenesis Research Center Timisoara, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Cimpean AM; Department of Microscopic Morphology/Histology, Angiogenesis Research Center Timisoara, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Mazzanti M; Department of Biosciences, Laboratory of Cellular and Molecular Physiology, University of Milano, Milan, Italy.
Raica M; Department of Microscopic Morphology/Histology, Angiogenesis Research Center Timisoara, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6879-6884.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Chloride Channels/*genetics
Urinary Bladder Neoplasms/*genetics
Urinary Bladder Neoplasms/*pathology
Aged ; Biomarkers, Tumor ; Chloride Channels/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/mortality
Czasopismo naukowe
Tytuł :
TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation.
Autorzy :
Ma G; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China; Cardiovascular Divison, Department of Internal Medicine, the First Hospital of Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China.
Zhang J; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China.
Yang X; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China.
Guo P; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China.
Hou X; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China.
Fan Y; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China.
Liu Y; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China. Electronic address: .
Zhang M; Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110766. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Anoctamin-1/*metabolism
Chloride Channels/*antagonists & inhibitors
Flavonoids/*pharmacology
Vasodilation/*drug effects
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Animals ; Calcium/metabolism ; Chloride Channels/metabolism ; Coronary Vessels/drug effects ; Coronary Vessels/metabolism ; Cyclic GMP/metabolism ; Dose-Response Relationship, Drug ; Flavonoids/administration & dosage ; Male ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Nitric Oxide/metabolism ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Vasoconstriction/drug effects
Czasopismo naukowe
Tytuł :
SLC26A7 constitutes the thiocyanate-selective anion conductance of the basolateral membrane of the retinal pigment epithelium.
Autorzy :
Cao X; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
Soleimani M; Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.
Hughes BA; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Oct 01; Vol. 319 (4), pp. C641-C656. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chloride Channels/*genetics
Chloride-Bicarbonate Antiporters/*genetics
Retinal Pigment Epithelium/*metabolism
Retinal Pigments/*genetics
Sulfate Transporters/*genetics
Animals ; Anions/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Chloride Channels/metabolism ; Chlorides/metabolism ; Gene Expression Regulation/genetics ; Humans ; Membrane Potentials/genetics ; Mice ; Mice, Knockout ; Retinal Pigments/metabolism ; Thiocyanates/metabolism
Czasopismo naukowe
Tytuł :
PGF stimulates the 10-pS Cl cotransporter in the distal convoluted tubule.
Autorzy :
Wang LJ; Department of Physiology, Harbin Medical University, Harbin, China.
Xiao Y; Department of Physiology, Harbin Medical University, Harbin, China.
Fang J; Department of Physiology, Harbin Medical University, Harbin, China.
Wang JL; Department of Physiology, Harbin Medical University, Harbin, China.
Zhang H; Department of Physiology, Harbin Medical University, Harbin, China.
Meng XX; Department of Physiology, Harbin Medical University, Harbin, China.
Gong RL; Department of Physiology, Harbin Medical University, Harbin, China.
Gu R; Department of Physiology, Harbin Medical University, Harbin, China.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Sep 01; Vol. 319 (3), pp. F414-F422. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anion Transport Proteins/*metabolism
Chloride Channels/*metabolism
Dinoprost/*pharmacology
Gene Expression Regulation/*drug effects
Kidney Tubules, Distal/*metabolism
Receptors, Drug/*metabolism
Sodium Chloride Symporters/*metabolism
Animals ; Anion Transport Proteins/genetics ; Chloride Channels/genetics ; Female ; Kidney Tubules, Distal/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Oxytocics/pharmacology ; Patch-Clamp Techniques ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Receptors, Drug/genetics ; Sodium Chloride Symporters/genetics ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Genome-wide identification and expression analysis of the CLC superfamily genes in tea plants (Camellia sinensis).
Autorzy :
Xing A; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Ma Y; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Wu Z; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Nong S; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Zhu J; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Sun H; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Tao J; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Wen B; College of Landscape Architecture, Nanjing Forestry University, Nanjing, 210037, China.
Zhu X; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Fang W; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
Li X; Jiaozhou Vocational Education Center School, Qingdao, 266300, China.
Wang Y; College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China. .
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Źródło :
Functional & integrative genomics [Funct Integr Genomics] 2020 Jul; Vol. 20 (4), pp. 497-508. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article
MeSH Terms :
Camellia sinensis/*genetics
Chloride Channels/*genetics
Plant Proteins/*genetics
Camellia sinensis/metabolism ; Chloride Channels/chemistry ; Chloride Channels/metabolism ; Conserved Sequence ; Genome, Plant ; Multigene Family ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Plant Roots/genetics ; Plant Roots/metabolism ; Protein Domains
Czasopismo naukowe
Tytuł :
From protein uptake to Dent disease: An overview of the CLCN5 gene.
Autorzy :
Gianesello L; Kidney Histomorphology and Molecular Biology Laboratory, Clinical Nephrology Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy. Electronic address: .
Del Prete D; Kidney Histomorphology and Molecular Biology Laboratory, Clinical Nephrology Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy. Electronic address: .
Ceol M; Kidney Histomorphology and Molecular Biology Laboratory, Clinical Nephrology Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy. Electronic address: .
Priante G; Kidney Histomorphology and Molecular Biology Laboratory, Clinical Nephrology Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy. Electronic address: .
Calò LA; Kidney Histomorphology and Molecular Biology Laboratory, Clinical Nephrology Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy. Electronic address: .
Anglani F; Kidney Histomorphology and Molecular Biology Laboratory, Clinical Nephrology Unit, Department of Medicine - DIMED, University of Padua, Padua, Italy. Electronic address: .
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Źródło :
Gene [Gene] 2020 Jul 15; Vol. 747, pp. 144662. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Endocytosis*
Chloride Channels/*genetics
Chloride Channels/*metabolism
Dent Disease/*genetics
Animals ; Chloride Channels/chemistry ; Dent Disease/pathology ; Humans ; Kidney/metabolism ; Mutation/genetics ; Phenotype
Czasopismo naukowe
Tytuł :
CLIC4 abrogation promotes epithelial-mesenchymal transition in gastric cancer.
Autorzy :
Wang B; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Zheng J; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Chen Q; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Wu C; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Li Y; Department of Cardiovascular Surgery and Institute of Cardiovascular Science, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P. R. China.
Yu XY; Key Laboratory of Molecular Clinical Pharmacology and Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Liu B; Department of Cardiology, Second Hospital of Jilin University, Changchun, Jilin, P. R. China.
Liang C; Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, P. R. China.
Liu SB; Suzhou Vocational Health College, Suzhou Key Laboratory of Biotechnology for Laboratory Medicine, Suzhou, Jiangsu Province, China.
Ding H; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Wang S; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Xue T; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Song D; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Lei Z; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Amin HM; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Song YH; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P. R. China.
Zhou J; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, P. R. China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (6), pp. 841-849.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*
Biomarkers, Tumor/*metabolism
Chloride Channels/*antagonists & inhibitors
Neoplastic Stem Cells/*pathology
Stomach Neoplasms/*pathology
Animals ; Antimetabolites, Antineoplastic/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Chloride Channels/genetics ; Chloride Channels/metabolism ; Female ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Prognosis ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
[Expression of ANO1 during cardiac fibroblasts differentiation and its electrophysiological characteristics as calcium-activated chloride channel protein].
Autorzy :
Tian XQ; Department of Physiology, Medical College of Shihezi University, Shihezi 832002.; Key Open Laboratory for Tissue Regeneration of Henan Province, Xinxiang Medical University, Xinxiang 453003.
Tan CY; Department of Physiology, Medical College of Shihezi University, Shihezi 832002.; Karamay Army Division of Chinese People's Liberation Army, Karamay 834000.
Li NN; Key Open Laboratory for Tissue Regeneration of Henan Province, Xinxiang Medical University, Xinxiang 453003.
Chang YQ; Key Open Laboratory for Tissue Regeneration of Henan Province, Xinxiang Medical University, Xinxiang 453003.
Zhang AM; First Affiliated Hospital, Medical College of Shihezi University, Shihezi 832002, China.
Zhou Y; Department of Physiology, Medical College of Shihezi University, Shihezi 832002.
Ma KT; Department of Physiology, Medical College of Shihezi University, Shihezi 832002.
Si JQ; Department of Physiology, Medical College of Shihezi University, Shihezi 832002.
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Źródło :
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2020 Jul; Vol. 36 (4), pp. 358-362.
Typ publikacji :
Journal Article
MeSH Terms :
Anoctamin-1*/metabolism
Calcium*/metabolism
Chloride Channels*
Fibroblasts*/metabolism
Animals ; Cell Differentiation ; Rats
Czasopismo naukowe
Tytuł :
Dynamic measurement of cytosolic pH and [NO 3 ] uncovers the role of the vacuolar transporter AtCLCa in cytosolic pH homeostasis.
Autorzy :
Demes E; Institute for Integrative Biology of the Cell, Commissariat à l'Energie Atomique et aux Énergies Alternatives, CNRS, University Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette Cedex, France.
Besse L; Institute for Integrative Biology of the Cell, Commissariat à l'Energie Atomique et aux Énergies Alternatives, CNRS, University Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette Cedex, France.
Cubero-Font P; Biochemistry and Plant Molecular Physiolgy, University Montpellier, CNRS, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Montpellier SupAgro, 34060 Montpellier Cedex 2, France.
Satiat-Jeunemaitre B; Institute for Integrative Biology of the Cell, Commissariat à l'Energie Atomique et aux Énergies Alternatives, CNRS, University Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette Cedex, France.
Thomine S; Institute for Integrative Biology of the Cell, Commissariat à l'Energie Atomique et aux Énergies Alternatives, CNRS, University Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette Cedex, France.
De Angeli A; Institute for Integrative Biology of the Cell, Commissariat à l'Energie Atomique et aux Énergies Alternatives, CNRS, University Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette Cedex, France; .; Biochemistry and Plant Molecular Physiolgy, University Montpellier, CNRS, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Montpellier SupAgro, 34060 Montpellier Cedex 2, France.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 30; Vol. 117 (26), pp. 15343-15353. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
Chloride Channels/*metabolism
Cytosol/*chemistry
Homeostasis/*physiology
Nitrates/*chemistry
Arabidopsis Proteins/genetics ; Chloride Channels/genetics ; Cytosol/metabolism ; Gene Expression Regulation, Plant/physiology ; Hydrogen-Ion Concentration ; Nitrates/metabolism
Czasopismo naukowe
Tytuł :
A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter.
Autorzy :
Hannigan KI; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Bossey AP; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Foulkes HJL; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Drumm BT; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Baker SA; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Ward SM; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Sanders KM; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Keef KD; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Cobine CA; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 25; Vol. 10 (1), pp. 10378. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Pacemaker, Artificial*
Anal Canal/*innervation
Calcium/*metabolism
Chloride Channels/*metabolism
Interstitial Cells of Cajal/*physiology
Muscle, Smooth/*physiology
Animals ; Calcium Signaling ; Chloride Channels/genetics ; Interstitial Cells of Cajal/cytology ; Mice ; Muscle Contraction ; Muscle, Smooth/cytology
Czasopismo naukowe
Tytuł :
Myotonia congenita and periodic hypokalemia paralysis in a consanguineous marriage pedigree: Coexistence of a novel CLCN1 mutation and an SCN4A mutation.
Autorzy :
Zhao C; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tang D; The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Huang H; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tang H; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang Y; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Intensive Care Unit, Peking University Cancer Hospital & Institute, Beijing, China.
Yang M; Department of Rehabilitation, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Luo Y; Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tao H; Depatment of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Tang J; Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhou X; The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
Shi X; Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Źródło :
PloS one [PLoS One] 2020 May 14; Vol. 15 (5), pp. e0233017. Date of Electronic Publication: 2020 May 14 (Print Publication: 2020).
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chloride Channels/*genetics
Hypokalemic Periodic Paralysis/*complications
Hypokalemic Periodic Paralysis/*genetics
Myotonia Congenita/*complications
Myotonia Congenita/*genetics
NAV1.4 Voltage-Gated Sodium Channel/*genetics
Adolescent ; Adult ; Aged ; Amino Acid Sequence ; China ; Chloride Channels/chemistry ; Chloride Channels/metabolism ; Consanguinity ; Conserved Sequence ; Diagnosis, Differential ; Female ; HEK293 Cells ; Humans ; Hypokalemic Periodic Paralysis/metabolism ; Male ; Middle Aged ; Models, Molecular ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutation ; Myotonia Congenita/metabolism ; NAV1.4 Voltage-Gated Sodium Channel/metabolism ; Pedigree ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Whole Exome Sequencing ; Young Adult
SCR Disease Name :
Hypokalemic Periodic Paralysis, Type 2
Czasopismo naukowe
Tytuł :
Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth.
Autorzy :
Francisco MA; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Wanggou S; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fan JJ; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Dong W; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Chen X; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Momin A; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Abeysundara N; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Min HK; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Chan J; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
McAdam R; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Sia M; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Pusong RJ; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Liu S; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Patel N; Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ramaswamy V; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Kijima N; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Wang LY; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.; Department of Physiology, University of Toronto, Toronto, Canada.
Song Y; The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
Kafri R; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Taylor MD; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Li X; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huang X; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 May 04; Vol. 217 (5).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Chloride Channels/*metabolism
Ether-A-Go-Go Potassium Channels/*metabolism
Medulloblastoma/*metabolism
Medulloblastoma/*pathology
Animals ; Body Weight ; Cell Line, Tumor ; Cell Proliferation ; Cell Size ; Chloride Channels/deficiency ; Chloride Channels/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Gene Knockdown Techniques ; Homeostasis ; Mice ; Mitosis ; Mutation/genetics ; Potassium Channels, Sodium-Activated/metabolism ; Protein Binding ; RNA/biosynthesis ; Survival Analysis ; Xenograft Model Antitumor Assays ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Isolation and characterization of a novel member of the ACC ligand-gated chloride channel family, Hco-LCG-46, from the parasitic nematode Haemonchus contortus.
Autorzy :
Habibi SA; Applied Bioscience Graduate Program, Faculty of Science, Ontario Tech University, 2000 Simcoe Street North, Oshawa, ON, L1H 7K4, Canada.
Blazie SM; Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, United States.
Jin Y; Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, United States.
Forrester SG; Applied Bioscience Graduate Program, Faculty of Science, Ontario Tech University, 2000 Simcoe Street North, Oshawa, ON, L1H 7K4, Canada. Electronic address: .
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2020 May; Vol. 237, pp. 111276. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholine/*metabolism
Chloride Channels/*chemistry
Cysteine Loop Ligand-Gated Ion Channel Receptors/*chemistry
Haemonchus/*metabolism
Helminth Proteins/*chemistry
Acetylcholine/pharmacology ; Action Potentials/drug effects ; Action Potentials/physiology ; Aldicarb/pharmacology ; Amino Acid Sequence ; Animals ; Anthelmintics/pharmacology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Carbachol/metabolism ; Carbachol/pharmacology ; Chloride Channels/genetics ; Chloride Channels/isolation & purification ; Chloride Channels/metabolism ; Choline/analogs & derivatives ; Choline/metabolism ; Choline/pharmacology ; Cloning, Molecular ; Cysteine Loop Ligand-Gated Ion Channel Receptors/genetics ; Cysteine Loop Ligand-Gated Ion Channel Receptors/isolation & purification ; Cysteine Loop Ligand-Gated Ion Channel Receptors/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Haemonchus/genetics ; Helminth Proteins/genetics ; Helminth Proteins/isolation & purification ; Helminth Proteins/metabolism ; Models, Molecular ; Oocytes/cytology ; Oocytes/metabolism ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Xenopus laevis/genetics ; Xenopus laevis/metabolism
Czasopismo naukowe
Tytuł :
Structural and functional characterization of the bestrophin-2 anion channel.
Autorzy :
Owji AP; Department of Pharmacology, Columbia University, New York, NY, USA.
Zhao Q; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.; Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.
Ji C; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Kittredge A; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Hopiavuori A; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Fu Z; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Ward N; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Clarke OB; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Shen Y; Eye Center, Renmin Hospital of Wuhan University, Wuhan, China. .
Zhang Y; Department of Ophthalmology, Columbia University, New York, NY, USA. .
Hendrickson WA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. .; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. .; New York Structural Biology Center, New York, NY, USA. .
Yang T; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA. .; Department of Ophthalmology, Columbia University, New York, NY, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Apr; Vol. 27 (4), pp. 382-391. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Conformation*
Bestrophins/*ultrastructure
Chloride Channels/*ultrastructure
Animals ; Bestrophins/chemistry ; Bestrophins/genetics ; Calcium/chemistry ; Cattle ; Chloride Channels/chemistry ; Chloride Channels/genetics ; Cryoelectron Microscopy ; Cytoplasm/chemistry ; Cytoplasm/genetics ; Cytoplasm/ultrastructure ; Humans ; Ion Channel Gating/genetics ; Protein Binding/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
[Progress of research on the role of CLCNKB gene in classical Bartter syndrome].
Autorzy :
Zhou J; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China. .
Wang C
Bao H
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Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2020 May 10; Vol. 37 (5), pp. 573-577.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Bartter Syndrome*/genetics
Bartter Syndrome*/pathology
Chloride Channels*/genetics
Asian Continental Ancestry Group ; Genetic Association Studies ; Humans ; Research/trends
Czasopismo naukowe
Tytuł :
CLCA2 expression is associated with survival among African American women with triple negative breast cancer.
Autorzy :
Purrington KS; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.; Population Studies and Disparities Research Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.
Knight J 3rd; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.
Dyson G; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.; Population Studies and Disparities Research Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.
Ali-Fehmi R; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.
Schwartz AG; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.; Population Studies and Disparities Research Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.
Boerner JL; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.
Bandyopadhyay S; Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America.; Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Apr 16; Vol. 15 (4), pp. e0231712. Date of Electronic Publication: 2020 Apr 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
African Americans*
Chloride Channels/*metabolism
Triple Negative Breast Neoplasms/*ethnology
Triple Negative Breast Neoplasms/*mortality
Biomarkers, Tumor ; Chloride Channels/genetics ; Cohort Studies ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Adenosine inhibits the basolateral Cl ClC-K2/b channel in collecting duct intercalated cells.
Autorzy :
Zaika O; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas.
Tomilin VN; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas.
Pochynyuk O; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Apr 01; Vol. 318 (4), pp. F870-F877. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine/*pharmacology
Adenosine A1 Receptor Agonists/*pharmacology
Anion Transport Proteins/*antagonists & inhibitors
Chloride Channels/*antagonists & inhibitors
Chlorides/*metabolism
Kidney Tubules, Collecting/*drug effects
Receptor, Adenosine A1/*drug effects
Renal Reabsorption/*drug effects
Animals ; Anion Transport Proteins/metabolism ; Calcium Signaling/drug effects ; Cells, Cultured ; Chloride Channels/metabolism ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/metabolism ; Male ; Membrane Potentials/drug effects ; Mice, Inbred C57BL ; Receptor, Adenosine A1/metabolism
Czasopismo naukowe

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