- Tytuł :
-
Development and validation of a potent and specific inhibitor for the CLC-2
chloride channel. - Autorzy :
- Źródło :
- Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32711-32721. Date of Electronic Publication: 2020 Dec 04.
- Typ publikacji :
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
- MeSH Terms :
-
Chloride Channels /*antagonists & inhibitorsChloride Channels /*chemistry
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
Animals ; Binding Sites ; CHO Cells ; Cell Line ;Chloride Channels /genetics ;Chloride Channels /metabolism ; Cricetulus ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Hippocampus/metabolism ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Docking Simulation ; Organ Culture Techniques ; Patch-Clamp Techniques ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Small Molecule Libraries/metabolism ; Structure-Activity Relationship -
Czasopismo naukowe