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Wyszukujesz frazę ""Chlorocebus aethiops"" wg kryterium: Temat


Tytuł :
ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies.
Autorzy :
Schmitt CA; Department of Anthropology, Boston University, Boston, Massachusetts, United States of America.
Bergey CM; Department of Genetics, Rutgers University, New Brunswick, New Jersey, United States of America.
Jasinska AJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior,University of California-Los Angeles, Los Angeles, California, United States of America.; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.; Eye on Primates, Los Angeles, California, United States of America.
Ramensky V; Federal State Institution 'National Medical Research Center for Therapy and Preventive Medicine' of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Burt F; Division of Medical Virology, National Health Laboratory Service, Bloemfontein, Free State, South Africa.; Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, Free State, South Africa.
Svardal H; Department of Biology, University of Antwerp, Antwerp, Belgium.; Naturalis Biodiversity Center, Leiden, The Netherlands.
Jorgensen MJ; Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Freimer NB; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior,University of California-Los Angeles, Los Angeles, California, United States of America.
Grobler JP; Department of Genetics, University of the Free State, Bloemfontein, Free State, South Africa.
Turner TR; Department of Genetics, University of the Free State, Bloemfontein, Free State, South Africa.; Department of Anthropology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jun 23; Vol. 15 (6), pp. e0235106. Date of Electronic Publication: 2020 Jun 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chlorocebus aethiops*
Coronavirus Infections/*veterinary
Pandemics/*veterinary
Peptidyl-Dipeptidase A/*genetics
Pneumonia, Viral/*veterinary
Primate Diseases/*genetics
Serine Endopeptidases/*genetics
Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/genetics ; Coronavirus Infections/transmission ; Disease Susceptibility ; Pneumonia, Viral/genetics ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Whole Genome Sequencing ; Zoonoses/transmission
Czasopismo naukowe
Tytuł :
Mutational analysis of BFSP1, CRYBB1, GALK1, and GJA8 in captive-bred vervet monkeys (Chlorocebus aethiops).
Autorzy :
Ngqaneka T; Primate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, South Africa.
Khoza S; Primate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, South Africa.
Magwebu ZE; Primate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, South Africa.
Chauke CG; Primate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Tygerberg, South Africa.
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Źródło :
Journal of medical primatology [J Med Primatol] 2020 Apr; Vol. 49 (2), pp. 79-85. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chlorocebus aethiops*
Cataract/*veterinary
Eye Proteins/*genetics
Monkey Diseases/*genetics
Animals ; Cataract/congenital ; Cataract/genetics ; Eye Proteins/metabolism ; Female ; Male ; Monkey Diseases/congenital ; Mutation
Czasopismo naukowe
Tytuł :
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.
Autorzy :
Luban J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01605, USA; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA, 02142, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA.
Sattler RA; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.
Mühlberger E; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA; Department of Microbiology, Boston University School of Medicine, Boston, MA, 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, 02118, USA.
Graci JD; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Cao L; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Weetall M; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Trotta C; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Colacino JM; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Bavari S; United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, 21702, USA.
Strambio-De-Castillia C; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Suder EL; Department of Microbiology, Boston University School of Medicine, Boston, MA, 02118, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, 02118, USA.
Wang Y; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Soloveva V; United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, 21702, USA.
Cintron-Lue K; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Naryshkin NA; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Pykett M; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Welch EM; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
O'Keefe K; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Kong R; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Goodwin E; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA.
Jacobson A; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Paessler S; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA.
Peltz SW; PTC Therapeutics, Inc. South Plainfield, NJ, 07080, USA. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Jan 15; Vol. 292, pp. 198246. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antiviral Agents/*pharmacology
Carbamates/*pharmacology
Carbazoles/*pharmacology
Cytokines/*antagonists & inhibitors
Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Virus Replication/*drug effects
Animals ; COVID-19/drug therapy ; Chlorocebus aethiops ; Cytokine Release Syndrome/drug therapy ; Cytokines/immunology ; HeLa Cells ; Humans ; Inflammation/drug therapy ; Inflammation/virology ; Vero Cells
Czasopismo naukowe
Tytuł :
Systemic and intestinal porcine epidemic diarrhea virus-specific antibody response and distribution of antibody-secreting cells in experimentally infected conventional pigs.
Autorzy :
Suda Y; Kyushu Research Station, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), 2702 Chuzan, Kagoshima, Kagoshima, 891-0105, Japan. .; Division of Viral Disease and Epidemiology, NIAH, NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan. .
Miyazaki A; Division of Viral Disease and Epidemiology, NIAH, NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.
Miyazawa K; Division of Viral Disease and Epidemiology, NIAH, NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.
Shibahara T; Division of Pathology and Pathophysiology, NIAH, NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.; Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano, Osaka, 598-8531, Japan.
Ohashi S; Division of Viral Disease and Epidemiology, NIAH, NARO, 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.
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Źródło :
Veterinary research [Vet Res] 2021 Jan 04; Vol. 52 (1), pp. 2. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article
MeSH Terms :
Porcine epidemic diarrhea virus*
Antibodies, Viral/*blood
Coronavirus Infections/*veterinary
Swine Diseases/*virology
Animals ; Chlorocebus aethiops ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Feces/chemistry ; Feces/virology ; Immunoglobulin A/blood ; Immunoglobulin A/chemistry ; Immunoglobulin A/metabolism ; Immunoglobulin G/blood ; Intestinal Mucosa/metabolism ; RNA, Viral ; Swine ; Swine Diseases/blood ; Swine Diseases/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Neutralizing antibody titres in SARS-CoV-2 infections.
Autorzy :
Lau EHY; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Tsang OTY; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Hui DSC; Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
Kwan MYW; Department of Paediatric and Adolescent Medicine, Princess of Margaret Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Chan WH; Department of Paediatrics, Queen Elizabeth Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Chiu SS; Department of Paediatric and Adolescent Medicine, The University of Hong Kong and Queen Mary Hospital, Hospital Authority of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Ko RLW; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Chan KH; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Cheng SMS; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Perera RAPM; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Cowling BJ; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Poon LLM; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.
Peiris M; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China. .; HKU-Pasteur Research Pole, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 63. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Adolescent ; Adult ; Animals ; Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Nucleic Acid Testing ; COVID-19 Testing ; Chlorocebus aethiops ; Cohort Studies ; Female ; Hong Kong/epidemiology ; Humans ; Male ; Middle Aged ; Neutralization Tests ; Pandemics ; Vero Cells ; Young Adult
Czasopismo naukowe
Tytuł :
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
Autorzy :
Bracken CJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Lim SA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Solomon P; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Rettko NJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Nguyen DP; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.; Lyell Immunopharma Inc., Seattle, WA, USA.
Zha BS; Department of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
Schaefer K; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Byrnes JR; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Zhou J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Lui I; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Liu J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.; Merck & Co., South San Francisco, CA, USA.
Pance K; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Zhou XX; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Wells JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA. .; Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. .; Chan Zuckerberg Biohub, San Francisco, CA, USA. .
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Corporate Authors :
QCRG Structural Biology Consortium
Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Jan; Vol. 17 (1), pp. 113-121. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*chemistry
Antibodies, Neutralizing/*chemistry
Antibodies, Viral/*chemistry
Single-Chain Antibodies/*chemistry
Spike Glycoprotein, Coronavirus/*chemistry
Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Animals ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Binding Sites, Antibody/genetics ; Binding Sites, Antibody/immunology ; Chlorocebus aethiops ; Cryoelectron Microscopy ; HEK293 Cells ; Humans ; Models, Molecular ; Peptide Library ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; SARS-CoV-2 ; Single-Chain Antibodies/genetics ; Single-Chain Antibodies/immunology ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2.
Autorzy :
Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Noh S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kwak Y; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jeon S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Kwon S; Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.
Jin YH; KM Application Center, Korea Institute of Oriental Medicine, Dong-gu, Daegu 41062, South Korea.
Jang MS; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jan 01; Vol. 31, pp. 127667. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Antiviral Agents/*pharmacology
SARS-CoV-2/*drug effects
Sulfonamides/*pharmacology
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; COVID-19/drug therapy ; Cell Line ; Chlorocebus aethiops ; Cricetulus ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Rats ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2.
Autorzy :
Park JG; Texas Biomedical Research Institute, San Antonio, TX, USA.
Oladunni FS; Texas Biomedical Research Institute, San Antonio, TX, USA; Department of Veterinary Microbiology, University of Ilorin, Nigeria.
Chiem K; Texas Biomedical Research Institute, San Antonio, TX, USA.
Ye C; Texas Biomedical Research Institute, San Antonio, TX, USA.
Pipenbrink M; Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Moran T; Department of Microbiology, Center for Therapeutic Antibody Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Walter MR; Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Kobie J; Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: .
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Źródło :
Journal of virological methods [J Virol Methods] 2021 Jan; Vol. 287, pp. 113995. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antiviral Agents/*pharmacology
Neutralization Tests/*methods
SARS-CoV-2/*drug effects
SARS-CoV-2/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/blood ; Chlorocebus aethiops ; High-Throughput Screening Assays ; Humans ; Vero Cells ; Viral Plaque Assay ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Is recurrence possible in coronavirus disease 2019 (COVID-19)? Case series and systematic review of literature.
Autorzy :
Gidari A; Department of Medicine, Clinic of Infectious Diseases, 'Santa Maria della Misericordia' Hospital, University of Perugia, Perugia, Italy. .
Nofri M; Department of Medicine, Clinic of Infectious Diseases, 'Santa Maria della Misericordia' Hospital, University of Perugia, Perugia, Italy.
Saccarelli L; Department of Anesthesiology, Intensive Care and Pain therapy Center, 'Santa Maria della Misericordia' Hospital, University of Perugia, Perugia, Italy.
Bastianelli S; Department of Medicine, Clinic of Infectious Diseases, 'Santa Maria della Misericordia' Hospital, University of Perugia, Perugia, Italy.
Sabbatini S; Department of Medicine, Medical Microbiology Section, University of Perugia, Perugia, Italy.
Bozza S; Department of Medicine, Medical Microbiology Section, University of Perugia, Perugia, Italy.
Camilloni B; Department of Medicine, Medical Microbiology Section, University of Perugia, Perugia, Italy.
Fusco-Moffa I; Department of Prevention, Local Health Unit Umbria 1, Travel Medicine Unit, Perugia, Italy.
Monari C; Department of Medicine, Medical Microbiology Section, University of Perugia, Perugia, Italy.
De Robertis E; Department of Anesthesiology, Intensive Care and Pain therapy Center, 'Santa Maria della Misericordia' Hospital, University of Perugia, Perugia, Italy.
Mencacci A; Department of Medicine, Medical Microbiology Section, University of Perugia, Perugia, Italy.
Francisci D; Department of Medicine, Clinic of Infectious Diseases, 'Santa Maria della Misericordia' Hospital, University of Perugia, Perugia, Italy.
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Źródło :
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2021 Jan; Vol. 40 (1), pp. 1-12. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Case Reports; Journal Article; Systematic Review
MeSH Terms :
COVID-19/*diagnosis
COVID-19/*physiopathology
COVID-19 Testing/*statistics & numerical data
Adult ; Aged ; Animals ; Chlorocebus aethiops ; Female ; Humans ; Italy ; Male ; Middle Aged ; Nasopharynx/virology ; RNA, Viral/analysis ; Recurrence ; Vero Cells ; Virus Replication
Czasopismo naukowe
Tytuł :
High-speed large-scale automated isolation of SARS-CoV-2 from clinical samples using miniaturized co-culture coupled to high-content screening.
Autorzy :
Francis R; Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France; Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), UMR Microbes Evolution Phylogeny and Infections (MEPHI), AP-HM, Marseille, France.
Le Bideau M; Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), UMR Microbes Evolution Phylogeny and Infections (MEPHI), AP-HM, Marseille, France.
Jardot P; Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), UMR Microbes Evolution Phylogeny and Infections (MEPHI), AP-HM, Marseille, France.
Grimaldier C; Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), UMR Microbes Evolution Phylogeny and Infections (MEPHI), AP-HM, Marseille, France.
Raoult D; Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France; Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), UMR Microbes Evolution Phylogeny and Infections (MEPHI), AP-HM, Marseille, France.
Bou Khalil JY; Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France. Electronic address: .
La Scola B; Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France; Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), UMR Microbes Evolution Phylogeny and Infections (MEPHI), AP-HM, Marseille, France. Electronic address: .
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Źródło :
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2021 Jan; Vol. 27 (1), pp. 128.e1-128.e7. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*diagnosis
COVID-19 Testing/*methods
Image Processing, Computer-Assisted/*statistics & numerical data
RNA, Viral/*analysis
SARS-CoV-2/*isolation & purification
Animals ; Automation, Laboratory ; Biomarkers/analysis ; COVID-19/virology ; Chlorocebus aethiops ; Hospitalization ; Humans ; Microscopy/methods ; Nasopharynx/virology ; RNA, Viral/genetics ; Reverse Transcriptase Polymerase Chain Reaction/standards ; SARS-CoV-2/genetics ; Specimen Handling/methods ; Vero Cells ; Viral Load
Czasopismo naukowe
Tytuł :
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.
Autorzy :
Yao H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Sun Y; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Deng YQ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Wang N; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Tan Y; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Zhang NN; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Li XF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Kong C; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Xu YP; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Chen Q; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Cao TS; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Zhao H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Yan X; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Cao L; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Lv Z; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Zhu D; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Feng R; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Wu N; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Zhang W; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Hu Y; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Chen K; Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Zhang RR; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Lv Q; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Sun S; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Zhou Y; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Yan R; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Yang G; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Sun X; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Liu C; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China.
Lu X; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Cheng L; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Qiu H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Huang XY; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Weng T; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Shi D; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Jiang W; Shanghai Henlius Biotech, Inc, Shanghai, 200233, China.
Shao J; Shanghai ZJ Bio-Tech Co., Ltd., Shanghai, 201114, China.
Wang L; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Zhang J; Shanghai ZJ Bio-Tech Co., Ltd., Shanghai, 201114, China.
Jiang T; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
Lang G; Sanyou Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, 201114, China. .
Qin CF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China. .
Li L; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases/National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China. .
Wang X; CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. .; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, Guangdong, 510200, China. .
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Źródło :
Cell research [Cell Res] 2021 Jan; Vol. 31 (1), pp. 25-36. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/immunology
COVID-19*/prevention & control
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Epitopes/*immunology
SARS-CoV-2/*immunology
Single-Chain Antibodies/*immunology
Animals ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral/pharmacology ; Chlorocebus aethiops ; Disease Models, Animal ; Humans ; Single-Chain Antibodies/pharmacology ; Vero Cells
Czasopismo naukowe
Tytuł :
Pasteurization Inactivates SARS-CoV-2-Spiked Breast Milk.
Autorzy :
Conzelmann C; Institute of Molecular Virology and.; Institute of Molecular Virology and.
Groß R; Institute of Molecular Virology and.; Institute of Molecular Virology and.
Meister TL; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
Todt D; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; European Virus Bioinformatics Center, Jena, Germany; and.
Krawczyk A; Department of Infectious Diseases, West German Centre of Infectious Diseases and.; Institute for Virology, University Hospital of Essen and University of Duisburg-Essen, Essen, Germany.
Dittmer U; Institute for Virology, University Hospital of Essen and University of Duisburg-Essen, Essen, Germany.
Stenger S; Institute for Microbiology and Hygiene, Ulm University Medical Center, Ulm, Germany.
Münch J; Institute of Molecular Virology and.
Steinmann E; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
Müller JA; Institute of Molecular Virology and .
Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany; .
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Źródło :
Pediatrics [Pediatrics] 2021 Jan; Vol. 147 (1). Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*prevention & control
COVID-19/*transmission
Milk, Human/*virology
Pasteurization/*methods
SARS-CoV-2/*isolation & purification
Animals ; Caco-2 Cells ; Chlorocebus aethiops ; Female ; Humans ; Vero Cells
Czasopismo naukowe
Tytuł :
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models.
Autorzy :
Wang G; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Yang ML; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China.
Duan ZL; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Liu FL; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Jin L; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Long CB; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Zhang M; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Tang XP; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.; Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei, 430074, China.
Xu L; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Li YC; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Kamau PM; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei, 430074, China.
Yang L; Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
Liu HQ; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China.
Xu JW; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China.
Chen JK; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, 510530, China.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China. .; Kunming National High-level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology Chinese Academic of Sciences, Kunming, Yunnan, 650107, China. .
Peng XZ; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China. .
Lai R; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China. .; Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei, 430074, China. .; Kunming National High-level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology Chinese Academic of Sciences, Kunming, Yunnan, 650107, China. .; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, 201203, China. .
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Źródło :
Cell research [Cell Res] 2021 Jan; Vol. 31 (1), pp. 17-24. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/pharmacokinetics
Antiviral Agents*/pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Teicoplanin/*analogs & derivatives
Animals ; Caco-2 Cells ; Chlorocebus aethiops ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Protein Binding/drug effects ; Teicoplanin/pharmacokinetics ; Teicoplanin/pharmacology ; Vero Cells
Czasopismo naukowe
Tytuł :
Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets.
Autorzy :
Cox RM; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Wolf JD; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Plemper RK; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. .
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Źródło :
Nature microbiology [Nat Microbiol] 2021 Jan; Vol. 6 (1), pp. 11-18. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*prevention & control
COVID-19/*transmission
Cytidine/*analogs & derivatives
Hydroxylamines/*pharmacology
SARS-CoV-2/*drug effects
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Animals ; COVID-19/immunology ; Chlorocebus aethiops ; Cytidine/pharmacology ; Cytokines/immunology ; Disease Models, Animal ; Disease Transmission, Infectious/prevention & control ; Female ; Ferrets ; Random Allocation ; Vero Cells
Czasopismo naukowe
Tytuł :
The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro.
Autorzy :
Song J; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Zhang L; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Xu Y; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Yang D; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Zhang L; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Yang S; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Zhang W; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Wang J; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Tian S; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Yang S; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Yuan T; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Liu A; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Lv Q; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Li F; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Liu H; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650031, China.
Hou B; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Peng X; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650031, China.
Lu Y; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China. Electronic address: .
Du G; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114302. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*therapeutic use
COVID-19/*drug therapy
COVID-19/*pathology
Flavanones/*therapeutic use
Acute Lung Injury/drug therapy ; Acute Lung Injury/metabolism ; Acute Lung Injury/pathology ; Animals ; Antioxidants/pharmacokinetics ; COVID-19/metabolism ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; Female ; Flavanones/pharmacokinetics ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome ; Vero Cells
Czasopismo naukowe
Tytuł :
A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro.
Autorzy :
Zhang H; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Yang Y; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Li J; Shenzhen Laboratory of Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University City of Shenzhen, Shenzhen, China.
Wang M; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Saravanan KM; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Wei J; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Tze-Yang Ng J; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Tofazzal Hossain M; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.; University of Chinese Academy of Sciences, Shijingshan District, Beijing, China.
Liu M; Shenzhen Laboratory of Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University City of Shenzhen, Shenzhen, China.
Zhang H; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Ren X; Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Pan Y; Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America.
Peng Y; Department of Pathology, School of Medicine, Shenzhen University, Shenzhen, China.
Shi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Wan X; Shenzhen Laboratory of Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University City of Shenzhen, Shenzhen, China.
Liu Y; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Wei Y; Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Dec 31; Vol. 16 (12), pp. e1008489. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Repositioning*
Aminopterin/*analogs & derivatives
Antiviral Agents/*pharmacology
Drug Evaluation, Preclinical/*methods
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
SARS-CoV-2/*physiology
Aminopterin/chemistry ; Aminopterin/pharmacology ; Animals ; Azithromycin/chemistry ; Azithromycin/pharmacology ; COVID-19/drug therapy ; Chlorocebus aethiops ; Computer Simulation ; Deep Learning ; Molecular Dynamics Simulation ; RNA-Dependent RNA Polymerase/chemistry ; Vero Cells ; Virus Replication/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.
Autorzy :
Zheng Y; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhuang MW; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Han L; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhang J; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Nan ML; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Gao C; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China. .
Wang PH; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China. .; Suzhou Research Institute, Shandong University, Shandong University, Suzhou, Jiangsu, 215123, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2020 Dec 28; Vol. 5 (1), pp. 299. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
COVID-19/*metabolism
DEAD Box Protein 58/*metabolism
Interferon Type I/*biosynthesis
Interferon-Induced Helicase, IFIH1/*metabolism
Interferons/*biosynthesis
SARS-CoV-2/*metabolism
Viral Matrix Proteins/*metabolism
Animals ; COVID-19/genetics ; Chlorocebus aethiops ; DEAD Box Protein 58/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Interferon Type I/genetics ; Interferon-Induced Helicase, IFIH1/genetics ; Interferons/genetics ; SARS-CoV-2/genetics ; Vero Cells ; Viral Matrix Proteins/genetics
Czasopismo naukowe
Tytuł :
Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization.
Autorzy :
Kula-Pacurar A; Malopolska Centre of Biotechnology, Jagiellonian University; .
Wadas J; Microbiology Department Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University.
Suder A; Malopolska Centre of Biotechnology, Jagiellonian University.
Szczepanski A; Malopolska Centre of Biotechnology, Jagiellonian University; Microbiology Department Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University.
Milewska A; Malopolska Centre of Biotechnology, Jagiellonian University; Microbiology Department Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University.
Ochman M; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, The Medical University of Silesia in Katowice; Silesian Centre for Heart Diseases.
Stacel T; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, The Medical University of Silesia in Katowice; Silesian Centre for Heart Diseases.
Pyrc K; Malopolska Centre of Biotechnology, Jagiellonian University; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2020 Dec 23 (166). Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
COVID-19 Testing*
RNA, Viral*
COVID-19/*diagnosis
COVID-19/*virology
Respiratory Mucosa/*virology
SARS-CoV-2/*genetics
Animals ; Chlorocebus aethiops ; Fluorescence ; Humans ; In Situ Hybridization, Fluorescence ; Respiratory System ; Vero Cells
Czasopismo naukowe
Tytuł :
A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters.
Autorzy :
Fagre AC; Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Manhard J; AvantGen, Inc. San Diego, CA, United States.
Adams R; AvantGen, Inc. San Diego, CA, United States.
Eckley M; Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Zhan S; Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Lewis J; Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Rocha SM; Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Woods C; AvantGen, Inc. San Diego, CA, United States.
Kuo K; AvantGen, Inc. San Diego, CA, United States.
Liao W; AvantGen, Inc. San Diego, CA, United States.
Li L; AvantGen, Inc. San Diego, CA, United States.
Corper A; AvantGen, Inc. San Diego, CA, United States.
Challa D; AvantGen, Inc. San Diego, CA, United States.
Mount E; AvantGen, Inc. San Diego, CA, United States.
Tumanut C; AvantGen, Inc. San Diego, CA, United States.
Tjalkens RB; Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Aboellail T; Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Fan X; AvantGen, Inc. San Diego, CA, United States.
Schountz T; Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Dec 18; Vol. 11, pp. 614256. Date of Electronic Publication: 2020 Dec 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/pharmacology
Antibodies, Neutralizing*/immunology
Antibodies, Neutralizing*/pharmacology
Antibodies, Viral*/immunology
Antibodies, Viral*/pharmacology
COVID-19*/blood
COVID-19*/drug therapy
COVID-19*/immunology
Immunoglobulin G*/immunology
Immunoglobulin G*/pharmacology
SARS-CoV-2/*immunology
Animals ; Chlorocebus aethiops ; Humans ; Male ; Mesocricetus ; Severity of Illness Index ; Vero Cells ; Viral Load/drug effects ; Viral Load/immunology
Czasopismo naukowe
Tytuł :
SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 Virus.
Autorzy :
Havranek KE; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Jimenez AR; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Acciani MD; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Lay Mendoza MF; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Reyes Ballista JM; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Diaz DA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Brindley MA; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
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Źródło :
Viruses [Viruses] 2020 Dec 18; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Replication*
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Vesicular stomatitis Indiana virus/*genetics
Viral Envelope Proteins/*genetics
Animals ; Cell Line ; Cells, Cultured ; Chlorocebus aethiops ; Fluorescent Antibody Technique ; Gene Expression ; Genes, Reporter ; Genetic Engineering ; Giant Cells ; Humans ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; Vesicular stomatitis Indiana virus/metabolism ; Virus Internalization
Czasopismo naukowe

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