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Tytuł :
Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients.
Autorzy :
Yao X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.
Yan X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, 999077, China.
Wang X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Cai T; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Zhang S; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Cui C; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.
Wang X; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Hou Z; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Liu Q; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China.
Li H; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China.
Lin J; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Xiong Z; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No.2 Hospital), Ningbo, 315010, China.
Liu D; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, 100191, China. .
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Źródło :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2021 Apr; Vol. 77 (4), pp. 583-593. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Drug Repositioning*
Models, Biological*
COVID-19/*drug therapy
Chloroquine/*analogs & derivatives
Administration, Oral ; Adult ; Aged ; COVID-19/virology ; Chloroquine/administration & dosage ; Chloroquine/adverse effects ; Chloroquine/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Gastrointestinal Absorption ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; SARS-CoV-2/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals.
Autorzy :
Brüggemann RJ; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands.
Moes DJAR; Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, Leiden, The Netherlands. Electronic address: .
van Rhee KP; Tergooi Hospital, Department of Clinical Pharmacy, Hilversum, The Netherlands. Electronic address: .
van 't Veer NE; Department of Clinical Pharmacy, Amphia hospital, Breda, The Netherlands. Electronic address: .
Koch BCP; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: .
van Rossum M; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: .
Windsant-van den Tweel AV; Jeroen Bosch Hospital, Department of Pharmacy, 's Hertogenbosch, The Netherlands. Electronic address: .
Reijers MHE; Radboud University Medical Center, Department of Pulmonary Diseases, Nijmegen, The Netherlands. Electronic address: .
van Kimmenade RRJ; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: .
Rahamat-Langedoen JC; Radboud Institute for Molecular Life Sciences, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: .
Rettig TCD; Department of Intensive Care and Pain Medicine, Amphia hospital, Breda, The Netherlands. Electronic address: .
van Raalte R; Department of Intensive Care, Tergooi Hospital, Hilversum, The Netherlands. Electronic address: .
van Paassen J; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: .
Polderman FN; Jeroen Bosch Hospital, Department of Intensive Care, 's Hertogenbosch, The Netherlands. Electronic address: .
van der Linden PD; Department of Clinical Pharmacy, Tergooi Hospital, Hilversum, The Netherlands. Electronic address: .
Frenzel T; Radboud university medical center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: .
de Mast Q; Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: .
Burger DM; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: .
Schouten J; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: .
van de Veerdonk FL; Department of Internal Medicine, Radboudumc, Nijmegen, The Netherlands. Electronic address: .
Pickkers P; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: .
Ter Heine R; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: .
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2021 Mar; Vol. 57 (3), pp. 106293. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Letter
MeSH Terms :
COVID-19/*drug therapy
Chloroquine/*adverse effects
Chloroquine/*analogs & derivatives
Chloroquine/*pharmacokinetics
Long QT Syndrome/*chemically induced
Aged ; Chloroquine/blood ; Chloroquine/therapeutic use ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2/drug effects
SCR Protocol :
COVID-19 drug treatment
Opinia redakcyjna
Tytuł :
Composition analysis of falsified chloroquine phosphate samples seized during the COVID-19 pandemic.
Autorzy :
Waffo Tchounga CA; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium; University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Cameroon.
Sacre PY; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium. Electronic address: .
Ciza P; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium; University of Kinshasa, Faculty of Pharmaceutical Sciences, LACOMEDA, Lemba, 212 Kinshasa XI, Democratic Republic of Congo.
Ngono R; University of Yaoundé I, Faculty of Medicine and Biomedical Sciences, Cameroon; National Drug Control and Valuation (LANACOME), Yaoundé, Cameroon.
Ziemons E; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium.
Hubert P; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium.
Marini RD; University of Liege (ULiege), CIRM, VibraSante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Liege, Belgium.
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Feb 05; Vol. 194, pp. 113761. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Pandemics*
COVID-19/*epidemiology
Chloroquine/*analogs & derivatives
Counterfeit Drugs/*analysis
Spectrum Analysis, Raman/*methods
Anti-Inflammatory Agents, Non-Steroidal/analysis ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antimalarials/analysis ; Antimalarials/therapeutic use ; COVID-19/drug therapy ; Chloroquine/analysis ; Chloroquine/therapeutic use ; Chromatography, High Pressure Liquid/methods ; Counterfeit Drugs/therapeutic use ; Humans ; Tablets
Czasopismo naukowe
Tytuł :
Efficacy and safety outcomes of proposed randomized controlled trials investigating hydroxychloroquine and chloroquine during the early stages of the COVID-19 pandemic.
Autorzy :
Junqueira DR; Department of Emergency Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Rowe BH; Department of Emergency Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.; School of Public Health, University of Alberta, Edmonton, AB, Canada.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Apr; Vol. 87 (4), pp. 1758-1767. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Antiviral Agents/adverse effects ; COVID-19/diagnosis ; COVID-19/virology ; Chloroquine/adverse effects ; Databases, Factual ; Endpoint Determination ; Female ; Humans ; Hydroxychloroquine/adverse effects ; Male ; Randomized Controlled Trials as Topic ; Research Design ; Time Factors ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress.
Autorzy :
Gregório P; Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, PR, Brazil.
da Cunha RS; Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Biagini G; Department of Internal Medicine, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Bosquetti B; Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Budag J; Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Ortiz A; Nephrology and Hypertension, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; IIS-Fundación Jimenez Diaz UAM, Madrid, Spain.
Sánchez-Niño MD; IIS-Fundación Jimenez Diaz UAM, Madrid, Spain; Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.
Barreto FC; Department of Internal Medicine, Division of Nephrology, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Stinghen AEM; Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Mar 01; Vol. 414, pp. 115412. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*drug therapy
Chloroquine/*adverse effects
Endothelial Cells/*drug effects
Endothelium, Vascular/*drug effects
Lysosomes/*drug effects
Oxidative Stress/*drug effects
Cell Survival/drug effects ; Cells, Cultured ; Chloroquine/administration & dosage ; Chloroquine/therapeutic use ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Fabry Disease/chemically induced ; Humans ; Pandemics ; Reactive Oxygen Species ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of pre-COVID-19 reports.
Autorzy :
Goldman A; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Bomze D; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Israel.; School of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.; Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
Dankner R; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Israel.; Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Ramat Gan, Israel.
Hod H; School of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.; Leviev Heart Center, Sheba Medical Center, Ramat Gan, Israel.
Meirson T; Azrieli Faculty of Medicine, Bar-Ilan University, Israel.
Boursi B; School of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.; Department of Oncology, Sheba Medical Center, Tel HaShomer, Israel.; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
Maor E; School of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.; Leviev Heart Center, Sheba Medical Center, Ramat Gan, Israel.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Mar; Vol. 87 (3), pp. 1432-1442. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Pharmacovigilance*
Antimalarials/*adverse effects
COVID-19/*drug therapy
Cardiovascular Diseases/*chemically induced
Chloroquine/*adverse effects
Hydroxychloroquine/*adverse effects
Adult ; Aged ; Antimalarials/therapeutic use ; COVID-19/complications ; Cardiovascular Diseases/epidemiology ; Chloroquine/therapeutic use ; Databases, Factual ; Drug Overdose ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Male ; Middle Aged ; Odds Ratio ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Chloroquine commonly induces hormetic dose responses.
Autorzy :
Calabrese EJ; Department of Environmental Sciences, University of Massachusetts, Amherst, MA 01003, United States of America. Electronic address: .
Hanekamp JC; University College Roosevelt, Lange Noordstraat 1, NL-4331 CB Middelburg, the Netherlands. Electronic address: .
Hanekamp YN; University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.
Kapoor R; Saint Francis Hospital and Medical Center, Hartford, CT, United States of America.
Dhawan G; University of Massachusetts, Human Research Protection Office, Research Compliance, University of Massachusetts, Mass Venture Center, Hadley, MA 01035, United States of America.
Agathokleous E; Key Laboratory of Agrometeorology of Jiangsu Province, Institute of Ecology, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Feb 10; Vol. 755 (Pt 1), pp. 142436. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/drug therapy
Chloroquine*/pharmacology
Hormesis*
Dose-Response Relationship, Drug ; Humans ; Male ; SARS-CoV-2 ; Sperm Motility
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story.
Autorzy :
Gasmi A; Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Peana M; Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100, Sassari, Italy. .
Noor S; Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
Lysiuk R; Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.; CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Menzel A; Laboratoires Réunis, Junglinster, Luxembourg.
Gasmi Benahmed A; Académie Internationale de Médecine Dentaire Intégrative, Paris, France.
Bjørklund G; Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 Feb; Vol. 105 (4), pp. 1333-1343. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
SARS-CoV-2*
Antimalarials/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Antimalarials/chemistry ; Antiviral Agents/chemistry ; Chloroquine/chemistry ; Humans ; Hydroxychloroquine/chemistry
Czasopismo naukowe
Tytuł :
An umbrella review of systematic reviews with meta-analyses evaluating positive and negative outcomes of Hydroxychloroquine and chloroquine therapy.
Autorzy :
Celotto S; Primary Care Department, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Veronese N; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Barbagallo M; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Ometto F; Rheumatological Unit, Local Health Unit 1, 6, Veneto Region, Italy.
Smith L; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom. Electronic address: .
Pardhan S; Vision and Eye Research Institute, School of Medicine, Anglia Ruskin Univerity, Cambridge, United Kingdom.
Barnett Y; School of Life Scinces, Anglia Ruskin University, Cambridge, United Kingdom.
Ilie PC; Research and Innovation Department, The Queen Elizabeth Hospital Foundation Trust, King's Lynn, United Kingdom.
Soysal P; Department of Geriatric Medicine, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
Lagolio E; Emergency Medicine (A&E) - Asl2 - H Santa Corona, Pietra Ligure and First Aid, H Santa Maria Misericordia, Albenga, Italy.
Kurotschka PK; Department of Medical Sciences and Public Health, University of Cagliari, Italy.
Tonelli R; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy; Respiratory Intensive Care Unit, University Hospital of Modena, Modena, Italy.
Demurtas J; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy; Primary Care Department, USL Toscana Sud Est-Grosseto, Grosseto, Italy.
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Źródło :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Feb; Vol. 103, pp. 599-606. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
SARS-CoV-2*
COVID-19/*drug therapy
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Chloroquine/adverse effects ; Humans ; Hydroxychloroquine/adverse effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Chloroquine and hydroxychloroquine for COVID-19: Perspectives on their failure in repurposing.
Autorzy :
Shah RR; Pharmaceutical Consultant, Gerrards Cross, UK.
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Źródło :
Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2021 Feb; Vol. 46 (1), pp. 17-27. Date of Electronic Publication: 2020 Sep 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*drug therapy
Chloroquine/*administration & dosage
Hydroxychloroquine/*administration & dosage
Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Azithromycin/administration & dosage ; Azithromycin/adverse effects ; COVID-19/virology ; Chloroquine/adverse effects ; Dose-Response Relationship, Drug ; Drug Repositioning ; Humans ; Hydroxychloroquine/adverse effects ; Long QT Syndrome/chemically induced ; Treatment Outcome ; Viral Load
Czasopismo naukowe
Tytuł :
Extracorporeal cardiopulmonary resuscitation for severe chloroquine intoxication in a child - a case report.
Autorzy :
Ferry T; Paediatric Intensive Care, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland. .
Amiet V; Paediatric Intensive Care, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Natterer J; Paediatric Intensive Care, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Perez MH; Paediatric Intensive Care, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Pfister R; Department of Cardiovascular Surgery, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Colombier S; Department of Cardiovascular Surgery, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Longchamp D; Paediatric Intensive Care, Lausanne University Hospital, University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland. .
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Źródło :
Scandinavian journal of trauma, resuscitation and emergency medicine [Scand J Trauma Resusc Emerg Med] 2021 Mar 15; Vol. 29 (1), pp. 48. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
COVID-19/*drug therapy
Cardiopulmonary Resuscitation/*methods
Chloroquine/*adverse effects
Extracorporeal Membrane Oxygenation/*methods
Heart Arrest/*therapy
Adolescent ; Antimalarials/adverse effects ; Antimalarials/therapeutic use ; COVID-19/epidemiology ; Chloroquine/therapeutic use ; Female ; Heart Arrest/chemically induced ; Humans ; Pandemics ; SARS-CoV-2 ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasma.
Autorzy :
Sok V; Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco, San Francisco, California, United States of America.
Marzan F; Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco, San Francisco, California, United States of America.
Gingrich D; Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco, San Francisco, California, United States of America.
Aweeka F; Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco, San Francisco, California, United States of America.
Huang L; Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco, San Francisco, California, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Mar 05; Vol. 16 (3), pp. e0247356. Date of Electronic Publication: 2021 Mar 05 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Anti-Bacterial Agents/*blood
Antimalarials/*blood
Azithromycin/*blood
Chloroquine/*analogs & derivatives
Hydroxychloroquine/*analogs & derivatives
Hydroxychloroquine/*blood
Blood Specimen Collection/methods ; Chloroquine/blood ; Chromatography, High Pressure Liquid/methods ; Drug Monitoring/methods ; Edetic Acid/blood ; Humans ; Limit of Detection ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?
Źródło :
Saudi medical journal [Saudi Med J] 2021 Mar; Vol. 42 (3), pp. 342-343.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
COVID-19/*prevention & control
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Antiviral Agents/adverse effects ; Chloroquine/adverse effects ; Humans ; Hydroxychloroquine/adverse effects ; SARS-CoV-2 ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19.
Autorzy :
Singh B; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool, UK.; Department of Infectious Diseases, Christian Medical College, Vellore, India.
Ryan H; Department of Clinical Pharmacology, Royal Liverpool University Hospital, Liverpool, UK.
Kredo T; Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
Chaplin M; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Fletcher T; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2021 Feb 12; Vol. 2. Cochrane AN: CD013587. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
SARS-CoV-2*
Antimalarials/*therapeutic use
COVID-19/*drug therapy
COVID-19/*prevention & control
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Adult ; Aged ; Antimalarials/adverse effects ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Bias ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19 Nucleic Acid Testing/statistics & numerical data ; Cause of Death ; Chloroquine/adverse effects ; Humans ; Hydroxychloroquine/adverse effects ; Middle Aged ; Pandemics ; Prognosis ; Randomized Controlled Trials as Topic ; Respiration, Artificial/statistics & numerical data ; Standard of Care ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Chloroquine-Induced First-Episode Psychosis in a Patient Self-medicated for COVID-19.
Autorzy :
Ambar Akkaoui M; Department of Psychiatry and Addictive Medicine, Hôpital Bichat-Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: .
Lejoyeux M; Department of Psychiatry and Addictive Medicine, Hôpital Bichat-Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France; Université de Paris, Paris, France.
Geoffroy PA; Department of Psychiatry and Addictive Medicine, Hôpital Bichat-Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France; Joint Research Unit 1141, Université de Paris, NeuroDiderot, Inserm, F-75019. Paris, France.
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Źródło :
Biological psychiatry [Biol Psychiatry] 2021 Feb 01; Vol. 89 (3), pp. e9. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Antiviral Agents*/adverse effects
COVID-19*/drug therapy
Chloroquine*/adverse effects
Psychoses, Substance-Induced*
Humans ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Raport
Tytuł :
Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine.
Autorzy :
Sarayani A; Center for Drug Evaluation and Safety, Department of Pharmaceutical Outcomes & Policy, University of Florida College of Pharmacy, Gainesville, FL, USA.
Cicali B; Center for Systems Pharmacology and Pharmacometrics, Department of Pharmaceutics, University of Florida College of Pharmacy, Orlando, FL, USA.
Henriksen CH; Center for Drug Evaluation and Safety, Department of Pharmaceutical Outcomes & Policy, University of Florida College of Pharmacy, Gainesville, FL, USA.
Brown JD; Center for Drug Evaluation and Safety, Department of Pharmaceutical Outcomes & Policy, University of Florida College of Pharmacy, Gainesville, FL, USA. Electronic address: .
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Źródło :
Research in social & administrative pharmacy : RSAP [Res Social Adm Pharm] 2021 Feb; Vol. 17 (2), pp. 483-486. Date of Electronic Publication: 2020 Apr 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
Azithromycin/*therapeutic use
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Long QT Syndrome/*chemically induced
Torsades de Pointes/*chemically induced
Antiviral Agents/adverse effects ; Azithromycin/adverse effects ; COVID-19/complications ; COVID-19/drug therapy ; Chloroquine/adverse effects ; Drug Interactions ; Drug Therapy, Combination ; Humans ; Hydroxychloroquine/adverse effects ; Long QT Syndrome/mortality ; Pharmacovigilance ; Torsades de Pointes/mortality ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Chloroquine in fighting COVID-19: good, bad, or both?
Autorzy :
Tang D; The Third Affiliated Hospital, Guangzhou Medical University , Guangzhou, Guangdong, China.; Department of Surgery, UT Southwestern Medical Center , Dallas, TX, USA.
Li J; Department of Surgery, UT Southwestern Medical Center , Dallas, TX, USA.
Zhang R; Department of Surgery, UT Southwestern Medical Center , Dallas, TX, USA.
Kang R; Department of Surgery, UT Southwestern Medical Center , Dallas, TX, USA.
Klionsky DJ; Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, MI, USA.
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Źródło :
Autophagy [Autophagy] 2020 Dec; Vol. 16 (12), pp. 2273-2275. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*drug therapy
Chloroquine/*adverse effects
Chloroquine/*therapeutic use
SARS-CoV-2/*drug effects
Autophagy/drug effects ; COVID-19/epidemiology ; COVID-19/pathology ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/epidemiology ; China/epidemiology ; Chloroquine/analogs & derivatives ; Chloroquine/pharmacology ; Clinical Trials as Topic/statistics & numerical data ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; France/epidemiology ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Italy/epidemiology ; Pandemics ; SARS-CoV-2/physiology ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Safety and Utility of Chloroquine/ Hydroxychloroquine in Palliative Care Patients.
Autorzy :
Prommer E; Greater Los Angeles Healthcare, Los Angeles, CA, USA.
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Źródło :
The American journal of hospice & palliative care [Am J Hosp Palliat Care] 2021 May; Vol. 38 (5), pp. 480-488. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Chloroquine/*therapeutic use
Hydroxychloroquine/*therapeutic use
Palliative Care/*methods
Antiviral Agents/adverse effects ; Chloroquine/adverse effects ; Humans ; Hydroxychloroquine/adverse effects ; Polypharmacy ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.
Autorzy :
Badraoui R; Laboratory of General Biology, Department of Biology, University of Ha'il, Ha'il 81451, Saudi Arabia.; Section of Histology-Cytology, Medicine College of Tunis, University of Tunis El Manar, Djebel Lakhdhar Road, La Rabta-Tunis 1007, Tunisia.; Laboratory of Histo-Embryology and Cytogenetic, Medicine College of Sfax, University of Sfax, Majida Boulila Road, Sfax 3029, Tunisia.
Adnan M; Laboratory of General Biology, Department of Biology, University of Ha'il, Ha'il 81451, Saudi Arabia.
Bardakci F; Laboratory of General Biology, Department of Biology, University of Ha'il, Ha'il 81451, Saudi Arabia.; Laboratory of Genetics, Department of Biology, Aydin Adnan Menderes University, Aydin 09010, Turkey.
Alreshidi MM; Laboratory of General Biology, Department of Biology, University of Ha'il, Ha'il 81451, Saudi Arabia.; Molecular Diagnostic and Personalized Therapeutics Unit, University of Ha'il, Ha'il 81451, Saudi Arabia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 28; Vol. 26 (3). Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2*/chemistry
Angiotensin-Converting Enzyme 2*/genetics
Angiotensin-Converting Enzyme 2*/metabolism
Molecular Docking Simulation*
Polymorphism, Genetic*
SARS-CoV-2*/chemistry
SARS-CoV-2*/metabolism
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/metabolism
Chloroquine/*chemistry
Hydroxychloroquine/*chemistry
COVID-19/drug therapy ; COVID-19/metabolism ; Chloroquine/pharmacokinetics ; Chloroquine/therapeutic use ; Humans ; Hydroxychloroquine/pharmacokinetics ; Hydroxychloroquine/therapeutic use ; Protein Domains
Czasopismo naukowe
Tytuł :
Cracking the Chloroquine Conundrum: The Application of Defective UiO-66 Metal-Organic Framework Materials to Prevent the Onset of Heart Defects-In Vivo and In Vitro.
Autorzy :
Jodłowski PJ; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
Kurowski G; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
Kuterasiński Ł; Polish Academy of Sciences, Jerzy Haber Institute of Catalysis and Surface Chemistry, Niezapominajek 8, 30-239 Kraków, Poland.
Sitarz M; Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
Jeleń P; Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
Jaśkowska J; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
Kołodziej A; Institute of Chemical Engineering, Polish Academy of Sciences, Bałtycka 5, 44-100 Gliwice, Poland.
Pajdak A; Strata Mechanics Research Institute, Polish Academy of Sciences, Reymonta 27, 30-059 Kraków, Poland.
Majka Z; TM LABS Sp. z o. o., Al. Beliny-Prażmowskiego 14, 31-514 Kraków, Poland.
Boguszewska-Czubara A; Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Jan 13; Vol. 13 (1), pp. 312-323. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Chloroquine/*analogs & derivatives
Heart Diseases/*drug therapy
Metal-Organic Frameworks/*pharmacology
Nanoparticles/*chemistry
Animals ; Chloroquine/adverse effects ; Chloroquine/chemistry ; Chloroquine/pharmacology ; Disease Models, Animal ; Drug Delivery Systems/adverse effects ; Drug Liberation/drug effects ; HEK293 Cells ; Heart Diseases/chemically induced ; Heart Diseases/pathology ; Humans ; Hydrochloric Acid/pharmacology ; Metal-Organic Frameworks/chemistry ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Phthalic Acids/chemistry ; Phthalic Acids/pharmacology ; Zebrafish/genetics
Czasopismo naukowe

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