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Wyszukujesz frazę ""Cholinesterase Inhibitors"" wg kryterium: Temat


Tytuł :
Tuning the activity of iminosugars: novel N -alkylated deoxynojirimycin derivatives as strong BuChE inhibitors.
Autorzy :
Ahuja-Casarín AI; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Merino-Montiel P; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Vega-Baez JL; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Montiel-Smith S; Facultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Fernandes MX; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.
Lagunes I; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.
Maya I; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Padrón JM; BioLab, Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.
López Ó; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Fernández-Bolaños JG; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 138-146.
Typ publikacji :
Journal Article
MeSH Terms :
1-Deoxynojirimycin/*pharmacology
Butyrylcholinesterase/*metabolism
Cholinesterase Inhibitors/*pharmacology
1-Deoxynojirimycin/chemical synthesis ; 1-Deoxynojirimycin/chemistry ; Animals ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Horses ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase.
Autorzy :
Evangelista TCS; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.; Department of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
López Ó; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Ferreira SB; Department of Organic Chemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Fernández-Bolaños JG; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain.
Sydnes MO; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Lindbäck E; Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1659-1664.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Acetylcholinesterase/*metabolism
Cholinesterase Inhibitors/*pharmacology
Tacrine/*pharmacology
Animals ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Molecular Structure ; Structure-Activity Relationship ; Tacrine/chemical synthesis ; Tacrine/chemistry
Czasopismo naukowe
Tytuł :
Analogues of 2'-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase.
Autorzy :
Sukumaran SD; Faculty of Medicine, Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
Nasir SB; Faculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Tee JT; Faculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Buckle MJC; Faculty of Medicine, Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
Othman R; Faculty of Medicine, Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
Rahman NA; Faculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Lee VS; Faculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Bukhari SNA; College of Pharmacy, Jouf University, Al-Jouf, Kingdom of Saudi Arabia.
Chee CF; Nanotechnology and Catalysis Research Centre, University of Malaya, Kuala Lumpur, Malaysia.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 130-137.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*metabolism
Chalcones/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Butyrylcholinesterase/metabolism ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates.
Autorzy :
Lee HM; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Jonczyk J; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
Kim K; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
Vishakantegowda AG; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
Malinak D; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Skarka A; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Schmidt M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Vaskova M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Latka K; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
Bajda M; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
Jung YS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.; Department of Medicinal Chemistry and Pharmacology, Daejeon, Republic of Korea.
Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
Musilek K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 437-449.
Typ publikacji :
Journal Article
MeSH Terms :
Cholinesterase Inhibitors/*pharmacology
Pyridinium Compounds/*pharmacology
Quinolinium Compounds/*pharmacology
Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Pyridinium Compounds/chemical synthesis ; Pyridinium Compounds/chemistry ; Quinolinium Compounds/chemical synthesis ; Quinolinium Compounds/chemistry ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
New 3- O -substituted xanthone derivatives as promising acetylcholinesterase inhibitors.
Autorzy :
Loh ZH; School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Malaysia.
Kwong HC; School of Chemical Sciences, Universiti Sains Malaysia, George Town, Malaysia.
Lam KW; Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Teh SS; Energy and Environment Unit, Engineering and Processing Division, Malaysian Palm Oil Board, Bandar Baru Bangi, Malaysia.
Ee GCL; Department of Chemistry, Faculty of Science, University Putra Malaysia, Serdang, Malaysia.
Quah CK; X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, George Town, Malaysia.
Ho ASH; School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Malaysia.
Mah SH; School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Malaysia.; Centre for Drug Discovery and Molecular Pharmacology, Faculty of Health and Medical Sciences, Taylor's University, Lakeside Campus.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 627-639.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*metabolism
Butyrylcholinesterase/*metabolism
Cholinesterase Inhibitors/*pharmacology
Xanthones/*pharmacology
Animals ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Electrophorus ; Horses ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Xanthones/chemical synthesis ; Xanthones/chemistry
Czasopismo naukowe
Tytuł :
Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.
Autorzy :
Sasidharan R; College of Pharmaceutical Science, Government T.D. Medical College, Alappuzha, India.; Organic Chemistry Division, SAS, VIT University, Vellore, India.
Eom BH; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.
Heo JH; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.
Park JE; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.
Abdelgawad MA; Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni Suef, Egypt.
Musa A; Department of Pharmacogonosy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.; Department of Pharmacogonosy, Al-Azhar University, Cairo, Egypt.
Gambacorta N; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Bari, Italy.
Nicolotti O; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Bari, Italy.
Manju SL; Organic Chemistry Division, SAS, VIT University, Vellore, India.
Mathew B; Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 188-197.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*metabolism
Chalcones/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Morpholines/*pharmacology
Animals ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Chlorocebus aethiops ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; HeLa Cells ; Humans ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Morpholines/chemistry ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Vero Cells
Czasopismo naukowe
Tytuł :
Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in the brain without affecting that in intestine.
Autorzy :
Jiang X; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Liu C; Department of Pharmaceutical Analysis, Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, 211198, China.
Zou M; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Xie H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Lin T; College of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.
Lyu W; Department of Pharmaceutical Analysis, Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, 211198, China.
Xu J; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Li Y; Jiangsu Food and Pharmaceutical Science College, Huai'an, 223003, China.
Feng F; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; Jiangsu Food and Pharmaceutical Science College, Huai'an, 223003, China. Electronic address: .
Sun H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: .
Liu W; Department of Pharmaceutical Analysis, Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113663. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholine/*metabolism
Acetylcholinesterase/*chemistry
Brain/*metabolism
Cholinesterase Inhibitors/*chemistry
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Niacinamide/*chemistry
Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Animals ; Binding Sites ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Brain/drug effects ; Cholinesterase Inhibitors/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Drug Design ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Intestines/drug effects ; Mice ; Mice, Inbred ICR ; Molecular Dynamics Simulation ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Niacinamide/metabolism ; Niacinamide/pharmacology ; Niacinamide/therapeutic use ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.
Autorzy :
Jiang X; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Zhang Z; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Zuo J; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Wu C; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Zha L; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Xu Y; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Wang S; Center for Scientific Research, Anhui Medical University, Hefei, 230032, China.
Shi J; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Liu XH; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Zhang J; Anhui Prevention and Treatment Center for Occupational Disease, Anhui No. 2 Provincial People's Hospital, Hefei, 230041, China. Electronic address: .
Tang W; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113735. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Butyrylcholinesterase/*chemistry
Cannabidiol/*chemistry
Carbamates/*chemistry
Cholinesterase Inhibitors/*chemistry
Neuroprotective Agents/*chemistry
Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Animals ; Binding Sites ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Butyrylcholinesterase/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cholinesterase Inhibitors/metabolism ; Cholinesterase Inhibitors/therapeutic use ; Drug Design ; Humans ; Kinetics ; Maze Learning/drug effects ; Mice ; Mice, Inbred ICR ; Molecular Docking Simulation ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.
Autorzy :
Chowdhury SR; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Gu J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Hu Y; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Wang J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Lei S; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Tavallaie MS; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Lam C; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Lu D; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Jiang F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China.
Fu L; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China; SJTU-Agilent Technologies Joint Laboratory for Pharmaceutical Analysis, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China; Academy of Pharmacy, Xi'an Jiaotong - Liverpool University, Suzhou, 215123, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113541. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*antagonists & inhibitors
Benzofurans/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Piperidines/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Protein Aggregates/drug effects ; Protein Aggregation, Pathological/drug therapy ; Protein Aggregation, Pathological/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).
Autorzy :
Ferreira JPS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Albuquerque HMT; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Cardoso SM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: .
Silva VLM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113492. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Amyloid Precursor Protein Secretases/*antagonists & inhibitors
Aspartic Acid Endopeptidases/*antagonists & inhibitors
Biological Products/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/metabolism ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Humans ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry
Czasopismo naukowe
Tytuł :
Cholinesterases, carbonic anhydrase inhibitory properties and in silico studies of novel substituted benzylamines derived from dihydrochalcones.
Autorzy :
Akıncıoğlu A; Agri Ibrahim Cecen University, Central Researching Laboratory, 04100 Agri, Turkey.
Göksu S; Atatürk University, Faculty of Science, Department of Chemistry, Erzurum, Turkey. Electronic address: .
Naderi A; Atatürk University, Faculty of Science, Department of Chemistry, Erzurum, Turkey.
Akıncıoğlu H; Agri Ibrahim Cecen University, Faculty of Arts and Science, Agri, Turkey.
Kılınç N; Igdir University, Vocational School of Health Services, Department of Medical Services and Techniques, Igdir, Turkey.
Gülçin İ; Atatürk University, Faculty of Science, Department of Chemistry, Erzurum, Turkey.
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Źródło :
Computational biology and chemistry [Comput Biol Chem] 2021 Oct; Vol. 94, pp. 107565. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylamines/*pharmacology
Carbonic Anhydrase Inhibitors/*pharmacology
Chalcones/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Acetylcholinesterase/metabolism ; Animals ; Benzylamines/chemical synthesis ; Benzylamines/chemistry ; Butyrylcholinesterase/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrases/metabolism ; Chalcones/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Horses ; Humans ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure-activity relationship and molecular modelling simulations.
Autorzy :
Mughal EU; Department of Chemistry, University of Gujrat, Gujrat, Pakistan.
Sadiq A; Department of Chemistry, Govt. College Women University, Sialkot, Pakistan.
Ayub M; Department of Chemistry, Govt. College Women University, Sialkot, Pakistan.
Naeem N; Department of Chemistry, University of Gujrat, Gujrat, Pakistan.
Javid A; Department of Chemistry, University of Gujrat, Gujrat, Pakistan.
Sumrra SH; Department of Chemistry, University of Gujrat, Gujrat, Pakistan.
Zafar MN; Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Khan BA; Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Malik FP; RCMS, National University of Science and Technology, Islamabad, Pakistan.
Ahmed I; Department of Engineering & Biotechnology, University of Cambridge, Cambridge, UK.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Oct; Vol. 39 (16), pp. 6154-6167. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Butyrylcholinesterase*/metabolism
Cholinesterase Inhibitors*/pharmacology
Acetylcholinesterase/metabolism ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation.
Autorzy :
Zaki AG; Plant Research Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt.
El-Sayed ER; Plant Research Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 Dec; Vol. 105 (23), pp. 8869-8880. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Alternaria*
Cholinesterase Inhibitors*
Acetylcholinesterase ; Alkaloids ; Fermentation ; Gamma Rays ; Sesquiterpenes
SCR Organism :
Alternaria brassicae
Czasopismo naukowe
Tytuł :
Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and in vitro characterisation.
Autorzy :
David B; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany, Düsseldorf.
Schneider P; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.
Schäfer P; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.
Pietruszka J; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.; IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, Jülich, Germany.
Gohlke H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany, Düsseldorf.; John von Neumann Institute for Computing (NIC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Jülich, Germany.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 491-496.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Physostigmine/*pharmacology
Alzheimer Disease/metabolism ; Animals ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemistry ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Electrophorus ; Molecular Docking Simulation ; Molecular Structure ; Physostigmine/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Structure-activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease.
Autorzy :
Wu C; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Zhang G; Management Center of Anhui Continuing Education Network Park, Anhui Open University, Hefei, China.
Zhang ZW; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, China.
Jiang X; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Zhang Z; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Li H; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Qin HL; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, China.
Tang W; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1860-1873.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*chemistry
Cholinesterases/*metabolism
Neuroprotective Agents/*chemistry
Sulfinic Acids/*chemistry
Alkynes/chemistry ; Amyloid/metabolism ; Animals ; Behavior, Animal ; Blood-Brain Barrier/metabolism ; Cell Survival/drug effects ; Cholinesterase Inhibitors/pharmacology ; Drug Design ; Humans ; Liver ; Male ; Mice, Inbred ICR ; Molecular Docking Simulation ; Molecular Structure ; Morris Water Maze Test ; Nervous System ; Neuroprotective Agents/pharmacology ; Structure-Activity Relationship ; Sulfinic Acids/pharmacology
Czasopismo naukowe
Tytuł :
New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation.
Autorzy :
Bortolami M; Department of Scienze di Base e Applicate per l'Ingegneria, Sapienza University of Rome, via Castro Laurenziano 7, I-00161 Rome, Italy.
Pandolfi F; Department of Scienze di Base e Applicate per l'Ingegneria, Sapienza University of Rome, via Castro Laurenziano 7, I-00161 Rome, Italy.
Tudino V; Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Messore A; Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Madia VN; Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
De Vita D; Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Di Santo R; Istituto Pasteur, Fondazione Cenci Bolognetti, Department of Chemistry and Technology of Drug, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Costi R; Istituto Pasteur, Fondazione Cenci Bolognetti, Department of Chemistry and Technology of Drug, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Romeo I; Net4Science s.r.l., Campus universitario ″S. Venuta″, Viale Europa, 88100 Catanzaro, Italy.; Dipartimento di Scienze della Salute, Università ″Magna Græcia″ di Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Alcaro S; Net4Science s.r.l., Campus universitario ″S. Venuta″, Viale Europa, 88100 Catanzaro, Italy.; Dipartimento di Scienze della Salute, Università ″Magna Græcia″ di Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Colone M; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena, 00161 Rome, Italy.
Stringaro A; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena, 00161 Rome, Italy.
Espargaró A; Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Avda. Joan XXIII, 27-31 Barcelona, Catalonia, Spain.
Sabatè R; Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Avda. Joan XXIII, 27-31 Barcelona, Catalonia, Spain.
Scipione L; Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Nov 03; Vol. 12 (21), pp. 4090-4112. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
Cholinesterase Inhibitors*/pharmacology
Acetylcholinesterase/metabolism ; Animals ; Butyrylcholinesterase/metabolism ; Horses ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Pyridines ; Pyrimidines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Acetylcholinesterase inhibitors and cognitive stimulation, combined and alone, in treating individuals with mild Alzheimer's disease.
Autorzy :
Devita M; Department of General Psychology, University of Padua, Via Venezia 8, 35131, Padua, Italy. .
Masina F; IRCCS San Camillo Hospital, Via Alberoni 70, 30126, Venice, Italy.
Mapelli D; Department of General Psychology, University of Padua, Via Venezia 8, 35131, Padua, Italy.
Anselmi P; Department of Philosophy, Sociology, Education and Applied Psychology-FISPPA, University of Padua, Via Venezia 14, 35131, Padua, Italy.
Sergi G; Geriatric Division, Department of Medicine-DIMED, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
Coin A; Geriatric Division, Department of Medicine-DIMED, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
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Źródło :
Aging clinical and experimental research [Aging Clin Exp Res] 2021 Nov; Vol. 33 (11), pp. 3039-3045. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/drug therapy
Cholinesterase Inhibitors*/therapeutic use
Acetylcholinesterase ; Cognition ; Humans ; Linear Models
Czasopismo naukowe
Tytuł :
Essential oil of Cymbopogon citratus cultivated in Egypt: seasonal variation in chemical composition and anticholinesterase activity.
Autorzy :
Madi YF; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Choucry MA; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Meselhy MR; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
El-Kashoury EA; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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Źródło :
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (21), pp. 4063-4067. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cholinesterase Inhibitors*/pharmacology
Cymbopogon*/chemistry
Oils, Volatile*/chemistry
Oils, Volatile*/pharmacology
Seasons*
Acetylcholinesterase ; Egypt ; Plant Oils/chemistry ; Plant Oils/pharmacology
Czasopismo naukowe
Tytuł :
Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells.
Autorzy :
Liu EYL; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.).
Mak S; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.).
Kong X; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.).
Xia Y; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.).
Kwan KKL; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.).
Xu ML; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.).
Tsim KWK; Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou, China (E.Y.L.L.); Institute of Pharmaceutical & Food Engineering, Chinese Medicine Master Studio of Wang Shimin, Shanxi University of Chinese Medicine, Jinzhong, China (X.K.); Shenzhen Key Laboratory of Edible and Medicinal Bioresources, SRI, The Hong Kong University of Science and Technology Shenzhen, China (S.M., X.K., Y.X., K.K.L.K., M.L.X., K.W.K.T.); and Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China (E.Y.L.L., S.M., Y.X., K.K.L.K., M.L.X., K.W.K.T.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2021 Nov; Vol. 100 (5), pp. 456-469. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholinesterase/*metabolism
Apoptosis/*drug effects
Cholinesterase Inhibitors/*pharmacology
Endoplasmic Reticulum Stress/*drug effects
Neurons/*drug effects
Tacrine/*pharmacology
Animals ; Apoptosis/physiology ; Cell Line, Tumor ; Cells, Cultured ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Endoplasmic Reticulum Stress/physiology ; HEK293 Cells ; Humans ; Mice ; Molecular Docking Simulation/methods ; Neurons/enzymology ; RAW 264.7 Cells ; Rats ; Rats, Sprague-Dawley ; Tacrine/chemistry
Czasopismo naukowe
Tytuł :
Acetylcholinesterase Inhibitors in Myasthenic Crisis: A Systematic Review of Observational Studies.
Autorzy :
Prado MB Jr; Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. .; Department of Epidemiology and Biostatistics, College of Public Health, University of the Philippines-Manila, Manila, Philippines. .
Adiao KJ; Section of Neurology, Department of the Neurosciences, Philippine General Hospital, University of the Philippines-Manila, Manila, Philippines.
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Źródło :
Neurocritical care [Neurocrit Care] 2021 Oct; Vol. 35 (2), pp. 528-544. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review; Systematic Review
MeSH Terms :
Cholinesterase Inhibitors*/adverse effects
Myasthenia Gravis*/drug therapy
Acetylcholinesterase ; Humans ; Neostigmine ; Plasmapheresis
Czasopismo naukowe

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