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Tytuł:
The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease.
Autorzy:
Valis M; Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. Electronic address: .
Dlabkova A; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defense in Brno, Hradec Kralove, Czech Republic. Electronic address: .
Hort J; Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address: .
Angelucci F; Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
Pejchal J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defense in Brno, Hradec Kralove, Czech Republic.
Kuca K; Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Electronic address: .
Pavelek Z; Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Karasova JZ; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defense in Brno, Hradec Kralove, Czech Republic; Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
Novotny M; Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Mar; Vol. 159, pp. 114223. Date of Electronic Publication: 2023 Jan 09.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Alzheimer Disease*/blood
Alzheimer Disease*/cerebrospinal fluid
Alzheimer Disease*/drug therapy
Cholinesterase Inhibitors*/blood
Cholinesterase Inhibitors*/cerebrospinal fluid
Cholinesterase Inhibitors*/therapeutic use
Donepezil*/blood
Donepezil*/cerebrospinal fluid
Donepezil*/therapeutic use
Humans ; Acetylcholinesterase ; Indans/therapeutic use ; Indans/pharmacology ; Piperidines/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
New thiourea and benzamide derivatives of 2-aminothiazole as multi-target agents against Alzheimer's disease: Design, synthesis, and biological evaluation.
Autorzy:
Kilic B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkiye.
Bardakkaya M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkiye; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Biruni University, İstanbul, Turkiye.
Ilıkcı Sagkan R; Department of Medical Biology, Faculty of Medicine, Uşak University, Uşak, Turkiye.
Aksakal F; Department of Chemistry, Hacettepe University, Ankara, Turkiye; Department of Analytical Chemistry, Faculty of Pharmacy, Kocaeli Health and Technology University, Kocaeli, Turkiye.
Shakila S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkiye.
Dogruer DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkiye. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Feb; Vol. 131, pp. 106322. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/pharmacology
Neuroprotective Agents*/chemistry
Neuroprotective Agents*/pharmacology
Thiourea*/analogs & derivatives
Thiourea*/pharmacology
Benzamides*/chemistry
Benzamides*/pharmacology
Humans ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Hydrogen Peroxide/pharmacology ; Kinetics ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
New amides derived from sclareolide as anticholinesterase agents.
Autorzy:
Silva JG; Department of Chemistry, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Campus Pampulha, CEP 31270-901, Belo Horizonte, MG, Brazil. Electronic address: .
Borgati TF; Department of Chemistry, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Campus Pampulha, CEP 31270-901, Belo Horizonte, MG, Brazil; Department of Natural Sciences, State University of Minas Gerais, Av. Paraná, 3001 - Jardim Belvedere I, CEP 35501-170, Divinópolis - MG, Brazil.
Lopes SMG; Department of Chemistry, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Campus Pampulha, CEP 31270-901, Belo Horizonte, MG, Brazil.
Heise N; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Hoenke S; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Csuk R; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. Electronic address: .
Barbosa LCA; Department of Chemistry, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Campus Pampulha, CEP 31270-901, Belo Horizonte, MG, Brazil. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Jan; Vol. 130, pp. 106249. Date of Electronic Publication: 2022 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/chemistry
Acetylcholinesterase*/metabolism
Mice ; Animals ; Amides/pharmacology ; Molecular Docking Simulation
Czasopismo naukowe
Szczegóły
Tytuł:
Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain.
Autorzy:
Mushtaq A; Department of Pharmaceutical Sciences, Government College University, Lahore 54000, Pakistan.
Habib F; Gulab Devi Institute of Pharmacy, Gulab Devi Educational Complex, Lahore 54000, Pakistan.
Manea R; Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania.
Anwar R; Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
Gohar UF; Institute of Industrial Biotechnology, Government College University, Lahore 54000, Pakistan.
Zia-Ul-Haq M; Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54000, Pakistan.
Ahmad M; Gulab Devi Institute of Pharmacy, Gulab Devi Educational Complex, Lahore 54000, Pakistan.
Gavris CM; Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania.
Chicea L; Faculty of Medicine, University 'Lucian Blaga' Sibiu, 550169 Sibiu, Romania.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 27; Vol. 28 (5). Date of Electronic Publication: 2023 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors*/pharmacology
Pimpinella*/chemistry
Mice ; Animals ; Antioxidants/pharmacology ; Acetylcholinesterase/metabolism ; Plant Extracts/pharmacology ; Brain/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Validation of Acetylcholinesterase Inhibition Machine Learning Models for Multiple Species.
Autorzy:
Vignaux PA; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Lane TR; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Urbina F; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Gerlach J; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Puhl AC; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Snyder SH; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
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Źródło:
Chemical research in toxicology [Chem Res Toxicol] 2023 Feb 20; Vol. 36 (2), pp. 188-201. Date of Electronic Publication: 2023 Feb 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcholinesterase*/chemistry
Cholinesterase Inhibitors*/chemistry
Animals ; Humans ; Fishes ; Algorithms ; Machine Learning
Czasopismo naukowe
Szczegóły
Tytuł:
Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase.
Autorzy:
Mukherjee RP; Biomanufacturing Training and Education Center (BTEC), North Carolina State University, Raleigh, NC 27606, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA.
Yow GY; Prometic Bioseparations Ltd, Cambridge CB23 7AJ, UK.
Sarakbi S; Prometic Bioseparations Ltd, Cambridge CB23 7AJ, UK.
Menegatti S; Biomanufacturing Training and Education Center (BTEC), North Carolina State University, Raleigh, NC 27606, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA.
Gurgel PV; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA; Prometic Bioseparations Ltd, Cambridge CB23 7AJ, UK.
Carbonell RG; Biomanufacturing Training and Education Center (BTEC), North Carolina State University, Raleigh, NC 27606, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA; William R. Kenan, Jr. Institute for Engineering, Technology and Science North Carolina State University, Raleigh, NC 27606, USA. Electronic address: .
Bobay BG; Duke University NMR Center, Duke University Medical Center, Durham, NC 27710, USA; Department of Biochemistry, Duke University, Durham, NC 27710, USA; Department of Radiology, Duke University, Durham, NC 27710, USA. Electronic address: .
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Źródło:
Computational biology and chemistry [Comput Biol Chem] 2023 Feb; Vol. 102, pp. 107797. Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Butyrylcholinesterase*/metabolism
Cholinesterase Inhibitors*/chemistry
Ligands ; Molecular Docking Simulation ; Peptides
Czasopismo naukowe
Szczegóły
Tytuł:
Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach.
Autorzy:
Silva LB; Graduate Program in Medicinal Chemistry and Molecular Modeling, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Ferreira EFB; Laboratory of Organic Chemistry and Biochemistry, University of the State of Amapá, Macapá 68900-070, Brazil.
Maryam; COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad 45550, Pakistan.
Espejo-Román JM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.
Costa GV; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.; Laboratory of Biotechnology in Natural Products, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Cruz JV; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Kimani NM; Department of Physical Sciences, University of Embu, Embu P.O. Box 6-60100, Kenya.
Costa JS; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Bittencourt JAHM; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Cruz JN; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
Campos JM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.
Santos CBR; Graduate Program in Medicinal Chemistry and Molecular Modeling, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.; Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá 68902-280, Brazil.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 19; Vol. 28 (3). Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors*/chemistry
Alzheimer Disease*/drug therapy
Humans ; Galantamine/pharmacology ; Acetylcholinesterase/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Enzyme Inhibitors/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor.
Autorzy:
Gholami A; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30, Göteborg, Sweden.
Minai-Tehrani D; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. d_.
Eriksson LA; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30, Göteborg, Sweden. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 12; Vol. 13 (1), pp. 643. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Cholinesterase Inhibitors*/chemistry
Ondansetron*/pharmacology
Humans ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Molecular Docking Simulation ; Rivastigmine/pharmacology ; Structure-Activity Relationship ; Tacrine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Blood-brain barrier permeable benzylpiperidin-4-yl-linked benzylamino benzamides as dual cholinesterase inhibitors.
Autorzy:
Banoo R; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research, Ghaziabad, India.
Nuthakki VK; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research, Ghaziabad, India.
Abdullaha M; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research, Ghaziabad, India.
Sharma M; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research, Ghaziabad, India.
Bharate SB; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific and Innovative Research, Ghaziabad, India.
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Źródło:
Drug development research [Drug Dev Res] 2022 Dec; Vol. 83 (8), pp. 1791-1802. Date of Electronic Publication: 2022 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/chemistry
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Humans ; Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Blood-Brain Barrier/metabolism ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.
Autorzy:
Zhang H; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
Wang Y; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Wang Y; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
Li X; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: .
Wang S; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: .
Wang Z; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Oct 05; Vol. 240, pp. 114606. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/drug therapy
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/therapeutic use
Aged ; Carbamates/pharmacology ; Carbamates/therapeutic use ; Humans ; Ligands
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer's Disease Candidates: Evidence-Based In Vitro Study.
Autorzy:
Rahim F; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Ullah H; Department of Chemistry, University of Okara, Okara 56130, Pakistan.
Taha M; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Hussain R; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Sarfraz M; Department of Zoology, Wildlife and Fisheries, Sub-Campus Toba Tek Singh, University of Agriculture Faisalabad, Punjab 36050, Pakistan.
Iqbal R; Department of Agronomy, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Iqbal N; Department of Chemistry, University of Poonch, Rawalakot 12350, Pakistan.
Khan S; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Ali Shah SA; Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.; Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.
Albalawi MA; Department of Chemistry, Alwajh College, University of Tabuk, Tabuk 47512, Saudi Arabia.
Abdelaziz MA; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Alatawi FS; Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Alasmari A; Department of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Sakran MI; Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.; Biochemistry Section, Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.
Zidan N; Department of Nutrition and Food Science, Faculty of Home Economics, University of Tabuk, Tabuk 71491, Saudi Arabia.; Department of Home Economics, Faculty of Specific Education, Kafr ElSheikh University, Kafr ElSheikh 33516, Egypt.
Jafri I; Department of Biotechnology, Faculty of Sciences, Taif University, Taif 21944, Saudi Arabia.
Khan KM; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 20; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Cholinesterase Inhibitors*/chemical synthesis
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/therapeutic use
Thiosemicarbazones*/chemical synthesis
Thiosemicarbazones*/pharmacology
Thiosemicarbazones*/therapeutic use
Humans ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.
Autorzy:
Li X; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Li T; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
Zhan F; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Cheng F; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
Lu L; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
Zhang B; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
Li J; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Hu Z; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Zhou S; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Jia Y; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Allen S; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
White L; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
Phillips J; School of Pharmacy, University of College London, London WC1N 1AX, U.K.
Zhu Z; School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
Xu J; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
Yao H; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
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Źródło:
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Dec 07; Vol. 13 (23), pp. 3488-3501. Date of Electronic Publication: 2022 Nov 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Chromones*/chemical synthesis
Chromones*/pharmacology
Chromones*/therapeutic use
Cholinesterase Inhibitors*/chemical synthesis
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/therapeutic use
Monoamine Oxidase Inhibitors*/chemical synthesis
Monoamine Oxidase Inhibitors*/pharmacology
Monoamine Oxidase Inhibitors*/therapeutic use
Animals ; Humans ; Mice ; Acetylcholinesterase/metabolism ; Cell Line, Tumor ; Drug Design
Czasopismo naukowe
Szczegóły
Tytuł:
Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening.
Autorzy:
Agha KA; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abo-Dya NE; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Issahaku AR; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Agoni C; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Soliman MES; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Abdel-Aal EH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abdel-Samii ZK; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Ibrahim TS; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1241-1256.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/pharmacology
Nootropic Agents*
Acetylcholinesterase/metabolism ; Animals ; Carbamates/pharmacology ; Donepezil ; Piperazines ; Rats ; Receptors, N-Methyl-D-Aspartate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Guaiane-type sesquiterpenoids with various ring skeletons from Daphne bholua uncovered by molecular networking and structural revisions of previously reported analogues.
Autorzy:
Dong SH; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Duan ZK; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Ai YF; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhou XF; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhang X; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lian MY; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Bai M; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
Song SJ; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang 110016, People's Republic of China; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang 110016, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 Dec; Vol. 129, pp. 106208. Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Daphne*/chemistry
Sesquiterpenes, Guaiane*/chemistry
Sesquiterpenes, Guaiane*/isolation & purification
Sesquiterpenes, Guaiane*/pharmacology
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/isolation & purification
Cholinesterase Inhibitors*/pharmacology
Acetylcholinesterase/chemistry ; Molecular Structure
Czasopismo naukowe
Szczegóły
Tytuł:
Benzimidazolium Salts Containing Trifluoromethoxybenzyl: Synthesis, Characterization, Crystal Structure, Molecular Docking Studies and Enzymes Inhibitory Properties.
Autorzy:
Hamide M; Department of Chemistry, Faculty of Arts and Science, Cukurova University, 01330-, Adana, Türkiye.
Gök Y; Department of Chemistry, Faculty of Arts and Science, Inönü University, 44280-, Malatya, Türkiye.
Demir Y; Nihat Delibalta Göle Vocational High School, Ardahan University, 75700-, Ardahan, Türkiye.
Sevinçek R; Dokuz Eylül University, Faculty of Science, Department of Physics, 35160-, Buca, İzmir, Türkiye.
Taskin-Tok T; Department of Chemistry, Faculty of Arts and Sciences, Gaziantep University, 27310-, Gaziantep, Türkiye.; Department of Bioinformatics and Computational Biology, Institute of Health Sciences, Gaziantep University, 27310-, Gaziantep, Türkiye.
Tezcan B; Department of Chemistry, Faculty of Arts and Science, Cukurova University, 01330-, Adana, Türkiye.
Aktaş A; Vocational School of Health Service, Inonu University, 44280-, Malatya, Türkiye.
Gülçin İ; Department of Chemistry, Faculty of Science, Atatürk University, 25240-, Erzurum, Türkiye.
Aygün M; Dokuz Eylül University, Faculty of Science, Department of Physics, 35160-, Buca, İzmir, Türkiye.
Güzel B; Department of Chemistry, Faculty of Arts and Science, Cukurova University, 01330-, Adana, Türkiye.
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Źródło:
Chemistry & biodiversity [Chem Biodivers] 2022 Dec; Vol. 19 (12), pp. e202200257. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/chemistry
Benzimidazoles*/chemistry
Benzimidazoles*/pharmacology
Acetylcholinesterase/metabolism ; Carbonic Anhydrase I ; Carbonic Anhydrase II ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrase Inhibitors/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Spectroscopy, Fourier Transform Infrared ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides.
Autorzy:
Kohoutova Z; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Malinak D; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Andrys R; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Svobodova J; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Psotka M; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Schmidt M; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Prchal L; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Musilek K; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 760-767.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors/*pharmacology
Organophosphates/*pharmacology
Oximes/*pharmacology
Pyridinium Compounds/*pharmacology
Sulfhydryl Compounds/*pharmacology
Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Organophosphates/chemical synthesis ; Organophosphates/chemistry ; Oximes/chemical synthesis ; Oximes/chemistry ; Pyridinium Compounds/chemical synthesis ; Pyridinium Compounds/chemistry ; Structure-Activity Relationship ; Sulfhydryl Compounds/chemical synthesis ; Sulfhydryl Compounds/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chemical composition, enantiomeric analysis and anticholinesterase activity of Lepechinia betonicifolia essential oil from Ecuador.
Autorzy:
Calva J; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador.
Cartuche L; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador.
González S; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador.
Montesinos JV; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador.
Morocho V; Departamento de Química, Universidad Técnica Particular de Loja, Loja, Ecuador.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 206-211.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors/*pharmacology
Lamiaceae/*chemistry
Oils, Volatile/*pharmacology
Plant Extracts/*pharmacology
Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/isolation & purification ; Ecuador ; Gas Chromatography-Mass Spectrometry ; Oils, Volatile/chemistry ; Oils, Volatile/isolation & purification ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Stereoisomerism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease.
Autorzy:
Sang Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Song Q; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Cao Z; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Deng Y; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Zhang L; Department of Elderly Digestive, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 69-85.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Chalcone/chemistry ; Chalcone/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Humans ; Ligands ; Molecular Structure ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; PC12 Cells ; Protein Aggregates/drug effects ; Rats ; Structure-Activity Relationship ; Vitamin E/chemistry ; Vitamin E/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Development of naringenin- O -alkylamine derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Autorzy:
Yang J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Zhou Y; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Ban Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Mi J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
He Y; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Li X; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Liu Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Wang K; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Zhu G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Liu W; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Tan Z; Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
Sang Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Pokaż więcej
Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 792-816.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*drug therapy
Amines/*pharmacology
Antioxidants/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Flavanones/*pharmacology
Neuroprotective Agents/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amines/chemical synthesis ; Amines/chemistry ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Butyrylcholinesterase/metabolism ; Cell Line ; Cell Survival/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Development ; Flavanones/chemical synthesis ; Flavanones/chemistry ; Humans ; Mice ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Protein Aggregates/drug effects ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Divulging the anti-acetylcholinesterase activity of Colletotrichum lentis strain KU1 extract as sustainable AChE active site inhibitors.
Autorzy:
Kallingal A; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, 80-233, Gdansk, Poland.
Ayyolath A; Laboratory of Bacterial Genetics, Faculty of Chemistry, Gdansk University of Technology, 80-233, Gdansk, Poland.
Thachan Kundil V; Department of Biotechnology and Microbiology, School of Life Science, Kannur University, Palayad, Kannur, Kerala, India.
Maniyeri Suresh A; Laboratory of Bacterial Genetics, Faculty of Chemistry, Gdansk University of Technology, 80-233, Gdansk, Poland.
Muringayil Joseph T; Polymers Technology Department, Chemical Faculty, Gdansk University of Technology, Gdansk, Poland.
Haponiuk J; Polymers Technology Department, Chemical Faculty, Gdansk University of Technology, Gdansk, Poland.
Thomas S; International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, India.
Augustine A; Department of Biotechnology and Microbiology, School of Life Science, Kannur University, Palayad, Kannur, Kerala, India. .
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Źródło:
Archives of microbiology [Arch Microbiol] 2022 Nov 17; Vol. 204 (12), pp. 713. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors*/pharmacology
Cholinesterase Inhibitors*/analysis
Cholinesterase Inhibitors*/chemistry
Neurodegenerative Diseases*
Humans ; Aged ; Molecular Docking Simulation ; Catalytic Domain ; Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
SCR Organism:
Colletotrichum lentis
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 16297

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