Temat: "Cholinesterase Inhibitors" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and in vitro characterisation.
Autorzy:: David B; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany, Düsseldorf.
Schneider P; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.
Schäfer P; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.
Pietruszka J; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf at Forschungszentrum Jülich GmbH, Jülich, Germany.; IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, Jülich, Germany.
Gohlke H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Germany, Düsseldorf.; John von Neumann Institute for Computing (NIC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Jülich, Germany.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 491-496.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Discovery*
Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Physostigmine/*pharmacology
Alzheimer Disease/metabolism ; Animals ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemistry ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Electrophorus ; Molecular Docking Simulation ; Molecular Structure ; Physostigmine/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 2.

Tytuł:: Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice.
Autorzy:: Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Králové, Czech Republic.
Karasova JZ; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Králové, Czech Republic. .; Pokaż więcej
Źródło:: Neurotoxicity research [Neurotox Res] 2021 Oct; Vol. 39 (5), pp. 1487-1494. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji:: Journal Article
MeSH Terms:: Acetylcholinesterase/*metabolism
Cholinesterase Inhibitors/*administration & dosage
Donepezil/*administration & dosage
Memantine/*administration & dosage
Pre-Exposure Prophylaxis/*methods
Soman/*toxicity
Animals ; Antiparkinson Agents/administration & dosage ; Cholinesterase Inhibitors/toxicity ; Dopamine Agents/administration & dosage ; Drug Therapy, Combination ; Male ; Mice

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Skocz do pozycji: 3.

Tytuł:: Claulansine F-Donepezil Hybrids as Anti-Alzheimer's Disease Agents with Cholinergic, Free-Radical Scavenging, and Neuroprotective Activities.
Autorzy:: Zang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Liu K; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang W; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Ma J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chen X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Feb 28; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 28.
Typ publikacji:: Journal Article
MeSH Terms:: Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Carbazoles/*chemistry
Cholinesterase Inhibitors/*chemistry
Donepezil/*chemistry
Neuroprotective Agents/*chemistry
Animals ; Blood-Brain Barrier/metabolism ; Carbazoles/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Donepezil/pharmacology ; Drug Design ; Drug Therapy, Combination ; Free Radical Scavengers/metabolism ; Glucose/metabolism ; Humans ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Neuroprotective Agents/pharmacology ; Oxygen/metabolism ; Rats, Sprague-Dawley

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Skocz do pozycji: 4.

Tytuł:: First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease.
Autorzy:: Guieu B; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.
Lecoutey C; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.
Legay R; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.
Davis A; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.
Sopkova de Oliveira Santos J; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.
Altomare CD; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Catto M; Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
Rochais C; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.
Dallemagne P; Normandie Univ, UNICAEN, CERMN, 14000 Caen, France.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 27; Vol. 26 (1). Date of Electronic Publication: 2020 Dec 27.
Typ publikacji:: Journal Article
MeSH Terms:: Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Donepezil/*chemical synthesis
Donepezil/*therapeutic use
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/therapeutic use ; Donepezil/chemistry ; Donepezil/pharmacology ; Humans ; Models, Molecular ; Molecular Conformation ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase Inhibitors/therapeutic use ; Stereoisomerism

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Skocz do pozycji: 5.

Tytuł:: Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil.
Autorzy:: Sikora J; Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Podsiedlik M; Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Pietras T; Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Kosmalski M; Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Matłoka M; Research and Development Department, Celon Pharma S.A, Łomianki, Poland.
Moszczyński-Petkowski R; Research and Development Department, Celon Pharma S.A, Łomianki, Poland.
Wieczorek M; Research and Development Department, Celon Pharma S.A, Łomianki, Poland.
Markowicz-Piasecka M; Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1743-1750.
Typ publikacji:: Journal Article
MeSH Terms:: Antipsychotic Agents/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Phosphodiesterase Inhibitors/*pharmacology
Quetiapine Fumarate/*pharmacology
Acetylcholinesterase/metabolism ; Antipsychotic Agents/chemical synthesis ; Antipsychotic Agents/chemistry ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemical synthesis ; Donepezil/chemistry ; Dose-Response Relationship, Drug ; Healthy Volunteers ; Humans ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Phosphoric Diester Hydrolases/metabolism ; Quetiapine Fumarate/chemical synthesis ; Quetiapine Fumarate/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 6.

Tytuł:: Acute cholinergic syndrome in a patient taking the prescribed dose of donepezil for Alzheimer's disease.
Autorzy:: Hanazawa T; Emergency Center and Poison Center, Saitama Medical University Hospital, Saitama, Japan.
Kamijo Y; Emergency Center and Poison Center, Saitama Medical University Hospital, Saitama, Japan.
Yoshizawa T; Emergency Center and Poison Center, Saitama Medical University Hospital, Saitama, Japan.; Department of Pharmacy, Saitama Medical University Hospital, Saitama, Japan.
Fujita Y; Poisoning and Drug Laboratory Division, Critical Care and Emergency Center, Iwate Medical University Hospital, Morioka, Japan.
Usui K; Department of Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Haga Y; Emergency Center and Poison Center, Saitama Medical University Hospital, Saitama, Japan.; Pokaż więcej
Źródło:: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society [Psychogeriatrics] 2020 Jul; Vol. 20 (4), pp. 538-539. Date of Electronic Publication: 2020 Feb 17.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*poisoning
Donepezil/*adverse effects
Indans/*poisoning
Aged, 80 and over ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/therapeutic use ; Donepezil/therapeutic use ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Indans/administration & dosage

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Skocz do pozycji: 7.

Tytuł:: MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy.
Autorzy:: Shamsi A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Anwar S; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Mohammad T; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Alajmi MF; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Hussain A; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Rehman MT; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Hasan GM; Department of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
Islam A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 May 20; Vol. 10 (5). Date of Electronic Publication: 2020 May 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Nootropic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
RNA Helicases/*antagonists & inhibitors
Rivastigmine/*pharmacology
Binding Sites ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemistry ; Humans ; Molecular Docking Simulation ; Nootropic Agents/chemistry ; Protein Binding ; Protein Kinase Inhibitors/chemistry ; RNA Helicases/chemistry ; RNA Helicases/metabolism ; Rivastigmine/chemistry

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Skocz do pozycji: 8.

Tytuł:: Donepezil improves vascular function in a mouse model of Alzheimer's disease.
Autorzy:: Pellegrini C; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
D'Antongiovanni V; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Fornai M; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Duranti E; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Baldacci F; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Bernardini N; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, Pisa, Italy.
Taddei S; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Virdis A; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Blandizzi C; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Masi S; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.
Antonioli L; Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, Pisa, Italy.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Dec; Vol. 9 (6), pp. e00871.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Cognitive Dysfunction/*drug therapy
Donepezil/*pharmacology
Acetylcholine/pharmacology ; Alzheimer Disease/complications ; Animals ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Disease Models, Animal ; Inflammation/drug therapy ; Inflammation/pathology ; Maze Learning/drug effects ; Mice ; Nitric Oxide/metabolism ; Oxidative Stress/drug effects ; Vascular Remodeling/drug effects ; Vasodilation/drug effects

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Skocz do pozycji: 9.

Tytuł:: Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.
Autorzy:: Pachón-Angona I; a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.
Refouvelet B; a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.
Andrýs R; b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Martin H; c PEPITE EA4267, Laboratoire de Toxicologie Cellulaire , University Bourgogne Franche-Comté , Besançon , France.
Luzet V; a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.
Iriepa I; d Department of Organic Chemistry and Inorganic Chemistry , Alcalà University , Madrid , Spain.; e Institute of Chemical Research Andrés M. del Río , Alcalà University , Madrid , Spain.
Moraleda I; d Department of Organic Chemistry and Inorganic Chemistry , Alcalà University , Madrid , Spain.
Diez-Iriepa D; d Department of Organic Chemistry and Inorganic Chemistry , Alcalà University , Madrid , Spain.; e Institute of Chemical Research Andrés M. del Río , Alcalà University , Madrid , Spain.
Oset-Gasque MJ; f Instituto de Investigación en Neuroquímica , Universidad Complutense de Madrid , Madrid , Spain.; g Department of Biochemistry and Molecular Biology, School of Pharmacy , Plaza de Ramòn y Cajal , Madrid , Spain.
Marco-Contelles J; h Laboratory of Medicinal Chemistry (IQOG, CSIC) , Madrid , Spain.
Musilek K; b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Ismaili L; a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 479-489.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Chromones/*pharmacology
Donepezil/*pharmacology
Melatonin/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Chromones/chemistry ; Donepezil/chemistry ; Dose-Response Relationship, Drug ; Humans ; Melatonin/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 10.

Tytuł:: Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil.
Autorzy:: Mandal AKJ; Departments of Cardiology and Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.
Khan UF; Departments of Cardiology and Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.
Missouris CG; Departments of Cardiology and Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.; University of Cyprus Medical School, Nicosia, Cyprus.; Pokaż więcej
Źródło:: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2019 Dec; Vol. 57 (12), pp. 1157-1159. Date of Electronic Publication: 2019 Mar 21.
Typ publikacji:: Case Reports; Letter
MeSH Terms:: Cholinesterase Inhibitors/*adverse effects
Donepezil/*adverse effects
Intestinal Volvulus/*physiopathology
Tachycardia, Ventricular/*chemically induced
Aged, 80 and over ; Cholinesterase Inhibitors/administration & dosage ; Donepezil/administration & dosage ; Female ; Humans

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Skocz do pozycji: 11.

Tytuł:: Butyrylcholinesterase Protein Ends in the Pathogenesis of Alzheimer's Disease-Could BCHE Genotyping Be Helpful in Alzheimer's Therapy?
Autorzy:: Jasiecki J; Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Medical University of Gdańsk, 80-416 Gdańsk, Poland. .
Wasąg B; Department of Biology and Medical Genetics, Medical University of Gdańsk, 80-211 Gdańsk, Poland.; Laboratory of Clinical Genetics, University Clinical Centre, 80-952 Gdańsk, Poland.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2019 Oct 09; Vol. 9 (10). Date of Electronic Publication: 2019 Oct 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Alzheimer Disease/*drug therapy
Alzheimer Disease/*genetics
Butyrylcholinesterase/*genetics
Butyrylcholinesterase/*metabolism
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Rivastigmine/*pharmacology
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Cell Membrane/drug effects ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemistry ; Genotype ; Humans ; Rivastigmine/chemistry

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Skocz do pozycji: 12.

Tytuł:: Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease.
Autorzy:: Parween F; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, India.
Hossain MS; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, India.
Singh KP; Defence Research and Development Establishment (DRDO), Gwalior, India.
Gupta RD; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, India.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Oct 29; Vol. 16 (10), pp. e0258879. Date of Electronic Publication: 2021 Oct 29 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Aryldialkylphosphatase*/genetics
Aryldialkylphosphatase*/metabolism
Cholinesterase Inhibitors/*metabolism
Donepezil/*metabolism
Pyridostigmine Bromide/*metabolism
Humans ; Mutation ; Protein Binding

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Skocz do pozycji: 13.

Tytuł:: Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling.
Autorzy:: Kim J; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu 41062, Korea.
Lee HJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu 41062, Korea.
Park SK; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu 41062, Korea.
Park JH; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu 41062, Korea.
Jeong HR; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu 41062, Korea.
Lee S; G2GBIO, Inc., Science Park #411, 1646 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea.
Lee H; G2GBIO, Inc., Science Park #411, 1646 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea.
Seol E; G2GBIO, Inc., Science Park #411, 1646 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea.
Hoe HS; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), 61, Cheomdan-ro, Dong-gu, Daegu 41062, Korea.; Department of Brain and Cognitive Science, Daegu Gyeongbuk Institute of Science & Technology (DGIST), 333, Techno Jungang-daero, Hyeonpung-eup, Dalseong-gun, Daegu 42988, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease/*drug therapy
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*adverse effects
Cholinesterase Inhibitors/*administration & dosage
Donepezil/*administration & dosage
Inflammasomes/*metabolism
Lipopolysaccharides/*adverse effects
MAP Kinase Signaling System/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Rivastigmine/*pharmacology
STAT3 Transcription Factor/*metabolism
Alzheimer Disease/chemically induced ; Alzheimer Disease/genetics ; Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/drug effects ; Microglia/metabolism

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Skocz do pozycji: 14.

Tytuł:: Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease.
Autorzy:: Queda F; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Calò S; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Via E. Orabona 4, I-70125 Bari, Italy.
Gwizdala K; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Magalhães JD; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Cardoso SM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Institute of Molecular and Cell Biology, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Chaves S; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Piemontese L; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Via E. Orabona 4, I-70125 Bari, Italy.; National Research Council (CNR)-ISPA, via Amendola 122/O, 70126 Bari, Italy.
Santos MA; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Mar 16; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease/*drug therapy
Donepezil/*pharmacology
Sulfonamides/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Cell Line, Tumor ; Cholinesterase Inhibitors/pharmacology ; Humans ; Ligands ; Piperazines/pharmacology ; Piperidines/pharmacology ; Structure-Activity Relationship

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Skocz do pozycji: 15.

Tytuł:: Donepezil for mild cognitive impairment in Parkinson's disease.
Autorzy:: Baik K; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim SM; iMediSync Inc., Seoul, Republic of Korea.
Jung JH; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Lee YH; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Chung SJ; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yoo HS; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Ye BS; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Lee PH; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Sohn YH; Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kang SW; iMediSync Inc., Seoul, Republic of Korea. .; Data Center for Korean EEG, College of Nursing, Seoul National University, 103, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. .
Kang SY; Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7, Keunjaebong-gil, Hwaseong, Gyeonggi-do, 18450, Republic of Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Feb 26; Vol. 11 (1), pp. 4734. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cholinesterase Inhibitors/*therapeutic use
Cognitive Dysfunction/*drug therapy
Donepezil/*therapeutic use
Parkinson Disease/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies

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Skocz do pozycji: 16.

Tytuł:: Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease.
Autorzy:: Junaid M; Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Islam N; Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Hossain MK; Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Ullah MO; Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Halim MA; Division of Computer-Aided Drug Design, The Red-Green Research Centre, Dhaka, Bangladesh.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Feb 20; Vol. 14 (2), pp. e0211935. Date of Electronic Publication: 2019 Feb 20 (Print Publication: 2019).
Typ publikacji:: Journal Article
MeSH Terms:: Acetylcholinesterase*/chemistry
Drug Design*
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Cholinesterase Inhibitors/*chemistry
Donepezil/*analogs & derivatives
Donepezil/*chemistry
Alzheimer Disease ; Cholinesterase Inhibitors/pharmacokinetics ; Donepezil/pharmacokinetics ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/chemistry ; Humans ; Metals/chemistry ; Metals/pharmacokinetics

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Skocz do pozycji: 17.

Tytuł:: Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors.
Autorzy:: Green KD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA. .
Fosso MY; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA. .
Garneau-Tsodikova S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Dec 08; Vol. 23 (12). Date of Electronic Publication: 2018 Dec 08.
Typ publikacji:: Journal Article
MeSH Terms:: Aspartic Acid Endopeptidases/*antagonists & inhibitors
Cholinesterase Inhibitors/*pharmacology
Donepezil/*analogs & derivatives
Donepezil/*pharmacology
Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Donepezil/chemistry ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation

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Skocz do pozycji: 18.

Tytuł:: Disease state changes and safety of long-term donepezil hydrochloride administration in patients with Alzheimer's disease: Japan-Great Outcome of Long-term trial with Donepezil (J-GOLD).
Autorzy:: Arai H; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hashimoto N; Eisai Co., Ltd., Tokyo, Japan.
Sumitomo K; Eisai Co., Ltd., Tokyo, Japan.
Takase T; Eisai Co., Ltd., Tokyo, Japan.
Ishii M; Eisai Co., Ltd., Tokyo, Japan.; Pokaż więcej
Źródło:: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society [Psychogeriatrics] 2018 Sep; Vol. 18 (5), pp. 402-411. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji:: Journal Article
MeSH Terms:: Long-Term Care*
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*therapeutic use
Cognition/*drug effects
Cognition Disorders/*chemically induced
Donepezil/*therapeutic use
Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/psychology ; Cholinesterase Inhibitors/adverse effects ; Cognition Disorders/epidemiology ; Donepezil/adverse effects ; Drug Administration Schedule ; Female ; Humans ; Japan/epidemiology ; Male ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Time Factors ; Treatment Outcome

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Skocz do pozycji: 19.

Tytuł:: Donepezil protects glycerol-induced acute renal failure through the cholinergic anti-inflammatory and nitric oxide pathway in rats.
Autorzy:: Sun G; Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.
Wang J; Department of Urology, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.
Wang P; Department of Nephrology, Liaocheng Dongchangfu People's Hospital, Liaocheng, Shandong, P. R. China.
Ren H; Department of Eastern Operating Room, Liao Cheng People's Hospital, Liaocheng, Shandong, P. R. China.
Yue Y; Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.
Song Z; Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.
Fu X; Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.; Pokaż więcej
Źródło:: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2020 Dec; Vol. 42 (6), pp. 625-631. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji:: Journal Article
MeSH Terms:: Acute Kidney Injury/*prevention & control
Anti-Inflammatory Agents/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Donepezil/*pharmacology
Inflammation Mediators/*metabolism
Kidney/*drug effects
Nitric Oxide/*metabolism
Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Animals ; Disease Models, Animal ; Glycerol ; Interleukin-6/metabolism ; Kidney/metabolism ; Kidney/pathology ; Male ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism

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Skocz do pozycji: 20.

Tytuł:: Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments.
Autorzy:: Audira G; Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Ngoc Anh NT; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Ngoc Hieu BT; Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Malhotra N; Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Siregar P; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Villalobos O; Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines.
Villaflores OB; Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines.
Ger TR; Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Center of Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Huang JC; Department of Applied Chemistry, National Pingtung University, Pingtung 900391, Taiwan.
Chen KH; Department of Applied Chemistry, National Pingtung University, Pingtung 900391, Taiwan.
Hsiao CD; Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Center of Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Sep 18; Vol. 10 (9). Date of Electronic Publication: 2020 Sep 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Behavior, Animal/*drug effects
Brain/*drug effects
Donepezil/*toxicity
Environmental Exposure/*adverse effects
Toxicity Tests, Chronic/*methods
Zebrafish/*physiology
Animals ; Brain/metabolism ; Cholinesterase Inhibitors/toxicity ; Locomotion/drug effects ; Locomotion/physiology ; Malondialdehyde/metabolism ; Memory, Short-Term/drug effects ; Memory, Short-Term/physiology ; Motor Activity/drug effects ; Motor Activity/physiology ; Muscles/drug effects ; Muscles/metabolism ; Muscles/physiology ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism

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