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Tytuł:
Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1-HIF1α-mediated glycolysis-OXPHOS metabolism shift.
Autorzy:
Sun Y; Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.; Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
You Y; Department of Renal Diseases, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Wu Q; Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hu R; Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
Dai K; Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2024 Feb; Vol. 14 (2), pp. e1574.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cartilage, Articular*/metabolism
Cartilage, Articular*/pathology
Osteoarthritis*/etiology
Osteoarthritis*/metabolism
Osteoarthritis*/pathology
Humans ; Mice ; Animals ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Genome-Wide Association Study ; Organoids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
6-Shogaol (enexasogoal) treatment improves experimental knee osteoarthritis exerting a pleiotropic effect over immune innate signalling responses in chondrocytes.
Autorzy:
Gratal P; Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.
Mediero A; Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.
Lamuedra A; Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.
Matamoros-Recio A; Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, CIB-CSIC, Madrid, Spain.
Herencia C; Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.
Herrero-Beaumont G; Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.
Martín-Santamaría S; Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, CIB-CSIC, Madrid, Spain.
Largo R; Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, Spain.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (22), pp. 5089-5108. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chondrocytes*/metabolism
Osteoarthritis, Knee*/drug therapy
Osteoarthritis, Knee*/metabolism
Animals ; Catechols ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Mice, Inbred C57BL ; Toll-Like Receptor 4/metabolism ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes.
Autorzy:
Liang Y; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Shen L; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Ni W; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Ding Y; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Yang W; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Gu T; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Zhang C; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Yik JHN; Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California System, Davis, California, USA.
Haudenschild DR; Ellison Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of California System, Davis, California, USA.
Fan S; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Shen S; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
Hu Z; Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Aug; Vol. 13 (8), pp. e1358.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MicroRNAs*/genetics
MicroRNAs*/metabolism
Osteoarthritis*/genetics
Osteoarthritis*/metabolism
Mice ; Animals ; Humans ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Cells, Cultured ; Apoptosis/genetics ; Disease Models, Animal ; Oxidative Stress/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Small extracellular vesicles derived from human adipose-derived mesenchymal stromal cells cultured in a new chemically-defined contaminate-free media exhibit enhanced biological and therapeutic effects on human chondrocytes in vitro and in a mouse osteoarthritis model.
Autorzy:
Hanai H; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Hart DA; Department of Surgery and the McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Canada.
Jacob G; Department of Orthopaedics, VPS Lakeshore Hospital, Kerala, India.
Shimomura K; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Ando W; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Orthopaedic Surgery, Kansai Rosai Hospital, Hyogo, Japan.
Yoshioka Y; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Ochiya T; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Nakagawa S; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Nakamura M; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Okada S; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Nakamura N; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.; Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan.; Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2023 Jul; Vol. 12 (7), pp. e12337.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Extracellular Vesicles*
Mesenchymal Stem Cells*
Osteoarthritis*/therapy
Animals ; Mice ; Humans ; Chondrocytes ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Wnt signalling in the articular cartilage: A matter of balance.
Autorzy:
Gill AK; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, London, UK.
McCormick PJ; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, London, UK.
Sochart D; South West London Elective Orthopaedic Centre, Epsom, UK.
Nalesso G; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, UK.
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Źródło:
International journal of experimental pathology [Int J Exp Pathol] 2023 Apr; Vol. 104 (2), pp. 56-63. Date of Electronic Publication: 2023 Feb 26.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Cartilage, Articular*/metabolism
Osteoarthritis*
Humans ; Wnt Signaling Pathway/physiology ; Homeostasis ; Chondrocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes.
Autorzy:
Tuure L; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
Pemmari A; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
Hämäläinen M; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
Moilanen T; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.; Coxa Hospital for Joint Replacement, Tampere, Finland.
Moilanen E; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2020 Sep; Vol. 177 (18), pp. 4134-4146. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chondrocytes*/metabolism
Prostaglandins E*
Cells, Cultured ; Female ; Gene Expression ; Gene Expression Regulation ; Humans ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Male ; Microsomes/metabolism ; Prostaglandin-E Synthases/antagonists & inhibitors ; Prostaglandin-E Synthases/genetics ; Prostaglandin-E Synthases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification.
Autorzy:
Gong Z; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Wang K; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Chen J; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Zhu J; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Feng Z; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Song C; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Zhang Z; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Wang H; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Fan S; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Shen S; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
Fang X; Department, of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China.; Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.; Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Jan; Vol. 13 (1), pp. e1158.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MicroRNAs*/genetics
Cartilage, Articular*/metabolism
Chondrocytes/metabolism ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Homeostasis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock.
Autorzy:
Vágó J; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Katona É; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Takács R; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Dócs K; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Hajdú T; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Kovács P; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Zákány R; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
van der Veen DR; Chronobiology Section, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.
Matta C; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
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Źródło:
Journal of pineal research [J Pineal Res] 2022 Nov; Vol. 73 (4), pp. e12827. Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Circadian Clocks*
Melatonin*/pharmacology
Chondrogenesis ; Mechanotransduction, Cellular ; Transcription Factors/metabolism ; Chondrocytes/metabolism ; Cells, Cultured ; Cell Differentiation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis.
Autorzy:
Zhang Y; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Hou M; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Liu Y; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Liu T; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Chen X; Department of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Shi Q; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Geng D; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Yang H; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
He F; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
Zhu X; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.; Department of Orthopaedic Surgery, Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China.
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Źródło:
Journal of pineal research [J Pineal Res] 2022 Sep; Vol. 73 (2), pp. e12815. Date of Electronic Publication: 2022 Jul 03.
Typ publikacji:
Journal Article
MeSH Terms:
Cartilage, Articular*/pathology
Melatonin*/metabolism
Osteoarthritis*/metabolism
Animals ; Chondrocytes/metabolism ; Delayed-Action Preparations/metabolism ; Delayed-Action Preparations/pharmacology ; Delayed-Action Preparations/therapeutic use ; Homeostasis ; Mitochondria/metabolism ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Death of chondrocytes in Kashin-Beck disease: Apoptosis, necrosis or necroptosis?
Autorzy:
Zhang Y; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
He Y; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Zhang D; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Zhang M; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Wang M; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Zhang Y; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Ma T; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Chen J; School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
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Źródło:
International journal of experimental pathology [Int J Exp Pathol] 2018 Dec; Vol. 99 (6), pp. 312-322. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*physiology
Chondrocytes/*pathology
Kashin-Beck Disease/*pathology
Animals ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Cartilage, Articular/ultrastructure ; Caspase 3/metabolism ; Cell Death/physiology ; Child ; Child, Preschool ; Chondrocytes/metabolism ; Chondrocytes/ultrastructure ; Female ; Humans ; Kashin-Beck Disease/metabolism ; Male ; Microscopy, Electron, Scanning ; Necrosis ; Rats, Sprague-Dawley ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transforming growth factor-β1 (TGF-β1) induces mouse precartilaginous stem cell differentiation through TGFRII-CK1ε-β-catenin signalling.
Autorzy:
Qiong W; Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Xiaofeng G; Department of Orthopedics, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Junfang W; Department of Orthopedics, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
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Źródło:
International journal of experimental pathology [Int J Exp Pathol] 2018 Jun; Vol. 99 (3), pp. 113-120. Date of Electronic Publication: 2018 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adult Stem Cells/*drug effects
Casein Kinase 1 epsilon/*metabolism
Cell Differentiation/*drug effects
Chondrocytes/*drug effects
Chondrogenesis/*drug effects
Receptor, Transforming Growth Factor-beta Type II/*agonists
Transforming Growth Factor beta1/*pharmacology
beta Catenin/*metabolism
Adult Stem Cells/enzymology ; Aggrecans/genetics ; Aggrecans/metabolism ; Animals ; Animals, Newborn ; Casein Kinase 1 epsilon/genetics ; Cell Differentiation/genetics ; Cells, Cultured ; Chondrocytes/enzymology ; Chondrogenesis/genetics ; Collagen Type II/genetics ; Collagen Type II/metabolism ; Gene Expression Regulation, Developmental ; Glycogen Synthase Kinase 3 beta/metabolism ; Mice, Inbred C57BL ; Nuclear Transfer Techniques ; Phenotype ; Phosphorylation ; Receptor, Fibroblast Growth Factor, Type 3/genetics ; Receptor, Fibroblast Growth Factor, Type 3/metabolism ; Receptor, Transforming Growth Factor-beta Type II/genetics ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout.
Autorzy:
Franco-Trepat E; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Alonso-Pérez A; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Guillán-Fresco M; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Jorge-Mora A; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Crespo-Golmar A; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
López-Fagúndez M; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Pazos-Pérez A; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Gualillo O; NEIRID LAB, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Belén Bravo S; Proteomics Unit, Institute IDIS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
Gómez Bahamonde R; Musculoskeletal Pathology Group, Institute IDIS, SERGAS, Santiago University Clinical Hospital (CHUS), Santiago de Compostela, Spain.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Jan; Vol. 179 (2), pp. 270-286. Date of Electronic Publication: 2021 Dec 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gout*/metabolism
Gout*/pathology
Osteoarthritis*/metabolism
Aged ; Amitriptyline/adverse effects ; Chondrocytes/metabolism ; Humans ; Immunity, Innate ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Receptors, Interleukin-1/metabolism ; Receptors, Interleukin-1/therapeutic use ; Symptom Flare Up ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reversing the surface charge of MSC-derived small extracellular vesicles by εPL-PEG-DSPE for enhanced osteoarthritis treatment.
Autorzy:
Feng K; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Xie X; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Yuan J; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Gong L; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Zhu Z; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Zhang J; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Li H; Chemical and Environmental Engineering, School of Engineering, RMIT University, Melbourne, Australia.
Yang Y; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Wang Y; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2021 Nov; Vol. 10 (13), pp. e12160.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell- and Tissue-Based Therapy/*methods
Extracellular Vesicles/*drug effects
Mesenchymal Stem Cells/*cytology
Osteoarthritis/*therapy
Phosphatidylethanolamines/*chemistry
Phosphatidylethanolamines/*pharmacology
Polyethylene Glycols/*chemistry
Polyethylene Glycols/*pharmacology
Polylysine/*chemistry
Polylysine/*pharmacology
Adolescent ; Animals ; Cartilage/cytology ; Cells, Cultured ; Chondrocytes/metabolism ; Disease Models, Animal ; Humans ; Induced Pluripotent Stem Cells/cytology ; Injections, Intra-Articular ; Male ; Mice ; Mice, Inbred C57BL ; Swine ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The potential remedy of melatonin on osteoarthritis.
Autorzy:
Lu KH; Department of Orthopedics, Chung Shan Medical University Hospital, Taichung, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Lu PW; Morrison Academy Taichung, Taichung, Taiwan.
Lu EW; American School in Taichung, Taichung, Taiwan.
Tang CH; School of Medicine, China Medical University, Taichung, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
Su SC; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan.
Lin CW; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.; Department of Dentistry, Chung Shan Medical University Hospital 402, Taichung, Taiwan.
Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
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Źródło:
Journal of pineal research [J Pineal Res] 2021 Oct; Vol. 71 (3), pp. e12762. Date of Electronic Publication: 2021 Sep 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Circadian Clocks*
Melatonin*/pharmacology
Osteoarthritis*/drug therapy
Apoptosis ; Chondrocytes ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oxoglaucine mediates Ca influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK-II pathway.
Autorzy:
Zhong G; Center for Materials Synthetic Biology, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; Department of Neurology, Guangxi Medical University, Nanning, China.
Long H; Department of Neurology, Guangxi Medical University, Nanning, China.
Chen F; Center for Materials Synthetic Biology, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yu Y; Center for Materials Synthetic Biology, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2021 Aug; Vol. 178 (15), pp. 2931-2947. Date of Electronic Publication: 2021 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apomorphine*/analogs & derivatives
Calmodulin*/metabolism
Osteoarthritis*/drug therapy
TRPV Cation Channels*
Calcium/*metabolism
Animals ; Autophagy ; Cells, Cultured ; Chondrocytes/metabolism ; Humans ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
WNT3A-loaded exosomes enable cartilage repair.
Autorzy:
Thomas BL; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Eldridge SE; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Nosrati B; Dipartimento di scienza e tecnologia del farmaco Università degli Studi di Torino Torino Italy.
Alvarez M; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Thorup AS; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Nalesso G; School of Veterinary Medicine University of Surrey Daphne Jackson Road Guildford UK.
Caxaria S; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Barawi A; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Nicholson JG; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Perretti M; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Gaston-Massuet C; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Pitzalis C; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
Maloney A; UCB Pharma Slough Berkshire UK.
Moore A; UCB Pharma Slough Berkshire UK.
Jupp R; UCB Pharma Slough Berkshire UK.
Dell'Accio F; Barts and the London School of Medicine and Dentistry William Harvey Research Institute Queen Mary University of London London UK.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2021 May; Vol. 10 (7), pp. e12088. Date of Electronic Publication: 2021 May 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cartilage/*metabolism
Exosomes/*metabolism
Wnt3A Protein/*metabolism
Animals ; Cartilage/injuries ; Cartilage, Articular/metabolism ; Cell Differentiation ; Cell Line ; Chondrocytes/cytology ; Culture Media, Conditioned/pharmacology ; Drug Delivery Systems/methods ; Exosomes/physiology ; Extracellular Matrix/metabolism ; Extracellular Vesicles/metabolism ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Wnt Signaling Pathway ; Wnt3A Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin.
Autorzy:
Hosseinzadeh A; Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Kamrava SK; ENT and Head & Neck Research Center, Hazrate Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Joghataei MT; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Darabi R; Center for Stem Cell and Regenerative Medicine (CSCRM), Brown Foundation Institute of Molecular Medicine (IMM), University of Texas Health Science Center at Houston, Houston, TX, USA.
Shakeri-Zadeh A; Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Shahriari M; Ophthalmology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reiter RJ; Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX, USA.
Ghaznavi H; Zahedan University of Medical Sciences, Zahedan, Iran. .
Mehrzadi S; Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. sa_, .
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Źródło:
Journal of pineal research [J Pineal Res] 2016 Nov; Vol. 61 (4), pp. 411-425. Date of Electronic Publication: 2016 Sep 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Apoptosis*
Signal Transduction*
Chondrocytes/*metabolism
Melatonin/*metabolism
Osteoarthritis/*metabolism
Animals ; Chondrocytes/pathology ; Endoplasmic Reticulum Stress ; Humans ; Interleukin-1beta/metabolism ; Osteoarthritis/pathology ; Reactive Oxygen Species/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles
Autorzy:
Shanjun Huang
Yujiao Liu
Chenglong Wang
Wei Xiang
Nianwu Wang
Li Peng
Xuanang Jiang
Xiaomin Zhang
Zhijiang Fu
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Temat:
Cartilage repair
Chondrocytes
Extracellular matrix
Extracellular vesicles
Osteoarthritis
Mesenchymal stem cells
Orthopedic surgery
RD701-811
Źródło:
Orthopaedic Surgery, Vol 15, Iss 11, Pp 2749-2765 (2023)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/1757-7853; https://doaj.org/toc/1757-7861
Dostęp URL:
https://doaj.org/article/8fa4eb8ac26f4c0790b82e626a0cecdf  Link otwiera się w nowym oknie
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?
Autorzy:
Xiaohong Kong
Chuan‐Ju Liu
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Temat:
cartilage chondrocytes
osteoarthritis
sodium channel Nav1.7
therapeutic target
Medicine (General)
R5-920
Źródło:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2001-1326
Dostęp URL:
https://doaj.org/article/ea4a29c33feb45139f696784450ba6aa  Link otwiera się w nowym oknie
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disruption of endogenous perlecan function improves differentiation of rat articular chondrocytes in vitro.
Autorzy:
Nakamura R; Laboratory of Animal By-Product Science, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Nakamura F
Fukunaga S
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Źródło:
Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2015 Apr; Vol. 86 (4), pp. 449-58. Date of Electronic Publication: 2014 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*genetics
Chondrocytes/*cytology
Heparan Sulfate Proteoglycans/*antagonists & inhibitors
Heparan Sulfate Proteoglycans/*physiology
Animals ; Cartilage, Articular/cytology ; Cells, Cultured ; Chondrocytes/metabolism ; Collagen Type II/metabolism ; Glycosaminoglycans/metabolism ; Heparan Sulfate Proteoglycans/immunology ; Immune Sera/pharmacology ; Polysaccharide-Lyases/pharmacology ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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