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Tytuł :
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.
Autorzy :
Clemons PA; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Bittker JA; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA.; Vertex Pharmaceuticals, Boston, MA, USA.
Wagner FF; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA.
Hands A; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA.
Dančík V; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Choudhary A; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Wagner BK; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Jun 16, pp. 24725552211019410. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
LSD1-BDNF activity in lateral hypothalamus-medial forebrain bundle area is essential for reward seeking behavior.
Autorzy :
Sagarkar S; Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007, India; Department of Zoology, Savitribai Phule Pune University, Pune 411 007, India.
Choudhary AG; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Balasubramanian N; Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007, India.
Awathale SN; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Somalwar AR; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Pawar N; Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007, India.
Kokare DM; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Subhedar NK; Indian Institute of Science Education and Research (IISER), Pune 411 008, India.
Sakharkar AJ; Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007, India. Electronic address: .
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Źródło :
Progress in neurobiology [Prog Neurobiol] 2021 Jul; Vol. 202, pp. 102048. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage.
Autorzy :
Balasubramanian N; Department of Biotechnology, Savitribai Phule Pune University, Pune, 411 007, India.
Sagarkar S; Department of Biotechnology, Savitribai Phule Pune University, Pune, 411 007, India.; Department of Zoology, Savitribai Phule Pune University, Pune, 411 007, India.
Choudhary AG; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, 440 033, India.
Kokare DM; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, 440 033, India.
Sakharkar AJ; Department of Biotechnology, Savitribai Phule Pune University, Pune, 411 007, India. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2021 Mar; Vol. 58 (3), pp. 1162-1184. Date of Electronic Publication: 2020 Oct 25.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Chemical and optical control of CRISPR-associated nucleases.
Autorzy :
Modell AE; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Siriwardena SU; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Li X; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, 02115, USA. Electronic address: .
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Źródło :
Current opinion in chemical biology [Curr Opin Chem Biol] 2021 Feb; Vol. 60, pp. 113-121. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Czasopismo naukowe
Tytuł :
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells.
Autorzy :
Kahraman S; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Manna D; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, USA.
Dirice E; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.
Maji B; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, USA.
Small J; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Chemical Biology Program, Harvard University, Cambridge, MA, USA.
Wagner BK; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Choudhary A; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA .; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, USA.; Chemical Biology Program, Harvard University, Cambridge, MA, USA.
Kulkarni RN; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA .
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Źródło :
Life science alliance [Life Sci Alliance] 2021 Jan 29; Vol. 4 (4). Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes.
Autorzy :
Sreekanth V; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Zhou Q; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Kokkonda P; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Bermudez-Cabrera HC; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Lim D; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Law BK; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Holmes BR; McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02142, United States.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Chaudhary SK; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Pergu R; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Leger BS; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.
Walker JA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Gifford DK; McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02142, United States.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Sherwood RI; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Hubrecht Institute for Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht 3584 CT, The Netherlands.
Choudhary A; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
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Źródło :
ACS central science [ACS Cent Sci] 2020 Dec 23; Vol. 6 (12), pp. 2228-2237. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Core commitments for field trials of gene drive organisms.
Autorzy :
Long KC; See supplementary materials for author affiliations.
Alphey L; See supplementary materials for author affiliations.
Annas GJ; See supplementary materials for author affiliations.
Bloss CS; See supplementary materials for author affiliations.
Campbell KJ; See supplementary materials for author affiliations.
Champer J; See supplementary materials for author affiliations.
Chen CH; See supplementary materials for author affiliations.
Choudhary A; See supplementary materials for author affiliations.
Church GM; See supplementary materials for author affiliations.
Collins JP; See supplementary materials for author affiliations.
Cooper KL; See supplementary materials for author affiliations.
Delborne JA; See supplementary materials for author affiliations.
Edwards OR; See supplementary materials for author affiliations.
Emerson CI; See supplementary materials for author affiliations.
Esvelt K; See supplementary materials for author affiliations.
Evans SW; See supplementary materials for author affiliations.
Friedman RM; See supplementary materials for author affiliations.
Gantz VM; See supplementary materials for author affiliations.
Gould F; See supplementary materials for author affiliations.
Hartley S; See supplementary materials for author affiliations.
Heitman E; See supplementary materials for author affiliations.
Hemingway J; See supplementary materials for author affiliations.
Kanuka H; See supplementary materials for author affiliations.
Kuzma J; See supplementary materials for author affiliations.
Lavery JV; See supplementary materials for author affiliations.
Lee Y; See supplementary materials for author affiliations.
Lorenzen M; See supplementary materials for author affiliations.
Lunshof JE; See supplementary materials for author affiliations.
Marshall JM; See supplementary materials for author affiliations.
Messer PW; See supplementary materials for author affiliations.
Montell C; See supplementary materials for author affiliations.
Oye KA; See supplementary materials for author affiliations.
Palmer MJ; See supplementary materials for author affiliations.
Papathanos PA; See supplementary materials for author affiliations.
Paradkar PN; See supplementary materials for author affiliations.
Piaggio AJ; See supplementary materials for author affiliations.
Rasgon JL; See supplementary materials for author affiliations.
Rašić G; See supplementary materials for author affiliations.
Rudenko L; See supplementary materials for author affiliations.
Saah JR; See supplementary materials for author affiliations.
Scott MJ; See supplementary materials for author affiliations.
Sutton JT; See supplementary materials for author affiliations.
Vorsino AE; See supplementary materials for author affiliations.
Akbari OS; See supplementary materials for author affiliations. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Dec 18; Vol. 370 (6523), pp. 1417-1419.
Typ publikacji :
Journal Article
MeSH Terms :
Organisms, Genetically Modified*
Safety*
Gene Drive Technology/*standards
Animals ; Guidelines as Topic
Czasopismo naukowe
Tytuł :
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells.
Autorzy :
Yang K; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA.
Lee M; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Jones PA; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
Liu SS; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zhou A; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xu J; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sreekanth V; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Wu JLY; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Vo L; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Lee EA; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
Pop R; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Lee Y; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
Wagner BK; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Melton DA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. .; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.; Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA.
Karp JM; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. .; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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Źródło :
Science advances [Sci Adv] 2020 Nov 18; Vol. 6 (47). Date of Electronic Publication: 2020 Nov 18 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Postoperative analgesic efficacy of fluoroscopy-guided erector spinae plane block after percutaneous nephrolithotomy (PCNL): A randomized controlled study.
Autorzy :
Prasad MK; Department of Anaesthesia and Pain, Teerthankar Mahaveer Medical College, Moradbad, Uttar Pradesh, India.
Varshney RK; Department of Anaesthesia and Pain, Teerthankar Mahaveer Medical College, Moradbad, Uttar Pradesh, India.
Jain P; Department of Anaesthesia and Pain, Teerthankar Mahaveer Medical College, Moradbad, Uttar Pradesh, India.
Choudhary AK; Consultant Anaesthesiologist, Indra Memorial Hospital, Patna, Bihar, India.
Khare A; Department of Anaesthesia and Pain, Teerthankar Mahaveer Medical College, Moradbad, Uttar Pradesh, India.
Jheetay GS; Department of Anaesthesia and Pain, Teerthankar Mahaveer Medical College, Moradbad, Uttar Pradesh, India.
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Źródło :
Saudi journal of anaesthesia [Saudi J Anaesth] 2020 Oct-Dec; Vol. 14 (4), pp. 480-486. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Correction: A universal method for sensitive and cell-free detection of CRISPR-associated nucleases.
Autorzy :
Cox KJ; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard 415 Main Street, Rm 3012 Cambridge MA 02142 USA +1 617 715 8969 +1 617 714 7445.; Department of Medicine, Harvard Medical School Boston MA 02115 USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital Boston MA 02115 USA.
Subramanian HKK; Department of Mechanical Engineering, University of California - Riverside Riverside CA - 92521 USA +1 951 827 2442.
Samaniego CC; Department of Mechanical Engineering, University of California - Riverside Riverside CA - 92521 USA +1 951 827 2442.
Franco E; Department of Mechanical Engineering, University of California - Riverside Riverside CA - 92521 USA +1 951 827 2442.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard 415 Main Street, Rm 3012 Cambridge MA 02142 USA +1 617 715 8969 +1 617 714 7445.; Department of Medicine, Harvard Medical School Boston MA 02115 USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital Boston MA 02115 USA.
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Źródło :
Chemical science [Chem Sci] 2020 Sep 17; Vol. 11 (37), pp. 10287. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Published Erratum
Tytuł :
Association of Urinary Vitamin D Binding Protein and Neutrophil Gelatinase-Associated Lipocalin with Steroid Responsiveness in Idiopathic Nephrotic Syndrome of Childhood.
Autorzy :
Choudhary A; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Mohanraj PS; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Krishnamurthy S; Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Rajappa M; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
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Źródło :
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia [Saudi J Kidney Dis Transpl] 2020 Sep-Oct; Vol. 31 (5), pp. 946-956.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Correlation between alignment geometries and memory effect in a surface-stabilized ferroelectric liquid crystal.
Autorzy :
Kumar S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi-110012, India.
Gangwar LK; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi-110012, India.
Bawa A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi-110012, India.
Choudhary A; Physics Department, Deshbandhu College (University of Delhi), Kalkaji, New Delhi-110019, India.
Rajesh; CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi-110012, India.
Singh SP; CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi-110012, India.
Biradar AM; CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi-110012, India.
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Źródło :
Physical review. E [Phys Rev E] 2020 Sep; Vol. 102 (3-1), pp. 032703.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Phosphorylation-Inducing Chimeric Small Molecules.
Autorzy :
Siriwardena SU; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Munkanatta Godage DNP; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Lai S; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Shi M; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Wu P; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Chaudhary SK; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Schreiber SL; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Aug 19; Vol. 142 (33), pp. 14052-14057. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Small Molecule Libraries/*metabolism
Molecular Structure ; Phosphorylation ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform.
Autorzy :
Lim D; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Sreekanth V; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Cox KJ; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Law BK; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Wagner BK; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Karp JM; Engineering in Medicine, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, 02139, USA.; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.
Choudhary A; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. .; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 13; Vol. 11 (1), pp. 4043. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CRISPR-Associated Protein 9/*chemistry
CRISPR-Associated Protein 9/*metabolism
Cell Engineering/*methods
Synthetic Biology/*methods
CRISPR-Associated Protein 9/genetics ; Cell Line ; Gene Editing ; Humans ; Insulin Infusion Systems
Czasopismo naukowe
Tytuł :
Assessment of Reliability of Cone-beam Computed Tomography in Skeletal and Dental Discrepancy.
Autorzy :
Khandelwal A; Department of Orthodontics and Dentofacial Orthopedics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
Raghav S; Department of Orthodontics and Dentofacial Orthopedics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India, Phone: +91 9669854055, e-mail: .
Baheti K; Department of Orthodontics and Dentofacial Orthopedics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
Jindal A; Department of Orthodontics and Dentofacial Orthopedics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
Bansod S; Department of Orthodontics and Dentofacial Orthopedics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
Choudhary AS; Department of Orthodontics and Dentofacial Orthopedics, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India.
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Źródło :
The journal of contemporary dental practice [J Contemp Dent Pract] 2020 Jul 01; Vol. 21 (7), pp. 765-768. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Cone-Beam Computed Tomography*
Mandible/*diagnostic imaging
Female ; Humans ; Male ; Maxilla/diagnostic imaging ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives.
Autorzy :
López Del Amo V; Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Leger BS; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Cox KJ; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Gill S; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Bishop AL; Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Scanlon GD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Walker JA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: .
Gantz VM; Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: .
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jun 30; Vol. 31 (13), pp. 107841.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Drive Technology*
Drosophila melanogaster/*genetics
Inheritance Patterns/*genetics
Small Molecule Libraries/*metabolism
Animals ; Animals, Genetically Modified ; CRISPR-Associated Protein 9/metabolism ; Pharmaceutical Preparations
Czasopismo naukowe
Tytuł :
Improved Handwritten Digit Recognition Using Convolutional Neural Networks (CNN).
Autorzy :
Ahlawat S; Department of Computer Science and Engineering, Maharaja Surajmal Institute of Technology, New Delhi 110058, India.
Choudhary A; Department of Computer Science, Maharaja Surajmal Institute, New Delhi 110058, India.
Nayyar A; Graduate School, Duy Tan University, Da Nang 550000, Vietnam.
Singh S; Department of Industrial & Systems Engineering, Dongguk University, Seoul 04620, Korea.
Yoon B; Department of Industrial & Systems Engineering, Dongguk University, Seoul 04620, Korea.
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Źródło :
Sensors (Basel, Switzerland) [Sensors (Basel)] 2020 Jun 12; Vol. 20 (12). Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems.
Autorzy :
Modell AE; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Siriwardena SU; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 May 26; Vol. 59 (20), pp. 1869-1870. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Comment
MeSH Terms :
Bacteriophages*/genetics
CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Genome, Viral ; Immune System
Czasopismo naukowe
Tytuł :
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells.
Autorzy :
Lee M; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Maji B; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Manna D; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Kahraman S; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, United States.; Harvard Stem Cell InstituteHarvard Medical School, Cambridge, Massachusetts 02138, United States.
Elgamal RM; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Small J; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Chemical Biology Program, Harvard University, Cambridge, Massachusetts 02138, United States.
Kokkonda P; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Vetere A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Goldberg JM; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Lippard SJ; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Kulkarni RN; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, United States.; Harvard Stem Cell InstituteHarvard Medical School, Cambridge, Massachusetts 02138, United States.
Wagner BK; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Chemical Biology Program, Harvard University, Cambridge, Massachusetts 02138, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Apr 08; Vol. 142 (14), pp. 6477-6482. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*metabolism
Diabetes Mellitus, Type 1/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Zinc/*therapeutic use
Catalysis ; Diabetes Mellitus, Type 1/physiopathology ; Diabetes Mellitus, Type 2/physiopathology ; Humans
Czasopismo naukowe
Tytuł :
Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.
Autorzy :
Upadhya MA; Indian Institute of Science Education and Research (IISER), Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra, India; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Upadhya HM; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Borkar CD; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Choudhary AG; Indian Institute of Science Education and Research (IISER), Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra, India; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India.
Singh U; School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, Jatni, Odisha 752 050, India.
Chavan P; Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007, India.
Sakharkar A; Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007, India.
Singru P; School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, Jatni, Odisha 752 050, India.
Subhedar NK; Indian Institute of Science Education and Research (IISER), Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra, India.
Kokare DM; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2020 Apr 01; Vol. 431, pp. 205-221. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nicotine*/pharmacology
Receptor, Melanocortin, Type 4*
Reward*
Brain/*drug effects
Animals ; Female ; Hypothalamus/metabolism ; Melanocortins ; Nucleus Accumbens/metabolism ; Ovariectomy ; Rats
Czasopismo naukowe

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