MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease.
Autorzy:
Li S; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Poon CH; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Zhang Z; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.; The Brain Cognition and Brain Disease Institute (BCBDI), CAS Key Laboratory of Brain Connectome and Manipulation, Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China. Yue M; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Chen R; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Zhang Y; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada. Hossain MF; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Pan Y; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Zhao J; Department of Clinical Immunology, Third Hospital of Sun Yat-sen University, Guangzhou, China. Rong L; Department of Medicine, The University of Hongkong-Shenzhen Hospital, Shenzhen, China. ChuLW; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. Shea YF; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada. Tu J; The Brain Cognition and Brain Disease Institute (BCBDI), CAS Key Laboratory of Brain Connectome and Manipulation, Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China. St George-Hyslop P; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada. Lim LW; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. Song YQ; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.; The Brain Cognition and Brain Disease Institute (BCBDI), CAS Key Laboratory of Brain Connectome and Manipulation, Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.; Department of Medicine, The University of Hongkong-Shenzhen Hospital, Shenzhen, China.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.
Pokaż więcej
Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Jul; Vol. 29 (7), pp. 1848-1864. Date of Electronic Publication: 2023 Mar 07.
Repurposing Astragalus Polysaccharide PG2 for Inhibiting ACE2 and SARS-CoV-2 Spike Syncytial Formation and Anti-Inflammatory Effects.
Autorzy:
Lee CY; Taiwan National Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 112304, Taiwan. Nguyen AT; Taiwan National Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 112304, Taiwan. Doan LH; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. ChuLW; Department and Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Chang CH; Department of Orthopedic Surgery, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan. Liu HK; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine (NRICM), Ministry of Health and Welfare, Taipei 112304, Taiwan. Lee IL; PhytoHeath Corporation, Taipei 105403, Taiwan. Wang TH; PhytoHeath Corporation, Taipei 105403, Taiwan. Lai JM; Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City 242062, Taiwan. Tsao SM; Division of Pulmonary Medicine, School of Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung 402306, Taiwan. Liao HJ; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan. Ping YH; Department and Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Huang CF; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Pokaż więcej
Źródło:
Viruses [Viruses] 2023 Feb 27; Vol. 15 (3). Date of Electronic Publication: 2023 Feb 27.
Development of Fluorescence-Tagged SARS-CoV-2 Virus-like Particles by a Tri-Cistronic Vector Expression System for Investigating the Cellular Entry of SARS-CoV-2.
Autorzy:
Chang YS; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404394, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404394, Taiwan. ChuLW; Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan. Chen ZY; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404394, Taiwan. Wu JS; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404394, Taiwan.; PhD Program for Health Science and Industry, China Medical University, Taichung 404394, Taiwan. Su WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404394, Taiwan.; International Master's Program of Biomedical Sciences, China Medical University, Taichung 404394, Taiwan. Yang CJ; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan. Ping YH; Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.; Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan. Lin CW; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404394, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404394, Taiwan.; PhD Program for Health Science and Industry, China Medical University, Taichung 404394, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Asia University, Wufeng, Taichung 413305, Taiwan.
Pokaż więcej
Źródło:
Viruses [Viruses] 2022 Dec 19; Vol. 14 (12). Date of Electronic Publication: 2022 Dec 19.
The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain.
Autorzy:
Cheng KI; Department of Anesthesiology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. Chang YC; Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. ChuLW; Department of Cosmetic Application and Management, Department of Nursing, Yuh-Ing Junior College of Health Care and Management, Kaohsiung 80776, Taiwan. Hsieh SL; Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. An LM; Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Dai ZK; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Pediatrics, Division of Pediatric Cardiology and Pulmonology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. Wu BN; Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Evidence-based lifestyle medicine interventions to enhance the mental health of law enforcers in Hong Kong: A pilot randomized controlled trial.
Autorzy:
ChuLW; Psychological Services Group, Hong Kong Police Force, Hong Kong SAR, Hong Kong. Lau RW; Psychological Services Group, Hong Kong Police Force, Hong Kong SAR, Hong Kong. Mak IW; Psychological Services Group, Hong Kong Police Force, Hong Kong SAR, Hong Kong.
Pokaż więcej
Źródło:
Behavioral sciences & the law [Behav Sci Law] 2022 Jul; Vol. 40 (4), pp. 540-555. Date of Electronic Publication: 2022 Feb 22.
Prevalence of mild behavioural impairment domains: a meta-analysis.
Autorzy:
Pan Y; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Shea YF; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China. Ismail Z; Departments of Psychiatry and Clinical Neurosciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada. Mak HK; Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China. Chiu PK; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China. ChuLW; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China. Song YQ; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Prevalence of mild behavioural impairment: a systematic review and meta-analysis.
Autorzy:
Pan Y; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Shea YF; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong. Li S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Chen R; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Mak HK; Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong. Chiu PK; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong. ChuLW; Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong. Song YQ; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation.
Autorzy:
Cheng YC; Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. ChuLW; Department of Nursing, and Department of Cosmetic Application and Management, Yuh-Ing Junior College of Health Care and Management, Kaohsiung 80776, Taiwan. Chen JY; Division of Neurosurgery, Fooyin University Hospital, Pingtung 92847, Taiwan.; School of Nursing, Fooyin University, Kaohsiung 83102, Taiwan. Hsieh SL; Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. Chang YC; Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Dai ZK; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Pediatrics, Division of Pediatric Cardiology and Pulmonology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. Wu BN; Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Pokaż więcej
Źródło:
Cells [Cells] 2020 Aug 23; Vol. 9 (9). Date of Electronic Publication: 2020 Aug 23.
Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Autorzy:
Wang IH; Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 112, Taiwan.; Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. Huang TT; Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. Chen JL; Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. ChuLW; Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. Ping YH; Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. Hsu KW; Research Center for Tumor Medical Science, China Medical University, Taichung 404, Taiwan.; Graduate Institutes of New Drug Development, China Medical University, Taichung 404, Taiwan. Huang KH; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.; Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan. Fang WL; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.; Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan. Lee HC; Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. Chen CF; Cancer Progression Research Center, National Yang-Ming University, Taipei 112, Taiwan. Liao CC; Proteomics Research Center, National Yang-Ming University, Taipei 112, Taiwan. Hsieh RH; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan. Yeh TS; Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.; Cancer Progression Research Center, National Yang-Ming University, Taipei 112, Taiwan.; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Pokaż więcej
Źródło:
Cancers [Cancers (Basel)] 2020 Apr 27; Vol. 12 (5). Date of Electronic Publication: 2020 Apr 27.
Hyperphagia in Alzheimer's disease, its transient nature, and potentially reversible causes.
Autorzy:
Leung WC; Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong. Shea YF; Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong. Lee SC; Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong. ChuLW; Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.; The Alzheimer's Disease Research Network, SRT Aging, The University of Hong Kong, Hong Kong.
TIM-1 As a Signal Receptor Triggers Dengue Virus-Induced Autophagy.
Autorzy:
ChuLW; Institute of Biophotonics, National Yang-Ming University, Taipei 11221, Taiwan. .; Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan. . Yang CJ; Faculty of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. .; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan. . Peng KJ; Department and Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan. . Chen PL; Department and Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan. . Wang SJ; Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan. .; Faculty of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. .; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan. . Ping YH; Institute of Biophotonics, National Yang-Ming University, Taipei 11221, Taiwan. .; Department and Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan. .
Souvenaid in the management of mild cognitive impairment: an expert consensus opinion.
Autorzy:
Cummings J; Department of Brain Health, School of Integrated Health Sciences, UNLV; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA. . Passmore P; Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast, Belfast, UK. McGuinness B; Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast, Belfast, UK. Mok V; Therese Pei Fong Chow Research Center for Prevention of Dementia, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Chen C; Departments of Pharmacology and Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore. Engelborghs S; Reference Centre for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.; Department of Neurology, Centre for Neurosciences, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium. Woodward M; Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia. Manzano S; Neurology Department, Infanta Leonor Hospital, Madrid, Spain. Garcia-Ribas G; Servicio de Neurología, Hospital Universitario Ramón y Cajal, Madrid, Spain. Cappa S; University School for Advanced Studies IUSS, Pavia and IRCCS Istituto Centro, S. Giovanni di Dio, Brescia, Italy. Bertolucci P; Service of Cognitive and Behavioral Neurology, Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil. ChuLW; Department of Medicine, The University of Hong Kong and Hong Kong Brain Memory Centre, Hong Kong Special Administrative Region, China.
Pokaż więcej
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Aug 17; Vol. 11 (1), pp. 73. Date of Electronic Publication: 2019 Aug 17.
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies