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Tytuł :
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.
Autorzy :
Robinot R; Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.; UMR 3569 CNRS, Paris, France.
Hubert M; Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.; UMR 3569 CNRS, Paris, France.
de Melo GD; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Lazarini F; Perception and Memory Unit, Institut Pasteur, Paris, France.; UMR 3571 CNRS, Paris, France.
Bruel T; Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.; UMR 3569 CNRS, Paris, France.
Smith N; Translational Immunology Lab, Department of Immunology, Institut Pasteur, Paris, France.
Levallois S; Biology of Infection Unit, Institut Pasteur, Paris, France.; INSERM U1117, Paris, France.
Larrous F; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Fernandes J; UtechS Photonics BioImaging, C2RT, Institut Pasteur, Paris, France.
Gellenoncourt S; Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France.; UMR 3569 CNRS, Paris, France.
Rigaud S; Image Analysis Hub, C2RT, Institut Pasteur, Paris, France.
Gorgette O; UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur, Paris, France.
Thouvenot C; UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur, Paris, France.
Trébeau C; Institut de l'Audition, Institut Pasteur, INSERM, Paris, France.
Mallet A; UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur, Paris, France.
Duménil G; UtechS Ultrastructural BioImaging UBI, C2RT, Institut Pasteur, Paris, France.
Gobaa S; Biomaterials and Microfluidics Core Facility, Institut Pasteur, Paris, France.
Etournay R; Institut de l'Audition, Institut Pasteur, INSERM, Paris, France.
Lledo PM; Perception and Memory Unit, Institut Pasteur, Paris, France.; UMR 3571 CNRS, Paris, France.
Lecuit M; Biology of Infection Unit, Institut Pasteur, Paris, France.; INSERM U1117, Paris, France.; Université de Paris, Necker-Enfants Malades University Hospital, Division of Infectious Diseases and Tropical Medicine, APHP, Institut Imagine, Paris, France.
Bourhy H; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Duffy D; Translational Immunology Lab, Department of Immunology, Institut Pasteur, Paris, France.
Michel V; Institut de l'Audition, Institut Pasteur, INSERM, Paris, France. .
Schwartz O; Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France. .; UMR 3569 CNRS, Paris, France. .; Vaccine Research Institute, Créteil, France. .
Chakrabarti LA; Virus & Immunity Unit, Department of Virology, Institut Pasteur, Paris, France. .; UMR 3569 CNRS, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 16; Vol. 12 (1), pp. 4354. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
COVID-19/*pathology
Cilia/*ultrastructure
Mucociliary Clearance/*physiology
Animals ; Axoneme ; Basal Bodies ; Cilia/metabolism ; Cilia/pathology ; Cricetinae ; Cytokines ; Epithelial Cells/pathology ; Forkhead Transcription Factors/metabolism ; Humans ; Lung/pathology ; Male ; Mesocricetus ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Virus Replication
Czasopismo naukowe
Tytuł :
Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases.
Autorzy :
Cardenas-Rodriguez M; Department of Medicine, Nephrology Division, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.; Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, Mataojo 2020, 11400 Montevideo, Uruguay.
Austin-Tse C; Department of Pathology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA.
Bergboer JGM; Cergentis BV, Yalelaan 62, 3584 CM Utrecht, The Netherlands.
Molinari E; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle NE1 3BZ, UK.
Sugano Y; Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Bachmann-Gagescu R; Institute of Medical Genetics, University of Zurich Wagistrasse 12, CH-8952 Schlieren, Switzerland.
Sayer JA; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle NE1 3BZ, UK.; Renal Services, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Road, Newcastle NE7 7DN, UK.
Drummond IA; Department of Medicine, Nephrology Division, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.; Davis Center for Regenerative Biology and Aging, Mount Desert Island Biological Laboratory, Salisbury Cove, Bar Harbor, ME 04609, USA.
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jul 15; Vol. 134 (14). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm*/genetics
Cell Cycle Proteins*/genetics
Cilia*/genetics
Cilia*/metabolism
Cytoskeletal Proteins*/genetics
Monomeric GTP-Binding Proteins*
Adaptor Proteins, Signal Transducing ; Animals ; Humans ; Microtubule-Associated Proteins ; Mutation/genetics ; Up-Regulation/genetics ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines.
Autorzy :
Roy S; Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543, Singapore; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119288, Singapore. Electronic address: .
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Źródło :
Trends in genetics : TIG [Trends Genet] 2021 Jul; Vol. 37 (7), pp. 612-615. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cilia/*genetics
Morphogenesis/*genetics
Scoliosis/*genetics
Urotensins/*genetics
Adolescent ; Animals ; Cilia/pathology ; Disease Models, Animal ; Humans ; Mutation/genetics ; Scoliosis/cerebrospinal fluid ; Scoliosis/pathology ; Signal Transduction/genetics ; Spine/pathology ; Urotensins/cerebrospinal fluid ; Zebrafish/genetics ; Zebrafish/growth & development
Czasopismo naukowe
Tytuł :
Mice Harboring a Non-Functional CILK1/ICK Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant CILK1/ICK .
Autorzy :
Salvati KA; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.; Department of Neurological Surgery and Weill Institute for Neuroscience, University of California, San Francisco, CA 94143, USA.
Mason AJ; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Gailey CD; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Wang EJ; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Fu Z; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.; UVA Cancer Center, Cancer Biology Program, University of Virginia, Charlottesville, VA 22908, USA.
Beenhakker MP; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.; UVA Brain Institute, University of Virginia, Charlottesville, VA 22908, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Phenotype*
Cilia/*pathology
Epilepsy/*pathology
Protein-Serine-Threonine Kinases/*physiology
Animals ; Cilia/metabolism ; Epilepsy/etiology ; Haploinsufficiency ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation
Czasopismo naukowe
Tytuł :
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.
Autorzy :
Blasius TL; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yue Y; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Prasad R; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Liu X; Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, New York, NY 10461, USA.
Gennerich A; Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, New York, NY 10461, USA.
Verhey KJ; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jul 01; Vol. 134 (13). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cilia*
Kinesin*/genetics
Axoneme ; Hedgehog Proteins ; Humans ; Microtubules
Czasopismo naukowe
Tytuł :
Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?
Autorzy :
Buqaileh R; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
Saternos H; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
Ley S; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
Aranda A; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
Forero K; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
AbouAlaiwi WA; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
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Źródło :
Physiological genomics [Physiol Genomics] 2021 Jun 01; Vol. 53 (6), pp. 249-258. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Virus Internalization*
Acute Kidney Injury/*virology
COVID-19/*virology
Cilia/*virology
Kidney/*virology
SARS-CoV-2/*pathogenicity
Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; COVID-19/complications ; Cilia/metabolism ; Cilia/pathology ; Host-Pathogen Interactions ; Humans ; Kidney/metabolism ; Kidney/pathology
Czasopismo naukowe
Tytuł :
Primary cilium and its role in tumorigenesis.
Autorzy :
Mao H; Department of Translation Medicine.
Sun Y; Department of Translation Medicine.
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Źródło :
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2021 Apr 25; Vol. 50 (2), pp. 245-260.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*
Cilia*
Autophagy ; Homeostasis ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
Exposure to 16 Hz Pulsed Electromagnetic Fields Protect the Structural Integrity of Primary Cilia and Associated TGF-β Signaling in Osteoprogenitor Cells Harmed by Cigarette Smoke.
Autorzy :
Chen Y; Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Aspera-Werz RH; Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Menger MM; Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Falldorf K; Sachtleben GmbH, Haus Spectrum am UKE, Martinistraße 64, D-20251 Hamburg, Germany.
Ronniger M; Sachtleben GmbH, Haus Spectrum am UKE, Martinistraße 64, D-20251 Hamburg, Germany.
Stacke C; Sachtleben GmbH, Haus Spectrum am UKE, Martinistraße 64, D-20251 Hamburg, Germany.
Histing T; Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Nussler AK; Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Ehnert S; Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 29; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cilia/*metabolism
Mesenchymal Stem Cells/*cytology
Smoke/*adverse effects
Transforming Growth Factor beta/*metabolism
Cell Differentiation/drug effects ; Cell Line ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cilia/drug effects ; Cilia/immunology ; Electromagnetic Fields ; Humans ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Osteogenesis ; Signal Transduction/drug effects ; Tobacco
Czasopismo naukowe
Tytuł :
The structural basis of intraflagellar transport at a glance.
Autorzy :
Jordan MA; Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstraße 108, 01307 Dresden, Germany.
Pigino G; Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstraße 108, 01307 Dresden, Germany.; Human Technopole, Via Cristina Belgioioso 171, 20157 Milan, Italy.
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jun 15; Vol. 134 (12). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cilia*/metabolism
Dyneins*/metabolism
Biological Transport ; Carrier Proteins/metabolism ; Flagella/metabolism ; Kinesin/genetics ; Kinesin/metabolism ; Microtubules/metabolism ; Protein Transport
Czasopismo naukowe
Tytuł :
Structure and Mechanics of Dynein Motors.
Autorzy :
Canty JT; Biophysics Graduate Group, University of California, Berkeley, California 94720, USA; email: .
Tan R; Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA.
Kusakci E; Biophysics Graduate Group, University of California, Berkeley, California 94720, USA; email: .
Fernandes J; Department of Chemistry, University of California, Berkeley, California 94720, USA.
Yildiz A; Biophysics Graduate Group, University of California, Berkeley, California 94720, USA; email: .; Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA.; Physics Department, University of California, Berkeley, California 94720, USA.
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Źródło :
Annual review of biophysics [Annu Rev Biophys] 2021 May 06; Vol. 50, pp. 549-574.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cilia/*chemistry
Dyneins/*chemistry
Animals ; Biological Transport ; Cilia/metabolism ; Dyneins/genetics ; Dyneins/metabolism ; Humans ; Intracellular Space/chemistry ; Intracellular Space/metabolism ; Microtubules/chemistry
Czasopismo naukowe
Tytuł :
Metachronal μ-Cilia for On-Chip Integrated Pumps and Climbing Robots.
Autorzy :
Zhang S; Microsystems Section, Department of Mechanical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Cui Z; Microsystems Section, Department of Mechanical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Wang Y; Microsystems Section, Department of Mechanical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
den Toonder J; Microsystems Section, Department of Mechanical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 May 05; Vol. 13 (17), pp. 20845-20857. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cilia*
Lab-On-A-Chip Devices*
Robotics*
Magnetic Fields
Czasopismo naukowe
Tytuł :
Primary cilia presence and implications in bladder cancer progression and invasiveness.
Autorzy :
Iruzubieta P; Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. .; Institute for Health Research Aragón (IIS), Domingo Miral s/n, 50009, Zaragoza, Spain. .
Castiella T; Institute for Health Research Aragón (IIS), Domingo Miral s/n, 50009, Zaragoza, Spain.; Department of Pathology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
Monleón E; Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain.
Berga C; Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain.; Institute for Health Research Aragón (IIS), Domingo Miral s/n, 50009, Zaragoza, Spain.
Muñoz G; Department of Pathology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
Junquera C; Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain.; Institute for Health Research Aragón (IIS), Domingo Miral s/n, 50009, Zaragoza, Spain.
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Źródło :
Histochemistry and cell biology [Histochem Cell Biol] 2021 May; Vol. 155 (5), pp. 547-560. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cilia/*metabolism
Urinary Bladder Neoplasms/*metabolism
Cilia/pathology ; Humans ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit.
Autorzy :
Wu YJ; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
Liu Y; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
Hu YQ; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
Wang L; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
Bai FR; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
Xu C; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
Wu JW; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
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Źródło :
Journal of cell science [J Cell Sci] 2021 May 01; Vol. 134 (9). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cilia*/genetics
MicroRNAs*/genetics
Animals ; Cell Cycle/genetics ; Cell Differentiation/genetics ; Cell Division ; Male ; Mice
Czasopismo naukowe
Tytuł :
Conserved role of ATP synthase in mammalian cilia.
Autorzy :
Lin W; Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Qiao C; Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Hu J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Wei Q; Center for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, 518055, China.
Xu T; Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Apr 01; Vol. 401 (1), pp. 112520. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cilia/*genetics
Mitochondrial Proton-Translocating ATPases/*genetics
Molecular Chaperones/*genetics
TRPP Cation Channels/*genetics
ATP Synthetase Complexes/chemistry ; ATP Synthetase Complexes/genetics ; Adenosine Triphosphate/genetics ; Animals ; Caenorhabditis elegans/genetics ; Cilia/metabolism ; Dogs ; Kinesin/genetics ; Madin Darby Canine Kidney Cells ; Mammals ; Mice ; Oligomycins/pharmacology ; Polycystic Kidney Diseases/enzymology ; Polycystic Kidney Diseases/genetics ; Polycystic Kidney Diseases/pathology ; Protein Processing, Post-Translational/genetics
Czasopismo naukowe
Tytuł :
CRISPR/Cas9-mediated mutagenesis reveals the roles of calaxin in gastropod larval cilia.
Autorzy :
Huan P; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 266071 Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, 266000 Qingdao, China; University of Chinese Academy of Sciences, 100039 Beijing, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, 266071 Qingdao, China.
Cui M; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 266071 Qingdao, China; University of Chinese Academy of Sciences, 100039 Beijing, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, 266071 Qingdao, China.
Wang Q; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 266071 Qingdao, China; University of Chinese Academy of Sciences, 100039 Beijing, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, 266071 Qingdao, China.
Liu B; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 266071 Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, 266000 Qingdao, China; University of Chinese Academy of Sciences, 100039 Beijing, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, 266071 Qingdao, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jun 30; Vol. 787, pp. 145640. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
Cilia/*physiology
Gastropoda/*physiology
Membrane Proteins/*physiology
Animals ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/physiology ; Cilia/genetics ; Gastropoda/genetics ; Gene Knockout Techniques ; Membrane Proteins/genetics ; Mutagenesis ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Autorzy :
Yamamoto Y; Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan.; Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Chino H; Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan.
Tsukamoto S; Laboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Ode KL; Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ueda HR; Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Osaka, Japan.
Mizushima N; Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 02; Vol. 12 (1), pp. 3292. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*genetics
Cilia/*metabolism
Microtubule-Associated Proteins/*genetics
Myosin Heavy Chains/*genetics
NIMA-Related Kinases/*genetics
Amino Acid Sequence ; Animals ; Brain/cytology ; Brain/metabolism ; Cell Line ; Cilia/genetics ; Female ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation ; Kidney/cytology ; Kidney/metabolism ; Liver/cytology ; Liver/metabolism ; Male ; Mice ; Mice, Knockout ; Microtubule-Associated Proteins/metabolism ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Myocardium/cytology ; Myocardium/metabolism ; Myosin Heavy Chains/metabolism ; NIMA-Related Kinases/deficiency ; Protein Binding ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Research on human gamete and embryo transport in fallopian tubes.
Autorzy :
Saridogan E; Women's Health Division, University College London Hospital, London, UK.
Kervancioglu ME; Department of Obstetrics and Gynaecology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Djahanbakhch O; Bart's Health NHS Trust, Centre for Reproductive Medicine, London, UK.
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Źródło :
Human reproduction (Oxford, England) [Hum Reprod] 2021 May 17; Vol. 36 (6), pp. 1724-1725.
Typ publikacji :
Letter; Comment
MeSH Terms :
Cilia*
Fallopian Tubes*
Epithelium ; Female ; Gene Expression ; Germ Cells ; Humans ; Testosterone
Opinia redakcyjna
Tytuł :
Reply: Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating.
Autorzy :
Jackson-Bey T; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Colina J; Department of Pharmaceutical Biosciences, University of Illinois at Chicago, Chicago, IL, USA.
Isenberg BC; Biological microsystems, Charles Stark Draper Laboratory, Cambridge, MA, USA.
Coppeta J; Biological microsystems, Charles Stark Draper Laboratory, Cambridge, MA, USA.
Urbanek M; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kim JJ; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Woodruff TK; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Burdette JE; Department of Pharmaceutical Biosciences, University of Illinois at Chicago, Chicago, IL, USA.
Russo A; Department of Pharmaceutical Biosciences, University of Illinois at Chicago, Chicago, IL, USA.
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Źródło :
Human reproduction (Oxford, England) [Hum Reprod] 2021 May 17; Vol. 36 (6), pp. 1725.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Cilia*
Follicular Phase*
Blastocyst ; Epithelium ; Fallopian Tubes ; Female ; Gene Expression ; Humans ; Luteal Phase ; Pregnancy ; Testosterone
Raport
Tytuł :
ARP-T1-associated Bazex-Dupré-Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies.
Autorzy :
Park HS; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Papanastasi E; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Blanchard G; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Chiticariu E; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Bachmann D; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Plomann M; Center for Biochemistry, University of Cologne, Cologne, Germany.
Morice-Picard F; Department of Dermatology, CHU, Hôpital Pellegrin, Bordeaux, France.
Vabres P; Department of Dermatology, CHU, Hôpital du Bocage, Dijon, France.
Smahi A; Paris Descartes University, Sorbonne Paris Cité, Paris, France.; IMAGINE Institute INSERM UMR 1163, Paris, France.
Huber M; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Pich C; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland.
Hohl D; Department of Dermatology, CHUV-FBM UNIL, Hôpital de Beaumont, Lausanne, Switzerland. .
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Źródło :
Communications biology [Commun Biol] 2021 May 10; Vol. 4 (1), pp. 544. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Basal Cell/*pathology
Cilia/*pathology
Ciliopathies/*pathology
Hypotrichosis/*pathology
Keratinocytes/*pathology
Microfilament Proteins/*metabolism
Neoplasms, Basal Cell/*pathology
Skin Neoplasms/*pathology
Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/metabolism ; Cilia/metabolism ; Ciliopathies/genetics ; Ciliopathies/metabolism ; Humans ; Hypotrichosis/genetics ; Hypotrichosis/metabolism ; Keratinocytes/metabolism ; Microfilament Proteins/genetics ; Mutation ; Neoplasms, Basal Cell/genetics ; Neoplasms, Basal Cell/metabolism ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism
SCR Disease Name :
Bazex-Dupre-Christol syndrome
Czasopismo naukowe

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