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Tytuł :
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells.
Autorzy :
So BR; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Di C; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Cai Z; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Venters CC; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Guo J; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Oh JM; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Arai C; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Dreyfuss G; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Nov 21; Vol. 76 (4), pp. 590-599.e4. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
RNA Cleavage*
Transcription, Genetic*
Cell Nucleus/*metabolism
Cleavage And Polyadenylation Specificity Factor/*metabolism
RNA Precursors/*biosynthesis
RNA, Messenger/*biosynthesis
Ribonucleoprotein, U1 Small Nuclear/*metabolism
3' Untranslated Regions ; Active Transport, Cell Nucleus ; Binding Sites ; Cell Nucleus/genetics ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage Stimulation Factor/genetics ; Cleavage Stimulation Factor/metabolism ; HeLa Cells ; Humans ; Multiprotein Complexes ; Poly A/metabolism ; Protein Binding ; RNA Precursors/genetics ; RNA, Messenger/genetics ; Ribonucleoprotein, U1 Small Nuclear/genetics
Czasopismo naukowe
Tytuł :
Characterization and Optimization of a Deoxyribozyme with a Short Left Binding Arm.
Autorzy :
Wang Y; Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yu H; Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, China. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2167, pp. 79-89.
Typ publikacji :
Journal Article
MeSH Terms :
Nucleic Acid Conformation*
DNA, Catalytic/*chemistry
DNA, Catalytic/*metabolism
Electrophoresis, Polyacrylamide Gel/*methods
Enzyme Assays/*methods
RNA Cleavage/*drug effects
Base Sequence ; Catalysis ; Catalytic Domain ; DNA, Catalytic/genetics ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Ions/chemistry ; Kinetics ; Metals/chemistry ; Models, Molecular ; Oligonucleotides/chemistry ; Oligonucleotides/genetics ; RNA Cleavage/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences.
Autorzy :
Staroseletz Y; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
Gaponova S; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
Patutina O; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
Bichenkova E; School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Rd., Manchester M13 9PT, UK.
Amirloo B; School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Rd., Manchester M13 9PT, UK.
Heyman T; School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Rd., Manchester M13 9PT, UK.
Chiglintseva D; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
Zenkova M; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 19; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Base Sequence*
RNA Cleavage*
DNA, Catalytic/*chemistry
Oligonucleotides/*chemistry
RNA/*chemistry
Ribonucleases/*chemistry
Czasopismo naukowe
Tytuł :
Integrator is a genome-wide attenuator of non-productive transcription.
Autorzy :
Lykke-Andersen S; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. Electronic address: .
Žumer K; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Molska EŠ; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Rouvière JO; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Wu G; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Demel C; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Schwalb B; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Schmid M; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Cramer P; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address: .
Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 514-529.e6. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Termination, Genetic*
Cleavage And Polyadenylation Specificity Factor/*metabolism
DNA-Binding Proteins/*metabolism
RNA Polymerase II/*metabolism
RNA, Small Nuclear/*biosynthesis
Cleavage And Polyadenylation Specificity Factor/genetics ; DNA-Binding Proteins/genetics ; HeLa Cells ; Humans ; Polyadenylation ; Promoter Regions, Genetic ; RNA Polymerase II/genetics ; RNA, Small Nuclear/genetics
Czasopismo naukowe
Tytuł :
Advances of functional consequences and regulation mechanisms of alternative cleavage and polyadenylation.
Autorzy :
Xu HD; Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China.; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Ning BL; Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China.; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Mu F; Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China.; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Li H; Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China.; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Wang N; Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China.; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2021 Jan 20; Vol. 43 (1), pp. 4-15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Cleavage*
Gene Expression Regulation*
Polyadenylation*
3' Untranslated Regions ; Animals ; Plants ; RNA Stability ; Yeasts
Czasopismo naukowe
Tytuł :
Comment on "Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides and Their Application to DNA Cleavage".
Autorzy :
Korth HG; Institut für Organische Chemie, Universität Duisburg-Essen, Universitätsstr. 7, 45117, Essen, Germany.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jan 18; Vol. 27 (4), pp. 1473-1475. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Letter
MeSH Terms :
DNA Cleavage*
Nitric Oxide*
Nitrogen Oxides/*chemistry
Free Radicals
Opinia redakcyjna
Tytuł :
Estrogen promotes increased breast cancer cell proliferation and migration through downregulation of CPEB1 expression.
Autorzy :
Sovijit W; Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Sovijit W; Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Ishii Y; Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Kambe J; Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Fujita T; Department of Breast Surgery, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami-cho, Ibaraki, 300-0395, Japan.
Watanabe G; Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Yamaguchi H; Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, P.O Box 34110, Doha, Qatar.
Nagaoka K; Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 01; Vol. 534, pp. 871-876. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Breast Neoplasms/*genetics
Estrogens/*metabolism
Transcription Factors/*genetics
mRNA Cleavage and Polyadenylation Factors/*genetics
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Movement ; Cell Proliferation ; Down-Regulation ; Female ; Humans ; MCF-7 Cells ; Middle Aged ; Transcription Factors/analysis ; Transcription Factors/metabolism ; mRNA Cleavage and Polyadenylation Factors/analysis ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
Molecular mechanism for the interaction between human CPSF30 and hFip1.
Autorzy :
Hamilton K; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Tong L; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
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Źródło :
Genes & development [Genes Dev] 2020 Dec 01; Vol. 34 (23-24), pp. 1753-1761. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Molecular*
Cleavage And Polyadenylation Specificity Factor/*chemistry
Cleavage And Polyadenylation Specificity Factor/*metabolism
mRNA Cleavage and Polyadenylation Factors/*chemistry
Binding Sites ; Cleavage And Polyadenylation Specificity Factor/genetics ; Escherichia coli/genetics ; Humans ; Mutation ; Protein Binding ; Protein Structure, Quaternary ; Zinc Fingers/physiology ; mRNA Cleavage and Polyadenylation Factors/genetics ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
Divalent Ion-Induced Switch in DNA Cleavage of KpnI Endonuclease Probed through Surface-Enhanced Raman Spectroscopy.
Autorzy :
Aggarwal S; Light Scattering Lab, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
Mondal S; Light Scattering Lab, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
Siddhanta S; Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Bharat E; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Nagamalleswari E; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Nagaraja V; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
Narayana C; Light Scattering Lab, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2021 Mar 11; Vol. 125 (9), pp. 2241-2250. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Cleavage*
Spectrum Analysis, Raman*
Cations, Divalent ; Deoxyribonucleases, Type II Site-Specific/genetics ; Ions
Czasopismo naukowe
Tytuł :
Mechanism of DNA cleavage by the endonuclease SauUSI: a major barrier to horizontal gene transfer and antibiotic resistance in Staphylococcus aureus.
Autorzy :
Tumuluri VS; Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India.
Rajgor V; Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India.
Xu SY; New England Biolabs Inc., Research Department, Ipswich, MA 01938, USA.
Chouhan OP; Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India.
Saikrishnan K; Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2161-2178.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Cleavage*
Endodeoxyribonucleases/*chemistry
Endodeoxyribonucleases/*metabolism
Staphylococcus aureus/*enzymology
Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/metabolism ; DNA/chemistry ; Drug Resistance, Bacterial ; Gene Transfer, Horizontal ; Models, Molecular ; Protein Multimerization ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/genetics
Czasopismo naukowe
Tytuł :
Forty Years after the Discovery of Its Nucleolytic Activity: [Cu(phen) 2 ] Shows Unattended DNA Cleavage Activity upon Fluorination.
Autorzy :
Lüdtke C; Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.
Sobottka S; Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.
Heinrich J; Institut für Chemie, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Liebing P; Institut für Chemie, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Wedepohl S; Institut für Chemie und Biochemie, Freie Universität Berlin, Arnimallee 22, 14195, Berlin, Germany.
Sarkar B; Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.; Institut für Anorganische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany.
Kulak N; Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.; Institut für Chemie, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Feb 15; Vol. 27 (10), pp. 3273-3277. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Cleavage*
Halogenation*
Copper ; Crystallography, X-Ray ; DNA/metabolism ; Ligands ; Phenanthrolines
Czasopismo naukowe
Tytuł :
Single-Molecule Dwell-Time Analysis of Restriction Endonuclease-Mediated DNA Cleavage.
Autorzy :
Etson CM; Department of Chemistry, Tufts University; Department of Physics, Wesleyan University; .
Todorov P; Department of Chemistry, Tufts University.
Shatery Nejad N; Department of Physics, Wesleyan University.
Shrestha N; Department of Physics, Wesleyan University.
Walt DR; Department of Chemistry, Tufts University; Wyss Institute at Harvard University.
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 07 (168). Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media
MeSH Terms :
DNA Cleavage*
DNA Restriction Enzymes/*metabolism
Single Molecule Imaging/*methods
Biotinylation ; DNA/metabolism ; Data Analysis ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Kinetics ; Microfluidics ; Quantum Dots/chemistry ; Substrate Specificity ; Surface Properties ; Time Factors
Czasopismo naukowe
Tytuł :
Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.
Autorzy :
Chen X; Department of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, 60208, USA.
Lloyd SM; Department of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, 60208, USA.
Kweon J; Department of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, 60208, USA.
Gamalong GM; Department of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, 60208, USA.
Bao X; Department of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, 60208, USA. .; Department of Dermatology; Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. .; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, 60611, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 19; Vol. 12 (1), pp. 448. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cleavage And Polyadenylation Specificity Factor/*metabolism
DNA-Binding Proteins/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*metabolism
Keratinocytes/*physiology
Re-Epithelialization/*genetics
Stem Cells/*physiology
Transcription Factors/*metabolism
CRISPR-Cas Systems/genetics ; Cell Differentiation/genetics ; Cell Self Renewal/genetics ; Cleavage And Polyadenylation Specificity Factor/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation ; Gene Knockdown Techniques ; Gene Knockout Techniques ; HEK293 Cells ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Humans ; Introns/genetics ; Polyadenylation/genetics ; Primary Cell Culture ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
TREND-DB-a transcriptome-wide atlas of the dynamic landscape of alternative polyadenylation.
Autorzy :
Marini F; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, 55131 Mainz, Germany.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany.
Scherzinger D; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, 55131 Mainz, Germany.
Danckwardt S; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, 55131 Mainz, Germany.; Posttranscriptional Gene Regulation, Cancer Research and Experimental Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany.; Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Rhine-Main, 55131 Mainz, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D243-D253.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions*
Databases, Genetic*
Polyadenylation*
Transcriptome*
Cleavage And Polyadenylation Specificity Factor/*genetics
Cleavage And Polyadenylation Specificity Factor/metabolism ; Gene Expression Regulation ; Humans ; Internet ; Transcription, Genetic ; User-Computer Interface
Czasopismo naukowe
Tytuł :
crisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assays.
Autorzy :
Störtz F; Department of Computer Science, University of Oxford, Parks Road, Oxford OX1 3QD, UK.
Minary P; Department of Computer Science, University of Oxford, Parks Road, Oxford OX1 3QD, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D855-D861.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Cleavage*
Databases, Genetic*
Biological Assay/*methods
CRISPR-Cas Systems/*genetics
Epigenesis, Genetic ; Streptococcus pyogenes/genetics ; User-Computer Interface
Czasopismo naukowe
Tytuł :
NUDT21 Links Mitochondrial IPS-1 to RLR-Containing Stress Granules and Activates Host Antiviral Defense.
Autorzy :
Aoyama-Ishiwatari S; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Okazaki T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; .
Iemura SI; Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.
Natsume T; Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.
Okada Y; Laboratory for Cell Dynamics Observation, Center for Biosystems Dynamics Research, RIKEN, Osaka 565-0874, Japan.; Department of Physics, Universal Biology Institute, Tokyo 113-0033, Japan; and.; International Research Center for Neurointelligence, World Premier International Research Center Initiative, The University of Tokyo, Tokyo 113-0033, Japan.
Gotoh Y; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.; International Research Center for Neurointelligence, World Premier International Research Center Initiative, The University of Tokyo, Tokyo 113-0033, Japan.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Jan 01; Vol. 206 (1), pp. 154-163. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Cardiovirus Infections/*metabolism
Cleavage And Polyadenylation Specificity Factor/*metabolism
DEAD Box Protein 58/*metabolism
Encephalomyocarditis virus/*physiology
Mitochondria/*metabolism
Newcastle Disease/*metabolism
Newcastle disease virus/*physiology
Receptors, Immunologic/*metabolism
Secretory Vesicles/*metabolism
Animals ; Cleavage And Polyadenylation Specificity Factor/genetics ; Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Humans ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Mice ; Poly I-C/immunology ; Protein Transport ; RAW 264.7 Cells ; RNA, Small Interfering/genetics ; RNA, Viral/immunology ; Stress, Physiological
Czasopismo naukowe
Tytuł :
Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery.
Autorzy :
Zhang Y; Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY 10065, USA.
Sun Y; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Shi Y; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Walz T; Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY 10065, USA. Electronic address: .
Tong L; Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Feb 20; Vol. 77 (4), pp. 800-809.e6. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cleavage And Polyadenylation Specificity Factor/*chemistry
Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage Stimulation Factor/chemistry ; Cryoelectron Microscopy ; Humans ; Models, Molecular ; Mutation ; RNA 3' End Processing ; RNA Precursors/metabolism ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Seasonal expressions of SF-1, StAR and P450scc in the scent glands of the muskrats (Ondatra zibethicus).
Autorzy :
Xie W; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Tang Z; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Xu L; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Zhong J; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Zhang H; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Han Y; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Yuan Z; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Weng Q; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Nov; Vol. 204, pp. 105766. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arvicolinae*/genetics
Arvicolinae*/metabolism
Cholesterol Side-Chain Cleavage Enzyme*/genetics
Cholesterol Side-Chain Cleavage Enzyme*/metabolism
Phosphoproteins*/genetics
Phosphoproteins*/metabolism
Steroidogenic Factor 1*/genetics
Steroidogenic Factor 1*/metabolism
Scent Glands/*metabolism
Animals ; Male ; MicroRNAs ; Seasons
Czasopismo naukowe
Tytuł :
A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.
Autorzy :
Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li L; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Connelly JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Porter SN; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kodali K; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gan H; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Park JM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tacer KF; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tillman H; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peng J; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li W; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Mar 19; Vol. 77 (6), pp. 1206-1221.e7. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions/*genetics
Antigens, Neoplasm/*metabolism
Lung Neoplasms/*pathology
Neoplasm Proteins/*metabolism
Ovarian Neoplasms/*pathology
RNA, Messenger/*metabolism
Ubiquitin/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Antigens, Neoplasm/genetics ; Apoptosis ; Biomarkers, Tumor ; Carcinogenesis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Proliferation ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Proteins/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Polyadenylation ; RNA Splicing ; RNA, Messenger/genetics ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Xenograft Model Antitumor Assays ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Structure of an active human histone pre-mRNA 3'-end processing machinery.
Autorzy :
Sun Y; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Zhang Y; Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY 10065, USA.
Aik WS; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Yang XC; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Marzluff WF; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Walz T; Laboratory of Molecular Electron Microscopy, Rockefeller University, New York, NY 10065, USA. .
Dominski Z; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Tong L; Department of Biological Sciences, Columbia University, New York, NY 10027, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Feb 07; Vol. 367 (6478), pp. 700-703.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Cleavage*
Cleavage And Polyadenylation Specificity Factor/*chemistry
Histones/*genetics
RNA Precursors/*metabolism
Catalytic Domain ; Cryoelectron Microscopy ; Humans ; Polyadenylation ; RNA, Small Nuclear/metabolism ; Recombinant Proteins ; Ribonucleoprotein, U7 Small Nuclear/chemistry
Czasopismo naukowe

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