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Wyszukujesz frazę ""Clem BF"" wg kryterium: Autor


Wyświetlanie 1-10 z 10
Tytuł:
Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells.
Autorzy:
Biyik-Sit R; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Kruer T; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Dougherty S; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Bradley JA; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Wilkey DW; Department of Medicine, Division of Nephrology and Hypertension, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Merchant ML; Department of Medicine, Division of Nephrology and Hypertension, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Trent JO; Department of Medicine, Division of Hematology and Oncology, University of Louisville School of Medicine, Louisville, KY 40202, USA.; Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Clem BF; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.; Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Aug 04; Vol. 13 (16). Date of Electronic Publication: 2021 Aug 04.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells.
Autorzy:
Conroy LR; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY USA.; Present Address: Department of Neuroscience, University of Kentucky, Lexington, KY USA.
Lorkiewicz P; Diabetes and Obesity Center, Christina Lee Brown Envirome Institute, Louisville, KY USA.; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY USA.
He L; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY USA.
Yin X; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY USA.
Zhang X; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY USA.; James Graham Brown Cancer Center, Louisville, KY USA.
Rai SN; Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY USA.; Biostatistics and Bioinformatics Facility, James Graham Brown Cancer Center, University of Louisville, Louisville, KY USA.; James Graham Brown Cancer Center, Louisville, KY USA.
Clem BF; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY USA.; James Graham Brown Cancer Center, Louisville, KY USA.
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Źródło:
Cancer cell international [Cancer Cell Int] 2020 Jul 01; Vol. 20, pp. 280. Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Loss of Rb1 Enhances Glycolytic Metabolism in Kras -Driven Lung Tumors In Vivo.
Autorzy:
Conroy LR; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Dougherty S; James Graham Brown Cancer Center, Louisville, KY 40202, USA.
Kruer T; James Graham Brown Cancer Center, Louisville, KY 40202, USA.
Metcalf S; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Lorkiewicz P; Diabetes and Obesity Center, Christina Lee Brown Envirome Institute, Louisville, KY 40202, USA.; Department of Chemistry, University of Louisville, Center for Regulatory and Environmental Analytical Metabolomics, Louisville, KY 40208, USA.
He L; Department of Chemistry, University of Louisville, Center for Regulatory and Environmental Analytical Metabolomics, Louisville, KY 40208, USA.
Yin X; Department of Chemistry, University of Louisville, Center for Regulatory and Environmental Analytical Metabolomics, Louisville, KY 40208, USA.
Zhang X; Department of Chemistry, University of Louisville, Center for Regulatory and Environmental Analytical Metabolomics, Louisville, KY 40208, USA.
Arumugam S; James Graham Brown Cancer Center, Louisville, KY 40202, USA.
Young LEA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.
Sun RC; Department of Neuroscience, University of Kentucky, College of Medicine, Lexington, KY 40536, USA.; Markey Cancer Center, Lexington, KY 40536, USA.
Clem BF; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.; James Graham Brown Cancer Center, Louisville, KY 40202, USA.
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Źródło:
Cancers [Cancers (Basel)] 2020 Jan 17; Vol. 12 (1). Date of Electronic Publication: 2020 Jan 17.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation.
Autorzy:
Lorkiewicz PK; Department of Medicine, Division of Environmental Medicine, Christina Lee Brown Envirome Institute, Diabetes and Obesity Center, University of Louisville, Louisville, USA.; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, USA.
Gibb AA; Department of Medicine, Division of Environmental Medicine, Christina Lee Brown Envirome Institute, Diabetes and Obesity Center, University of Louisville, Louisville, USA.; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Rood BR; Department of Medicine, Division of Environmental Medicine, Christina Lee Brown Envirome Institute, Diabetes and Obesity Center, University of Louisville, Louisville, USA.
He L; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, USA.
Zheng Y; Department of Medicine, Division of Environmental Medicine, Christina Lee Brown Envirome Institute, Diabetes and Obesity Center, University of Louisville, Louisville, USA.
Clem BF; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, USA.
Zhang X; Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, USA.
Hill BG; Department of Medicine, Division of Environmental Medicine, Christina Lee Brown Envirome Institute, Diabetes and Obesity Center, University of Louisville, Louisville, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Sep 23; Vol. 9 (1), pp. 13705. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Workflow*
Mass Spectrometry/*methods
Metabolomics/*methods
Data Interpretation, Statistical ; Isotope Labeling/methods ; Mass Spectrometry/standards ; Metabolic Networks and Pathways ; Metabolomics/standards ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
Expression of the lncRNA Maternally Expressed Gene 3 (MEG3) Contributes to the Control of Lung Cancer Cell Proliferation by the Rb Pathway.
Autorzy:
Kruer TL; Department of Biochemistry and Molecular Genetics, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.
Dougherty SM; Department of Biochemistry and Molecular Genetics, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.
Reynolds L; Department of Biochemistry and Molecular Genetics, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.
Long E; Department of Biochemistry and Molecular Genetics, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.
de Silva T; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
Lockwood WW; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
Clem BF; Department of Biochemistry and Molecular Genetics, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Nov 10; Vol. 11 (11), pp. e0166363. Date of Electronic Publication: 2016 Nov 10 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Signal Transduction*
Adenocarcinoma/*genetics
Lung/*pathology
Lung Neoplasms/*genetics
RNA, Long Noncoding/*genetics
Retinoblastoma Protein/*metabolism
A549 Cells ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adenocarcinoma of Lung ; Animals ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Gene Knockout Techniques ; Humans ; Lung/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Retinoblastoma Protein/genetics
Czasopismo naukowe
Tytuł:
Control of glutamine metabolism by the tumor suppressor Rb.
Autorzy:
Reynolds MR; 1] Department of Medicine, University of Louisville, Louisville, KY, USA [2] Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA [3] Molecular Targets Group, University of Louisville, Louisville, KY, USA.
Lane AN; 1] Department of Medicine, University of Louisville, Louisville, KY, USA [2] Structural Biology Program James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Robertson B; 1] Department of Medicine, University of Louisville, Louisville, KY, USA [2] Molecular Targets Group, University of Louisville, Louisville, KY, USA.
Kemp S; 1] Department of Medicine, University of Louisville, Louisville, KY, USA [2] Molecular Targets Group, University of Louisville, Louisville, KY, USA.
Liu Y; 1] Molecular Targets Group, University of Louisville, Louisville, KY, USA [2] Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA.
Hill BG; 1] Department of Medicine, University of Louisville, Louisville, KY, USA [2] Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA [3] Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA.
Dean DC; 1] Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA [2] Molecular Targets Group, University of Louisville, Louisville, KY, USA [3] Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA.
Clem BF; 1] Department of Medicine, University of Louisville, Louisville, KY, USA [2] Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA [3] Molecular Targets Group, University of Louisville, Louisville, KY, USA.
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Źródło:
Oncogene [Oncogene] 2014 Jan 30; Vol. 33 (5), pp. 556-66. Date of Electronic Publication: 2013 Jan 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
E2F3 Transcription Factor/*metabolism
Glutamine/*metabolism
Retinoblastoma Protein/*metabolism
Retinoblastoma-Like Protein p107/*metabolism
Retinoblastoma-Like Protein p130/*metabolism
Adenosine Triphosphate/biosynthesis ; Amino Acid Transport System ASC/biosynthesis ; Amino Acid Transport System ASC/genetics ; Amino Acid Transport System ASC/metabolism ; Animals ; Biological Transport/genetics ; Cell Cycle ; Cell Proliferation ; Cells, Cultured ; E2F3 Transcription Factor/biosynthesis ; Fibroblasts ; Glutamate-Cysteine Ligase/biosynthesis ; Glutaminase/biosynthesis ; Glutaminase/genetics ; Glutaminase/metabolism ; Glutathione/biosynthesis ; Ketoglutaric Acids/metabolism ; Mice ; Mice, Knockout ; Minor Histocompatibility Antigens ; Oxygen/metabolism ; Promoter Regions, Genetic ; RNA Interference ; RNA, Small Interfering ; Reactive Oxygen Species/metabolism ; Retinoblastoma Protein/genetics ; Retinoblastoma-Like Protein p107/genetics ; Retinoblastoma-Like Protein p130/genetics
Czasopismo naukowe
Tytuł:
Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth.
Autorzy:
Telang S; Molecular Targets Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Nelson KK
Siow DL
Yalcin A
Thornburg JM
Imbert-Fernandez Y
Klarer AC
Farghaly H
Clem BF
Eaton JW
Chesney J
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Źródło:
Molecular cancer [Mol Cancer] 2012 Aug 23; Vol. 11, pp. 60. Date of Electronic Publication: 2012 Aug 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma/*enzymology
Electron Transport Complex IV/*metabolism
Lung Neoplasms/*enzymology
ras Proteins/*metabolism
Adenocarcinoma/chemistry ; Adenocarcinoma/genetics ; Adenocarcinoma of Lung ; Adenosine Triphosphate/metabolism ; Animals ; Cell Line, Tumor ; Cell Survival/physiology ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/genetics ; Enzyme Activation ; Eukaryotic Initiation Factor-4E/metabolism ; Female ; Humans ; Lung Neoplasms/chemistry ; Lung Neoplasms/genetics ; Mice ; Mice, Nude ; Oxygen Consumption ; RNA, Small Interfering/genetics ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł:
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
Autorzy:
Telang S; James Graham Brown Cancer Center, Division of Medical Oncology and Hematology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA. />Clem BF
Klarer AC
Clem AL
Trent JO
Bucala R
Chesney J
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Źródło:
Journal of translational medicine [J Transl Med] 2012 May 16; Vol. 10, pp. 95. Date of Electronic Publication: 2012 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Lymphocyte Activation/*drug effects
Phosphofructokinase-2/*antagonists & inhibitors
T-Lymphocytes/*immunology
Animals ; Antigens, CD/immunology ; Enzyme-Linked Immunosorbent Assay ; Hypersensitivity, Delayed ; Immunohistochemistry ; Mice ; Mice, Inbred BALB C ; Real-Time Polymerase Chain Reaction ; Small Molecule Libraries
Czasopismo naukowe
Tytuł:
Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma.
Autorzy:
Telang S; Molecular Targets Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Rasku MA
Clem AL
Carter K
Klarer AC
Badger WR
Milam RA
Rai SN
Pan J
Gragg H
Clem BF
McMasters KM
Miller DM
Chesney J
Pokaż więcej
Źródło:
BMC cancer [BMC Cancer] 2011 Dec 13; Vol. 11, pp. 515. Date of Electronic Publication: 2011 Dec 13.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Diphtheria Toxin/*therapeutic use
Interleukin-2/*therapeutic use
Melanoma/*drug therapy
Skin Neoplasms/*drug therapy
Aged ; Female ; Humans ; Kentucky ; Male ; Melanoma/pathology ; Middle Aged ; Positron-Emission Tomography ; Recombinant Fusion Proteins/therapeutic use ; Skin Neoplasms/pathology ; Survival Analysis ; T-Lymphocytes ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł:
A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling.
Autorzy:
Clem BF; Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Clem AL
Yalcin A
Goswami U
Arumugam S
Telang S
Trent JO
Chesney J
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Źródło:
Oncogene [Oncogene] 2011 Jul 28; Vol. 30 (30), pp. 3370-80. Date of Electronic Publication: 2011 Mar 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetamides/*pharmacology
Choline Kinase/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
MAP Kinase Signaling System/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Triazoles/*pharmacology
Actins/metabolism ; Animals ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cell Proliferation/drug effects ; Choline Kinase/chemistry ; Choline Kinase/metabolism ; Computational Biology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; HeLa Cells ; Humans ; Mice ; Models, Molecular ; Phosphorylation/drug effects ; Phosphorylcholine/metabolism ; Protein Conformation ; Proto-Oncogene Proteins p21(ras)/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
    Wyświetlanie 1-10 z 10

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