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Wyświetlanie 1-20 z 195
Tytuł:
Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells.
Autorzy:
Kamen Y; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK. .
Evans KA; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK.
Sitnikov S; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK.
Spitzer SO; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK.
de Faria O Jr; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK.
Yucel M; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK.
Káradóttir RT; Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 A0W, UK. .; Department of Physiology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 19; Vol. 14 (1), pp. 4091. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Oligodendrocyte Precursor Cells*/metabolism
Metformin*/pharmacology
Metformin*/metabolism
Clemastine ; Receptors, N-Methyl-D-Aspartate/metabolism ; Myelin Sheath/metabolism ; Oligodendroglia/metabolism ; Cell Differentiation/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Autorzy:
Sabir H; Deutsche Zentrum für Neurodegenerative Erkrankungen (DZNE) e.v., Venusberg-Campus 1, 53127, Bonn, Germany. .; Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, Bonn, Germany. .
Maes E; Deutsche Zentrum für Neurodegenerative Erkrankungen (DZNE) e.v., Venusberg-Campus 1, 53127, Bonn, Germany.; Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, Bonn, Germany.
Zweyer M; Deutsche Zentrum für Neurodegenerative Erkrankungen (DZNE) e.v., Venusberg-Campus 1, 53127, Bonn, Germany.; Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, Bonn, Germany.
Schleehuber Y; Deutsche Zentrum für Neurodegenerative Erkrankungen (DZNE) e.v., Venusberg-Campus 1, 53127, Bonn, Germany.
Imam FB; Bill & Melinda Gates Foundation, Seattle, WA, USA.
Silverman J; Gates Medical Research Institute, Boston, MA, USA.
White Y; Department of Pediatrics, The University of California, San Francisco, CA, USA.
Pang R; Institute for Women's Health, University College London, London, WC1E 6HU, UK.
Pasca AM; Division of Neonatology, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Robertson NJ; Institute for Women's Health, University College London, London, WC1E 6HU, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.
Maltepe E; Department of Pediatrics, The University of California, San Francisco, CA, USA.
Bernis ME; Deutsche Zentrum für Neurodegenerative Erkrankungen (DZNE) e.v., Venusberg-Campus 1, 53127, Bonn, Germany.; Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, Bonn, Germany.
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 10; Vol. 13 (1), pp. 9467. Date of Electronic Publication: 2023 Jun 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Asphyxia Neonatorum*/drug therapy
Brain Injuries*/drug therapy
Hypothermia, Induced*/methods
Hypoxia-Ischemia, Brain*/drug therapy
Melatonin*/pharmacology
Melatonin*/therapeutic use
Neuroprotective Agents*/pharmacology
Neuroprotective Agents*/therapeutic use
Animals ; Humans ; Infant, Newborn ; Rats ; Allopurinol/pharmacology ; Animals, Newborn ; Brain ; Caffeine/pharmacology ; Clemastine/pharmacology ; Disease Models, Animal ; Hedgehog Proteins ; Hydroxybutyrates/pharmacology ; Hypoxia/drug therapy ; Ischemia/therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clemastine improves hypomyelination in rats with hypoxic-ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway.
Autorzy:
Xie D; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China.
Ge X; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China.
Ma Y; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China.
Tang J; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China.
Wang Y; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China.
Zhu Y; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China.
Gao C; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China. .
Pan S; Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, Shanghai, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2020 Feb 15; Vol. 17 (1), pp. 57. Date of Electronic Publication: 2020 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Clemastine/*pharmacology
Demyelinating Diseases/*drug therapy
Hypoxia-Ischemia, Brain/*drug therapy
Interleukin-1beta/*metabolism
Microglia/*drug effects
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Clemastine/therapeutic use ; Histamine H1 Antagonists/pharmacology ; Histamine H1 Antagonists/therapeutic use ; Male ; Microglia/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systematic Analysis of Clemastine, a Candidate Apicomplexan Parasite-Selective Tubulin-Targeting Agent.
Autorzy:
Abbaali I; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Truong DA; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Day SD; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Haro-Ramirez N; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Morrissette NS; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 22; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Antiparasitic Agents/*pharmacology
Apicoplasts/*drug effects
Clemastine/*pharmacology
Parasites/*drug effects
Tubulin/*metabolism
Animals ; Cells, Cultured ; Histamine Antagonists/pharmacology ; Humans ; Microtubules/metabolism ; Protozoan Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clemastine improves electrophysiologic and histomorphometric changes through promoting myelin repair in a murine model of compression neuropathy.
Autorzy:
Lee JI; Department of Orthopedic Surgery, Korea University Guro Hospital, 148, Gurodong-ro, Guro-gu, Seoul, 08308, South Korea. .
Park JW; Department of Orthopedic Surgery, Korea University Anam Hospital, Seoul, South Korea.
Lee KJ; Department of Orthopedic Surgery, Hanyang University Guri Hospital, Guri, South Korea.
Lee DH; Department of Emergency Medicine, Ewha Women's University Mokdong Hospital, Seoul, South Korea.
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Źródło:
Scientific reports [Sci Rep] 2021 Oct 22; Vol. 11 (1), pp. 20886. Date of Electronic Publication: 2021 Oct 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthrogryposis/*drug therapy
Clemastine/*pharmacology
Electrophysiological Phenomena/*drug effects
Hereditary Sensory and Motor Neuropathy/*drug therapy
Myelin Sheath/*drug effects
Nerve Compression Syndromes/*drug therapy
Sciatic Nerve/*drug effects
Animals ; Axons/drug effects ; Disease Models, Animal ; Female ; Mice ; Mice, Inbred C57BL ; Recovery of Function/drug effects
SCR Disease Name:
Tomaculous neuropathy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clemastine-induced enhancement of hippocampal myelination alleviates memory impairment in mice with chronic pain
Autorzy:
Ting-ting Zhu
He Wang
Pan-miao Liu
Han-wen Gu
Wei-tong Pan
Ming-ming Zhao
Kenji Hashimoto
Jian-jun Yang
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Temat:
Clemastine
hippocampus
Memory impairment
Myelin
Neuronal activity
Neuropathic pain
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Źródło:
Neurobiology of Disease, Vol 190, Iss , Pp 106375- (2024)
Opis pliku:
electronic resource
Relacje:
http://www.sciencedirect.com/science/article/pii/S0969996123003911; https://doaj.org/toc/1095-953X
Dostęp URL:
https://doaj.org/article/d7a8a7b7fd204cd4bac4bc8f96e3db48  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Effect of the H 1 -antihistamine clemastine on PACAP38 induced migraine.
Autorzy:
Vollesen LH; 1 Danish Headache Centre and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Guo S; 1 Danish Headache Centre and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Andersen MR; 2 Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Hellerup, Denmark.
Ashina M; 1 Danish Headache Centre and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2019 Apr; Vol. 39 (5), pp. 597-607. Date of Electronic Publication: 2018 Aug 30.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Clemastine/*therapeutic use
Histamine H1 Antagonists/*therapeutic use
Migraine Disorders/*chemically induced
Migraine Disorders/*prevention & control
Pituitary Adenylate Cyclase-Activating Polypeptide/*adverse effects
Adult ; Cross-Over Studies ; Double-Blind Method ; Female ; Headache/chemically induced ; Headache/prevention & control ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clemastine improves optic nerve myelin sheath regeneration and visual function in aged mice
Autorzy:
RAN Qi
CHEN Lin
YE Jian
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Temat:
aging
clemastine
vision
myelin
visual evoked potential
Medicine (General)
R5-920
Źródło:
陆军军医大学学报, Vol 44, Iss 23, Pp 2377-2383 (2022)
Opis pliku:
electronic resource
Relacje:
http://aammt.tmmu.edu.cn/Upload/rhtml/202209207.htm; https://doaj.org/toc/2097-0927
Dostęp URL:
https://doaj.org/article/da7ca8c5056440928ea2a06e853ed039  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Clemastine fumarate attenuates intestinal ischemia-reperfusion injury in mice
Autorzy:
LIU Yang, LU Ya-peng, HAO Wei, ZHONG Hai-lian, LIU Jie-ting, WANG Ying-bin
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Temat:
clemastine fumarate
reperfusion injury
intestine
nod-like receptor protein 3(nlrp3)
inflammasome
Medicine
Źródło:
Jichu yixue yu linchuang, Vol 42, Iss 9, Pp 1381-1384 (2022)
Opis pliku:
electronic resource
Relacje:
http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-42-9-1381.pdf; https://doaj.org/toc/1001-6325
Dostęp URL:
https://doaj.org/article/b9c66b2524b54ff9a0f49ae44da5ae84  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression.
Autorzy:
Apolloni S; Santa Lucia Foundation, IRCCS, Rome, Italy.; Institute of Cell Biology and Neurobiology, CNR, Via del Fosso di Fiorano, 65, 00143, Rome, Italy.
Fabbrizio P; Santa Lucia Foundation, IRCCS, Rome, Italy.
Amadio S; Santa Lucia Foundation, IRCCS, Rome, Italy.; Institute of Cell Biology and Neurobiology, CNR, Via del Fosso di Fiorano, 65, 00143, Rome, Italy.
Volonté C; Santa Lucia Foundation, IRCCS, Rome, Italy. .; Institute of Cell Biology and Neurobiology, CNR, Via del Fosso di Fiorano, 65, 00143, Rome, Italy. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2016 Aug 22; Vol. 13 (1), pp. 191. Date of Electronic Publication: 2016 Aug 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*genetics
Amyotrophic Lateral Sclerosis/*prevention & control
Clemastine/*therapeutic use
Histamine Antagonists/*therapeutic use
Superoxide Dismutase/*genetics
Amyotrophic Lateral Sclerosis/pathology ; Animals ; Animals, Newborn ; Asymptomatic Diseases/therapy ; Autophagy/drug effects ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Disease Progression ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/drug effects ; Motor Neurons/drug effects ; Motor Neurons/pathology ; Receptors, Purinergic P2X4/metabolism ; Signal Transduction/drug effects ; Spinal Cord/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clemastine protects against sepsis-induced myocardial injury in vivo and in vitro
Autorzy:
Xiaowan Wang
Di Xie
Hui Dai
Jiawei Ye
Yuqi Liu
Aihua Fei
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Temat:
Sepsis-induced myocardial dysfunction
clemastine
autophagy
apoptosis
mitochondrial damage
histamine receptor blocker
Biotechnology
TP248.13-248.65
Źródło:
Bioengineered, Vol 13, Iss 3, Pp 7134-7146 (2022)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2165-5979; https://doaj.org/toc/2165-5987
Dostęp URL:
https://doaj.org/article/925eb3d6ddf9458a884cf56421a9e701  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Drug repurposing: Clemastine fumarate and neurodegeneration
Autorzy:
Jiahui Zhu
Rong Ma
Gang Li
Pokaż więcej
Temat:
Clemastine
Dimethyl fumarate
Remyelination
Autophagy
Neurodegeneration
Therapeutics. Pharmacology
RM1-950
Źródło:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 113904- (2023)
Opis pliku:
electronic resource
Relacje:
http://www.sciencedirect.com/science/article/pii/S0753332222012938; https://doaj.org/toc/0753-3322
Dostęp URL:
https://doaj.org/article/1587bec118044f778b660b66cb6f8c89  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.
Autorzy:
De Rycker M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Thomas J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Brough SJ; GlaxoSmithKline, Biological Sciences, Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom.
Miles TJ; GlaxoSmithKline, Diseases of the Developing World, Parque Tecnologico de Madrid, Servero Ochoa, Madrid, Spain.
Gray DW; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Apr 15; Vol. 10 (4), pp. e0004584. Date of Electronic Publication: 2016 Apr 15 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
Trypanocidal Agents/*isolation & purification
Trypanocidal Agents/*pharmacology
Trypanosoma cruzi/*drug effects
Animals ; Antipyretics/pharmacology ; Cell Line ; Chagas Disease/drug therapy ; Chagas Disease/parasitology ; Chlorocebus aethiops ; Clemastine/pharmacology ; Drug Repositioning ; High-Throughput Screening Assays ; Parasitic Sensitivity Tests ; Sterol 14-Demethylase ; Trypanocidal Agents/chemistry ; Trypanosoma cruzi/growth & development ; Trypanosoma cruzi/ultrastructure ; Vero Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 195

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