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Wyszukujesz frazę ""Coenzymes"" wg kryterium: Temat


Tytuł :
Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide.
Autorzy :
Wang X; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.
Feng Y; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.
Guo X; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.
Wang Q; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.
Ning S; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.
Li Q; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.; University of Chinese Academy of Sciences, Beijing, PR China.
Wang J; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.; University of Chinese Academy of Sciences, Beijing, PR China.
Wang L; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China.
Zhao ZK; Laboratory of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China. .; Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, PR China. .; State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, CAS, Dalian, PR China. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 09; Vol. 12 (1), pp. 2116. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Coenzymes/*biosynthesis
Escherichia coli Proteins/*genetics
Niacinamide/*biosynthesis
Nicotinamide-Nucleotide Adenylyltransferase/*genetics
Coenzymes/chemistry ; Cytidine Triphosphate/metabolism ; Enzyme Assays ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins/metabolism ; High-Throughput Screening Assays ; Lactic Acid/metabolism ; Malates/metabolism ; Niacinamide/chemistry ; Nicotinamide Mononucleotide/metabolism ; Nicotinamide-Nucleotide Adenylyltransferase/metabolism ; Oxidation-Reduction ; Substrate Specificity/genetics ; Synthetic Biology/methods
Czasopismo naukowe
Tytuł :
DNAmoreDB, a database of DNAzymes.
Autorzy :
Ponce-Salvatierra A; Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland.
Boccaletto P; Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland.
Bujnicki JM; Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, PL-02-109 Warsaw, Poland.; Bioinformatics Laboratory, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, PL-61-614 Poznan, Poland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D76-D81.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Software*
Coenzymes/*genetics
DNA, Catalytic/*genetics
DNA, Single-Stranded/*genetics
Databases, Nucleic Acid/*organization & administration
Base Sequence ; Biocatalysis ; Coenzymes/chemistry ; Coenzymes/metabolism ; DNA, Catalytic/chemistry ; DNA, Catalytic/metabolism ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/metabolism ; Internet ; Kinetics ; Nucleic Acid Conformation ; Sequence Analysis, DNA ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.
Autorzy :
Pan M; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, 60637, USA.
Zheng Q; Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, 100084, Beijing, China.
Yu Y; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, 60637, USA.
Ai H; Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, 100084, Beijing, China.
Xie Y; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, 60637, USA.
Zeng X; Peking-Tsinghua Center for Life Sciences, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China.
Wang C; Peking-Tsinghua Center for Life Sciences, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China.
Liu L; Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, 100084, Beijing, China. .
Zhao M; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, 60637, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 05; Vol. 12 (1), pp. 121. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coenzymes/*chemistry
Ditiocarb/*analogs & derivatives
Intracellular Signaling Peptides and Proteins/*chemistry
Nuclear Proteins/*chemistry
Organometallic Compounds/*chemistry
Ubiquitin/*chemistry
Valosin Containing Protein/*chemistry
Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Binding Sites ; Cloning, Molecular ; Coenzymes/genetics ; Coenzymes/metabolism ; Cryoelectron Microscopy ; Disulfiram/chemistry ; Disulfiram/metabolism ; Ditiocarb/chemistry ; Ditiocarb/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Models, Molecular ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Organometallic Compounds/metabolism ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Unfolding ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Valosin Containing Protein/antagonists & inhibitors ; Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Molybdenum cofactor biology, evolution and deficiency.
Autorzy :
Mayr SJ; Institute of Biochemistry, Department of Chemistry, Center for Molecular Medicine, University of Cologne, Zuelpicher Str. 47, 50674 Koeln, Germany.
Mendel RR; Institute of Plant Biology, Braunschweig University of Technology, Humboldtstr. 1, 38106 Braunschweig, Germany.
Schwarz G; Institute of Biochemistry, Department of Chemistry, Center for Molecular Medicine, University of Cologne, Zuelpicher Str. 47, 50674 Koeln, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Jan; Vol. 1868 (1), pp. 118883. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Coenzymes/*genetics
Eukaryota/*genetics
Metalloproteins/*genetics
Molybdenum/*metabolism
Coenzymes/biosynthesis ; Coenzymes/classification ; Gene Fusion/genetics ; Humans ; Metalloproteins/biosynthesis ; Metalloproteins/classification ; Pteridines/classification ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor.
Autorzy :
Oozeki T; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Nakai T; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.; Faculty of Life Sciences, Hiroshima Institute of Technology, Hiroshima, Japan.
Kozakai K; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Okamoto K; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Kuroda S; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Kobayashi K; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Tanizawa K; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Okajima T; Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 10; Vol. 12 (1), pp. 933. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Coenzymes/*metabolism
Dipeptides/*metabolism
Flavoproteins/*metabolism
Indolequinones/*metabolism
Mixed Function Oxygenases/*metabolism
Paracoccus denitrificans/*enzymology
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Catalysis ; Coenzymes/chemistry ; Dipeptides/chemistry ; Flavin-Adenine Dinucleotide/chemistry ; Flavin-Adenine Dinucleotide/metabolism ; Flavoproteins/chemistry ; Indolequinones/chemistry ; Mixed Function Oxygenases/chemistry ; Paracoccus denitrificans/chemistry ; Paracoccus denitrificans/genetics ; Paracoccus denitrificans/metabolism ; Tryptophan/chemistry ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
A second riboswitch class for the enzyme cofactor NAD .
Autorzy :
Panchapakesan SSS; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA.
Corey L; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA.
Malkowski SN; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8103, USA.
Higgs G; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA.
Breaker RR; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8103, USA.; Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520-8103, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Jan; Vol. 27 (1), pp. 99-105. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Riboswitch*
Bacterial Proteins/*genetics
Carrier Proteins/*genetics
Coenzymes/*chemistry
NAD/*chemistry
Niacinamide/*analogs & derivatives
Pyridinium Compounds/*chemistry
Streptococcus/*genetics
Bacterial Proteins/metabolism ; Base Sequence ; Binding Sites ; Carrier Proteins/metabolism ; Coenzymes/metabolism ; Computational Biology/methods ; Corynebacterium glutamicum/genetics ; Corynebacterium glutamicum/metabolism ; Haemophilus influenzae/genetics ; Haemophilus influenzae/metabolism ; Lactobacillus acidophilus/genetics ; Lactobacillus acidophilus/metabolism ; NAD/metabolism ; Niacinamide/chemistry ; Niacinamide/metabolism ; Nucleic Acid Conformation ; Protein Binding ; Pyridinium Compounds/metabolism ; Shewanella/genetics ; Shewanella/metabolism ; Streptococcus/metabolism
SCR Organism :
Shewanella woodyi
Czasopismo naukowe
Tytuł :
Identification and characterisation of the Volvox carteri Moco carrier protein.
Autorzy :
Hercher TW; TU Braunschweig, Institute of Plant Biology, Spielmannstrasse 7, 38106 Braunschweig, Germany.
Krausze J; TU Braunschweig, Institute of Plant Biology, Spielmannstrasse 7, 38106 Braunschweig, Germany.
Yang J; Department of Chemistry and Chemical Biology, The University of New Mexico, MSC03 2060, 1 University of New Mexico, Albuquerque, NM 87131-0001, U.S.A.
Kirk ML; Department of Chemistry and Chemical Biology, The University of New Mexico, MSC03 2060, 1 University of New Mexico, Albuquerque, NM 87131-0001, U.S.A.
Kruse T; TU Braunschweig, Institute of Plant Biology, Spielmannstrasse 7, 38106 Braunschweig, Germany.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Nov 27; Vol. 40 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*metabolism
Coenzymes/*metabolism
Metalloproteins/*metabolism
Plant Proteins/*metabolism
Pteridines/*metabolism
Volvox/*metabolism
Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Coenzymes/chemistry ; Coenzymes/genetics ; Metalloproteins/chemistry ; Metalloproteins/genetics ; Models, Molecular ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Pteridines/chemistry ; Structure-Activity Relationship ; Volvox/genetics
Czasopismo naukowe
Tytuł :
Multicopper oxidases: modular structure, sequence space, and evolutionary relationships.
Autorzy :
Gräff M; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Stuttgart, Germany.
Buchholz PCF; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Stuttgart, Germany.
Le Roes-Hill M; Applied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Bellville, South Africa.
Pleiss J; Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Stuttgart, Germany.
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Źródło :
Proteins [Proteins] 2020 Oct; Vol. 88 (10), pp. 1329-1339. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Azurin/*chemistry
Coenzymes/*chemistry
Copper/*chemistry
Fungal Proteins/*chemistry
Oxidoreductases/*chemistry
Amino Acid Sequence ; Azurin/metabolism ; Binding Sites ; Coenzymes/metabolism ; Copper/metabolism ; Data Mining ; Databases, Protein ; Evolution, Molecular ; Fungal Proteins/classification ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Fungi/chemistry ; Fungi/enzymology ; Models, Molecular ; Oxidation-Reduction ; Oxidoreductases/classification ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Oxygen/chemistry ; Oxygen/metabolism ; Protein Binding ; Protein Engineering ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Sequence Alignment ; Sequence Homology, Amino Acid ; Structure-Activity Relationship ; Substrate Specificity ; Water/chemistry ; Water/metabolism
Czasopismo naukowe
Tytuł :
Nanozymes: created by learning from nature.
Autorzy :
Zhang R; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Fan K; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. .; Joint Laboratory of Nanozymes in Zhengzhou University, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China. .
Yan X; CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. .; Joint Laboratory of Nanozymes in Zhengzhou University, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China. .
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Źródło :
Science China. Life sciences [Sci China Life Sci] 2020 Aug; Vol. 63 (8), pp. 1183-1200. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biomimetic Materials/*chemistry
Coenzymes/*chemistry
Coordination Complexes/*chemistry
Nanostructures/*chemistry
Biomimetic Materials/metabolism ; Catalysis ; Cations/chemistry ; Coenzymes/metabolism ; Hydrogen-Ion Concentration ; Models, Molecular ; Molecular Structure ; Nanotechnology ; Structure-Activity Relationship ; Surface Properties
Czasopismo naukowe
Tytuł :
Relevance of Essential Trace Elements in Nutrition and Drinking Water for Human Health and Autoimmune Disease Risk.
Autorzy :
Cannas D; Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, 09042 Cagliari, Italy.
Loi E; Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, 09042 Cagliari, Italy.
Serra M; Department of Civil, Environmental Engineering and Architecture, University of Cagliari, 09123 Cagliari, Italy.
Firinu D; Department of Medical Sciences and Public Health, Monserrato Campus, University of Cagliari, 09042 Cagliari, Italy.
Valera P; Department of Civil, Environmental Engineering and Architecture, University of Cagliari, 09123 Cagliari, Italy.
Zavattari P; Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, 09042 Cagliari, Italy.
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Źródło :
Nutrients [Nutrients] 2020 Jul 13; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antioxidants*
Coenzymes*
Food Analysis*
Immunity, Cellular*
Immunity, Humoral*
Nutrients*
Risk Assessment*
Trace Elements*/analysis
Trace Elements*/immunology
Trace Elements*/metabolism
Trace Elements*/toxicity
Autoimmune Diseases/*chemically induced
Drinking Water/*analysis
Animals ; Diabetes Mellitus, Type 1/chemically induced ; Humans ; Multiple Sclerosis/chemically induced ; Risk
Czasopismo naukowe
Tytuł :
Enzyme-Substrate-Cofactor Dynamical Networks Revealed by High-Resolution Field Cycling Relaxometry.
Autorzy :
Rosenberg MM; Department of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.
Yao T; Department of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.
Patton GC; Department of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.
Redfield AG; Department of Biochemistry, Brandeis University, MS009, 415 South Street, Waltham, Massachusetts 02453-9110, United States.
Roberts MF; Department of Chemistry, Boston College, 140 Commonwealth Avenue, Chestnut Hill, Massachusetts 02467-9110, United States.
Hedstrom L; Department of Biology, Brandeis University, MS009, 415 South St., Waltham, Massachusetts 02453-9110, United States.; Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453-3808, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Jun 30; Vol. 59 (25), pp. 2359-2370. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Coenzymes/*metabolism
GMP Reductase/*metabolism
NADP/*metabolism
Ammonia/metabolism ; Biocatalysis ; Coenzymes/chemistry ; GMP Reductase/genetics ; Guanosine Monophosphate/chemistry ; Humans ; Inosine Monophosphate/chemistry ; Kinetics ; Molecular Conformation ; Mutation ; NADP/chemistry ; Protein Binding
Czasopismo naukowe
Tytuł :
Molecular Characterization of Bacterial Fibrinolytic Proteins from Indonesian Traditional Fermented Foods.
Autorzy :
Purwaeni E; Laboratory of Pharmaceutical Biotechnology, School of Pharmacy, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia.
Riani C; Laboratory of Pharmaceutical Biotechnology, School of Pharmacy, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia.
Retnoningrum DS; Laboratory of Pharmaceutical Biotechnology, School of Pharmacy, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia. .
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Źródło :
The protein journal [Protein J] 2020 Jun; Vol. 39 (3), pp. 258-267.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*genetics
Coenzymes/*chemistry
Fermented Foods and Beverages/*analysis
Fibrinogen/*chemistry
Subtilisins/*genetics
Amino Acid Substitution ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Calcium/chemistry ; Calcium/metabolism ; Cations, Divalent ; Cations, Monovalent ; Cloning, Molecular ; Coenzymes/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fermented Foods and Beverages/microbiology ; Fibrinolysis ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Hydrogen-Ion Concentration ; Potassium/chemistry ; Potassium/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sodium/chemistry ; Sodium/metabolism ; Subtilisins/chemistry ; Subtilisins/metabolism ; Temperature
Czasopismo naukowe
Tytuł :
The biosynthesis of the molybdenum cofactors in Escherichia coli.
Autorzy :
Leimkühler S; Department of Molecular Enzymology, Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam, Germany.
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Źródło :
Environmental microbiology [Environ Microbiol] 2020 Jun; Vol. 22 (6), pp. 2007-2026. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Coenzymes/*biosynthesis
Escherichia coli/*metabolism
Metalloproteins/*biosynthesis
Coenzymes/chemistry ; Metalloproteins/chemistry ; Molybdenum/metabolism ; Organophosphorus Compounds ; Pteridines/chemistry ; Pterins/chemistry
Czasopismo naukowe
Tytuł :
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase.
Autorzy :
Knox HL; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.
Chen PY; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA.
Blaszczyk AJ; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.; Catalent Pharma Solutions, Gaithersburg, MD, USA.
Mukherjee A; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.
Grove TL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Schwalm EL; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.; Merck & Co., Inc., Rahway, NJ, USA.
Wang B; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.
Drennan CL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. .
Booker SJ; Department of Chemistry, Pennsylvania State University, University Park, PA, USA. .; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA. .; Howard Hughes Medical Institute, Pennsylvania State University, University Park, PA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Apr; Vol. 17 (4), pp. 485-491. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Methyltransferases/*metabolism
Methyltransferases/*ultrastructure
Arginine/chemistry ; Catalysis ; Coenzymes ; Iron-Sulfur Proteins/metabolism ; Methylation ; S-Adenosylmethionine ; Streptomycetaceae/genetics ; Streptomycetaceae/metabolism ; Thiostrepton/biosynthesis ; Tryptophan/metabolism ; Vitamin B 12/chemistry ; X-Ray Diffraction/methods
SCR Organism :
Kitasatospora setae
Czasopismo naukowe
Tytuł :
Cofactor-free oxidase-mimetic nanomaterials from self-assembled histidine-rich peptides.
Autorzy :
Liu Q; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China.
Wan K; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China.
Shang Y; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China.
Wang ZG; State Key Laboratory of Organic-Inorganic Composites, Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China. .
Zhang Y; Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China.
Dai L; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China.
Wang C; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China.; University of the Chinese Academy of Sciences, Beijing, People's Republic of China.
Wang H; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China. .
Shi X; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China.; University of the Chinese Academy of Sciences, Beijing, People's Republic of China.
Liu D; Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China.
Ding B; CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People's Republic of China. .; University of the Chinese Academy of Sciences, Beijing, People's Republic of China. .
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Źródło :
Nature materials [Nat Mater] 2021 Mar; Vol. 20 (3), pp. 395-402. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomimetic Materials/*chemistry
Nanostructures/*chemistry
Oxidoreductases/*chemistry
Peptides/*chemistry
Catalysis ; Circular Dichroism ; Coenzymes ; Crystallography, X-Ray ; Histidine/chemistry ; Horseradish Peroxidase/chemistry ; Horseradish Peroxidase/metabolism ; Hydrogen Peroxide/chemistry ; Models, Molecular ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Protein Conformation ; Quantitative Structure-Activity Relationship ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Cofactor Engineering Redirects Secondary Metabolism and Enhances Erythromycin Production in Saccharopolyspora erythraea .
Autorzy :
Li X; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.; National Food Institute, Technical University of Denmark, Kemitorvet Building 201, DK2800 Kongens Lyngby, Denmark.
Chen J; National Food Institute, Technical University of Denmark, Kemitorvet Building 201, DK2800 Kongens Lyngby, Denmark.
Andersen JM; National Food Institute, Technical University of Denmark, Kemitorvet Building 201, DK2800 Kongens Lyngby, Denmark.
Chu J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
Jensen PR; National Food Institute, Technical University of Denmark, Kemitorvet Building 201, DK2800 Kongens Lyngby, Denmark.
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Źródło :
ACS synthetic biology [ACS Synth Biol] 2020 Mar 20; Vol. 9 (3), pp. 655-670. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coenzymes/*genetics
Erythromycin/*biosynthesis
Metabolic Engineering/*methods
Saccharopolyspora/*genetics
Saccharopolyspora/*metabolism
Acetyl Coenzyme A/metabolism ; Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Coenzymes/metabolism ; Electron Transport ; Gene Expression Regulation, Bacterial ; Microorganisms, Genetically-Modified ; NAD/genetics ; NAD/metabolism ; Pigments, Biological/genetics ; Pigments, Biological/metabolism ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism ; Secondary Metabolism
Czasopismo naukowe
Tytuł :
Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1.
Autorzy :
Banchenko S; Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany; Institut für Chemie und Biochemie, Freie Universität Berlin, 14195 Berlin, Germany.
Arumughan A; Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany; Institut für Chemie und Biochemie, Freie Universität Berlin, 14195 Berlin, Germany.
Petrović S; Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany; Institut für Chemie und Biochemie, Freie Universität Berlin, 14195 Berlin, Germany.
Schwefel D; Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.
Wanker EE; Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany.
Roske Y; Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany. Electronic address: .
Heinemann U; Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany; Institut für Chemie und Biochemie, Freie Universität Berlin, 14195 Berlin, Germany. Electronic address: .
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Źródło :
Structure (London, England : 1993) [Structure] 2019 Dec 03; Vol. 27 (12), pp. 1830-1841.e3. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATPases Associated with Diverse Cellular Activities/*chemistry
Adenosine Triphosphatases/*chemistry
Arabidopsis/*genetics
Arabidopsis Proteins/*chemistry
Carrier Proteins/*chemistry
Cell Cycle Proteins/*chemistry
Coenzymes/*chemistry
Intracellular Signaling Peptides and Proteins/*chemistry
Nuclear Proteins/*chemistry
ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Amino Acid Motifs ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Binding Sites ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cloning, Molecular ; Coenzymes/genetics ; Coenzymes/metabolism ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Models, Molecular ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Stability ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Structural Homology, Protein ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Autorzy :
Steimle S; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
van Eeuwen T; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ozturk Y; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Biochemistry and Molecular Biology, Faculty of Medicine, Albert-Ludwigs University of Freiburg, Freiburg, Germany.
Kim HJ; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Braitbard M; School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Selamoglu N; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Garcia BA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Schneidman-Duhovny D; School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Murakami K; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
Daldal F; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 10; Vol. 12 (1), pp. 929. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Electron Transport Complex III/*chemistry
Electron Transport Complex III/*metabolism
Electron Transport Complex IV/*chemistry
Electron Transport Complex IV/*metabolism
Rhodobacter capsulatus/*enzymology
Bacterial Proteins/genetics ; Catalytic Domain ; Coenzymes/chemistry ; Coenzymes/metabolism ; Cryoelectron Microscopy ; Electron Transport ; Electron Transport Complex III/genetics ; Electron Transport Complex IV/genetics ; Genetic Engineering ; Rhodobacter capsulatus/chemistry ; Rhodobacter capsulatus/genetics ; Rhodobacter capsulatus/metabolism
Czasopismo naukowe
Tytuł :
Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism.
Autorzy :
Han Y; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Zhuang Q; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.
Sun B; Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China.
Lv W; Warshel Institute for Computational Biology, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Wang S; Tencent AI lab, Shenzhen, Guangdong, 518000, China.
Xiao Q; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, 610041, China.
Pang B; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Zhou Y; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Wang F; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Chi P; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, 610041, China.
Wang Q; Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China.
Li Z; School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Zhu L; Warshel Institute for Computational Biology, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.
Li F; Human Sperm Bank, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, West China Second Hospital, Sichuan University, Chengdu, 610041, China.
Deng D; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, 610041, China. .
Chiang YC; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China. .
Li Z; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China. .
Ren R; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 19; Vol. 12 (1), pp. 449. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*ultrastructure
Bacterial Proteins/*ultrastructure
Steroids/*metabolism
3-Oxo-5-alpha-Steroid 4-Dehydrogenase/chemistry ; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/metabolism ; 5-alpha Reductase Inhibitors/pharmacology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Binding Sites ; Coenzymes/chemistry ; Coenzymes/metabolism ; Coenzymes/ultrastructure ; Crystallography, X-Ray ; Drug Design ; Hydrogen Bonding ; NADP/chemistry ; NADP/metabolism ; NADP/ultrastructure ; Oxidation-Reduction ; Proteobacteria/enzymology ; Structure-Activity Relationship
Czasopismo naukowe

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