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Tytuł :
Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food
Autorzy :
Cohen, SM
Eisenbrand, G
Fukushima, S
Gooderham, NJ
Guengerich, FP
Hecht, SS
Rietjens, IMCM
Davidsen, JM
Harman, CL
Taylor, SV
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Temat :
Toxicology
Complex mixtures
Botanicals
0908 Food Sciences
Flavoring
Threshold of toxicological concern
Food Science
GRAS
Food
Źródło :
Food and Chemical Toxicology, 113, 171 - 178
Opis pliku :
application/octet-stream
Tytuł :
Bayesian benchmark dose analysis for inorganic arsenic in drinking water associated with bladder and lung cancer using epidemiological data.
Autorzy :
Shao K; Department of Environmental and Occupational Health, School of Public Health - Bloomington, Indiana University, Bloomington, IN, 47405, USA.
Zhou Z; Department of Environmental and Occupational Health, School of Public Health - Bloomington, Indiana University, Bloomington, IN, 47405, USA.
Xun P; Department of Epidemiology and Biostatistics, School of Public Health - Bloomington, Indiana University, Bloomington, IN, 47405, USA.
Cohen SM; Department of Pathology and Microbiology and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 May 15; Vol. 455, pp. 152752. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array.
Autorzy :
Yagel S; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: .
Cohen SM; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Goldman-Wohl D; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2021 Mar 09. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential.
Autorzy :
Jaeschke H; University of Kansas Medical Center, Department of Pharmacology, Toxicology & Therapeutics, Kansas City, KS, USA.
Murray FJ; Murray & Associates, San Jose, CA, USA.
Monnot AD; Cardno ChemRisk, San Fransisco, CA, USA.
Jacobson-Kram D; ToxRox Consulting, McLean, VA, USA.
Cohen SM; University of Nebraska Medical Center, Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, Omaha, NE, USA.
Hardisty JF; Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA.
Atillasoy E; Johnson & Johnson Consumer Health, Fort Washington, PA, USA.
Hermanowski-Vosatka A; Johnson & Johnson Consumer Health, Fort Washington, PA, USA.
Kuffner E; Johnson & Johnson Consumer Health, Fort Washington, PA, USA.
Wikoff D; ToxStrategies, Asheville, NC, USA.
Chappell GA; ToxStrategies, Asheville, NC, USA.
Bandara SB; Cardno ChemRisk, San Fransisco, CA, USA.
Deore M; Johnson & Johnson Consumer Products, India.
Pitchaiyan SK; Johnson & Johnson Consumer Products, India.
Eichenbaum G; Johnson & Johnson, New Brunswick, NJ, USA. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Mar; Vol. 120, pp. 104859. Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Preliminary preclinical study of Chol-DsiRNA polyplexes formed with PLL[30]-PEG[5K] for the RNAi-based therapy of breast cancer.
Autorzy :
Ye Z; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Abdelmoaty MM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA; Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt.
Ambardekar VV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Curran SM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Dyavar SR; Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Arnold LL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Cohen SM; Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Kumar D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Alnouti Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Coulter DW; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Department of Radiation Oncology, J. Bruce Henriksen Cancer Research Laboratories, University of Nebraska Medical Center, Omaha, NE, USA.
Singh RK; Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Vetro JA; Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: .
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Źródło :
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2021 Feb 03; Vol. 33, pp. 102363. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.
Autorzy :
Suzuki S; Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Osaka 545-8585, Japan; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan. Electronic address: .
Cohen SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA; Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE, 68198-3135, USA.
Arnold LL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA.
Pennington KL; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198- 6849, USA.
Gi M; Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Osaka 545-8585, Japan.
Kato H; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.
Naiki T; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.
Naiki-Ito A; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.
Wanibuchi H; Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Osaka 545-8585, Japan.
Takahashi S; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jan 01; Vol. 336, pp. 32-38. Date of Electronic Publication: 2020 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Nicotine*
Acetophenones/*pharmacology
Cell Proliferation/*drug effects
Enzyme Inhibitors/*pharmacology
NADPH Oxidases/*antagonists & inhibitors
Urinary Bladder/*drug effects
Urinary Bladder Neoplasms/*prevention & control
Urothelium/*drug effects
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Hyperplasia ; Male ; NADPH Oxidases/metabolism ; Oxidative Stress/drug effects ; Rats, Inbred F344 ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Urinary Bladder/enzymology ; Urinary Bladder/ultrastructure ; Urinary Bladder Neoplasms/chemically induced ; Urinary Bladder Neoplasms/enzymology ; Urinary Bladder Neoplasms/ultrastructure ; Urothelium/enzymology ; Urothelium/ultrastructure
Czasopismo naukowe
Tytuł :
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential.
Autorzy :
Murray FJ; Murray & Associates, San Jose, CA, USA.
Monnot AD; Cardno ChemRisk, San Francisco, CA, USA.
Jacobson-Kram D; ToxRox Consulting, McLean, VA, USA.
Cohen SM; Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Hardisty JF; Experimental Pathology Laboratories, Inc., Durham, NC, USA.
Bandara SB; Cardno ChemRisk, San Francisco, CA, USA.
Kovochich M; Cardno ChemRisk, Chicago, IL, USA.
Deore M; Johnson & Johnson Consumer, India.
Pitchaiyan SK; Johnson & Johnson Consumer, India.
Gelotte CK; Johnson & Johnson Consumer Products, USA.
Lai JCK; Johnson & Johnson Consumer Products, USA.
Atillasoy E; Johnson & Johnson Consumer Products, USA.
Hermanowski-Vosatka A; Johnson & Johnson Consumer Products, USA.
Kuffner E; Johnson & Johnson Consumer Products, USA.
Unice KM; Cardno ChemRisk, Pittsburgh, PA, USA.
Yang K; DILIsym Services Inc., Research Triangle Park, NC, USA.
Gebremichael Y; DILIsym Services Inc., Research Triangle Park, NC, USA.
Howell BA; DILIsym Services Inc., Research Triangle Park, NC, USA.
Eichenbaum G; Johnson & Johnson, New Brunswick, NJ, USA. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Dec; Vol. 118, pp. 104801. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Real-time data analysis using a machine learning model significantly improves prediction of successful vaginal deliveries.
Autorzy :
Guedalia J; The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Lipschuetz M; The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Novoselsky-Persky M; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Cohen SM; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Rottenstreich A; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Levin G; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Yagel S; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Electronic address: .
Unger R; The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Sompolinsky Y; Division of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
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Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2020 Sep; Vol. 223 (3), pp. 437.e1-437.e15. Date of Electronic Publication: 2020 May 17.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Delivery, Obstetric*
Machine Learning*
Models, Theoretical*
Prenatal Diagnosis*
Electronic Health Records ; Female ; Humans ; Predictive Value of Tests ; Pregnancy ; Trial of Labor
Czasopismo naukowe
Tytuł :
Probing the mechanisms of inhibition for various inhibitors of metallo-β-lactamases VIM-2 and NDM-1.
Autorzy :
Thomas CA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Cheng Z; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Yang K; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Hellwarth E; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Yurkiewicz CJ; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Baxter FM; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Fullington SA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Klinsky SA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Otto JL; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America.
Chen AY; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, United States of America.
Cohen SM; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, United States of America.
Crowder MW; Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America. Electronic address: .
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Źródło :
Journal of inorganic biochemistry [J Inorg Biochem] 2020 Sep; Vol. 210, pp. 111123. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Prediction of vaginal birth after cesarean deliveries using machine learning.
Autorzy :
Lipschuetz M; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Guedalia J; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Rottenstreich A; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Novoselsky Persky M; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Cohen SM; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Kabiri D; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Levin G; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Yagel S; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: .
Unger R; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Sompolinsky Y; Obstetrics & Gynecology Division, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2020 Jun; Vol. 222 (6), pp. 613.e1-613.e12. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Machine Learning*
Trial of Labor*
Cesarean Section/*statistics & numerical data
Vaginal Birth after Cesarean/*statistics & numerical data
Adult ; Apgar Score ; Area Under Curve ; Delivery, Obstetric ; Extraction, Obstetrical/statistics & numerical data ; Feasibility Studies ; Female ; Fetal Weight ; Gestational Age ; Head/anatomy & histology ; Humans ; Infant, Newborn ; Male ; Organ Size ; Parity ; Pregnancy ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Tertiary Care Centers ; Uterine Rupture/epidemiology
Czasopismo naukowe
Tytuł :
Cell proliferation analysis is a reliable predictor of lack of carcinogenicity: Case study using the pyrethroid imiprothrin on lung tumorigenesis in mice.
Autorzy :
Kawamoto K; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Ogata K; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Asano H; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Miyata K; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Sukata T; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Utsumi T; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Cohen SM; Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Omaha, Nebraska, 68198-3135, USA.
Yamada T; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jun; Vol. 113, pp. 104646. Date of Electronic Publication: 2020 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogens/*administration & dosage
Lung Neoplasms/*pathology
Pyrethrins/*administration & dosage
Administration, Oral ; Animals ; Carcinogenicity Tests ; Cell Proliferation ; Male ; Mice ; Mice, Inbred ICR
Czasopismo naukowe
Tytuł :
Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo.
Autorzy :
Suzuki S; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan; Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. Electronic address: .
Cohen SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA; Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA.
Arnold LL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA.
Pennington KL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA.
Kato H; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.
Naiki T; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.
Naiki-Ito A; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.
Yamashita Y; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.
Takahashi S; Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.
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Źródło :
Toxicology [Toxicology] 2020 Jan 15; Vol. 429, pp. 152325. Date of Electronic Publication: 2019 Nov 01.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*drug effects
Cotinine/*toxicity
Nicotine/*toxicity
Urothelium/*drug effects
Animals ; Apoptosis/drug effects ; Carcinogenesis/chemically induced ; Cell Line, Tumor ; Cotinine/analogs & derivatives ; Humans ; Male ; Nicotine/metabolism ; Nitrosamines/toxicity ; Rats ; Rats, Inbred F344 ; Urinary Bladder/drug effects ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/chemically induced ; Urinary Bladder Neoplasms/pathology ; Urothelium/cytology
Czasopismo naukowe
Tytuł :
Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice.
Autorzy :
Yamada T; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan. Electronic address: .
Asano H; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Miyata K; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Rhomberg LR; Gradient, 20 University Road, Cambridge, MA, 02138, USA.
Haseman JK; J.K. Haseman Consulting, Raleigh, NC, USA.
Greaves P; Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
Greim H; Technical University of Munich, Munich, Germany.
Berry C; Queen Mary University of London, Mile End Rd, London, E1 4NS, UK.
Cohen SM; Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Omaha, NE, 68198-3135, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jul; Vol. 105, pp. 1-14. Date of Electronic Publication: 2019 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*chemically induced
Adenoma/*chemically induced
Lung Neoplasms/*chemically induced
Pesticides/*toxicity
Pyrethrins/*toxicity
Adenocarcinoma/epidemiology ; Adenoma/epidemiology ; Animals ; Carcinogenicity Tests/methods ; Diet ; Dose-Response Relationship, Drug ; Female ; Lung Neoplasms/epidemiology ; Male ; Maximum Tolerated Dose ; Mice ; Mice, Inbred ICR ; Pyrethrins/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Sex Factors ; Species Specificity
Czasopismo naukowe
Tytuł :
Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans.
Autorzy :
Cohen SM; Department of Pathology and Microbiology, Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE, 68198-3135, USA.
Boobis AR; Centre for Pharmacology & Therapeutics, Toxicology Unit, Department of Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN, UK.
Dellarco VL; Independent Consultant, Silver Spring, MD, 20901, USA.
Doe JE; Parker Doe LLP, Carpenter Court, Maple Road, Bramhall, Stockport, Cheshire, SK7 2DH, UK. Electronic address: .
Fenner-Crisp PA; Independent Consultant, North Garden, VA, 22959, USA.
Moretto A; Dipartimento di Scienze Biochimiche e Cliniche, Università degli Studi di Milano, Milan, Italy.
Pastoor TP; Pastoor Science Communication, LLC, Greensboro, NC, 27455, USA.
Schoeny RS; Rita Schoeny LLC, Washington DC, 20002, USA.
Seed JG; Independent Consultant, Alexandria, VA, 22301, USA.
Wolf DC; Syngenta Crop Protection, LLC, Greensboro, NC, 27419, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Apr; Vol. 103, pp. 100-105. Date of Electronic Publication: 2019 Jan 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinogenicity Tests*
Carcinogenesis/*chemically induced
Carcinogens/*chemistry
Humans ; Risk Assessment
Czasopismo naukowe
Tytuł :
Chemical carcinogenicity revisited 1: A unified theory of carcinogenicity based on contemporary knowledge.
Autorzy :
Wolf DC; Syngenta Crop Protection LLC, Greensboro, NC, 27419, USA.
Cohen SM; Department of Pathology and Microbiology, Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE, 68198-3135, USA.
Boobis AR; Centre for Pharmacology & Therapeutics, Toxicology Unit, Department of Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN, UK.
Dellarco VL; Independent Consultant, Silver Spring, MD, 20901, USA.
Fenner-Crisp PA; Independent Consultant, North Garden, VA, 22959, USA.
Moretto A; Dipartimento di Scienze Biochimiche e Cliniche (Department of Biomedical and Clinical Sciences), Università degli Studi di Milano, Milan, Italy.
Pastoor TP; Pastoor Science Communication, LLC, Greensboro, NC, 27455, USA.
Schoeny RS; Rita Schoeny LLC, Washington DC, 20002, USA.
Seed JG; Independent Consultant, Alexandria, VA, 22301, USA.
Doe JE; Parker Doe LLP, Carpenter Court, Maple Road, Bramhall, Stockport, Cheshire, SK7 2DH, UK. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Apr; Vol. 103, pp. 86-92. Date of Electronic Publication: 2019 Jan 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinogenicity Tests*
Carcinogens/*chemistry
Carcinogens/*pharmacology
Neoplasms/*chemically induced
Animals ; DNA, Neoplasm/drug effects ; Humans
Czasopismo naukowe
Tytuł :
Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action.
Autorzy :
Hard GC; Independent Consultant, Tairua, New Zealand.
Cohen SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-3135, USA; Havlik-Wall Professor of Oncology, USA. Electronic address: .
Ma J; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198-4375, USA.
Yu F; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, 68198-4375, USA.
Arnold LL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-3135, USA.
Banton MI; LyondellBasell, Houston, TX, 77010, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Mar; Vol. 102, pp. 65-73. Date of Electronic Publication: 2018 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Alpha-Globulins/*metabolism
Kidney/*drug effects
Kidney Diseases/*chemically induced
tert-Butyl Alcohol/*toxicity
Animals ; Carcinogenicity Tests ; Female ; Hyperplasia/chemically induced ; Hyperplasia/pathology ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Male ; Rats, Inbred F344 ; Risk Assessment ; Toxicity Tests, Subchronic
Czasopismo naukowe
Tytuł :
Editorial.
Autorzy :
Aschner M; Department of Molecular Pharmacology Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY, USA. Electronic address: .
Autrup HN; Institute of Public Health, University of Aarhus, Aarhus, Denmark. Electronic address: .
Cohen SM; Department of Pathology and Microbiology University of Nebraska Medical Center Omaha, NE; USA. Electronic address: .
Dekant W; Department of Toxicology University of Wuerzburg Wuerzburg, Germany. Electronic address: .
Eisenbrand G; Food Chemistry & Toxicology University of Heildelberg Heildelberg, Germany. Electronic address: .
Galli CL; Toxicology and Risk Assessment Pharmacological and Biomolecular Sciences University of Milan. Milan, Italy. Electronic address: .
Gori GB; The Health Policy Center Editor, Regulatory Toxicology and Pharmacology Bethesda, MD, USA. Electronic address: .
Kaminski NE; Pharmacology & Toxicology Director, Institute for Integrative Toxicology Michigan State University, East Lansing, MI, USA. Electronic address: .
Klaassen CD; Department of Pharmacology and Toxicology School of Medicine, University of Kansas Kansas City, Kansas, USA. Electronic address: .
Klaunig JE; Department of Environmental Health University of Indiana, Ellettsville, IN, USA. Electronic address: .
Levy L; Institute of Environment and Health Cranfield University, Cranfield, UK. Electronic address: .
Lotti M; Department of Cardiology, Thoracic and Vascular Sciences, School of Medicine, University of Padua, Padua, Italy. Electronic address: .
Marquardt HW; Experimental and Clinical Toxicology University of Hamburg Medical School Hambug, Germany. Electronic address: .
Pelkonen O; Department of Pharmacology and Toxicology Faculty of Medicine University of Oulu, Oulu, Finland. Electronic address: .
Schrenk DF; University of Kaiserslautern Kaiserslautern Germany. Electronic address: .
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics Showa Pharmaceutical University Machida, Tokyo, Japan. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Feb; Vol. 101, pp. A1-A2.
Typ publikacji :
Editorial
MeSH Terms :
Academies and Institutes/*organization & administration
Advisory Committees/*ethics
Advisory Committees/*organization & administration
Conflict of Interest ; Germany ; Humans
Opinia redakcyjna
Tytuł :
Concordance Between Proxy Level of Care Preference and Advance Directives Among Nursing Home Residents With Advanced Dementia: A Cluster Randomized Clinical Trial.
Autorzy :
Cohen SM; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA.
Volandes AE; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Shaffer ML; Department of Statistics, University of Washington, Seattle, Washington, USA.
Hanson LC; Division of Geriatric Medicine, Cecil G. Sheps Center for Health Services Research and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Habtemariam D; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA.
Mitchell SL; Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Electronic address: .
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Źródło :
Journal of pain and symptom management [J Pain Symptom Manage] 2019 Jan; Vol. 57 (1), pp. 37-46.e1. Date of Electronic Publication: 2018 Sep 29.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Advance Directives*
Nursing Homes*
Dementia/*therapy
Proxy/*psychology
Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Patient Comfort ; Terminal Care
Czasopismo naukowe
Tytuł :
Obfuscating transparency?
Autorzy :
Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: .
Autrup H; Institute of Public Health, University of Aarhus, Aarhus, Denmark. Electronic address: .
Berry CL; Emeritus of Pathology, Queen Mary, London, UK. Electronic address: .
Boobis AR; Department of Medicine, Imperial College London, London, UK. Electronic address: .
Cohen SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: .
Dekant W; Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany. Electronic address: .
Galli CL; Toxicology and Risk Assessment, Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy. Electronic address: .
Goodman JI; Pharmacology & Toxicology Department, Michigan State University East Lansing, MI, USA. Electronic address: .
Gori GB; The Health Policy Center, Editor, Regulatory Toxicology and Pharmacology, Bethesda, MD, USA. Electronic address: .
Greim HA; Technical University of Munich, Munich, Germany. Electronic address: .
Kaminski NE; Pharmacology & Toxicology, Director, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA. Electronic address: .
Klaassen CD; Department of Pharmacology, Toxicology and Therapeutics, College of Medicine, University of Kansas, Kansas City, KS, USA. Electronic address: .
Klaunig JE; Department of Environmental Health, School of Public Health, Indiana University Bloomington, IN, USA. Electronic address: .
Lotti M; Department of Cardiology, Thoracic and Vascular Sciences, School of Medicine, University of Padua, Padua, Italy. Electronic address: .
Marquardt HW; Experimental and Clinical Toxicology, University of Hamburg Medical School, Hambug, Germany. Electronic address: .
Moretto A; Department of, Biomedical and Clinical Sciences, University of Milan, Milan, Italy. Electronic address: .
Pelkonen O; Pharmacology and Toxicology, University of Oulu, Oulu, Finland. Electronic address: .
Sipes IG; Pharmacology, University of Arizona, Tucson, AZ, USA. Electronic address: .
Wallace KB; Biochemistry & Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA. Electronic address: .
Yamazaki H; The Japanese Society for the Study of Xenobiotics, Showa Pharmaceutical University, Machida, Tokyo, Japan. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2018 Aug; Vol. 97, pp. A1-A3. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Editorial
MeSH Terms :
Policy Making*
Government Agencies/*organization & administration
Animals ; Humans ; United States ; United States Environmental Protection Agency
Opinia redakcyjna
Tytuł :
Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer.
Autorzy :
Qi B; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE.
Crawford AJ; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.
Wojtynek NE; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.
Holmes MB; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE.
Souchek JJ; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE.
Almeida-Porada G; Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC.
Ly QP; Department of Surgery, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE.
Cohen SM; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE.
Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE.
Mohs AM; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE. Electronic address: .
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Źródło :
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2018 Apr; Vol. 14 (3), pp. 769-780. Date of Electronic Publication: 2018 Jan 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyaluronic Acid/*chemistry
Indocyanine Green/*administration & dosage
Nanoparticles/*administration & dosage
Optical Imaging/*methods
Pancreatic Neoplasms/*pathology
Pancreatic Neoplasms/*surgery
Surgery, Computer-Assisted/*methods
Animals ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Chemotaxis ; Disease Models, Animal ; Female ; Fluorescence ; Indocyanine Green/metabolism ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence ; Nanoparticles/metabolism ; Pancreatic Neoplasms/diagnostic imaging ; Phagocytosis ; Tumor Cells, Cultured
Czasopismo naukowe

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