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Tytuł :
A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate.
Autorzy :
Aw SS; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore. Electronic address: .
Lim IKH; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Tang MXM; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Cohen SM; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2017 May 30; Vol. 19 (9), pp. 1783-1793.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila melanogaster/*genetics
Glutamic Acid/*toxicity
MicroRNAs/*metabolism
Neuroglia/*metabolism
Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Cell Death/drug effects ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Drosophila melanogaster/metabolism ; Female ; Glutamates/metabolism ; Membrane Potentials/drug effects ; MicroRNAs/genetics ; Movement ; Mutation/genetics ; Neuroglia/drug effects ; Neuroglia/pathology ; Phenotype ; Receptors, Glutamate/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain.
Autorzy :
Foo LC; Institute of Molecular and Cell Biology, Singapore City, Singapore .
Song S; Institute of Molecular and Cell Biology, Singapore City, Singapore.
Cohen SM; Institute of Molecular and Cell Biology, Singapore City, Singapore .
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Źródło :
The EMBO journal [EMBO J] 2017 May 02; Vol. 36 (9), pp. 1215-1226. Date of Electronic Publication: 2017 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis*
Brain/*cytology
Drosophila/*physiology
MicroRNAs/*metabolism
Neuroglia/*physiology
Animals ; MicroRNAs/genetics ; Mutation
Czasopismo naukowe
Tytuł :
A conformation-induced fluorescence method for microRNA detection.
Autorzy :
Aw SS; Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore .
Tang MX; Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore.
Teo YN; Molecular Engineering Laboratory, Biomolecular Sciences Institutes, A*STAR, 61 Biopolis Drive, 138673, Singapore Division of Chemistry and Biological Chemistry, SPMS, Nanyang Technological University, 637371, Singapore .
Cohen SM; Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore Department of Cellular and Molecular Medicine,University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2016 Jun 02; Vol. 44 (10), pp. e92. Date of Electronic Publication: 2016 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aptamers, Nucleotide/*chemistry
Biosensing Techniques/*methods
MicroRNAs/*analysis
Benzyl Compounds/metabolism ; Fluorescence ; Fluorescent Dyes ; Imidazolines/metabolism ; MicroRNAs/chemistry ; Nucleic Acid Conformation
Czasopismo naukowe
Tytuł :
Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA.
Autorzy :
Weng R; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Cohen SM; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark .
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Źródło :
Development (Cambridge, England) [Development] 2015 Nov 01; Vol. 142 (21), pp. 3713-20. Date of Electronic Publication: 2015 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila/*cytology
Drosophila/*physiology
MicroRNAs/*metabolism
Animals ; Brain/cytology ; Brain/metabolism ; Cell Lineage ; Cell Proliferation ; DNA-Binding Proteins/metabolism ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila Proteins/metabolism ; Larva/metabolism ; Nerve Tissue Proteins/metabolism ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen.
Autorzy :
Verma P; Institute of Molecular and Cell Biology, Singapore, Singapore.
Cohen SM; Institute of Molecular and Cell Biology, Singapore, Singapore.
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Źródło :
ELife [Elife] 2015 Jul 30; Vol. 4. Date of Electronic Publication: 2015 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Cell Proliferation*
Gene Expression Regulation*
Morphogenesis*
Abdomen/*embryology
Drosophila/*embryology
MicroRNAs/*metabolism
Animals ; Cell Cycle Proteins/metabolism ; Drosophila Proteins/metabolism ; Protein Tyrosine Phosphatases/metabolism ; Wnt1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA.
Autorzy :
Ge W; Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China 310058 .
Deng Q; Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China 310058.
Guo T; Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China 310058.
Hong X; Institute of Molecular and Cell Biology, Singapore 138673.
Kugler JM; Institute of Molecular and Cell Biology, Singapore 138673.
Yang X; Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China 310058.
Cohen SM; Institute of Molecular and Cell Biology, Singapore 138673 Department of Biological Sciences, National University of Singapore, Singapore 117543.
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Źródło :
Genetics [Genetics] 2015 May; Vol. 200 (1), pp. 255-65. Date of Electronic Publication: 2015 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Body Patterning*
Gene Amplification*
Oogenesis*
Drosophila melanogaster/*genetics
MicroRNAs/*genetics
Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/embryology ; Drosophila melanogaster/metabolism ; Female ; Gene Expression Regulation, Developmental ; Mutation ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity.
Autorzy :
Verma P; 1] Institute of Molecular and Cell Biology, Singapore. [2] Department of Biological Sciences, National University of Singapore, Singapore.
Augustine GJ; 1] Institute of Molecular and Cell Biology, Singapore. [2] Duke-NUS Graduate Medical School, Singapore. [3] Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Republic of Korea. [4] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Ammar MR; 1] Warwick-Nanyang Technological University Neuroscience Programme, School of Biological Sciences, Nanyang Technological University, Singapore. [2] School of Life Sciences, University of Warwick, Coventry, UK.
Tashiro A; 1] Warwick-Nanyang Technological University Neuroscience Programme, School of Biological Sciences, Nanyang Technological University, Singapore. [2] School of Life Sciences, University of Warwick, Coventry, UK.
Cohen SM; 1] Institute of Molecular and Cell Biology, Singapore. [2] Department of Biological Sciences, National University of Singapore, Singapore.
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Źródło :
Nature neuroscience [Nat Neurosci] 2015 Mar; Vol. 18 (3), pp. 379-85. Date of Electronic Publication: 2015 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental/*genetics
MicroRNAs/*metabolism
Neurodegenerative Diseases/*prevention & control
Age Factors ; Aging/genetics ; Animals ; Animals, Genetically Modified ; Cells, Cultured ; Drosophila ; Drosophila Proteins/genetics ; Embryo, Mammalian ; Embryo, Nonmammalian ; Female ; Gene Deletion ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Neurodegenerative Diseases/genetics ; Synaptic Transmission/drug effects ; Synaptic Transmission/genetics ; Vesicular Glutamate Transport Protein 2/genetics ; Vesicular Glutamate Transport Protein 2/metabolism
Czasopismo naukowe
Tytuł :
Systematic study of Drosophila microRNA functions using a collection of targeted knockout mutations.
Autorzy :
Chen YW; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Song S; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Weng R; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Verma P; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Kugler JM; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Buescher M; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Rouam S; Procter and Gamble International Operations SA Singapore Branch, Quantitative Sciences, Statistics Asia, 70 Biopolis Street, Singapore 138547, Singapore.
Cohen SM; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2014 Dec 22; Vol. 31 (6), pp. 784-800.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Drosophila/*genetics
MicroRNAs/*genetics
Alleles ; Animals ; Computational Biology ; Drosophila melanogaster/genetics ; Female ; Genetic Vectors ; Male ; MicroRNAs/metabolism ; Multigene Family ; Phenotype ; Recombination, Genetic
Czasopismo naukowe
Tytuł :
Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut.
Autorzy :
Foronda D; Institute of Molecular and Cell Biology, Singapore 138673, Singapore;
Weng R; Institute of Molecular and Cell Biology, Singapore 138673, Singapore;
Verma P; Institute of Molecular and Cell Biology, Singapore 138673, Singapore;
Chen YW; Institute of Molecular and Cell Biology, Singapore 138673, Singapore;
Cohen SM; Institute of Molecular and Cell Biology, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore .
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Źródło :
Genes & development [Genes Dev] 2014 Nov 01; Vol. 28 (21), pp. 2421-31.
Typ publikacji :
Journal Article
MeSH Terms :
Drosophila/*physiology
Drosophila Proteins/*metabolism
Homeostasis/*genetics
Insulin/*metabolism
Intestinal Mucosa/*metabolism
MicroRNAs/*metabolism
Receptors, Notch/*metabolism
Stem Cells/*cytology
Animal Nutritional Physiological Phenomena ; Animals ; Cell Differentiation ; Cell Proliferation ; Drosophila/cytology ; Drosophila/genetics ; Drosophila/metabolism ; Gene Expression Regulation ; Gene Knockout Techniques ; MicroRNAs/genetics ; Signal Transduction ; Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
miRNAs and aging: a genetic perspective.
Autorzy :
Garg D; Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
Cohen SM; Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2014 Sep; Vol. 17, pp. 3-8. Date of Electronic Publication: 2014 Apr 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging/*metabolism
Caenorhabditis elegans/*metabolism
Drosophila/*metabolism
MicroRNAs/*metabolism
Aging/genetics ; Animals ; Caenorhabditis elegans/genetics ; Drosophila/genetics ; MicroRNAs/genetics
Czasopismo naukowe
Tytuł :
Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster.
Autorzy :
Kugler JM; Institute of Molecular and Cell Biology, Singapore 138673, Republic of Singapore.
Chen YW
Weng R
Cohen SM
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2013 Sep 04; Vol. 3 (9), pp. 1573-6. Date of Electronic Publication: 2013 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila melanogaster/*genetics
Germ Cells/*cytology
MicroRNAs/*genetics
Animals ; Drosophila melanogaster/growth & development ; Embryo, Nonmammalian/metabolism ; Female ; Genotype ; MicroRNAs/metabolism ; Mutation ; Phenotype
Czasopismo naukowe
Tytuł :
miR-989 is required for border cell migration in the Drosophila ovary.
Autorzy :
Kugler JM; Institute of Molecular and Cell Biology, Singapore, Singapore.
Verma P
Chen YW
Weng R
Cohen SM
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Źródło :
PloS one [PLoS One] 2013 Jul 03; Vol. 8 (7), pp. e67075. Date of Electronic Publication: 2013 Jul 03 (Print Publication: 2013).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement/*genetics
Drosophila/*genetics
Drosophila/*metabolism
MicroRNAs/*genetics
Ovary/*metabolism
Animals ; Animals, Genetically Modified ; Female ; Gene Expression ; Gene Expression Regulation, Developmental ; Morphogenesis/genetics ; Mutation ; Oogenesis/genetics ; Phenotype
Czasopismo naukowe
Tytuł :
miR-124 controls male reproductive success in Drosophila.
Autorzy :
Weng R; Institute for Molecular and Cell Biology , Singapore , Singapore ; Department of Biological Sciences , National University of Singapore , Singapore , Singapore.
Chin JS
Yew JY
Bushati N
Cohen SM
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Źródło :
ELife [Elife] 2013 Jun 11; Vol. 2, pp. e00640. Date of Electronic Publication: 2013 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs/*physiology
Reproduction/*physiology
Animals ; Female ; Male ; MicroRNAs/genetics ; Mutation ; Reproduction/genetics ; Sex Attractants/biosynthesis ; Sexual Behavior, Animal
Czasopismo naukowe
Tytuł :
The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs.
Autorzy :
Vodala S; Howard Hughes Medical Institute, National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454, USA.
Pescatore S
Rodriguez J
Buescher M
Chen YW
Weng R
Cohen SM
Rosbash M
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Źródło :
Cell metabolism [Cell Metab] 2012 Nov 07; Vol. 16 (5), pp. 601-12. Date of Electronic Publication: 2012 Nov 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drosophila melanogaster/*metabolism
MicroRNAs/*metabolism
Animals ; Circadian Clocks/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Eating ; Gene Expression Regulation ; Gene Knock-In Techniques ; Gene Knockout Techniques ; Immunity, Innate ; MicroRNAs/genetics ; Multigene Family ; RNA, Messenger/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Time is of the essence: microRNAs and age-associated neurodegeneration.
Autorzy :
Aw S; Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673.
Cohen SM
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Źródło :
Cell research [Cell Res] 2012 Aug; Vol. 22 (8), pp. 1218-20. Date of Electronic Publication: 2012 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*
Gene Expression Regulation, Developmental*
Brain/*pathology
Drosophila/*metabolism
Drosophila Proteins/*metabolism
MicroRNAs/*metabolism
Neurodegenerative Diseases/*metabolism
Animals ; Behavior, Animal/physiology ; Brain/metabolism ; Cellular Senescence ; Drosophila/genetics ; Drosophila Proteins/genetics ; MicroRNAs/genetics ; Neurodegenerative Diseases/genetics ; Risk Factors ; Time Factors ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.
Autorzy :
Ge W; Institute of Molecular Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore.
Chen YW
Weng R
Lim SF
Buescher M
Zhang R
Cohen SM
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Źródło :
Cell death and differentiation [Cell Death Differ] 2012 May; Vol. 19 (5), pp. 839-46. Date of Electronic Publication: 2011 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Drosophila/*embryology
Embryonic Development/*physiology
MicroRNAs/*genetics
Animals ; Animals, Genetically Modified ; Apoptosis/genetics ; Central Nervous System/embryology ; Central Nervous System/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Embryonic Development/genetics ; MicroRNAs/metabolism ; Neuropeptides/genetics ; Neuropeptides/metabolism
Czasopismo naukowe
Tytuł :
Drosophila miR-124 regulates neuroblast proliferation through its target anachronism.
Autorzy :
Weng R; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore.
Cohen SM
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Źródło :
Development (Cambridge, England) [Development] 2012 Apr; Vol. 139 (8), pp. 1427-34. Date of Electronic Publication: 2012 Feb 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
MicroRNAs/*physiology
Neurons/*cytology
Animals ; Cell Lineage ; Cell Proliferation ; Central Nervous System/cytology ; Crosses, Genetic ; Drosophila melanogaster ; In Situ Hybridization, Fluorescence ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Microscopy, Fluorescence/methods ; Mutation ; Stem Cells/cytology ; Transgenes
Czasopismo naukowe
Tytuł :
MicroRNA transgene overexpression complements deficiency-based modifier screens in Drosophila.
Autorzy :
Szuplewski S; Institute of Molecular and Cell Biology, Singapore 138673.
Kugler JM
Lim SF
Verma P
Chen YW
Cohen SM
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Źródło :
Genetics [Genetics] 2012 Feb; Vol. 190 (2), pp. 617-26. Date of Electronic Publication: 2011 Nov 17.
Typ publikacji :
Journal Article
MeSH Terms :
Transgenes*
Drosophila/*genetics
MicroRNAs/*genetics
Animals ; Base Sequence ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Female ; Gene Dosage ; Gene Expression ; Gene Order ; Genetic Vectors/genetics ; Heat-Shock Proteins/genetics ; Ligases/genetics ; Ligases/metabolism ; Male ; Molecular Sequence Data ; Mutation ; Phenotype
Czasopismo naukowe

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