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Wyświetlanie 1-13 z 13
Tytuł :
Avirulins, a Novel Class of HIV-1 Reverse Transcriptase Inhibitors Effective in the Female Reproductive Tract Mucosa.
Autorzy :
Cherne MD; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. .
Hall J; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. .
Kellner A; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. .
Chong CF; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. .
Cole AL; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. amy.cole@ucf.edu.
Cole AM; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA. .
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Źródło :
Viruses [Viruses] 2019 May 01; Vol. 11 (5). Date of Electronic Publication: 2019 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genitalia, Female*
HIV Infections/*virology
HIV-1/*drug effects
Mucous Membrane/*virology
Reverse Transcriptase Inhibitors/*pharmacology
Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Discovery ; Drug Evaluation, Preclinical ; Female ; Genotype ; HIV Infections/drug therapy ; HIV Infections/transmission ; HIV-1/genetics ; Humans ; Mutation ; Reverse Transcriptase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
HIV-Enhancing and HIV-Inhibiting Properties of Cationic Peptides and Proteins.
Autorzy :
Cole AM; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, UCF College of Medicine, 4110 Libra Drive, Orlando, FL 32816, USA. .
Cole AL; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, UCF College of Medicine, 4110 Libra Drive, Orlando, FL 32816, USA. amy.cole@ucf.edu.
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Źródło :
Viruses [Viruses] 2017 May 15; Vol. 9 (5). Date of Electronic Publication: 2017 May 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antimicrobial Cationic Peptides/*immunology
HIV Infections/*immunology
HIV-1/*drug effects
HIV-1/*immunology
Antimicrobial Cationic Peptides/pharmacology ; Antiviral Agents/pharmacology ; Female ; HIV Infections/prevention & control ; HIV Infections/virology ; HIV-1/pathogenicity ; Humans ; Immunity, Innate ; Mucous Membrane/immunology ; Mucous Membrane/virology ; Semen/virology ; Vagina/immunology ; Vagina/virology
Czasopismo naukowe
Tytuł :
Synthesis and bioevaluation of substituted chalcones, coumaranones and other flavonoids as anti-HIV agents.
Autorzy :
Cole AL; Burnett School for Biomedical Sciences, College of Medicine, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826-3227, United States.
Hossain S; Department of Medical Education, College of Medicine, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826-3227, United States.
Cole AM; Burnett School for Biomedical Sciences, College of Medicine, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826-3227, United States.
Phanstiel O 4th; Department of Medical Education, College of Medicine, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826-3227, United States. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Jun 15; Vol. 24 (12), pp. 2768-76. Date of Electronic Publication: 2016 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-HIV Agents/*pharmacology
Benzofurans/*pharmacology
Chalcones/*pharmacology
Flavonoids/*pharmacology
HIV Infections/*drug therapy
HIV-1/*drug effects
Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Cell Line ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Flavonoids/chemical synthesis ; Flavonoids/chemistry ; Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Morphology-Dependent HIV-Enhancing Effect of Semen-Derived Enhancer of Viral Infection.
Autorzy :
Qiao X; Department of Physics, University of Central Florida, Orlando, Florida.
Jeon J; Department of Physics, University of Central Florida, Orlando, Florida.
Cole AL; Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida.
Matos JO; Department of Physics, University of Central Florida, Orlando, Florida.
Bautista S; Department of Physics, University of Central Florida, Orlando, Florida.
Castillo J; Department of Physics, University of Central Florida, Orlando, Florida.
Hung I; National High Magnetic Field Laboratory, Tallahassee, Florida.
Gan Z; National High Magnetic Field Laboratory, Tallahassee, Florida.
Tatulian SA; Department of Physics, University of Central Florida, Orlando, Florida.
Cole AM; Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida.
Chen B; Department of Physics, University of Central Florida, Orlando, Florida. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2015 Apr 21; Vol. 108 (8), pp. 2028-37.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Acid Phosphatase/*pharmacology
Amyloid/*pharmacology
HIV-1/*pathogenicity
Acid Phosphatase/chemistry ; Amyloid/chemistry ; Cell Line, Tumor ; Humans ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacology ; Virulence/drug effects
Czasopismo naukowe
Tytuł :
Retrocyclins and their activity against HIV-1.
Autorzy :
Penberthy WT; Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL 32816, USA.
Chari S
Cole AL
Cole AM
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2011 Jul; Vol. 68 (13), pp. 2231-42. Date of Electronic Publication: 2011 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Defensins/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Defensins/chemistry ; Humans ; Virus Internalization
Czasopismo naukowe
Tytuł :
HIV-1 enhancing effect of prostatic acid phosphatase peptides is reduced in human seminal plasma.
Autorzy :
Martellini JA; Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at the University of Central Florida College of Medicine, Orlando, Florida, United States of America.
Cole AL
Svoboda P
Stuchlik O
Chen LM
Chai KX
Gangrade BK
Sørensen OE
Pohl J
Cole AM
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Źródło :
PloS one [PLoS One] 2011 Jan 20; Vol. 6 (1), pp. e16285. Date of Electronic Publication: 2011 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HIV-1/*physiology
Peptide Fragments/*pharmacology
Protein Tyrosine Phosphatases/*pharmacology
Semen/*virology
Acid Phosphatase ; Amyloid ; Dose-Response Relationship, Drug ; HIV Enhancer ; HIV-1/drug effects ; Humans ; Prostate-Specific Antigen/metabolism ; Serine Endopeptidases/metabolism
Czasopismo naukowe
Tytuł :
Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin.
Autorzy :
Micewicz ED; Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America.
Cole AL
Jung CL
Luong H
Phillips ML
Pratikhya P
Sharma S
Waring AJ
Cole AM
Ruchala P
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Źródło :
PloS one [PLoS One] 2010 Dec 16; Vol. 5 (12), pp. e14360. Date of Electronic Publication: 2010 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Algal Proteins/*chemistry
HIV Infections/*prevention & control
HIV-1/*metabolism
Lectins/*chemistry
Rhodophyta/*metabolism
Amino Acid Sequence ; Disulfides/chemistry ; Drug Design ; HIV Core Protein p24/chemistry ; HIV Fusion Inhibitors/pharmacology ; Humans ; Molecular Sequence Data ; Peptides/chemistry ; Plant Proteins ; Protein Conformation ; Protein Structure, Secondary ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Cationic polypeptides contribute to the anti-HIV-1 activity of human seminal plasma.
Autorzy :
Martellini JA; Department of Molecular Biology and Microbiology, Biomolecular Science Center, Burnett School of Biomedical Sciences at University of Central Florida, Orlando, Florida, USA.
Cole AL
Venkataraman N
Quinn GA
Svoboda P
Gangrade BK
Pohl J
Sørensen OE
Cole AM
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2009 Oct; Vol. 23 (10), pp. 3609-18. Date of Electronic Publication: 2009 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antimicrobial Cationic Peptides/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Semen/*immunology
Seminal Vesicle Secretory Proteins/*immunology
Amino Acid Sequence ; Antimicrobial Cationic Peptides/pharmacology ; Cell Line ; HIV-1/drug effects ; Humans ; Male ; Molecular Sequence Data ; Seminal Vesicle Secretory Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Reawakening retrocyclins: ancestral human defensins active against HIV-1.
Autorzy :
Venkataraman N; Department of Molecular Biology and Microbiology, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America.
Cole AL
Ruchala P
Waring AJ
Lehrer RI
Stuchlik O
Pohl J
Cole AM
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Źródło :
PLoS biology [PLoS Biol] 2009 Apr 28; Vol. 7 (4), pp. e95.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aminoglycosides/*pharmacology
Defensins/*biosynthesis
HIV-1/*immunology
Amino Acid Sequence ; Cervix Uteri/metabolism ; Codon, Nonsense ; Defensins/genetics ; Epithelial Cells/metabolism ; Female ; Gene Expression Regulation ; Granulocyte Precursor Cells ; HIV Infections/prevention & control ; HIV Infections/transmission ; HL-60 Cells ; Humans ; RNA, Messenger/immunology ; RNA, Messenger/metabolism ; Transfection ; Vagina/metabolism
Czasopismo naukowe
Tytuł :
Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense.
Autorzy :
Cole AM; Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL, USA. />Cole AL
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Źródło :
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2008 Jan; Vol. 59 (1), pp. 27-34.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Antimicrobial Cationic Peptides/*immunology
Cervix Uteri/*immunology
Defensins/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Vagina/*immunology
Bacteria/immunology ; Cervix Uteri/microbiology ; Cervix Uteri/virology ; Defensins/metabolism ; Female ; HIV Infections/prevention & control ; HIV Infections/virology ; Humans ; Immunity, Innate ; Mucous Membrane/immunology ; Mucous Membrane/metabolism ; Vagina/microbiology ; Vagina/virology
Czasopismo naukowe
Tytuł :
The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct.
Autorzy :
Cole AL; Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett College of Biomedical Sciences at University of Central Florida, Orlando, FL 32816, USA. />Herasimtschuk A
Gupta P
Waring AJ
Lehrer RI
Cole AM
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Źródło :
Immunology [Immunology] 2007 May; Vol. 121 (1), pp. 140-5. Date of Electronic Publication: 2007 Jan 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV Infections/*virology
HIV-1/*drug effects
Peptides/*pharmacology
Vagina/*virology
Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/toxicity ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Humans ; Inflammation Mediators/metabolism ; Models, Biological ; Peptides/pharmacokinetics ; Peptides/toxicity ; Tissue Culture Techniques ; Vagina/drug effects
Czasopismo naukowe
Tytuł :
HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41.
Autorzy :
Cole AL; Department of Molecular Biology and Microbiology, Burnett College of Biomedical Sciences, University of Central Florida, FL 32816, USA. />Yang OO
Warren AD
Waring AJ
Lehrer RI
Cole AM
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2006 Jun 01; Vol. 176 (11), pp. 6900-5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amino Acid Substitution*/genetics
Down-Regulation*/genetics
Membrane Fusion*/genetics
Defensins/*physiology
HIV Envelope Protein gp41/*metabolism
HIV-1/*pathogenicity
Viral Fusion Proteins/*metabolism
Adaptation, Biological/genetics ; Amino Acid Sequence ; Anti-HIV Agents/metabolism ; Anti-HIV Agents/pharmacology ; Cell Line ; Defensins/metabolism ; Drug Resistance, Viral/genetics ; HIV Envelope Protein gp41/genetics ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Molecular Sequence Data ; Viral Fusion Proteins/genetics ; Virus Replication/drug effects ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid.
Autorzy :
Venkataraman N; Department of Molecular Biology and Microbiology, Biomolecular Science Center, University of Central Florida, Orlando, FL 32816-2364, USA.
Cole AL
Svoboda P
Pohl J
Cole AM
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2005 Dec 01; Vol. 175 (11), pp. 7560-7.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antimicrobial Cationic Peptides/*immunology
Body Fluids/*chemistry
Body Fluids/*immunology
HIV-1/*immunology
Mucous Membrane/*immunology
Vagina/*immunology
Animals ; Antimicrobial Cationic Peptides/chemistry ; Electrophoresis, Gel, Two-Dimensional ; Female ; HIV-1/genetics ; Humans ; Reverse Transcriptase Polymerase Chain Reaction ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
    Wyświetlanie 1-13 z 13

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