Mechanism and dynamics of fatty acid photodecarboxylase.
Autorzy:
Sorigué D; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Hadjidemetriou K; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. Blangy S; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Gotthard G; European Synchrotron Radiation Facility, 38043 Grenoble, France. Bonvalet A; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. Coquelle N; Large-Scale Structures Group, Institut Laue Langevin, 38042 Grenoble Cedex 9, France. Samire P; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France.; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Aleksandrov A; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. Antonucci L; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. Benachir A; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. Boutet S; Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA. Byrdin M; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. Cammarata M; Department of Physics, UMR UR1-CNRS 6251, University of Rennes 1, F-Rennes, France. . Carbajo S; Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA. Cuiné S; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Doak RB; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Foucar L; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Gorel A; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Grünbein M; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Hartmann E; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Hienerwadel R; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Hilpert M; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Kloos M; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. . Lane TJ; Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA. Légeret B; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Legrand P; Synchrotron SOLEIL. L'Orme des Merisiers Saint-Aubin, BP 48, 91192 Gif-sur-Yvette, France. Li-Beisson Y; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Moulin SLY; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Nurizzo D; European Synchrotron Radiation Facility, 38043 Grenoble, France. Peltier G; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. Schirò G; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. Shoeman RL; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. Sliwa M; Univ. Lille, CNRS, UMR 8516, LASIRE, LAboratoire de Spectroscopie pour les Interactions, la Réactivité et l'Environnement, 59000 Lille, France. Solinas X; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. Zhuang B; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Barends TRM; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. ColletierJP; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. Joffre M; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. Royant A; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France.; European Synchrotron Radiation Facility, 38043 Grenoble, France. Berthomieu C; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. . Weik M; Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. . Domratcheva T; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. .; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia. Brettel K; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Vos MH; LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France. . Schlichting I; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. . Arnoux P; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. . Müller P; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. . Beisson F; Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. .
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes.
Autorzy:
Pajk S; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. Knez D; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. Košak U; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. Zorović M; Faculty of Medicine, Institute of Pathological Physiology, University of Ljubljana, Ljubljana, Slovenia. Brazzolotto X; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France. Coquelle N; Institut Laue Langvein, Grenoble, France. Nachon F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France. ColletierJP; CNRS, CEA, IBS, Université Grenoble Alpes, Grenoble, France. Živin M; Faculty of Medicine, Institute of Pathological Physiology, University of Ljubljana, Ljubljana, Slovenia. Stojan J; Faculty of Medicine, Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia. Gobec S; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.
Autorzy:
Zárate-Potes A; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Yang W; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Pees B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Schalkowski R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Segler P; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Andresen B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Haase D; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Nakad R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Rosenstiel P; Institute for Clinical Molecular Biology (IKMB), Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Tetreau G; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France. ColletierJP; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France. Schulenburg H; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Ploen, Germany. Dierking K; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2020 Sep 24; Vol. 16 (9), pp. e1008826. Date of Electronic Publication: 2020 Sep 24 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.
Autorzy:
Galdeano C; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028 Barcelona, Spain. . Coquelle N; Institut de Biologie Structurale, Université Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'Énergie Atomique (CEA) (UMR 5075), F-38054 Grenoble, France. .; Large-Scale Structures Group, Institut Laue-Langevin, 71 Avenue des Martyrs, 38000 Grenoble, France. . Cieslikiewicz-Bouet M; Laboratory COBRA (UMR 6014), Normandie Université, UNIROUEN, Institut National des Sciences Appliquées (INSA) Rouen, CNRS, 76000 Rouen, France. . Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy. . Pérez B; Department of Pharmacology, Therapeutics and Toxicology, Neuroscience Institute, Autonomous University of Barcelona, E-08193 Barcelona, Spain. . Clos MV; Department of Pharmacology, Therapeutics and Toxicology, Neuroscience Institute, Autonomous University of Barcelona, E-08193 Barcelona, Spain. . Silman I; Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. . Jean L; Laboratory COBRA (UMR 6014), Normandie Université, UNIROUEN, Institut National des Sciences Appliquées (INSA) Rouen, CNRS, 76000 Rouen, France. . ColletierJP; Institut de Biologie Structurale, Université Grenoble Alpes, Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'Énergie Atomique (CEA) (UMR 5075), F-38054 Grenoble, France. colletier@ibs.fr. Renard PY; Laboratory COBRA (UMR 6014), Normandie Université, UNIROUEN, Institut National des Sciences Appliquées (INSA) Rouen, CNRS, 76000 Rouen, France. . Muñoz-Torrero D; Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII 27-31, E-08028 Barcelona, Spain. .
Providencia stuartii form biofilms and floating communities of cells that display high resistance to environmental insults.
Autorzy:
El Khatib M; Institut de Biologie Structurale, Université Grenoble Alpes - Commissariat à l'Énergie Atomique - Centre National de la Recherche Scientifique, Grenoble, France. Tran QT; School of Biophysics, Jacobs University of Bremen, Bremen, Germany. Nasrallah C; Institut de Biologie Structurale, Université Grenoble Alpes - Commissariat à l'Énergie Atomique - Centre National de la Recherche Scientifique, Grenoble, France. Lopes J; Institut de Biologie Structurale, Université Grenoble Alpes - Commissariat à l'Énergie Atomique - Centre National de la Recherche Scientifique, Grenoble, France. Bolla JM; Équipe Transporteurs Membranaires, Chimiorésistance et Drug-Design, Université Aix-Marseille - Institut de Recherche Biomédicale des Armées, Marseille, France. Vivaudou M; Institut de Biologie Structurale, Université Grenoble Alpes - Commissariat à l'Énergie Atomique - Centre National de la Recherche Scientifique, Grenoble, France. Pagès JM; Équipe Transporteurs Membranaires, Chimiorésistance et Drug-Design, Université Aix-Marseille - Institut de Recherche Biomédicale des Armées, Marseille, France. ColletierJP; Institut de Biologie Structurale, Université Grenoble Alpes - Commissariat à l'Énergie Atomique - Centre National de la Recherche Scientifique, Grenoble, France.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2017 Mar 23; Vol. 12 (3), pp. e0174213. Date of Electronic Publication: 2017 Mar 23 (Print Publication: 2017).
The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril.
Autorzy:
Tayeb-Fligelman E; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel. Tabachnikov O; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel. Moshe A; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel. Goldshmidt-Tran O; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel. Sawaya MR; Department of Biological Chemistry, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA. Coquelle N; Institut de Biologie Structurale (IBS), Université Grenoble Alpes-CEA-CNRS UMR 5075, Grenoble 38044, France. ColletierJP; Institut de Biologie Structurale (IBS), Université Grenoble Alpes-CEA-CNRS UMR 5075, Grenoble 38044, France. Landau M; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel. .
Development of an in-vivo active reversible butyrylcholinesterase inhibitor.
Autorzy:
Košak U; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Brus B; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Knez D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Šink R; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Žakelj S; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Trontelj J; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Pišlar A; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Šlenc J; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Gobec M; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Živin M; Institute of Pathological Physiology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Tratnjek L; Institute of Pathological Physiology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Perše M; Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. Sałat K; Faculty of Pharmacy, Jagiellonian University, Medyczna 9 St., 30-688 Krakow, Poland. Podkowa A; Faculty of Pharmacy, Jagiellonian University, Medyczna 9 St., 30-688 Krakow, Poland. Filipek B; Faculty of Pharmacy, Jagiellonian University, Medyczna 9 St., 30-688 Krakow, Poland. Nachon F; Institut de Recherche Biomédicale des Armées, 91223 Brétigny sur Orge, France. Brazzolotto X; Institut de Recherche Biomédicale des Armées, 91223 Brétigny sur Orge, France. Więckowska A; Faculty of Pharmacy, Jagiellonian University, Medyczna 9 St., 30-688 Krakow, Poland. Malawska B; Faculty of Pharmacy, Jagiellonian University, Medyczna 9 St., 30-688 Krakow, Poland. Stojan J; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia. Raščan IM; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Kos J; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia. Coquelle N; University Grenoble Alpes, IBS, F-38044 Grenoble, France.; CNRS, IBS, F-38044 Grenoble, France.; CEA, IBS, F-38044 Grenoble, France. ColletierJP; University Grenoble Alpes, IBS, F-38044 Grenoble, France.; CNRS, IBS, F-38044 Grenoble, France.; CEA, IBS, F-38044 Grenoble, France. Gobec S; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2016 Dec 21; Vol. 6, pp. 39495. Date of Electronic Publication: 2016 Dec 21.
Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ40 and Aβ42.
Autorzy:
Song W; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China. Wang Y; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China. ColletierJP; 1] Univ. Grenoble Alpes, IBS, F-38044 Grenoble, France [2] CNRS, IBS, F-38044 Grenoble, France [3] CEA, IBS, F-38044 Grenoble, France. Yang H; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China. Xu Y; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2015 Jun 05; Vol. 5, pp. 11024. Date of Electronic Publication: 2015 Jun 05.
Understanding Voltage Gating of Providencia stuartii Porins at Atomic Level.
Autorzy:
Song W; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, China. Bajaj H; School of Engineering and Sciences, Jacobs University Bremen, Bremen, Germany. Nasrallah C; University Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble, France; CNRS, Institut de Biologie Structurale (IBS), Grenoble, France; CEA, Institut de Biologie Structurale (IBS), Grenoble, France. Jiang H; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, China. Winterhalter M; School of Engineering and Sciences, Jacobs University Bremen, Bremen, Germany. ColletierJP; University Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble, France; CNRS, Institut de Biologie Structurale (IBS), Grenoble, France; CEA, Institut de Biologie Structurale (IBS), Grenoble, France. Xu Y; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, China.
Pokaż więcej
Źródło:
PLoS computational biology [PLoS Comput Biol] 2015 May 08; Vol. 11 (5), pp. e1004255. Date of Electronic Publication: 2015 May 08 (Print Publication: 2015).
Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1.
Autorzy:
Choudhary OP; 1] Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, Pennsylvania, USA. [2]. Paz A; 1] Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. [2]. Adelman JL; 1] Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [2]. ColletierJP; 1] Université Grenoble Alpes, Institut de Biologie Structurale, Grenoble, France. [2] Centre National de la Recherche Scientifique, Institut de Biologie Structurale, Grenoble, France. [3] Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Direction des Sciences du Vivant, Institut de Biologie Structurale, Grenoble, France. [4]. Abramson J; 1] Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. [2] Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences-Tata Institute of Fundamental Research, Bangalore, India. Grabe M; 1] Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [2] Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA.
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies