Author: "Colombel, Jean-Frédéric" - OpacWWW

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Title:: Review article: withdrawal of 5-aminosalicylates in inflammatory bowel disease.
Authors:: Chapman TP; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.
Frias Gomes C; Surgical Department, Gastroenterology Division, Hospital Beatriz Ângelo, Loures, Portugal.
Louis E; Department of Gastroenterology, CHU Liège University Hospital, Liège, Belgium.
Colombel JF; The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Satsangi J; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, UK.; Show more
Source:: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2020 Jul; Vol. 52 (1), pp. 73-84. Date of Electronic Publication: 2020 May 26.
Publication Type:: Journal Article; Review
MeSH Terms:: Aminosalicylic Acids/*therapeutic use
Colitis, Ulcerative/*drug therapy
Crohn Disease/*drug therapy
Colorectal Neoplasms/prevention & control ; Humans ; Randomized Controlled Trials as Topic ; Withholding Treatment

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Title:: IM-UNITI: Three-year Efficacy, Safety, and Immunogenicity of Ustekinumab Treatment of Crohn's Disease.
Authors:: Hanauer SB; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sandborn WJ; University of California San Diego, La Jolla, CA USA.
Feagan BG; Robarts Clinical Trials, Western University, London, ON, Canada.
Gasink C; Janssen Scientific Affairs, LLC, Horsham, PA, USA.
Jacobstein D; Janssen Research & Development, LLC, Spring House, PA, USA.
Zou B; Janssen Research & Development, LLC, Spring House, PA, USA.
Johanns J; Janssen Research & Development, LLC, Spring House, PA, USA.
Adedokun OJ; Janssen Research & Development, LLC, Spring House, PA, USA.
Sands BE; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rutgeerts P; University Hospital, Gasthuisberg, Leuven, Belgium.
de Villiers WJS; Stellenbosch University, Stellenbosch, South Africa.
Colombel JF; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ghosh S; NIHR Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2020 Jan 01; Vol. 14 (1), pp. 23-32.
Publication Type:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Crohn Disease/*drug therapy
Ustekinumab/*therapeutic use
Double-Blind Method ; Drug Administration Schedule ; Humans ; Injections, Subcutaneous ; Maintenance Chemotherapy ; Treatment Outcome

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Title:: Incidence of Arthritis/Arthralgia in Inflammatory Bowel Disease with Long-term Vedolizumab Treatment: Post Hoc Analyses of the GEMINI Trials.
Authors:: Feagan BG; Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Sandborn WJ; Division of Gastroenterology, University of California San Diego, La Jolla, CA, USA.
Colombel JF; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Byrne SO; Takeda Pharmaceuticals International AG, Zurich, Switzerland.
Khalid JM; Takeda International - UK Branch, London, UK.
Kempf C; Takeda Pharmaceuticals International AG, Zurich, Switzerland.
Geransar P; Takeda Pharmaceuticals International AG, Zurich, Switzerland.
Bhayat F; Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
Rubin DT; University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, IL, USA.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2019 Jan 01; Vol. 13 (1), pp. 50-57.
Publication Type:: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
MeSH Terms:: Adrenal Cortex Hormones/*administration & dosage
Antibodies, Monoclonal, Humanized/*therapeutic use
Arthralgia/*epidemiology
Arthritis/*epidemiology
Colitis, Ulcerative/*drug therapy
Crohn Disease/*drug therapy
Gastrointestinal Agents/*therapeutic use
Disease Progression ; Humans ; Incidence

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Title:: Exposure-efficacy Relationships for Vedolizumab Induction Therapy in Patients with Ulcerative Colitis or Crohn's Disease.
Authors:: Rosario M; Clinical Pharmacology Department, Millennium Pharmaceuticals Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.
French JL; Metrum Research Group LLC, Tariffville, CT, USA.
Dirks NL; Metrum Research Group LLC, Tariffville, CT, USA.
Sankoh S; Clinical Pharmacology Department, Millennium Pharmaceuticals Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.
Parikh A; Clinical Pharmacology Department, Millennium Pharmaceuticals Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.
Yang H; Clinical Pharmacology Department, Millennium Pharmaceuticals Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.
Danese S; Inflammatory Bowel Disease Clinical and Research Unit, Istituto Clinico Humanitas, Milan, Italy.
Colombel JF; Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Smyth M; Takeda Development Centre Europe Ltd, London, UK.
Sandborn WJ; Division of Gastroenterology, University of California San Diego, La Jolla, CA, USA.
Feagan BG; Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Reinisch W; Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, and Department of Internal Medicine, McMaster University, Hamilton, ON, Canada.
Sands BE; Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Sans M; Digestive Diseases Service, Centro Médico Teknon, Barcelona, Spain.
Fox I; Clinical Pharmacology Department, Millennium Pharmaceuticals Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2017 Aug 01; Vol. 11 (8), pp. 921-929.
Publication Type:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Antibodies, Monoclonal, Humanized/*therapeutic use
Colitis, Ulcerative/*drug therapy
Crohn Disease/*drug therapy
Gastrointestinal Agents/*therapeutic use
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/blood ; Dose-Response Relationship, Drug ; Double-Blind Method ; Feces/chemistry ; Female ; Gastrointestinal Agents/administration & dosage ; Humans ; Leukocyte L1 Antigen Complex/analysis ; Male ; Middle Aged ; Remission Induction/methods ; Serum Albumin/analysis ; Treatment Outcome ; Young Adult

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Title:: Eldelumab [anti-interferon-γ-inducible protein-10 antibody] Induction Therapy for Active Crohn's Disease: a Randomised, Double-blind, Placebo-controlled Phase IIa Study.
Authors:: Sandborn WJ; Inflammatory Bowel Disease Center, University of California San Diego, La Jolla, CA, USA.
Rutgeerts P; Department of Gastroenterology, Catholic University Leuven, Belgium.
Colombel JF; Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ghosh S; Division of Gastroenterology, University of Calgary, Calgary, AB, Canada.
Petryka R; NZOZ Vivamed, Zespól Lekarzy Specjalistów, Warszawa, Poland.
Sands BE; Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mitra P; Bristol-Myers Squibb, Lawrenceville, NJ, USA.
Luo A; Bristol-Myers Squibb, Lawrenceville, NJ, USA.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2017 Jul 01; Vol. 11 (7), pp. 811-819.
Publication Type:: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms:: Antibodies, Monoclonal/*therapeutic use
Crohn Disease/*drug therapy
Gastrointestinal Agents/*therapeutic use
Adult ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Colonoscopy ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Gastrointestinal Agents/administration & dosage ; Gastrointestinal Agents/adverse effects ; Humans ; Male ; Middle Aged ; Remission Induction ; Severity of Illness Index ; Young Adult

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Title:: Characterisation of Mucosal Healing with Adalimumab Treatment in Patients with Moderately to Severely Active Crohn's Disease: Results from the EXTEND Trial.
Authors:: Reinisch W; Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON, Canada; and Department of Internal Medicine III, Division of Gastroenterology & Hepatology, Medical University of Vienna, Vienna, Austria.
Colombel JF; Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
D'Haens G; Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands; and Imelda GI Clinical Research Center, Bonheiden, Belgium.
Sandborn WJ; Division of Gastroenterology, University of California San Diego, La Jolla, CA, USA.
Rutgeerts P; Division of Gastroenterology, Department of Internal Medicine, University of Leuven, Leuven, Belgium.
Geboes K; Department of Pathology, University of Leuven, Leuven, Belgium.
Petersson J; Global Medical Affairs Gastroenterology, AbbVie Inc., North Chicago, IL, USA.
Eichner S; Global Medical Affairs Gastroenterology, AbbVie Inc., North Chicago, IL, USA.
Zhou Q; Data and Statistical Sciences, AbbVie Inc., North Chicago, IL, USA.
Robinson AM; Global Medical Affairs Gastroenterology, AbbVie Inc., North Chicago, IL, USA.
Read HA; Global Medical Affairs Gastroenterology, AbbVie Inc., North Chicago, IL, USA.
Thakkar R; Global Medical Affairs Gastroenterology, AbbVie Inc., North Chicago, IL, USA.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2017 Apr 01; Vol. 11 (4), pp. 425-434.
Publication Type:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Adalimumab/*therapeutic use
Crohn Disease/*drug therapy
Adult ; Colonoscopy ; Crohn Disease/pathology ; Double-Blind Method ; Female ; Humans ; Intestinal Mucosa/pathology ; Male ; Treatment Outcome

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Title:: Long-term Efficacy of Vedolizumab for Crohn's Disease.
Authors:: Vermeire S; University Hospitals Leuven, Belgium.
Loftus EV Jr; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Colombel JF; Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, New York, USA.
Feagan BG; Robarts Clinical Trials, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
Sandborn WJ; University of California San Diego and UC San Diego Health System, La Jolla, California, USA.
Sands BE; Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, New York, USA.
Danese S; Istituto Clinico Humanitas, Milan, Italy.
D'Haens GR; Academic Medical Center, Amsterdam, The Netherlands.
Kaser A; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Panaccione R; Inflammatory Bowel Disease Clinic, University of Calgary, Calgary, Alberta, Canada.
Rubin DT; University of Chicago Inflammatory Bowel Disease Center, Chicago, Illinois, USA.
Shafran I; Shafran Gastroenterology Center, Winter Park, Florida, USA.
McAuliffe M; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
Kaviya A; Takeda Development Centre Europe Ltd, London, UK.
Sankoh S; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
Mody R; Takeda Pharmaceuticals International, Inc., Deerfield, Illinois, USA.
Abhyankar B; Takeda Development Centre Europe Ltd, London, UK.
Smyth M; Takeda Development Centre Europe Ltd, London, UK.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2017 Apr 01; Vol. 11 (4), pp. 412-424.
Publication Type:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Antibodies, Monoclonal, Humanized/*therapeutic use
Crohn Disease/*drug therapy
Gastrointestinal Agents/*therapeutic use
Adult ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Double-Blind Method ; Female ; Gastrointestinal Agents/administration & dosage ; Gastrointestinal Agents/adverse effects ; Humans ; Male ; Quality of Life ; Remission Induction ; Treatment Outcome

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Title:: Previous Exposure to Multiple Anti-TNF Is Associated with Decreased Efficiency in Preventing Postoperative Crohn's Disease Recurrence.
Authors:: Collins M; Gastroenterology and Hepatology Department, Lille University Hospital, Lille, France.; Gastroenterology Department, Kremlin-Bicêtre University Hospital, Le Kremlin-Bicêtre, France.
Sarter H; Lille Inflammation Research International Center, Université Lille, CHRU de Lille, France.
Gower-Rousseau C; Lille Inflammation Research International Center, Université Lille, CHRU de Lille, France.
Koriche D; Colorectal Surgery Department, Lille University Hospital, Lille, France.
Libier L; Gastroenterology and Hepatology Department, Lille University Hospital, Lille, France.
Nachury M; Gastroenterology and Hepatology Department, Lille University Hospital, Lille, France.
Cortot A; Gastroenterology and Hepatology Department, Lille University Hospital, Lille, France.
Zerbib P; Colorectal Surgery Department, Lille University Hospital, Lille, France.
Blanc P; Gastroenterology and Hepatology Department, Montpellier University Hospital, Montpellier, France.
Desreumaux P; Gastroenterology and Hepatology Department, Lille University Hospital, Lille, France.; Lille Inflammation Research International Center, Université Lille, CHRU de Lille, France.
Colombel JF; Department of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peyrin-Biroulet L; Gastroenterology Department, Nancy University Hospital, Lorraine University, Vandoeuvre, France.
Pineton de Chambrun G; Gastroenterology and Hepatology Department, Lille University Hospital, Lille, France.; Gastroenterology and Hepatology Department, Montpellier University Hospital, Montpellier, France.; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2017 Mar 01; Vol. 11 (3), pp. 281-288.
Publication Type:: Journal Article
MeSH Terms:: Adalimumab/*therapeutic use
Crohn Disease/*prevention & control
Crohn Disease/*surgery
Gastrointestinal Agents/*therapeutic use
Infliximab/*therapeutic use
Tumor Necrosis Factor-alpha/*antagonists & inhibitors
Adolescent ; Adult ; Colonoscopy ; Crohn Disease/diagnostic imaging ; Female ; Humans ; Male ; Postoperative Period ; Preoperative Period ; Recurrence ; Retrospective Studies ; Risk Factors ; Secondary Prevention ; Smoking/adverse effects ; Young Adult

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Title:: Interobserver Variation Study of the Rutgeerts Score to Assess Endoscopic Recurrence after Surgery for Crohn's Disease.
Authors:: Marteau P; Service d'Hépatogastroentérologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris cedex, France Denis Diderot - Paris7 University, Paris, France.
Laharie D; CHU de Bordeaux, Hôpital Haut-Lévêque, Service d'Hépato-gastroentérologie - Université Bordeaux, Laboratoire de bactériologie, F-33000 Bordeaux, Pessac, France .
Colombel JF; CHRU de Lille, Hôpital Claude Huriez, Service des Maladies de l'Appareil Digestif -Endoscopie Digestive, Lille, France Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Martin L; Service d'Hépatogastroentérologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris cedex, France.
Coevoet H; CHRU de Lille, Hôpital Claude Huriez, Service des Maladies de l'Appareil Digestif -Endoscopie Digestive, Lille, France.
Allez M; Department of Hepatogastroenterology, Hôpital Saint-Louis, Paris, France.
Cadiot G; Department of Hepato-Gastroenterology and Digestive Oncology, Hôpital Robert Debré, Boulevard du Général Koenig, 51100 Reims Cedex, France.
Bourreille A; CHU de Nantes, Hôtel-Dieu, Hépato-Gastroentérologie, Institut des Maladies de l'Appareil Digestif, F-44093 Nantes, France.
Carbonnel F; Department of Gastroenterology, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Paris-Sud, Site de Bicêtre, Paris Sud University, Paris XI, Le Kremlin Bicêtre, Villejuif, France.
Bouhnik Y; Hôpital Beaujon, Gastroentérologie, Maladies Inflammatoires Chroniques de l'Intestin et Assistance Nutritive, APHP- Université Paris Diderot Paris 7, Clichy, France.
Coffin B; Hôpital Louis Mourier, service d'Hépato-Gastroentérologie, Pôle Maladie Appareil Digestif, APHP - Université Paris VII, F-92700 Colombes, France.
Duclos B; Service d'Hépato-Gastroentérologie et Assistance Nutritive, CHU Strasbourg, Strasbourg, France.
Dupas JL; Service d'Hépato- Gastroentérologie, CHU Amiens, Université de Picardie Jules Verne, Amiens, France.
Moreau J; CHU de Toulouse, Hôpital Rangueil, Service de Gastro-entérologie et Nutrition, F-31059 Toulouse, France.
Louis E; Centre Hospitalier, Universitaire de Liège, Liège, Belgium.
Mary JY; Inserm UMR 1153, Equipe Epidemiologie Clinique, Statistique pour la Recherche en Santé, Hôpital Saint-Louis, Université Paris Diderot - Paris 7, Paris, France.; Show more
Corporate Authors:: GETAID
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2016 Sep; Vol. 10 (9), pp. 1001-5. Date of Electronic Publication: 2016 Apr 11.
Publication Type:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Colectomy*
Endoscopy, Gastrointestinal*
Health Status Indicators*
Colon/*diagnostic imaging
Crohn Disease/*diagnostic imaging
Crohn Disease/*surgery
Ileum/*diagnostic imaging
Adult ; Aftercare ; Anastomosis, Surgical ; Colon/surgery ; Female ; Follow-Up Studies ; Humans ; Ileum/surgery ; Male ; Observer Variation ; Recurrence ; Reproducibility of Results ; Video Recording

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Title:: High-dose infliximab therapy in Crohn's disease: clinical experience, safety, and efficacy.
Authors:: Hendler SA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cohen BL; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Colombel JF; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sands BE; Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mayer L; Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Agarwal S; Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Show more
Source:: Journal of Crohn's & colitis [J Crohns Colitis] 2015 Mar; Vol. 9 (3), pp. 266-75. Date of Electronic Publication: 2014 Dec 24.
Publication Type:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Crohn Disease/*drug therapy
Gastrointestinal Agents/*administration & dosage
Infliximab/*administration & dosage
Adolescent ; Adult ; Drug Administration Schedule ; Female ; Gastrointestinal Agents/therapeutic use ; Humans ; Infliximab/therapeutic use ; Male ; Retrospective Studies ; Treatment Outcome ; Young Adult