Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Comparative Genomic Hybridization"" wg kryterium: Temat


Tytuł :
Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed.
Autorzy :
Szabó PM; 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Tamási V
Molnár V
Andrásfalvy M
Tömböl Z
Farkas R
Kövesdi K
Patócs A
Tóth M
Szalai C
Falus A
Rácz K
Igaz P
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2010 May 27; Vol. 29 (21), pp. 3163-72. Date of Electronic Publication: 2010 Mar 22.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms :
Comparative Genomic Hybridization*
Genomics*
Meta-Analysis as Topic*
Adrenal Cortex Neoplasms/*genetics
Chromosome Aberrations ; Gene Expression Profiling ; Humans ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł :
Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer.
Autorzy :
Hosoda F; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Arai Y; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Okada N; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Shimizu H; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Miyamoto M; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Kitagawa N; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Katai H; Division of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan.
Taniguchi H; Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.
Yanagihara K; Division of Translational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba, Japan.
Imoto I; 1] Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan [2] Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
Inazawa J; Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Ohki M; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Shibata T; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2015 Feb 26; Vol. 34 (9), pp. 1196-206. Date of Electronic Publication: 2014 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human, Pair 6/*genetics
Genomics/*methods
Lactoylglutathione Lyase/*genetics
Receptor, ErbB-2/*genetics
Stomach Neoplasms/*genetics
Animals ; Cell Line, Tumor ; Comparative Genomic Hybridization ; Gene Amplification ; Gene Dosage ; Glutathione/analogs & derivatives ; Glutathione/metabolism ; HEK293 Cells ; Humans ; Lactoylglutathione Lyase/metabolism ; Mice ; NF-kappa B/genetics ; NIH 3T3 Cells ; Signal Transduction ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Transcription Factor AP-1/genetics
Czasopismo naukowe
Tytuł :
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.
Autorzy :
Mukherjee M; Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.
Ge G; Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.
Zhang N; Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.
Edwards DG; Molecular and Cellular Biology; Baylor College of Medicine, Houston, TX 77030.
Sumazin P; Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.
Sharan SK; Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702.
Rao PH; Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.
Medina D; Molecular and Cellular Biology; Baylor College of Medicine, Houston, TX 77030.
Pati D; Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.; Molecular and Cellular Biology; Baylor College of Medicine, Houston, TX 77030.
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2014 Nov 27; Vol. 33 (48), pp. 5511-5522. Date of Electronic Publication: 2013 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Adenocarcinoma/*genetics
Adenocarcinoma/*pathology
Mammary Neoplasms, Experimental/*genetics
Mammary Neoplasms, Experimental/*pathology
Separase/*genetics
Adenocarcinoma/metabolism ; Aneuploidy ; Animals ; Blotting, Western ; Comparative Genomic Hybridization ; Estrogen Receptor alpha/biosynthesis ; Female ; Fluorescent Antibody Technique ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Mammary Neoplasms, Experimental/metabolism ; Mammary Tumor Virus, Mouse ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Separase/metabolism
Czasopismo naukowe
Tytuł :
Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model.
Autorzy :
Berger T; The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada.
Ueda T
Arpaia E
Chio II
Shirdel EA
Jurisica I
Hamada K
You-Ten A
Haight J
Wakeham A
Cheung CC
Mak TW
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2013 Oct 10; Vol. 32 (41), pp. 4989-94. Date of Electronic Publication: 2012 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Neoplasms/*genetics
Lung Neoplasms/*secondary
Mammary Neoplasms, Experimental/*pathology
Membrane Proteins/*deficiency
Membrane Proteins/*genetics
Animals ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Comparative Genomic Hybridization ; Disease Models, Animal ; Female ; Gene Silencing ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.
Autorzy :
Tobin LA; Department of Radiation Oncology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Robert C
Rapoport AP
Gojo I
Baer MR
Tomkinson AE
Rassool FV
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2013 Apr 04; Vol. 32 (14), pp. 1784-93. Date of Electronic Publication: 2012 May 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Poly(ADP-ribose) Polymerase Inhibitors*
Benzamides/*pharmacology
DNA Breaks, Double-Stranded/*drug effects
DNA End-Joining Repair/*drug effects
DNA Ligases/*antagonists & inhibitors
Drug Resistance, Neoplasm/*drug effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Piperazines/*pharmacology
Pyrimidines/*pharmacology
Antineoplastic Combined Chemotherapy Protocols ; Apoptosis/drug effects ; Blotting, Western ; Cell Proliferation/drug effects ; Comparative Genomic Hybridization ; DNA Ligase ATP ; DNA Ligases/genetics ; DNA Ligases/metabolism ; Enzyme Inhibitors/pharmacology ; Fluorescent Antibody Technique ; Fusion Proteins, bcr-abl/metabolism ; Humans ; Imatinib Mesylate ; Immunoenzyme Techniques ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Poly-ADP-Ribose Binding Proteins ; Protein Kinase Inhibitors/pharmacology ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Cells, Cultured ; Xenopus Proteins
Czasopismo naukowe
Tytuł :
Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness.
Autorzy :
Huang S; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5176, USA.
Gulzar ZG
Salari K
Lapointe J
Brooks JD
Pollack JR
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2012 Sep 13; Vol. 31 (37), pp. 4164-70. Date of Electronic Publication: 2011 Dec 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Sequence Deletion*
DNA Helicases/*genetics
DNA-Binding Proteins/*genetics
Prostatic Neoplasms/*genetics
Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Chromatin Assembly and Disassembly ; Comparative Genomic Hybridization ; DNA Helicases/biosynthesis ; DNA-Binding Proteins/biosynthesis ; Gene Expression Profiling ; Humans ; Male ; Neoplasm Invasiveness/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; RNA Interference ; RNA, Small Interfering
Czasopismo naukowe
Tytuł :
Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
Autorzy :
Rusiniak ME; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Kunnev D
Freeland A
Cady GK
Pruitt SC
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2012 Sep 06; Vol. 31 (36), pp. 4034-44. Date of Electronic Publication: 2011 Dec 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Neoplasm*
Sequence Deletion*
Cell Cycle Proteins/*deficiency
Nuclear Proteins/*deficiency
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Thymus Neoplasms/*genetics
Animals ; Base Sequence ; Cell Cycle Proteins/genetics ; Chromosome Breakpoints ; Chromosomes, Mammalian/genetics ; Comparative Genomic Hybridization ; DNA Copy Number Variations ; Humans ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Minichromosome Maintenance Complex Component 2 ; Molecular Sequence Data ; Nuclear Proteins/genetics ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.
Autorzy :
Li L; Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong and CUHK Shenzhen Research Institute, Hong Kong.
Ying J
Li H
Zhang Y
Shu X
Fan Y
Tan J
Cao Y
Tsao SW
Srivastava G
Chan AT
Tao Q
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2012 Aug 23; Vol. 31 (34), pp. 3901-12. Date of Electronic Publication: 2011 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Cadherins/*metabolism
Tumor Suppressor Proteins/*metabolism
Wnt Proteins/*metabolism
beta Catenin/*metabolism
Apoptosis/genetics ; Blotting, Western ; Cadherins/genetics ; Cell Line ; Cell Line, Tumor ; Cell Membrane/metabolism ; Chromosomes, Human, Pair 16/genetics ; Comparative Genomic Hybridization/methods ; CpG Islands/genetics ; DNA Methylation ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; HCT116 Cells ; Humans ; Microscopy, Confocal ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Promoter Regions, Genetic/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma.
Autorzy :
Santo EE; Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Ebus ME
Koster J
Schulte JH
Lakeman A
van Sluis P
Vermeulen J
Gisselsson D
Øra I
Lindner S
Buckley PG
Stallings RL
Vandesompele J
Eggert A
Caron HN
Versteeg R
Molenaar JJ
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2012 Mar 22; Vol. 31 (12), pp. 1571-81. Date of Electronic Publication: 2011 Aug 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human, Pair 11*
Recombination, Genetic*
Neuroblastoma/*genetics
Animals ; Cell Line, Tumor ; Comparative Genomic Hybridization ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Haploinsufficiency ; Humans ; Loss of Heterozygosity ; Mice ; Oncogene Fusion ; Polymorphism, Single Nucleotide ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT.
Autorzy :
de Andrea CE; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Reijnders CM
Kroon HM
de Jong D
Hogendoorn PC
Szuhai K
Bovée JV
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2012 Mar 01; Vol. 31 (9), pp. 1095-104. Date of Electronic Publication: 2011 Aug 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*genetics
Bone Neoplasms/*pathology
Chondrosarcoma/*genetics
N-Acetylglucosaminyltransferases/*genetics
Neoplasms, Second Primary/*genetics
Osteochondroma/*pathology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/metabolism ; Child ; Chondrosarcoma/metabolism ; Chondrosarcoma/pathology ; Chromosomes, Human, Pair 8 ; Comparative Genomic Hybridization ; Gene Deletion ; Homozygote ; Humans ; Middle Aged ; N-Acetylglucosaminyltransferases/metabolism ; Neoplasms, Second Primary/metabolism ; Neoplasms, Second Primary/pathology ; Osteochondroma/genetics ; Osteochondroma/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.
Autorzy :
Chin, S.-F.
Wang, Y.
Thorne, N. P.
Teschendorff, A. E.
Pinder, S. E.
Vias, M.
Naderi, A.
Roberts, I.
Barbosa-Morais, N. L.
Garcia, M. J.
Iyer, N. G.
Kranjac, T.
Robertson, J. F. R.
Aparicio, S.
Tavaré, S.
Ellis, I.
Brenton, J. D.
Caldas, C.
Pokaż więcej
Źródło :
Oncogene. 3/22/2007, Vol. 26 Issue 13, p1959-1970. 12p. 2 Charts, 4 Graphs.
Czasopismo naukowe
Tytuł :
Shared acquired genomic changes in zebrafish and human T-ALL.
Autorzy :
Rudner LA; Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Brown KH
Dobrinski KP
Bradley DF
Garcia MI
Smith AC
Downie JM
Meeker ND
Look AT
Downing JR
Gutierrez A
Mullighan CG
Schiffman JD
Lee C
Trede NS
Frazer JK
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2011 Oct 13; Vol. 30 (41), pp. 4289-96. Date of Electronic Publication: 2011 May 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Comparative Genomic Hybridization/*methods
Genomics/*methods
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Zebrafish/*genetics
Animals ; Gene Expression Regulation, Neoplastic ; Genome/genetics ; Humans ; Kaplan-Meier Estimate ; Neoplasm Transplantation ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours.
Autorzy :
Rajan N; Institute of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. />Elliott R
Clewes O
Mackay A
Reis-Filho JS
Burn J
Langtry J
Sieber-Blum M
Lord CJ
Ashworth A
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2011 Oct 13; Vol. 30 (41), pp. 4243-60. Date of Electronic Publication: 2011 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms/*genetics
Protein Kinases/*genetics
Signal Transduction/*genetics
Tumor Suppressor Proteins/*genetics
Adenoma, Sweat Gland/genetics ; Adenoma, Sweat Gland/metabolism ; Adenoma, Sweat Gland/pathology ; Carbazoles/pharmacology ; Carcinoma, Adenoid Cystic/genetics ; Carcinoma, Adenoid Cystic/metabolism ; Carcinoma, Adenoid Cystic/pathology ; Cluster Analysis ; Comparative Genomic Hybridization ; Deubiquitinating Enzyme CYLD ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunoblotting ; Immunohistochemistry ; Mutation ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms, Basal Cell/genetics ; Neoplasms, Basal Cell/metabolism ; Neoplasms, Basal Cell/pathology ; Oligonucleotide Array Sequence Analysis ; Primary Cell Culture ; Protein Kinases/metabolism ; RNA Interference ; Receptor, trkB/antagonists & inhibitors ; Receptor, trkB/genetics ; Receptor, trkB/metabolism ; Receptor, trkC/antagonists & inhibitors ; Receptor, trkC/genetics ; Receptor, trkC/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sweat Gland Neoplasms/genetics ; Sweat Gland Neoplasms/metabolism ; Sweat Gland Neoplasms/pathology ; Tissue Array Analysis ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.
Autorzy :
Ocak S; Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232-6838, USA.
Yamashita H
Udyavar AR
Miller AN
Gonzalez AL
Zou Y
Jiang A
Yi Y
Shyr Y
Estrada L
Quaranta V
Massion PP
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2010 Dec 02; Vol. 29 (48), pp. 6331-42. Date of Electronic Publication: 2010 Aug 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Focal Adhesions*
Gene Dosage*
Carcinoma, Small Cell/*genetics
Lung Neoplasms/*genetics
Carcinoma, Small Cell/pathology ; Cell Adhesion ; Cell Line, Tumor ; Comparative Genomic Hybridization ; Focal Adhesion Protein-Tyrosine Kinases/analysis ; Focal Adhesion Protein-Tyrosine Kinases/antagonists & inhibitors ; Focal Adhesion Protein-Tyrosine Kinases/physiology ; Humans ; Lung Neoplasms/pathology ; Quinolones/pharmacology ; Sulfones/pharmacology
Czasopismo naukowe
Tytuł :
Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.
Autorzy :
Cheng L; Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853-6401, USA.
Zhou Z
Flesken-Nikitin A
Toshkov IA
Wang W
Camps J
Ried T
Nikitin AY
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2010 Oct 21; Vol. 29 (42), pp. 5700-11. Date of Electronic Publication: 2010 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Inhibitor of Apoptosis Proteins/*genetics
Mammary Neoplasms, Experimental/*genetics
Phosphoproteins/*genetics
Retinoblastoma Protein/*genetics
Tumor Suppressor Protein p53/*genetics
Animals ; Baculoviral IAP Repeat-Containing 3 Protein ; Cell Cycle Proteins ; Cell Transformation, Neoplastic/genetics ; Comparative Genomic Hybridization ; Female ; Gene Amplification ; Genomic Instability ; Immunohistochemistry ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Transgenic ; Tumor Suppressor Protein p53/deficiency ; Ubiquitin-Protein Ligases
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies