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Tytuł:
The complement alternative pathway in health and disease-activation or amplification?
Autorzy:
Harrison RA; Cardiff University, Cardiff, UK.
Harris CL; Newcastle University, Newcastle upon Tyne, UK.
Thurman JM; University of Colorado Denver School of Medicine, Aurora, Colorado, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 6-14. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Complement Activation*
Complement Pathway, Alternative*
Humans ; Complement System Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alternative pathway amplification and infections.
Autorzy:
Shaughnessy J; Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Chabeda A; Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Lewis LA; Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Ram S; Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 162-180. Date of Electronic Publication: 2022 Nov 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Complement Activation*/physiology
Complement Pathway, Alternative*
Bacterial Infections*/metabolism
Humans ; Properdin/metabolism ; Complement C3b/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low-molecular weight inhibitors of the alternative complement pathway.
Autorzy:
Schubart A; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Flohr S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Junt T; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Eder J; Novartis Institutes for BioMedical Research, Basel, Switzerland.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 339-357. Date of Electronic Publication: 2022 Oct 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Complement Pathway, Alternative*
Atypical Hemolytic Uremic Syndrome*/metabolism
Humans ; Molecular Weight ; Complement System Proteins/metabolism ; Complement Activation ; Complement Factor D/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alternative pathway activation: Ever ancient and ever new.
Autorzy:
Liszewski MK; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Atkinson JP; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 60-63. Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Complement Pathway, Alternative*/genetics
Complement Activation*
Humans ; Complement System Proteins/metabolism ; Inflammation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The susceptibility of the kidney to alternative pathway activation-A hypothesis.
Autorzy:
Thurman JM; Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
Harrison RA; School of Medicine, Cardiff University, Cardiff, UK.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 327-338. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Complement Pathway, Alternative*/genetics
Atypical Hemolytic Uremic Syndrome*/genetics
Atypical Hemolytic Uremic Syndrome*/pathology
Humans ; Complement C3/genetics ; Complement C3/metabolism ; Kidney ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/pathology ; Autoantibodies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Factor D.
Autorzy:
Sekine H; Department of Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Machida T; Department of Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Fujita T; Fukushima Prefectural General Hygiene Institute, Fukushima, Japan.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 15-24. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Factor D*/genetics
Complement Factor D*/metabolism
Complement Pathway, Alternative*/physiology
Humans ; Animals ; Mice ; Mannose-Binding Protein-Associated Serine Proteases/genetics ; Mannose-Binding Protein-Associated Serine Proteases/metabolism ; Complement System Proteins ; Mice, Knockout
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)-driven Complement-mediated Diseases.
Autorzy:
Gibson BG; Complement Therapeutics Research Group and Newcastle University Translational and Clinical Research Institute, Faculty of Medical Science, Newcastle-upon-Tyne, UK.; National Renal Complement Therapeutics Centre, aHUS Service, Newcastle upon Tyne, UK.
Cox TE; Complement Therapeutics Research Group and Newcastle University Translational and Clinical Research Institute, Faculty of Medical Science, Newcastle-upon-Tyne, UK.; National Renal Complement Therapeutics Centre, aHUS Service, Newcastle upon Tyne, UK.
Marchbank KJ; Complement Therapeutics Research Group and Newcastle University Translational and Clinical Research Institute, Faculty of Medical Science, Newcastle-upon-Tyne, UK.; National Renal Complement Therapeutics Centre, aHUS Service, Newcastle upon Tyne, UK.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 194-216. Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Pathway, Alternative*
Properdin*/metabolism
Animals ; Mice ; Humans ; Adaptive Immunity ; Mice, Knockout ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
To interpret and analyze the changing patterns of histology and direct immunofluorescence findings in membranoproliferative glomerulonephritis.
Autorzy:
Nayak PP; Department of Patholgy, Srirama Chandra Bhanja Medical College, Cuttack, Odisha, India.
Pradhan P; Department of Patholgy, Srirama Chandra Bhanja Medical College, Cuttack, Odisha, India.
Pradhan D; Department of Patholgy, Srirama Chandra Bhanja Medical College, Cuttack, Odisha, India.
Mohapatra N; Department of Patholgy, Srirama Chandra Bhanja Medical College, Cuttack, Odisha, India.
Raman S; Department of Patholgy, Srirama Chandra Bhanja Medical College, Cuttack, Odisha, India.
Sahoo P; Department of Patholgy, Srirama Chandra Bhanja Medical College, Cuttack, Odisha, India.
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Źródło:
Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2024 Jan-Mar; Vol. 67 (1), pp. 80-85.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Glomerulonephritis, Membranoproliferative*/diagnosis
Glomerulonephritis*/diagnosis
Humans ; Complement C3 ; Fluorescent Antibody Technique, Direct ; Antigen-Antibody Complex ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway.
Autorzy:
Shahraz A; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Lin Y; Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Mbroh J; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Winkler J; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Liao H; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Lackmann M; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Bungartz A; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Zipfel PF; Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.; Infection Biology, Institute of Microbiology, Friedrich Schiller University, Jena, Germany.
Skerka C; Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Neumann H; Neural Regeneration Unit, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 06; Vol. 12 (1), pp. 5818. Date of Electronic Publication: 2022 Apr 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Pathway, Alternative*
Properdin*/metabolism
Humans ; Molecular Weight ; Sialic Acids/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Autorzy:
Siggins MK; National Heart & Lung Institute, Imperial College London, London, UK.
Davies K; Division of Infection and Immunity and UK Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK.
Fellows R; Translational & Clinical Research Institute, Newcastle University, Newcastle, UK.
Thwaites RS; National Heart & Lung Institute, Imperial College London, London, UK.
Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, UK.
Semple MG; NIHR Health Protection Research Unit, Institute of Infection, Veterinary, and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
Openshaw PJM; National Heart & Lung Institute, Imperial College London, London, UK.
Zelek WM; Division of Infection and Immunity and UK Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK.
Harris CL; Translational & Clinical Research Institute, Newcastle University, Newcastle, UK.
Morgan BP; Division of Infection and Immunity and UK Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK.
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Corporate Authors:
ISARIC4C Investigators
Źródło:
Immunology [Immunology] 2023 Mar; Vol. 168 (3), pp. 473-492. Date of Electronic Publication: 2022 Nov 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Humans ; Complement Activation ; Complement System Proteins/metabolism ; Complement C3b ; Biomarkers ; Disease Progression ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease.
Autorzy:
Caruso A; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Vollmer J; LYO-X GmbH, Allschwil, Switzerland.
Machacek M; LYO-X GmbH, Allschwil, Switzerland.
Kortvely E; Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2020 Oct 02; Vol. 16 (10), pp. e1008139. Date of Electronic Publication: 2020 Oct 02 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Models, Immunological*
Complement Pathway, Alternative/*physiology
Hemolysis/*physiology
Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Complement Activation/drug effects ; Complement Activation/physiology ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use ; Complement Pathway, Alternative/drug effects ; Computational Biology ; Hemoglobinuria, Paroxysmal/drug therapy ; Hemoglobinuria, Paroxysmal/physiopathology ; Hemolysis/drug effects ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond.
Autorzy:
Pedersen DV; Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
Lorentzen J; Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 46-59. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Properdin*/genetics
Properdin*/metabolism
Complement Activation*
Humans ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop.
Autorzy:
Ekdahl KN; Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, Uppsala, Sweden.; Linnaeus Center of Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
Fromell K; Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, Uppsala, Sweden.
Mannes M; Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.
Grinnemo KH; Department of Surgical Sciences, Division of Cardiothoracic Surgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden.
Huber-Lang M; Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.
Teramura Y; Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, Uppsala, Sweden.; Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Master's/Doctoral Program in Life Science Innovation (T-LSI), University of Tsukuba, Tsukuba, Japan.
Nilsson B; Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, Uppsala, Sweden.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 91-103. Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Activation*
Complement System Proteins*
Humans ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Initiation of the alternative pathway of complement and the history of "tickover".
Autorzy:
Pangburn MK; Center for Biomedical Research, University of Texas Health Science Center, Tyler, Texas, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 64-70. Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Complement C3*/metabolism
Complement C3b*/metabolism
Humans ; Complement Activation ; Antibodies ; Sulfur Compounds ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway.
Autorzy:
Dreismann AK; Gyroscope Therapeutics Limited, London, UK.
Hallam TM; Gyroscope Therapeutics Limited, London, UK.
Tam LC; Gyroscope Therapeutics Limited, London, UK.
Nguyen CV; Gyroscope Therapeutics Limited, London, UK.
Hughes JP; Gyroscope Therapeutics Limited, London, UK.
Ellis S; Gyroscope Therapeutics Limited, London, UK.
Harris CL; Gyroscope Therapeutics Limited, London, UK.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 402-419. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement System Proteins*/genetics
Complement System Proteins*/metabolism
Hemoglobinuria, Paroxysmal*/drug therapy
Hemoglobinuria, Paroxysmal*/genetics
Humans ; Gene Targeting ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases.
Autorzy:
Rodríguez de Córdoba S; Centro de Investigaciones Biológicas Margarita Salas and Ciber de Enfermedades Raras, Madrid, Spain.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 71-90. Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Complement System Proteins*/genetics
Humans ; Genetic Association Studies ; Complement Pathway, Alternative/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop.
Autorzy:
Holers VM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 181-193. Date of Electronic Publication: 2022 Sep 16.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Activation*
Complement System Proteins*
Humans ; Animals ; Mice ; Disease Models, Animal ; Biomarkers ; Autoantibodies ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Factor H protein family: The switchers of the complement alternative pathway.
Autorzy:
Lucientes-Continente L; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University and Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain.
Márquez-Tirado B; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University and Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain.
Goicoechea de Jorge E; Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University and Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 25-45. Date of Electronic Publication: 2022 Nov 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Complement Factor H*/metabolism
Complement System Proteins*/metabolism
Humans ; Complement Activation ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alternative pathway diagnostics.
Autorzy:
Thurman JM; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Fremeaux-Bacchi V; Assistance Publique-Hôpitaux de Paris, European Hospital Georges Pompidou, Department of Immunology Biology and INSERM UMRS1138, Centre de Recherche des Cordeliers, Team 'Inflammation, Complement and Cancer', Paris, France.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 225-238. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Complement System Proteins*/genetics
Complement Activation*
Humans ; Prognosis ; Complement Pathway, Alternative/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Semi-solid phase assay for the alternative complement pathway activity assessment (AP 100 ).
Autorzy:
Kerboua KE; Laboratory of Immunology, Faculty of Medicine, University of Kasdi Merbah Ouargla, Algeria.
Djenouhat K; Laboratory of Immunology, Faculty of Medicine, University of Algiers I, Algeria.
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Źródło:
Journal of immunoassay & immunochemistry [J Immunoassay Immunochem] 2020; Vol. 41 (2), pp. 144-151. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Complement Pathway, Alternative*
Antibodies, Monoclonal, Humanized/*therapeutic use
Complement Inactivating Agents/*therapeutic use
Kidney Diseases/*drug therapy
Animals ; Chickens ; Complement System Proteins/analysis ; Humans ; Kidney Diseases/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 311

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