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Wyszukujesz frazę ""Complementarity Determining Regions"" wg kryterium: Temat


Tytuł :
Electrostatic Complementarity of T-Cell Receptor-Alpha CDR3 Domains and Mutant Amino Acids Is Associated with Better Survival Rates for Sarcomas.
Autorzy :
Yeagley M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Chobrutskiy BI; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Medikonda N; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Patel DN; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Falasiri S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Callahan BM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Huda T; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
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Źródło :
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2021 Apr; Vol. 38 (3), pp. 251-264. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Complementarity Determining Regions/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Sarcoma/*genetics
Amino Acids/genetics ; Child ; Complementarity Determining Regions/chemistry ; Exome ; Humans ; Kaplan-Meier Estimate ; Mutation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Sarcoma/epidemiology ; Static Electricity ; Survival Rate
Czasopismo naukowe
Tytuł :
Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.
Autorzy :
Gordin M; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Philip H; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Zilberberg A; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Gidoni M; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
Margalit R; Science in Action Ltd., Ness Ziona, Israel.
Clouser C; Juno Therapeutics, Seattle, Washington, United States of America.
Adams K; Juno Therapeutics, Seattle, Washington, United States of America.
Vigneault F; Juno Therapeutics, Seattle, Washington, United States of America.
Cohen IR; Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Yaari G; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
Efroni S; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Jan 19; Vol. 17 (1), pp. e1008486. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/genetics
Breast Neoplasms*/immunology
Breast Neoplasms*/metabolism
Receptors, Antigen, T-Cell*/chemistry
Receptors, Antigen, T-Cell*/genetics
Receptors, Antigen, T-Cell*/metabolism
Complementarity Determining Regions/*genetics
Animals ; Cells, Cultured ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/metabolism ; Databases, Genetic ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Mice, Transgenic ; T-Lymphocytes
Czasopismo naukowe
Tytuł :
Identification of new potential antigen recognized by γδT cells in hepatocellular carcinoma.
Autorzy :
Xi X; Institute of Basic Medical Sciences, Hubei University of Medicine, No.30 Renmin Nanlu, Shiyan, 442000, Hubei, China. .; Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China. .; Department of Rheumatology, Renmin Hospital, Hubei University of Medicine, Shiyan, China. .
Guo Y; Institute of Basic Medical Sciences, Hubei University of Medicine, No.30 Renmin Nanlu, Shiyan, 442000, Hubei, China.
Zhu M; Institute of Basic Medical Sciences, Hubei University of Medicine, No.30 Renmin Nanlu, Shiyan, 442000, Hubei, China.
Qiu F; Institute of Basic Medical Sciences, Hubei University of Medicine, No.30 Renmin Nanlu, Shiyan, 442000, Hubei, China.
Lei F; Department of Rheumatology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Li G; Department of Rheumatology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Du B; Institute of Basic Medical Sciences, Hubei University of Medicine, No.30 Renmin Nanlu, Shiyan, 442000, Hubei, China. .; Department of Rheumatology, Renmin Hospital, Hubei University of Medicine, Shiyan, China. .; Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jul; Vol. 70 (7), pp. 1917-1927. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*immunology
Complementarity Determining Regions/*immunology
Liver Neoplasms/*immunology
Lymphocyte Activation/*immunology
Peptide Fragments/*immunology
Receptors, Antigen, T-Cell, gamma-delta/*immunology
T-Lymphocytes/*immunology
Adult ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Complementarity Determining Regions/metabolism ; Female ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Peptide Fragments/metabolism ; Prognosis ; Receptors, Antigen, T-Cell, gamma-delta/metabolism
Czasopismo naukowe
Tytuł :
Exploring the different states of wild-type T-cell receptor and mutant conformational changes towards understanding the antigen recognition.
Autorzy :
Tripathi SK; Structural Immunology Group, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, India.
Salunke DM; Structural Immunology Group, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, India.; Structural Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Jan; Vol. 39 (1), pp. 188-201. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Complementarity Determining Regions*/metabolism
Receptors, Antigen, T-Cell*/genetics
Receptors, Antigen, T-Cell*/metabolism
Molecular Conformation ; Peptides/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions.
Autorzy :
Bozhanova NG; Department of Chemistry, Vanderbilt University, Nashville, TN 37235.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.
Sangha AK; Department of Chemistry, Vanderbilt University, Nashville, TN 37235.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.
Sevy AM; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550.
Nargi RS; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Reidy JX; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Trivette A; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.
Carnahan RH; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville TN 37232.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550.; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville TN 37232.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
Meiler J; Department of Chemistry, Vanderbilt University, Nashville, TN 37235; .; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.; Institute for Drug Discovery, Leipzig University Medical School, Leipzig, SAC 04103, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31142-31148. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Viral/*genetics
Complementarity Determining Regions/*genetics
Marburg Virus Disease/*immunology
Marburgvirus/*immunology
Animals ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Complementarity Determining Regions/immunology ; Epitopes/genetics ; Epitopes/immunology ; Glycoproteins/genetics ; Glycoproteins/immunology ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Marburg Virus Disease/drug therapy ; Marburg Virus Disease/genetics ; Marburg Virus Disease/virology ; Marburgvirus/pathogenicity ; Mutation/genetics ; Mutation/immunology ; Viral Envelope Proteins ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Czasopismo naukowe
Tytuł :
Reconstitution of an Anti-HER2 Antibody Paratope by Grafting Dual CDR-Derived Peptides onto a Small Protein Scaffold.
Autorzy :
See K; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan.
Kadonosono T; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan.
Ota Y; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan.
Miyamoto K; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan.
Yimchuen W; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan.
Kizaka-Kondoh S; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan.
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Źródło :
Biotechnology journal [Biotechnol J] 2020 Dec; Vol. 15 (12), pp. e2000078. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Binding Sites, Antibody*
Complementarity Determining Regions*
Antibodies, Monoclonal ; Peptides
Czasopismo naukowe
Tytuł :
Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions.
Autorzy :
Sun Y; Biological Technologies, Genentech, Inc., South San Francisco, CA 94080, USA; Protein Analytical Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
Cai H; DevSci PTPK, Genentech, Inc., South San Francisco, CA 94080, USA.
Hu Z; Early Stage Cell Culture, Genentech, Inc., South San Francisco, CA 94080, USA.
Boswell CA; DevSci PTPK, Genentech, Inc., South San Francisco, CA 94080, USA.
Diao J; Purification Development, Genentech, Inc., South San Francisco, CA 94080, USA.
Li C; Protein Analytical Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
Zhang L; Protein Analytical Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
Shen A; Early Stage Cell Culture, Genentech, Inc., South San Francisco, CA 94080, USA.
Teske CA; Purification Development, Genentech, Inc., South San Francisco, CA 94080, USA.
Zhang B; Protein Analytical Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
Kamath AV; DevSci PTPK, Genentech, Inc., South San Francisco, CA 94080, USA.
Jiang G; Biological Technologies, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address: .
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2020 Dec; Vol. 109 (12), pp. 3690-3696. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Complementarity Determining Regions*/genetics
Immunoglobulin G*
Humans
Czasopismo naukowe
Tytuł :
TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells.
Autorzy :
Aparicio-Soto M; Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Riedel F; Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Leddermann M; Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Bacher P; Institute of Immunology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany.; Institute of Clinical Molecular Biology, Christian-Albrechts Universität zu Kiel, Kiel, Germany.
Scheffold A; Institute of Immunology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany.
Kuhl H; Sequencing Core Facility, Max-Planck-Institute of Molecular Genetics, Berlin, Germany.
Timmermann B; Sequencing Core Facility, Max-Planck-Institute of Molecular Genetics, Berlin, Germany.
Chudakov DM; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.; Center of Molecular Medicine, CEITEC, Masaryk University, Brno, Czech Republic.
Molin S; Division of Dermatology, Queen's University, Kingston, ON, Canada.; Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany.
Worm M; Division of Allergy and Immunology, Department of Dermatology, Venerology, and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Heine G; Division of Allergy and Immunology, Department of Dermatology, Venerology, and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Thierse HJ; Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Luch A; Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Siewert K; Department of Chemical and Product Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
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Źródło :
Allergy [Allergy] 2020 Oct; Vol. 75 (10), pp. 2574-2586. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complementarity Determining Regions*
Nickel*
CD4-Positive T-Lymphocytes ; Histidine ; Patch Tests
Czasopismo naukowe
Tytuł :
Structural basis of a shared antibody response to SARS-CoV-2.
Autorzy :
Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liu H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhao F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hua Y; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tien H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Landais E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Sok D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Jardine JG; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. .; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 28; Vol. 369 (6507), pp. 1119-1123. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Formation*
Antibodies, Neutralizing/*chemistry
Antibodies, Viral/*chemistry
Betacoronavirus/*immunology
Complementarity Determining Regions/*chemistry
Coronavirus Infections/*prevention & control
Immunoglobulin Heavy Chains/*chemistry
Pandemics/*prevention & control
Pneumonia, Viral/*prevention & control
Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Binding Sites ; COVID-19 ; COVID-19 Vaccines ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Crystallography, X-Ray ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Pneumonia, Viral/immunology ; Protein Domains ; SARS-CoV-2 ; Viral Vaccines/chemistry ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Czasopismo naukowe
Tytuł :
T-Cell Receptor CDR3 Loop Conformations in Solution Shift the Relative Vα-Vβ Domain Distributions.
Autorzy :
Fernández-Quintero ML; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Pomarici ND; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Loeffler JR; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Seidler CA; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Liedl KR; Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Jul 08; Vol. 11, pp. 1440. Date of Electronic Publication: 2020 Jul 08 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complementarity Determining Regions/*chemistry
Receptors, Antigen, T-Cell, alpha-beta/*chemistry
Adaptive Immunity ; Animals ; Antigens/metabolism ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/metabolism ; Crystallography, X-Ray ; Histocompatibility Antigens/metabolism ; Humans ; Molecular Dynamics Simulation ; Peptides/metabolism ; Protein Binding ; Protein Conformation ; Protein Domains/genetics ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Structure-Activity Relationship ; T-Cell Antigen Receptor Specificity
Czasopismo naukowe
Tytuł :
Replacement of TCR Dβ With Immunoglobulin D H DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development.
Autorzy :
Levinson M; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Khass M; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.; Division of Genetic Engineering and Biotechnology, National Research Center, Cairo, Egypt.
Burrows PD; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Schroeder HW Jr; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 29; Vol. 11, pp. 573413. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Complementarity Determining Regions*
Genes, Immunoglobulin Heavy Chain*
Genes, T-Cell Receptor beta*
Immunoglobulin Heavy Chains/*metabolism
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
T-Lymphocytes/*metabolism
Thymocytes/*metabolism
Animals ; Immunization ; Immunodominant Epitopes ; Immunoglobulin Heavy Chains/genetics ; Lymphocyte Activation ; Mice, Inbred C57BL ; Mice, Knockout ; Ovalbumin/administration & dosage ; Ovalbumin/immunology ; Phenotype ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes/immunology ; Thymocytes/immunology ; Tyrosine
Czasopismo naukowe
Tytuł :
Profiling the pattern of human TRB/IGH-CDR3 repertoire in liver transplantation patients via high-throughput sequencing analysis.
Autorzy :
Han FF; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Fan H; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Ren LL; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wang HG; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wang C; Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
Ma X; Department of Genetics, National Research Institute for Family Planning, Beijing, China.; Graduate School of Peking, Union Medical College, Beijing, China.
Liu LH; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
He Q; Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Guo CL; Department of Genetics, National Research Institute for Family Planning, Beijing, China.; Graduate School of Peking, Union Medical College, Beijing, China.
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Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Aug; Vol. 92 (2), pp. e12912. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Liver Transplantation*
Complementarity Determining Regions/*immunology
Graft Rejection/*immunology
Immunoglobulin Heavy Chains/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
Adult ; Complementarity Determining Regions/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Immunoglobulin Heavy Chains/genetics ; Male ; Middle Aged ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Czasopismo naukowe
Tytuł :
Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Autorzy :
Chan DTY; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Jenkinson L; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Haynes SW; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Austin M; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.; Antibody Discovery & Protein Engineering, BioPharmaceuticals Research & Development, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
Diamandakis A; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Burschowsky D; Leicester Institute of Structural and Chemical Biology, University of Leicester, LE1 7HB Leicester, United Kingdom.; Department of Molecular and Cell Biology, University of Leicester, LE1 7HB Leicester, United Kingdom.
Seewooruthun C; Leicester Institute of Structural and Chemical Biology, University of Leicester, LE1 7HB Leicester, United Kingdom.; Department of Molecular and Cell Biology, University of Leicester, LE1 7HB Leicester, United Kingdom.
Addyman A; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Fiedler S; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Ryman S; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Whitehouse J; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Slater LH; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Gowans E; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Shibata Y; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Barnard M; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Wilkinson RW; Early Oncology Discovery, Oncology Research & Development, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
Vaughan TJ; Antibody Discovery & Protein Engineering, BioPharmaceuticals Research & Development, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
Holt SV; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom.
Cerundolo V; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, United Kingdom.
Carr MD; Leicester Institute of Structural and Chemical Biology, University of Leicester, LE1 7HB Leicester, United Kingdom; .; Department of Molecular and Cell Biology, University of Leicester, LE1 7HB Leicester, United Kingdom.
Groves MAT; Cancer Research UK-AstraZeneca Antibody Alliance Laboratory, CB21 6GP Cambridge, United Kingdom; .; Antibody Discovery & Protein Engineering, BioPharmaceuticals Research & Development, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 21; Vol. 117 (29), pp. 16949-16960. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Affinity*
Antibodies/*chemistry
Arginase/*immunology
Complementarity Determining Regions/*chemistry
Antibodies/genetics ; Antibodies/immunology ; Binding Sites, Antibody ; Complementarity Determining Regions/immunology ; Humans
Czasopismo naukowe
Tytuł :
Major rise of a chronic lymphoid leukemia clone during the course of COVID-19.
Autorzy :
Largeaud L; Laboratory of Hematology, University Hospital of Toulouse, Toulouse, France.; Université Toulouse III - Paul Sabatier, Toulouse, France.
Ribes A; Laboratory of Hematology, University Hospital of Toulouse, Toulouse, France.; Université Toulouse III - Paul Sabatier, Toulouse, France.
Dubois-Galopin F; Laboratory of Hematology, University Hospital of Toulouse, Toulouse, France.
Mémier V; Laboratory of Hematology, University Hospital of Toulouse, Toulouse, France.
Rolland Y; Université Toulouse III - Paul Sabatier, Toulouse, France.; Department of Geriatric Medicine, University Hospital of Toulouse, Toulouse, France.
Gaudin C; Department of Geriatric Medicine, University Hospital of Toulouse, Toulouse, France.
Rousset D; Department of Anesthesiology and Critical Care, University Hospital of Toulouse, Toulouse, France.
Geeraerts T; Université Toulouse III - Paul Sabatier, Toulouse, France.; Department of Anesthesiology and Critical Care, University Hospital of Toulouse, Toulouse, France.
Noel-Savina E; Department of Pneumology, University Hospital of Toulouse, Toulouse, France.
Rieu JB; Laboratory of Hematology, University Hospital of Toulouse, Toulouse, France.
Vergez F; Laboratory of Hematology, University Hospital of Toulouse, Toulouse, France.; Université Toulouse III - Paul Sabatier, Toulouse, France.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2021 Apr; Vol. 43 (2), pp. e82-e83. Date of Electronic Publication: 2020 Nov 08.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
COVID-19/*pathology
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Lymphocytes/*pathology
Lymphocytosis/*pathology
SARS-CoV-2/*pathogenicity
Aged, 80 and over ; COVID-19/diagnostic imaging ; COVID-19/immunology ; COVID-19/virology ; Clone Cells ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Disease Progression ; Gene Expression ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnostic imaging ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/virology ; Lymphocytes/immunology ; Lymphocytes/virology ; Lymphocytosis/diagnostic imaging ; Lymphocytosis/immunology ; Lymphocytosis/virology ; Male ; Mutation ; Remission, Spontaneous ; SARS-CoV-2/immunology ; Severity of Illness Index ; Tomography, X-Ray Computed ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/immunology
Raport
Tytuł :
MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4 T cells.
Autorzy :
Logunova NN; Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, 107564, Russia.
Kriukova VV; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.; Center of Life Sciences, Skoltech, Moscow, 143026, Russia.
Shelyakin PV; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.
Egorov ES; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
Pereverzeva A; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.
Bozhanova NG; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.; Department of Chemistry, Vanderbilt University, Nashville, TN 37235.
Shugay M; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.; Center of Life Sciences, Skoltech, Moscow, 143026, Russia.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
Shcherbinin DS; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
Pogorelyy MV; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
Merzlyak EM; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
Zubov VN; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.
Meiler J; Center for Structural Biology, Vanderbilt University, Nashville, TN 37235.; Department of Chemistry, Vanderbilt University, Nashville, TN 37235.; Institute for Drug Discovery, Leipzig University, Leipzig, SAC 04103, Germany.
Chudakov DM; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.; Center of Life Sciences, Skoltech, Moscow, 143026, Russia.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
Apt AS; Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, 107564, Russia; .
Britanova OV; Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 16; Vol. 117 (24), pp. 13659-13669. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complementarity Determining Regions/*immunology
Histocompatibility Antigens Class II/*immunology
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes, Regulatory/*immunology
Tuberculosis/*genetics
Alleles ; Animals ; CD4-Positive T-Lymphocytes/immunology ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/genetics ; Histocompatibility Antigens Class II/genetics ; Humans ; Mice ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell/chemistry ; Receptors, Antigen, T-Cell/genetics ; Spleen/immunology ; T-Lymphocytes, Regulatory/chemistry ; Tuberculosis/immunology
Czasopismo naukowe
Tytuł :
A scoring system for the electrostatic complementarities of T-cell receptors and cancer-mutant amino acids: multi-cancer analyses of associated survival rates.
Autorzy :
Chobrutskiy BI; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Yeagley M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Diviney A; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Zaman S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Tipping P; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Koohestani DM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Roca AM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
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Źródło :
Immunology [Immunology] 2020 Apr; Vol. 159 (4), pp. 373-383. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Algorithms*
Antigens, Neoplasm/*chemistry
Breast Neoplasms/*genetics
Complementarity Determining Regions/*chemistry
Lung Neoplasms/*genetics
Receptor-CD3 Complex, Antigen, T-Cell/*chemistry
Skin Neoplasms/*genetics
Amino Acid Sequence ; Amino Acids ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Binding Sites ; Breast Neoplasms/diagnosis ; Breast Neoplasms/immunology ; Breast Neoplasms/mortality ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Exome ; Female ; Gene Expression ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Male ; Mutation ; Prognosis ; Protein Binding ; Receptor-CD3 Complex, Antigen, T-Cell/genetics ; Receptor-CD3 Complex, Antigen, T-Cell/immunology ; Research Design ; Skin Neoplasms/diagnosis ; Skin Neoplasms/immunology ; Skin Neoplasms/mortality ; Static Electricity ; Survival Rate ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
Czasopismo naukowe
Tytuł :
Multiple sevoflurane exposures don't disturb the T-cell receptor repertoire in infant rhesus monkeys' thymus.
Autorzy :
Cheng Y; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
Wang J; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
Wu N; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
Zhang L; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: .
Jiang H; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 May 01; Vol. 248, pp. 117457. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Anesthetics, Inhalation/*pharmacology
Complementarity Determining Regions/*genetics
Receptors, Antigen, T-Cell/*genetics
Sevoflurane/*pharmacology
T-Lymphocytes/*drug effects
Thymus Gland/*drug effects
Animals ; Animals, Newborn ; Complementarity Determining Regions/classification ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; High-Throughput Nucleotide Sequencing ; Macaca mulatta ; Male ; Receptors, Antigen, T-Cell/classification ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Thymus Gland/cytology ; Thymus Gland/immunology ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
Characterization of the TCR β Chain CDR3 Repertoire in Subarachnoid Hemorrhage Patients with Delayed Cerebral Ischemia.
Autorzy :
Kim BJ; Institute of New Frontier Stroke Research, Hallym University College of Medicine, Chuncheon 24253, Korea.
Youn DH; Institute of New Frontier Stroke Research, Hallym University College of Medicine, Chuncheon 24253, Korea.
Kim Y; Institute of New Frontier Stroke Research, Hallym University College of Medicine, Chuncheon 24253, Korea.
Jeon JP; Institute of New Frontier Stroke Research, Hallym University College of Medicine, Chuncheon 24253, Korea.; Genetic and Research Inc., Chuncheon 24253, Korea.; Department of Neurosurgery, Hallym University College of Medicine, Chuncheon 24253, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 29; Vol. 21 (9). Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Ischemia/*etiology
Complementarity Determining Regions/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Subarachnoid Hemorrhage/*etiology
Clonal Evolution/genetics ; Clonal Evolution/immunology ; Complementarity Determining Regions/metabolism ; Computational Biology/methods ; Disease Susceptibility ; Female ; Gene Expression Profiling ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Humans ; Male ; Middle Aged ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Antibody complementarity determining region design using high-capacity machine learning.
Autorzy :
Liu G; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zeng H; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mueller J; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carter B; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wang Z; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Schilz J; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Horny G; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Birnbaum ME; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.
Ewert S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Gifford DK; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2020 Apr 01; Vol. 36 (7), pp. 2126-2133.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Complementarity Determining Regions*
Machine Learning*
Antibodies ; Humans
Czasopismo naukowe
Tytuł :
Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb.
Autorzy :
Lan W; Drug Product Development, Bristol Myers Squibb, New Brunswick, United States.
Valente JJ; Drug Product Development, Bristol Myers Squibb, New Brunswick, United States.
Ilott A; Drug Product Development, Bristol Myers Squibb, New Brunswick, United States.
Chennamsetty N; Biophysics Center of Excellence, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, United States.
Liu Z; Drug Product Development, Bristol Myers Squibb, New Brunswick, United States.
Rizzo JM; Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States.
Yamniuk AP; Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States.
Qiu D; Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States.
Shackman HM; Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States.
Bolgar MS; Drug Product Development, Bristol Myers Squibb, New Brunswick, United States.
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Źródło :
MAbs [MAbs] 2020 Jan-Dec; Vol. 12 (1), pp. 1763138.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Conformation*
Antibodies, Monoclonal/*chemistry
Complementarity Determining Regions/*chemistry
Recombinant Proteins/*chemistry
Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antigen-Antibody Reactions/immunology ; CHO Cells ; Chromatography, Liquid/methods ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Cricetinae ; Cricetulus ; Humans ; Hydrogen-Ion Concentration ; Mass Spectrometry/methods ; Models, Molecular ; Peptide Mapping/methods ; Recombinant Proteins/immunology ; Recombinant Proteins/therapeutic use ; Surface Plasmon Resonance/methods
Czasopismo naukowe

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