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Tytuł:
High-throughput sequencing reveals the change of TCR α chain CDR3 with Takayasu arteritis.
Autorzy:
Zha B; Department of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Pan L; Department of Rheumatology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Gao N; Department of Rheumatology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Dec; Vol. 11 (12), pp. e1122.
Typ publikacji:
Journal Article
MeSH Terms:
Complementarity Determining Regions*/genetics
Takayasu Arteritis*/diagnosis
Takayasu Arteritis*/genetics
Humans ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; High-Throughput Nucleotide Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
KA-Search, a method for rapid and exhaustive sequence identity search of known antibodies.
Autorzy:
Olsen TH; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford, OX1 3LB, UK.
Abanades B; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford, OX1 3LB, UK.
Moal IH; GSK Medicines Research Centre, GlaxoSmithKline plc, Stevenage, SG1 2NY, UK.
Deane CM; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford, OX1 3LB, UK. .; Exscientia plc, Oxford, OX4 4GE, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 18; Vol. 13 (1), pp. 11612. Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complementarity Determining Regions*/chemistry
Antibodies*
Amino Acid Sequence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of CDR3 Sequences from T-Cell Receptor β in Acute Respiratory Distress Syndrome.
Autorzy:
Hey S; Department of Biology, University of Dallas, Irving, TX 75062, USA.
Whyte D; Department of Biology, University of Dallas, Irving, TX 75062, USA.
Hoang MC; Department of Biology, University of Dallas, Irving, TX 75062, USA.
Le N; Department of Biology, University of Dallas, Irving, TX 75062, USA.
Natvig J; Department of Biology, University of Dallas, Irving, TX 75062, USA.
Wingfield C; Department of Biology, University of Dallas, Irving, TX 75062, USA.
Onyeama C; T.C Pediatrics, Bedford, TX 76021, USA.
Howrylak J; Pulmonary, Allergy and Critical Care Division, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Toby IT; Department of Biology, University of Dallas, Irving, TX 75062, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 May 12; Vol. 13 (5). Date of Electronic Publication: 2023 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complementarity Determining Regions*/genetics
Respiratory Distress Syndrome*/genetics
Humans ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell ; Edema
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TCR CDR3-antigen chemical complementarity associated with poor ovarian cancer outcomes: A vestigial immune response to early cancer antigens?
Autorzy:
Barker VR; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Varkhedi M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Patel DN; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Hsiang M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Chobrutskiy A; Department of Pediatrics, Oregon Health and Science University Hospital, Portland, Oregon, USA.
Chobrutskiy BI; Department of Internal Medicine, Oregon Health and Science University Hospital, Portland, Oregon, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
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Źródło:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2023 Jan; Vol. 89 (1), pp. e13639. Date of Electronic Publication: 2022 Nov 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complementarity Determining Regions*/genetics
Complementarity Determining Regions*/chemistry
Ovarian Neoplasms*
Humans ; Female ; Immunity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Immune repertoire analysis of normal Chinese donors at different ages.
Autorzy:
Song C; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
Pan W; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.; Nanjing ARP Biotechnology Co., Ltd., Nanjing, China.
Brown B; iRepertoire Inc., Huntsville, Alabama, USA.
Tang C; Nanjing ARP Biotechnology Co., Ltd., Nanjing, China.
Huang Y; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
Chen H; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
Peng N; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
Wang Z; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.; Guangdong Provincial Hospital of Chinese Medicine & Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Weber D; iRepertoire Inc., Huntsville, Alabama, USA.
Byrne-Steele M; iRepertoire Inc., Huntsville, Alabama, USA.
Wu H; Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, China.
Liu H; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.; Nanjing ARP Biotechnology Co., Ltd., Nanjing, China.
Deng Y; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
He N; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
Li S; Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.
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Źródło:
Cell proliferation [Cell Prolif] 2022 Nov; Vol. 55 (11), pp. e13311. Date of Electronic Publication: 2022 Aug 04.
Typ publikacji:
Journal Article
MeSH Terms:
Complementarity Determining Regions*/genetics
Complementarity Determining Regions*/metabolism
Receptors, Antigen, T-Cell, alpha-beta*/genetics
Receptors, Antigen, T-Cell, alpha-beta*/metabolism
Humans ; T-Lymphocytes/metabolism ; High-Throughput Nucleotide Sequencing/methods ; China
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Significance of antibody numbering systems in the development of antibody engineering.
Autorzy:
Patel R; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Verma P; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Nagraj AK; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Gavade A; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
Sharma OP; Innoplexus AG, Eschborn, Germany.
Patil J; Innoplexus Consulting Services Pvt Ltd, Pune, Maharashtra, India.
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Źródło:
Human antibodies [Hum Antibodies] 2023; Vol. 31 (4), pp. 71-80.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antibodies*/genetics
Antibodies*/chemistry
Complementarity Determining Regions*/chemistry
Humans ; Antibody Affinity ; Binding Sites, Antibody
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimizing Antibody Affinity and Developability Using a Framework-CDR Shuffling Approach-Application to an Anti-SARS-CoV-2 Antibody.
Autorzy:
Gopal R; Discovery and Diagnostics Division, Peritia Inc., 12 Gill Street, Woburn, MA 01801, USA.
Fitzpatrick E; Discovery and Diagnostics Division, Peritia Inc., 12 Gill Street, Woburn, MA 01801, USA.
Pentakota N; Discovery and Diagnostics Division, Peritia Inc., 12 Gill Street, Woburn, MA 01801, USA.
Jayaraman A; Discovery and Diagnostics Division, Peritia Inc., 12 Gill Street, Woburn, MA 01801, USA.
Tharakaraman K; Discovery and Diagnostics Division, Peritia Inc., 12 Gill Street, Woburn, MA 01801, USA.
Capila I; Celltas Biosciences, 900 Middlesex Turnpike, Billerica, MA 01821, USA.
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Źródło:
Viruses [Viruses] 2022 Nov 30; Vol. 14 (12). Date of Electronic Publication: 2022 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Complementarity Determining Regions*/genetics
COVID-19*
Humans ; Antibody Affinity ; SARS-CoV-2/genetics ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Neutralizing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlation of IgH-CDR3 Immune Repertoire Diversity Test in Peripheral Blood of Neuromyelitis Spectrum Diseases.
Autorzy:
Peng Z; Internal Neurology, Shaoyang University Affiliated Second Hospital, Shaoyang, 422000 Hunan, China.
Deng H; Precision Medicine Center, First People's Hospital, Chenzhou, 423000 Hunan, China.
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Źródło:
BioMed research international [Biomed Res Int] 2022 Oct 10; Vol. 2022, pp. 6790145. Date of Electronic Publication: 2022 Oct 10 (Print Publication: 2022).
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Complementarity Determining Regions*/genetics
Neuromyelitis Optica*/diagnosis
Neuromyelitis Optica*/genetics
Humans ; High-Throughput Nucleotide Sequencing ; Receptors, Antigen, B-Cell
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Landscape of B Cell Receptor Repertoires in COVID-19 Patients Revealed Through CDR3 Sequencing of Immunoglobulin Heavy and Light Chains.
Autorzy:
Gao H; Central Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.; Department of Respiratory Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Yu L; Central Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Yan F; Central Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
Zheng Y; Department of Microbiology, Quanzhou Municipal Center for Disease Control and Prevention, Fujian Province, Quanzhou, China.
Huang H; Department of Pulmonary and Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian Province, China.
Zhuang X; Department of Pulmonary and Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian Province, China.
Zeng Y; Department of Respiratory Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
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Źródło:
Immunological investigations [Immunol Invest] 2022 Oct; Vol. 51 (7), pp. 1994-2008. Date of Electronic Publication: 2022 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/genetics
Complementarity Determining Regions*/genetics
B-Lymphocytes ; Humans ; Receptors, Antigen, B-Cell/genetics ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential performance of RoseTTAFold in antibody modeling.
Autorzy:
Liang T; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jiang C; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Yuan J; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Othman Y; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Xie XQ; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Feng Z; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2022 Sep 20; Vol. 23 (5).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antibodies*/chemistry
Complementarity Determining Regions*
Algorithms ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq.
Autorzy:
Heimli M; Department of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Tennebø Flåm S; Department of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Sagsveen Hjorthaug H; Department of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Bjørnstad PM; Department of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Chernigovskaya M; Department of Immunology, University of Oslo and Oslo University Hospital, 0372, Oslo, Norway.
Le QK; Department of Immunology, University of Oslo and Oslo University Hospital, 0372, Oslo, Norway.
Tekpli X; Department of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Greiff V; Department of Immunology, University of Oslo and Oslo University Hospital, 0372, Oslo, Norway.
Lie BA; Department of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 18; Vol. 13 (1), pp. 17714. Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Antigen, T-Cell*/metabolism
Thymocytes*/metabolism
Humans ; Child ; Thymus Gland/metabolism ; T-Lymphocytes, Regulatory ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/metabolism ; Cell Differentiation ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens.
Autorzy:
Peng HP; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 155.
Hsu HJ; Genomics Research Center, Academia Sinica, 128 Academia Rd., Sec.2, Nankang Dist., Taipei, Taiwan, 115.
Yu CM; Genomics Research Center, Academia Sinica, 128 Academia Rd., Sec.2, Nankang Dist., Taipei, Taiwan, 115.
Hung FH; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 155.
Tung CP; Genomics Research Center, Academia Sinica, 128 Academia Rd., Sec.2, Nankang Dist., Taipei, Taiwan, 115.
Huang YC; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 155.
Chen CY; Genomics Research Center, Academia Sinica, 128 Academia Rd., Sec.2, Nankang Dist., Taipei, Taiwan, 115.
Tsai PH; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 155.
Yang AS; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 155. .; Genomics Research Center, Academia Sinica, 128 Academia Rd., Sec.2, Nankang Dist., Taipei, Taiwan, 115. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 22; Vol. 12 (1), pp. 12555. Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids*
Complementarity Determining Regions*/chemistry
Antibody Affinity ; Antibody Specificity ; Antigen-Antibody Complex ; Antigens ; Humans ; Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Synthetic Antibody Library with Complementarity-Determining Region Diversities Designed for an Improved Amplification Profile.
Autorzy:
Bai X; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Jang M; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Lee NJ; Department of Bioinspired Science, Ewha Womans University, Seoul 03760, Korea.
Nguyen TTH; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Jung M; Department of Bioinspired Science, Ewha Womans University, Seoul 03760, Korea.
Hwang JY; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Shim H; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 02; Vol. 23 (11). Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Complementarity Determining Regions*/genetics
Single-Chain Antibodies*/genetics
High-Throughput Nucleotide Sequencing ; Peptide Library
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies.
Autorzy:
Löhr T; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Sormanni P; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Vendruscolo M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
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Źródło:
Biomolecules [Biomolecules] 2022 May 18; Vol. 12 (5). Date of Electronic Publication: 2022 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Complementarity Determining Regions*/chemistry
Single-Domain Antibodies*/chemistry
Antibodies ; Entropy ; Molecular Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biological Applications of Synthetic Binders Isolated from a Conceptually New Adhiron Library.
Autorzy:
D'Ercole C; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Rožna Dolina, 5000 Nova Gorica, Slovenia.
De March M; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Rožna Dolina, 5000 Nova Gorica, Slovenia.
Veggiani G; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Oloketuyi S; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Rožna Dolina, 5000 Nova Gorica, Slovenia.
Svigelj R; Department of Agrifood, Environmental and Animal Science, University of Udine, via Cotonificio 108, 33100 Udine, Italy.
de Marco A; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Rožna Dolina, 5000 Nova Gorica, Slovenia.
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Źródło:
Biomolecules [Biomolecules] 2023 Oct 17; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Peptide Library*
Single-Domain Antibodies*/pharmacology
Enzyme-Linked Immunosorbent Assay ; Complementarity Determining Regions ; Epitopes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human IgM B Cells Are Circulating Marginal Zone Memory B Cells That Respond to Pneumococcal Polysaccharides and Their Frequency Is Decreased in People Living with HIV.
Autorzy:
Vitallé J; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, 41013 Seville, Spain.
Zenarruzabeitia O; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Merino-Pérez A; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Terrén I; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Orrantia A; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Pacho de Lucas A; Regulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; Immunology Service, Cruces University Hospital, 48903 Barakaldo, Spain.
Iribarren JA; Department of Infectious Diseases, Donostia University Hospital, Biodonostia Health Research Institute, 20014 Donostia-San Sebastián, Spain.
García-Fraile LJ; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Internal Medicine, La Princesa University Hospital, 28006 Madrid, Spain.
Balsalobre L; Laboratory of Microbiology, UR Salud, Infanta Sofía University Hospital, 28702 Madrid, Spain.
Amo L; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain.
de Andrés B; Immunobiology Department, Carlos III Health Institute, 28220 Madrid, Spain.
Borrego F; Immunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 06; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 06.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections*
Pneumococcal Infections*
Humans ; Memory B Cells ; Streptococcus pneumoniae ; Adjuvants, Immunologic ; Complementarity Determining Regions ; Immunoglobulin M
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Similarity measurements of B cell receptor repertoire in baseline mice showed spectrum convergence of IgM.
Autorzy:
Wu H; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Zhou Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Xie S; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yan R; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Gong M; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Tian X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China. .
Wang Z; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China. .
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Źródło:
BMC immunology [BMC Immunol] 2022 Mar 04; Vol. 23 (1), pp. 11. Date of Electronic Publication: 2022 Mar 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complementarity Determining Regions*/genetics
Receptors, Antigen, B-Cell*/genetics
Animals ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M/genetics ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CDR1 Composition Can Affect Nanobody Recombinant Expression Yields.
Autorzy:
Orlando M; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100 Varese, Italy.
Fortuna S; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.
Oloketuyi S; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Rožna Dolina, 5000 Nova Gorica, Slovenia.
Bajc G; Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia.
Goldenzweig A; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
de Marco A; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Rožna Dolina, 5000 Nova Gorica, Slovenia.
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Źródło:
Biomolecules [Biomolecules] 2021 Sep 14; Vol. 11 (9). Date of Electronic Publication: 2021 Sep 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complementarity Determining Regions/*immunology
Recombinant Proteins/*biosynthesis
Single-Domain Antibodies/*immunology
Amino Acid Sequence ; Complementarity Determining Regions/chemistry ; Molecular Dynamics Simulation ; Single-Domain Antibodies/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.
Autorzy:
Gordin M; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Philip H; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Zilberberg A; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
Gidoni M; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
Margalit R; Science in Action Ltd., Ness Ziona, Israel.
Clouser C; Juno Therapeutics, Seattle, Washington, United States of America.
Adams K; Juno Therapeutics, Seattle, Washington, United States of America.
Vigneault F; Juno Therapeutics, Seattle, Washington, United States of America.
Cohen IR; Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Yaari G; Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.
Efroni S; The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Jan 19; Vol. 17 (1), pp. e1008486. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*/genetics
Breast Neoplasms*/immunology
Breast Neoplasms*/metabolism
Receptors, Antigen, T-Cell*/chemistry
Receptors, Antigen, T-Cell*/genetics
Receptors, Antigen, T-Cell*/metabolism
Complementarity Determining Regions/*genetics
Animals ; Cells, Cultured ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/metabolism ; Databases, Genetic ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Mice, Transgenic ; T-Lymphocytes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Electrostatic Complementarity of T-Cell Receptor-Alpha CDR3 Domains and Mutant Amino Acids Is Associated with Better Survival Rates for Sarcomas.
Autorzy:
Yeagley M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Chobrutskiy BI; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Medikonda N; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Patel DN; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Falasiri S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Callahan BM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Huda T; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
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Źródło:
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2021 Apr; Vol. 38 (3), pp. 251-264. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Complementarity Determining Regions/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Sarcoma/*genetics
Amino Acids/genetics ; Child ; Complementarity Determining Regions/chemistry ; Exome ; Humans ; Kaplan-Meier Estimate ; Mutation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Sarcoma/epidemiology ; Static Electricity ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
General Trends of the Camelidae Antibody V H Hs Domain Dynamics.
Autorzy:
Vattekatte AM; Université de Paris, INSERM, BIGR, F-75014 Paris, France.; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.
Diharce J; Université de Paris, INSERM, BIGR, F-75014 Paris, France.
Rebehmed J; Department of Computer Science and Mathematics, Lebanese American University, Beirut 1102 2801, Lebanon.
Cadet F; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.; Artificial Intelligence Department, PEACCEL, Square Albin Cachot, F-75013 Paris, France.
Gardebien F; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.
Etchebest C; Université de Paris, INSERM, BIGR, F-75014 Paris, France.
de Brevern AG; Université de Paris, INSERM, BIGR, F-75014 Paris, France.; Université de la Réunion, INSERM, BIGR, F-97715 Saint-Denis, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 24; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Camelidae*
Immunoglobulin Variable Region*/chemistry
Animals ; Complementarity Determining Regions/chemistry ; Immunoglobulin Heavy Chains/chemistry ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural basis of a shared antibody response to SARS-CoV-2.
Autorzy:
Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liu H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhao F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hua Y; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tien H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Landais E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Sok D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Jardine JG; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. .; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2020 Aug 28; Vol. 369 (6507), pp. 1119-1123. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibody Formation*
Antibodies, Neutralizing/*chemistry
Antibodies, Viral/*chemistry
Betacoronavirus/*immunology
Complementarity Determining Regions/*chemistry
Coronavirus Infections/*prevention & control
Immunoglobulin Heavy Chains/*chemistry
Pandemics/*prevention & control
Pneumonia, Viral/*prevention & control
Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Binding Sites ; COVID-19 ; COVID-19 Vaccines ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Crystallography, X-Ray ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Pneumonia, Viral/immunology ; Protein Domains ; SARS-CoV-2 ; Viral Vaccines/chemistry ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRB CDR3-cancer testis antigen chemical complementarity scoring for identifying productive immune responses in renal cell carcinoma.
Autorzy:
Hudock TR; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Barker VR; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Manley BJ; Department of Genitourinary Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Chobrutskiy A; Department of Pediatrics, Oregon Health and Science University Hospital, Portland, OR, USA.
Chobrutskiy BI; Department of Internal Medicine, Oregon Health and Science University Hospital, Portland, OR, USA.
Diaz MJ; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Song JJ; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
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Źródło:
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2023; Vol. 38 (1), pp. 103-110.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Renal Cell*/genetics
Kidney Neoplasms*/genetics
Male ; Humans ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Testis/metabolism ; Immunity ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of the Heterogeneity of CD4 T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALB/c Mice.
Autorzy:
Zhang T; Department of Breast Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China 563000.; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
Duan F; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
Su D; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
Ma L; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
Yang J; Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China 310003.
Shi B; Department of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, China 563000.
He X; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
Ma R; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
Sun S; Department of Breast Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China 563000.
Yao X; Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China 563000.
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Źródło:
Journal of immunology research [J Immunol Res] 2020 Sep 24; Vol. 2020, pp. 3184190. Date of Electronic Publication: 2020 Sep 24 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms/*immunology
Complementarity Determining Regions/*immunology
Lung Neoplasms/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
T-Lymphocyte Subsets/*immunology
T-Lymphocyte Subsets/*metabolism
Animals ; Breast Neoplasms/pathology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Clonal Evolution/genetics ; Complementarity Determining Regions/genetics ; Disease Models, Animal ; Female ; Genetic Variation ; Lung Neoplasms/secondary ; Mice ; Mice, Inbred BALB C ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombination, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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