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Tytuł:
Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Autorzy:
Song J; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Gooding AR; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Hemphill WO; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Love BD; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.
Robertson A; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Yao L; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
Zon LI; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
North TE; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.
Kasinath V; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
Cech TR; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Sep 22; Vol. 381 (6664), pp. 1331-1337. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:
Journal Article
MeSH Terms:
Polycomb Repressive Complex 2*/chemistry
Polycomb Repressive Complex 2*/genetics
RNA Precursors*
RNA, Long Noncoding*/chemistry
RNA, Long Noncoding*/genetics
G-Quadruplexes*
Animals ; Cryoelectron Microscopy ; Histones/genetics ; Zebrafish/genetics ; Zebrafish/growth & development ; Gain of Function Mutation ; Promoter Regions, Genetic ; Protein Binding ; Enhancer of Zeste Homolog 2 Protein/chemistry ; Enhancer of Zeste Homolog 2 Protein/genetics ; Crystallography, X-Ray ; Protein Conformation ; Protein Multimerization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinical Significance of Upregulation of EZH1 Expression in Hepatocellular Carcinoma Tissues.
Autorzy:
Chen SY; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Guangxi key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. . .
Li JD; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Guangxi key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. Jiandi_Li_.
Huang ZG; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Guangxi key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. .
He RQ; Guangxi key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Department of Internal Medicine-Oncology, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. .
Chen F; Department of Internal Medicine-Oncology, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China. feng_chen_.
Li JJ; Department of General Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China. .
Huang ZQ; Department of Pathology, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China. zhaoquanhuang_.
Chen JT; Department of Pathology, Lingshan People's Hospital, Qinzhou, Guangxi Zhuang Autonomous Region, People's Republic of China. ls_ji_.
Chen G; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Guangxi key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. .
Dang YW; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region; Guangxi key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. .
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Źródło:
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2024 Mar 30; Vol. 33 (1), pp. 44-56. Date of Electronic Publication: 2024 Mar 30.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Humans ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; Up-Regulation ; Clinical Relevance ; Prognosis ; Gene Expression Regulation, Neoplastic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma.
Autorzy:
Harachi M; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Masui K; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan. .
Shimizu E; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Murakami K; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Onizuka H; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Muragaki Y; Department of Neurosurgery, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.; Center for Advanced Medical Engineering Research and Development, Kobe University, Kobe, Hyogo, 650-0047, Japan.
Kawamata T; Department of Neurosurgery, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Nakayama H; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Miyata M; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Komori T; Department of Neuropathology, Tokyo Metropolitan Neurological Hospital, Musashinodai, Tokyo, 156-8506, Japan.
Cavenee WK; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.
Mischel PS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kurata A; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Shibata N; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Mar 13; Vol. 12 (1), pp. 40. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/pathology
Brain Neoplasms*/pathology
Mice ; Animals ; Cell Line, Tumor ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; DNA Methylation ; Phenotype ; DNA/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma.
Autorzy:
Cheng Y; Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410008, Hunan, China.; Clinical Research Center of Oral Major Diseases and Oral Health & Academician, Central South University, Changsha, 410008, Hunan, China.
Song Z; Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410008, Hunan, China.; Clinical Research Center of Oral Major Diseases and Oral Health & Academician, Central South University, Changsha, 410008, Hunan, China.
Fang X; Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410008, Hunan, China. .; Clinical Research Center of Oral Major Diseases and Oral Health & Academician, Central South University, Changsha, 410008, Hunan, China. .
Tang Z; Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410008, Hunan, China. .; Clinical Research Center of Oral Major Diseases and Oral Health & Academician, Central South University, Changsha, 410008, Hunan, China. .
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2024 Apr 10; Vol. 16 (1), pp. 54. Date of Electronic Publication: 2024 Apr 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein*/antagonists & inhibitors
Enhancer of Zeste Homolog 2 Protein*/metabolism
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Humans ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Head and Neck Neoplasms/drug therapy ; Mouth Neoplasms/drug therapy ; Polycomb Repressive Complex 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polyploidy and mTOR signaling: a possible molecular link.
Autorzy:
Choudhury D; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Ghosh D; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Mondal M; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Singha D; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India.
Pothuraju R; Cancer Research Program, Rajiv Gandhi Center for Biotechnology (RGCB), Thiruvananthapuram, 695014, Kerala, India.
Malakar P; Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Mar 27; Vol. 22 (1), pp. 196. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/metabolism
Diabetes Mellitus*
Animals ; Humans ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction ; Polyploidy ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteomic characterization of hUC-MSC extracellular vesicles and evaluation of its therapeutic potential to treat Alzheimer's disease.
Autorzy:
Li S; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Zhang J; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Liu X; Jianyuan Precision Medicines (Zhangjiakou) Co., Ltd., Zhangjiakou, 075000, China.
Wang N; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Sun L; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Liu J; Jianyuan Precision Medicines (Zhangjiakou) Co., Ltd., Zhangjiakou, 075000, China.; Cancer Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.
Liu X; Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.
Masoudi A; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Wang H; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China.
Li C; Obstetrics and Gynaecology, The Fifth Hospital of Zhangjiakou, Zhangjiakou, 075000, China.
Guo C; Hebei Key Laboratory of Neuropharmacology; Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, China. .
Liu X; Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Anti-Tumour Molecular Target Technology Innovation Center, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 12; Vol. 14 (1), pp. 5959. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Extracellular Vesicles*/metabolism
Mesenchymal Stem Cells*
Humans ; Proteomics ; Adaptor Protein Complex 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a complex intrachromosomal inverted insertion in the long arm of chromosome 9 as a cause of tuberous sclerosis complex in a Korean family.
Autorzy:
Ryu SW; 3billion, Inc, Seoul, South Korea.
Yoon JH; Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kim DW; 3billion, Inc, Seoul, South Korea.
Han B; 3billion, Inc, Seoul, South Korea.
Han H; 3billion, Inc, Seoul, South Korea.
Han J; 3billion, Inc, Seoul, South Korea.
Lee H; 3billion, Inc, Seoul, South Korea.
Seo GH; 3billion, Inc, Seoul, South Korea.
Lee BH; Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2024 Mar; Vol. 12 (3), pp. e2330. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Tumor Suppressor Proteins*/genetics
Tuberous Sclerosis*/genetics
Tuberous Sclerosis*/pathology
Humans ; Tuberous Sclerosis Complex 1 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/genetics ; Mutation ; Chromosomes, Human, Pair 9 ; Republic of Korea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis by Modulating the Expression of Apoptotic Genes, Members of Polycomb Repressive Complex 2, and Levels of Tri-Methylating Lysine 27 at Histone 3 in Human Malignant Melanoma Cells.
Autorzy:
Anestopoulos I; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.
Paraskevaidis I; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.
Kyriakou S; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.
Giova LE; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.
Trafalis DT; Laboratory of Pharmacology, Medical School, National & Kapodistrian University of Athens, 11527 Athens, Greece.
Botaitis S; Department of Surgery, School of Medicine, University Hospital, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Franco R; School of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Redox Biology Centre, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Pappa A; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Panayiotidis MI; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 27; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Histones*/metabolism
Melanoma*
Benzamides*
Biphenyl Compounds*
Morpholines*
Pyridones*
Humans ; Polycomb Repressive Complex 2/genetics ; Lysine/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Apoptosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.
Autorzy:
Jhanwar-Uniyal M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Zeller SL; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Spirollari E; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Das M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Hanft SJ; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Gandhi CD; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
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Źródło:
Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Glioblastoma*/metabolism
Sirolimus*/pharmacology
Neoplastic Stem Cells*/metabolism
Humans ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells.
Autorzy:
Zhao L; Department of Anesthesiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Peng J; Department of Anesthesiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Zhuang L; Department of Palliative Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Yan Z; Department of Gynaecologic Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Liao F; Department of Anesthesiology, The 6th Affiliated Hospital of Kunming Medical University (The People's Hospital of Yuxi City), Yuxi, 653100, Yunnan, China.
Wang Y; Department of Anesthesiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Shao S; Department of Anesthesiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
Wang W; Department of Thoracic Surgery Ⅱ, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650118, Yunnan, China.
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Źródło:
PloS one [PLoS One] 2024 Feb 23; Vol. 19 (2), pp. e0296671. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Progenitor Cells*/metabolism
Lung*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Antigens, CD34/metabolism ; Cell Movement ; Cell Proliferation ; Animals ; Mice ; Polycomb Repressive Complex 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis.
Autorzy:
Zhang P; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Fu HJ; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Lv LX; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Liu CF; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Han C; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Zhao XF; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Wang JX; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China. .; State Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, Shandong, China. .
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Źródło:
Communications biology [Commun Biol] 2023 Apr 03; Vol. 6 (1), pp. 361. Date of Electronic Publication: 2023 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
AMP-Activated Protein Kinases*/genetics
AMP-Activated Protein Kinases*/metabolism
Glycolysis*
Mechanistic Target of Rapamycin Complex 2*/metabolism
Penaeidae*/genetics
Penaeidae*/metabolism
Virus Replication*
White spot syndrome virus 1*/physiology
Aerobiosis ; Phosphorylation ; Signal Transduction ; Gene Knockdown Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The LINC00852/miR-29a-3p/JARID2 axis regulates the proliferation and invasion of prostate cancer cell.
Autorzy:
Zhang H; Department of Urology, The First Hospital of China Medical University, 155 North Nanjing Street, 110001, Shenyang, Liaoning, China.; Institute of Urology, China Medical University, Liaoning, Shenyang, China.
Du Y; Department of Urology, The First Hospital of China Medical University, 155 North Nanjing Street, 110001, Shenyang, Liaoning, China.
Xin P; Department of Urology, The First Hospital of China Medical University, 155 North Nanjing Street, 110001, Shenyang, Liaoning, China.
Man X; Department of Urology, The First Hospital of China Medical University, 155 North Nanjing Street, 110001, Shenyang, Liaoning, China. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Dec 05; Vol. 22 (1), pp. 1269. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
MicroRNAs*/metabolism
Polycomb Repressive Complex 2*/genetics
Polycomb Repressive Complex 2*/metabolism
Prostatic Neoplasms*/genetics
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Animals ; Humans ; Male ; Mice ; 3' Untranslated Regions ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Mice, Nude ; Neoplastic Processes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cortical wiring by synapse type-specific control of local protein synthesis.
Autorzy:
Bernard C; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Exposito-Alonso D; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Selten M; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Sanalidou S; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Hanusz-Godoy A; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Aguilera A; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Hamid F; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Oozeer F; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Maeso P; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Allison L; Centre for Ultrastructural Imaging, King's College London, London SE1 1UL, UK.
Russell M; Centre for Ultrastructural Imaging, King's College London, London SE1 1UL, UK.
Fleck RA; Centre for Ultrastructural Imaging, King's College London, London SE1 1UL, UK.
Rico B; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
Marín O; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Nov 25; Vol. 378 (6622), pp. eabm7466. Date of Electronic Publication: 2022 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cerebral Cortex*/metabolism
Interneurons*/metabolism
Receptor, ErbB-4*/genetics
Receptor, ErbB-4*/metabolism
Synapses*/metabolism
Protein Biosynthesis*
Tuberous Sclerosis Complex 2 Protein*/genetics
Tuberous Sclerosis Complex 2 Protein*/metabolism
Animals ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insight into the Inhibitory Mechanism of Embryonic Ectoderm Development Subunit by Triazolopyrimidine Derivatives as Inhibitors through Molecular Dynamics Simulation.
Autorzy:
Ju J; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2 Liutiao Road, Changchun 130023, China.
Zhang H; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2 Liutiao Road, Changchun 130023, China.
Guan S; College of Biology and Food Engineering, Jilin Engineering Normal University, Changchun 130052, China.; Key Laboratory of Molecular Nutrition at Universities of Jilin Province, Changchun 130052, China.
Liu C; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2 Liutiao Road, Changchun 130023, China.
Du J; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2 Liutiao Road, Changchun 130023, China.
Shen X; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2 Liutiao Road, Changchun 130023, China.
Wang S; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, 2 Liutiao Road, Changchun 130023, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 07; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Ectoderm*/metabolism
Polycomb Repressive Complex 2/chemistry ; Polycomb Repressive Complex 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of EZH2 Causes Retrotransposon Derepression and Immune Activation in Porcine Lung Alveolar Macrophages.
Autorzy:
Zhang L; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jin J; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Qin W; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Jiang J; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Bao W; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Sun MA; Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.; Joint International Research Laboratory of Important Animal Infectious Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 25; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein*/genetics
Enhancer of Zeste Homolog 2 Protein*/metabolism
Polycomb Repressive Complex 2*/genetics
Humans ; Animals ; Swine ; Retroelements/genetics ; Epigenesis, Genetic ; Macrophages, Alveolar/metabolism ; Lung/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells.
Autorzy:
Fu Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Yang K; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Wu K; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Wang H; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Li Q; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Zhang F; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Yang K; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Yao Q; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Ma X; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Deng Y; Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhang J; Department of Surgical Intensive Care Units, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .
Liu C; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .; Department of Surgical Intensive Care Units, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .
Qu K; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2022 Dec 24; Vol. 14 (1), pp. 184. Date of Electronic Publication: 2022 Dec 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/classification
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/classification
Liver Neoplasms*/genetics
Polycomb Repressive Complex 1*/genetics
Polycomb Repressive Complex 2*/genetics
Humans ; DNA Methylation ; Epigenesis, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain.
Autorzy:
Farley SJ; Department of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Grishok A; Department of Biochemistry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Boston University Genome Science Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Zeldich E; Department of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. .
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Źródło:
Epigenetics & chromatin [Epigenetics Chromatin] 2022 Dec 03; Vol. 15 (1), pp. 39. Date of Electronic Publication: 2022 Dec 03.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Brain*/metabolism
Down Syndrome*/genetics
HMGN1 Protein*/genetics
Polycomb Repressive Complex 2*/genetics
Humans ; Chromatin/genetics ; Histones ; Lysine ; Trisomy ; Epigenetic Repression/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Functional Single Nucleotide Polymorphism in the 3' Untranslated Region of the Porcine JARID2 Gene Is Associated with Aggressive Behavior of Weaned Pigs after Mixing.
Autorzy:
Yang H; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Zhang C; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Chao X; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Zhao J; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Liu M; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Chen J; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Liu S; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Wang T; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Muhammad A; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Schinckel AP; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Zhou B; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 19; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article
MeSH Terms:
Polymorphism, Single Nucleotide*
MicroRNAs*/genetics
Humans ; Swine/genetics ; Animals ; Mice ; 3' Untranslated Regions ; RNA, Messenger ; Luciferases ; Polycomb Repressive Complex 2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
EZH1/2 alteration as a potential biomarker for immune checkpoint inhibitors across multiple cancer types.
Autorzy:
Huang H; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China.
Deng X; Department of Dermatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, People's Republic of China.
Yu L; Department of Medical Oncology, Senior Ward and Phase I Clinical Trial Ward, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, Sichuan, People's Republic of China.
Huang H; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China.
Wang Z; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China.
Hong H; Department of Medical Oncology, Senior Ward and Phase I Clinical Trial Ward, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, Sichuan, People's Republic of China. .
Lin T; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People's Republic of China. .; Department of Medical Oncology, Senior Ward and Phase I Clinical Trial Ward, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, Sichuan, People's Republic of China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Dec 15; Vol. 21 (1), pp. 913. Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Letter
MeSH Terms:
Immune Checkpoint Inhibitors*/therapeutic use
Neoplasms*/drug therapy
Humans ; Biomarkers ; Polycomb Repressive Complex 2
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide Using Chromatin Isolation by RNA Purification (ChIRP)-seq.
Autorzy:
Hwang J; Neonatal/Congenital Heart Laboratory, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Children's Discovery and Innovation Institute, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Kang X; Neonatal/Congenital Heart Laboratory, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Wolf C; Neonatal/Congenital Heart Laboratory, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Medical and Life Science, College of Life Science, University of California Los Angeles, Los Angeles, CA 90095, USA.
Touma M; Neonatal/Congenital Heart Laboratory, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Children's Discovery and Innovation Institute, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Molecular Biology Institute, College of Life Science, University of California Los Angeles, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Stem Cell Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
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Źródło:
Cells [Cells] 2023 Dec 08; Vol. 12 (24). Date of Electronic Publication: 2023 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/genetics
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Animals ; Humans ; Mice ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Polycomb Repressive Complex 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 2090

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