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    Wyświetlanie 1-4 z 4
    Tytuł:
    An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.
    Autorzy:
    Han YC; 1] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Oncology Research Unit, Pfizer, Inc., Pearl River, New York, USA.
    Vidigal JA; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Mu P; 1] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York, USA.
    Yao E; 1] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York, USA.
    Singh I; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    González AJ; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Concepcion CP; 1] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York, USA.
    Bonetti C; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Ogrodowski P; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Carver B; 1] Human Oncology and Pathogenesis Program. Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Selleri L; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA.
    Betel D; 1] Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA. [2] Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA.
    Leslie C; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    Ventura A; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
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    Źródło:
    Nature genetics [Nat Genet] 2015 Jul; Vol. 47 (7), pp. 766-75. Date of Electronic Publication: 2015 Jun 01.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    MicroRNAs/*genetics
    Animals ; Apoptosis ; B-Lymphocytes/physiology ; Carcinogenesis/genetics ; Cells, Cultured ; Eyelids/abnormalities ; Gene Frequency ; Genes, Lethal ; Genome-Wide Association Study ; Intellectual Disability/genetics ; Limb Deformities, Congenital/genetics ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Microcephaly/genetics ; Multigene Family ; Mutation ; Tracheoesophageal Fistula/genetics
    SCR Disease Name:
    Oculodigitoesophagoduodenal syndrome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.
    Autorzy:
    Maddalo D; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
    Manchado E; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
    Concepcion CP; 1] Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA [2] Weill Cornell Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, New York 10065, USA.
    Bonetti C; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
    Vidigal JA; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
    Han YC; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
    Ogrodowski P; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
    Crippa A; Milano-Bicocca University, Department of Medical Oncology, San Gerardo Hospital, 20052, Via G B Pergolesi 33, Monza, Italy.
    Rekhtman N; Memorial Sloan Kettering Cancer Center, Thoracic Pathology and Cytopathology, 1275 York Avenue, New York, New York 10065, USA.
    de Stanchina E; Memorial Sloan Kettering Cancer Center, Molecular Pharmacology Program, 1275 York Avenue, New York, New York 10065, USA.
    Lowe SW; 1] Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA [2] Howard Hughes Medical Institute, 1275 York Avenue, New York, New York 10065, USA.
    Ventura A; Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.
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    Źródło:
    Nature [Nature] 2014 Dec 18; Vol. 516 (7531), pp. 423-7. Date of Electronic Publication: 2014 Oct 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    CRISPR-Cas Systems*
    CRISPR-Associated Proteins/*genetics
    Genetic Engineering/*methods
    Translocation, Genetic/*genetics
    Anaplastic Lymphoma Kinase ; Animals ; Antineoplastic Agents/therapeutic use ; Cells, Cultured ; Chromosome Inversion/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats ; Crizotinib ; Disease Models, Animal ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Lung Neoplasms/pathology ; Mice ; NIH 3T3 Cells ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Receptor Protein-Tyrosine Kinases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Intact p53-dependent responses in miR-34-deficient mice.
    Autorzy:
    Concepcion CP; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
    Han YC
    Mu P
    Bonetti C
    Yao E
    D'Andrea A
    Vidigal JA
    Maughan WP
    Ogrodowski P
    Ventura A
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    Źródło:
    PLoS genetics [PLoS Genet] 2012; Vol. 8 (7), pp. e1002797. Date of Electronic Publication: 2012 Jul 26.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*/genetics
    Tumor Suppressor Protein p53*/deficiency
    Tumor Suppressor Protein p53*/genetics
    Tumor Suppressor Protein p53*/metabolism
    Cell Transformation, Neoplastic/*genetics
    MicroRNAs/*genetics
    Animals ; Apoptosis/genetics ; Cell Cycle Checkpoints/genetics ; Cell Proliferation ; Cells, Cultured ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Mice ; Mice, Knockout ; MicroRNAs/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-4 z 4

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