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Tytuł:
Harnessing γδ T Cells against Human Gynecologic Cancers.
Autorzy:
Conejo-Garcia JR; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.; Duke Cancer Institute, Duke School of Medicine, 2128 MSRBIII, 3 Genome Ct, Durham, NC 27707, USA.
Anadon CM; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.; Duke Cancer Institute, Duke School of Medicine, 2128 MSRBIII, 3 Genome Ct, Durham, NC 27707, USA.
Lopez-Bailon LU; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.; Duke Cancer Institute, Duke School of Medicine, 2128 MSRBIII, 3 Genome Ct, Durham, NC 27707, USA.
Chaurio RA; Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.; Duke Cancer Institute, Duke School of Medicine, 2128 MSRBIII, 3 Genome Ct, Durham, NC 27707, USA.
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Źródło:
Life (Basel, Switzerland) [Life (Basel)] 2024 Feb 29; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dichotomous Nitric Oxide-Dependent Post-Translational Modifications of STAT1 Are Associated with Ipilimumab Benefits in Melanoma.
Autorzy:
Garg SK; Department of Cutaneous Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Sun J; Department of Cutaneous Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.; Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Kim Y; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Whiting J; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Sarnaik A; Department of Cutaneous Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33612, USA.
Conejo-Garcia JR; Department of Immunology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.; Department of Immunology, Duke University, Durham, NC 27710, USA.
Phelps M; Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Weber JS; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.
Mulé JJ; Department of Immunology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Markowitz J; Department of Cutaneous Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33612, USA.
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Źródło:
Cancers [Cancers (Basel)] 2023 Mar 14; Vol. 15 (6). Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors.
Autorzy:
Conejo-Garcia JR; Department of Immunology, Gynecologic Oncology and Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Guevara-Patino JA; b Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
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Źródło:
Immunological investigations [Immunol Invest] 2022 Nov; Vol. 51 (8), pp. 2215-2225. Date of Electronic Publication: 2022 Jul 07.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Receptors, Chimeric Antigen*/genetics
Receptors, Chimeric Antigen*/metabolism
Neoplasms*/therapy
Neoplasms*/metabolism
Hematologic Neoplasms*/therapy
Hematologic Neoplasms*/metabolism
Humans ; Immunotherapy, Adoptive ; T-Lymphocytes/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort.
Autorzy:
Newsome RC; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Gharaibeh RZ; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Pierce CM; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.; Present Address: Department of Epidemiology, BARDS, MRL, Merck Sharp & Dohme Corp., a Subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.
da Silva WV; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Paul S; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Hogue SR; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Yu Q; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Antonia S; Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Conejo-Garcia JR; Department of Immunology, Moffitt Cancer Center, Tampa, FL, USA.
Robinson LA; Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Jobin C; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA. .; Department of Infectious Diseases and Immunology, University of Florida College of Medicine, Gainesville, FL, USA. .; Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA. .
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Źródło:
Genome medicine [Genome Med] 2022 Mar 29; Vol. 14 (1), pp. 35. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*
Gastrointestinal Microbiome*
Lung Neoplasms*/drug therapy
Animals ; Humans ; Immune Checkpoint Inhibitors ; Mice ; Programmed Cell Death 1 Receptor ; United States
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression of epigenetic pathway related genes in association with PD-L1, ER/PgR and MLH1 in endometrial carcinoma.
Autorzy:
Saglam O; Department of Pathology, Moffitt Cancer Center, Tampa, FL, United States of America.
Cao B; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, United States of America.
Wang X; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, United States of America.
Toruner GA; Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Conejo-Garcia JR; Department of Immunology, Moffitt Cancer Center, Tampa, FL, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Feb 28; Vol. 17 (2), pp. e0264014. Date of Electronic Publication: 2022 Feb 28 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic*
B7-H1 Antigen/*biosynthesis
Endometrial Neoplasms/*metabolism
MutL Protein Homolog 1/*biosynthesis
Neoplasm Proteins/*biosynthesis
Receptors, Progesterone/*biosynthesis
Aged ; Endometrial Neoplasms/pathology ; Female ; Humans ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells.
Autorzy:
Payne KK; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Mine JA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Biswas S; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Chaurio RA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Perales-Puchalt A; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Anadon CM; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Costich TL; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Harro CM; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.; Department of Cell Biology, Microbiology, and Molecular Biology and Cancer Biology PhD Program, University of South Florida, Tampa, FL 33620, USA.
Walrath J; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Ming Q; Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Tcyganov E; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Buras AL; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Rigolizzo KE; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Mandal G; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Lajoie J; Compass Therapeutics, Cambridge, MA 02142, USA.
Ophir M; Compass Therapeutics, Cambridge, MA 02142, USA.
Tchou J; Division of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104-1693, USA.
Marchion D; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Luca VC; Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Bobrowicz P; Compass Therapeutics, Cambridge, MA 02142, USA.
McLaughlin B; Compass Therapeutics, Cambridge, MA 02142, USA.
Eskiocak U; Compass Therapeutics, Cambridge, MA 02142, USA.
Schmidt M; Compass Therapeutics, Cambridge, MA 02142, USA.
Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Gabrilovich DI; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. jose.conejo-garcia@moffitt.org.; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2020 Aug 21; Vol. 369 (6506), pp. 942-949.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, CD/*immunology
Butyrophilins/*antagonists & inhibitors
Butyrophilins/*immunology
Intraepithelial Lymphocytes/*immunology
Ovarian Neoplasms/*immunology
Ovarian Neoplasms/*therapy
Animals ; Antibodies, Monoclonal/therapeutic use ; Antigens, CD/genetics ; Butyrophilins/genetics ; Female ; Humans ; Immunotherapy/methods ; Mice ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Estimation of immune cell content in tumor using single-cell RNA-seq reference data.
Autorzy:
Yu X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Chen YA; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Chung CH; Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Wang X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA. .
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Źródło:
BMC cancer [BMC Cancer] 2019 Jul 19; Vol. 19 (1), pp. 715. Date of Electronic Publication: 2019 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
CD8-Positive T-Lymphocytes/*immunology
Head and Neck Neoplasms/*genetics
Head and Neck Neoplasms/*immunology
RNA-Seq/*methods
Single-Cell Analysis/*methods
Squamous Cell Carcinoma of Head and Neck/*genetics
Squamous Cell Carcinoma of Head and Neck/*immunology
T-Lymphocytes, Regulatory/*immunology
Databases, Genetic ; Datasets as Topic ; Ecosystem ; Genes, Neoplasm ; Genetic Heterogeneity ; Head and Neck Neoplasms/pathology ; Humans ; RNA, Small Cytoplasmic/genetics ; Software ; Squamous Cell Carcinoma of Head and Neck/pathology ; Transcriptome ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer.
Autorzy:
Sheen MR; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Marotti JD; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Norris Cotton Cancer Center, Lebanon, NH, USA.
Allegrezza MJ; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Rutkowski M; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Conejo-Garcia JR; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Fiering S; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.; Norris Cotton Cancer Center, Lebanon, NH, USA.; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
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Źródło:
Oncogenesis [Oncogenesis] 2016 Oct 31; Vol. 5 (10), pp. e267. Date of Electronic Publication: 2016 Oct 31.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.
Autorzy:
Bitler BG; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Aird KM; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Garipov A; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Li H; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Amatangelo M; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Kossenkov AV; Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Schultz DC; Center for Chemical Biology and Translational Medicine, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Liu Q; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Shih IeM; Department of Pathology, Oncology, and Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Conejo-Garcia JR; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Speicher DW; 1] Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, USA. [2] Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Zhang R; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
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Źródło:
Nature medicine [Nat Med] 2015 Mar; Vol. 21 (3), pp. 231-8. Date of Electronic Publication: 2015 Feb 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Indoles/*pharmacology
Membrane Proteins/*metabolism
Methyltransferases/*antagonists & inhibitors
Nuclear Proteins/*genetics
Ovarian Neoplasms/*genetics
Polycomb Repressive Complex 2/*antagonists & inhibitors
Proto-Oncogene Proteins c-akt/*metabolism
Pyridones/*pharmacology
Transcription Factors/*genetics
Animals ; Cell Line, Tumor ; DNA-Binding Proteins ; Enhancer of Zeste Homolog 2 Protein ; Female ; Humans ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Nude ; Mutation ; Nuclear Proteins/drug effects ; Proto-Oncogene Proteins c-akt/drug effects ; Signal Transduction ; Transcription Factors/drug effects ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.
Autorzy:
Nesbeth Y; Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Conejo-Garcia JR
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Źródło:
Clinical & developmental immunology [Clin Dev Immunol] 2010; Vol. 2010, pp. 139304. Date of Electronic Publication: 2010 Nov 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Immunotherapy, Adoptive*/trends
Neoplasms/*immunology
Neoplasms/*therapy
T-Lymphocytes/*immunology
Animals ; Antigens, Neoplasm/immunology ; Cell Differentiation ; Cell Proliferation ; Disease Progression ; Humans ; Immunologic Surveillance ; Lymphocyte Activation ; Neoplasms/pathology ; Neoplasms/physiopathology ; Tumor Escape
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 24

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