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Tytuł :
Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif.
Autorzy :
Nordeen SA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Turman DL; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Schwartz TU; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6060. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Conserved Sequence*
Cell Membrane/*metabolism
Nuclear Pore Complex Proteins/*chemistry
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*chemistry
Amino Acid Motifs ; Humans ; Models, Molecular ; Nuclear Pore Complex Proteins/metabolism ; Protein Domains ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Deep conservation of the enhancer regulatory code in animals.
Autorzy :
Wong ES; School of Biological Sciences, University of Queensland, Brisbane, Australia. .; Victor Chang Cardiac Research Institute, Sydney, Australia.; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, Australia.
Zheng D; Victor Chang Cardiac Research Institute, Sydney, Australia.
Tan SZ; Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.
Bower NL; Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.
Garside V; Australian Regenerative Medicine Institute, Monash University, Melbourne, Australia.
Vanwalleghem G; Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Gaiti F; School of Biological Sciences, University of Queensland, Brisbane, Australia.
Scott E; Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Hogan BM; Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.; Department of Anatomy and Neuroscience and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Kikuchi K; Victor Chang Cardiac Research Institute, Sydney, Australia.
McGlinn E; Australian Regenerative Medicine Institute, Monash University, Melbourne, Australia.
Francois M; Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia. .; Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.
Degnan BM; School of Biological Sciences, University of Queensland, Brisbane, Australia. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Nov 06; Vol. 370 (6517).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conserved Sequence*
Enhancer Elements, Genetic*
Gene Expression Regulation, Developmental*
LIM-Homeodomain Proteins/*metabolism
Porifera/*genetics
Transcription Factors/*metabolism
Animals ; Base Sequence ; Chromatin Immunoprecipitation ; Humans ; Mice ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
ConCysFind: a pipeline tool to predict conserved amino acids of protein sequences across the plant kingdom.
Autorzy :
Moore M; Biochemistry and Physiology of Plants, Bielefeld University, 33501, Bielefeld, Germany.
Wesemann C; Biochemistry and Physiology of Plants, Bielefeld University, 33501, Bielefeld, Germany.
Gossmann N; Biochemistry and Physiology of Plants, Bielefeld University, 33501, Bielefeld, Germany.
Sahm A; Biochemistry and Physiology of Plants, Bielefeld University, 33501, Bielefeld, Germany.; Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.
Krüger J; Computational Metagenomics, Bielefeld University, 33501, Bielefeld, Germany.
Sczyrba A; Computational Metagenomics, Bielefeld University, 33501, Bielefeld, Germany.
Dietz KJ; Biochemistry and Physiology of Plants, Bielefeld University, 33501, Bielefeld, Germany. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 Oct 31; Vol. 21 (1), pp. 490. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Algorithms*
Conserved Sequence*
Amino Acids/*chemistry
Plant Proteins/*chemistry
Plants/*metabolism
Amino Acid Sequence ; Arabidopsis/genetics ; Oxidation-Reduction ; Phylogeny ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity.
Autorzy :
Kinare V; Department of Life Sciences, Sophia College for Women, Mumbai 400026, India.
Iyer A; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Padmanabhan H; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Godbole G; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Khan T; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Khatri Z; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Maheshwari U; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Muralidharan B; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Tole S; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India .
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Źródło :
Development (Cambridge, England) [Development] 2020 Oct 19; Vol. 147 (20). Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Lineage*
Conserved Sequence*
Evolution, Molecular*
DNA-Binding Proteins/*genetics
Hippocampus/*cytology
LIM Domain Proteins/*genetics
LIM-Homeodomain Proteins/*genetics
Transcription Factors/*genetics
Animals ; Body Patterning ; DNA-Binding Proteins/metabolism ; LIM Domain Proteins/metabolism ; LIM-Homeodomain Proteins/metabolism ; Mice ; Mutation/genetics ; Neurogenesis ; Neuroglia/cytology ; Neuroglia/metabolism ; Protein Binding ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
Autorzy :
Yamaguchi A; Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan.
Narumi K; Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan.
Furugen A; Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan.
Iseki K; Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan.
Kobayashi M; Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Sep 03; Vol. 529 (4), pp. 1061-1065. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conserved Sequence*
Aspartic Acid/*metabolism
Monocarboxylic Acid Transporters/*chemistry
Monocarboxylic Acid Transporters/*metabolism
Amino Acid Sequence ; Animals ; Humans ; Hydrogen-Ion Concentration ; Lactic Acid/metabolism ; Mutant Proteins/metabolism ; Oocytes/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Molecular conservation and differential mutation on ORF3a gene in Indian SARS-CoV2 genomes.
Autorzy :
Hassan SS; Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram 721140, India. Electronic address: .
Choudhury PP; Applied Statistics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India. Electronic address: .
Basu P; Mandelstem Institute, School of Physics, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: .
Jana SS; School of Biological Sciences, Indian Association for the Cultivation of Science, West Bengal 700032, India. Electronic address: .
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Źródło :
Genomics [Genomics] 2020 Sep; Vol. 112 (5), pp. 3226-3237. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Conserved Sequence*
Mutation*
Betacoronavirus/*genetics
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
Viral Regulatory and Accessory Proteins/*genetics
Animals ; Base Sequence ; Biological Evolution ; COVID-19 ; Chiroptera/virology ; Coronavirus Infections/veterinary ; Eutheria/virology ; Genome, Viral ; Genomics ; Humans ; India ; Pandemics ; Phylogeny ; SARS-CoV-2 ; Viral Regulatory and Accessory Proteins/chemistry ; Viral Structural Proteins/chemistry ; Viral Structural Proteins/genetics ; Viroporin Proteins
Czasopismo naukowe
Tytuł :
Conserved sequence motifs in the abiotic stress response protein late embryogenesis abundant 3.
Autorzy :
Singh KK; Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Graether SP; Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.; Graduate Program in Bioinformatics, University of Guelph, Guelph, Ontario, Canada.
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Źródło :
PloS one [PLoS One] 2020 Aug 06; Vol. 15 (8), pp. e0237177. Date of Electronic Publication: 2020 Aug 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conserved Sequence*
Plant Proteins/*genetics
Amino Acid Motifs ; Evolution, Molecular ; Plant Proteins/chemistry ; Plants/genetics ; Protein Domains
Czasopismo naukowe
Tytuł :
OrthReg: a tool to predict cis -regulatory elements based on cross-species orthologous sequence conservation.
Autorzy :
Ma YF; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Huang CP; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Lu FR; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Li JX; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan, Yunnan University, Kunming, Yunnan 650091, China.; Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China.
Han XM; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
Adeola AC; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
Gao Y; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
Deng JK; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
Xie HB; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. E-mail: .
Zhang YP; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. E-mail: .
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Źródło :
Zoological research [Zool Res] 2020 Jul 18; Vol. 41 (4), pp. 471-475.
Typ publikacji :
Letter; Validation Study
MeSH Terms :
Base Sequence*
Conserved Sequence*
Genome*
Genome-Wide Association Study/*methods
Mice/*genetics
Sus scrofa/*genetics
Animals ; Genome-Wide Association Study/veterinary ; Humans
Opinia redakcyjna
Tytuł :
Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment.
Autorzy :
Al-Moubarak E; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Zhang Y; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Dempsey CE; School of Biochemistry, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Zhang H; Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL, UK.
Harmer SC; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. Electronic address: .
Hancox JC; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 11; Vol. 526 (4), pp. 1085-1091. Date of Electronic Publication: 2020 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conserved Sequence*
ERG1 Potassium Channel/*genetics
ERG1 Potassium Channel/*metabolism
Loss of Function Mutation/*genetics
Serine/*genetics
Threonine/*genetics
Action Potentials ; Amino Acid Sequence ; ERG1 Potassium Channel/chemistry ; Humans ; Ion Channel Gating ; Protein Transport
Czasopismo naukowe
Tytuł :
The RNA fold interactome of evolutionary conserved RNA structures in S. cerevisiae.
Autorzy :
Casas-Vila N; Institute of Molecular Biology, Ackermannweg 4, 55128, Mainz, Germany.
Sayols S; Institute of Molecular Biology, Ackermannweg 4, 55128, Mainz, Germany.
Pérez-Martínez L; Institute of Molecular Biology, Ackermannweg 4, 55128, Mainz, Germany.
Scheibe M; Institute of Molecular Biology, Ackermannweg 4, 55128, Mainz, Germany.
Butter F; Institute of Molecular Biology, Ackermannweg 4, 55128, Mainz, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 03; Vol. 11 (1), pp. 2789. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conserved Sequence*/genetics
Evolution, Molecular*
Nucleic Acid Conformation*
RNA, Fungal/*chemistry
Saccharomyces cerevisiae/*genetics
3' Untranslated Regions/genetics ; 5' Untranslated Regions/genetics ; Base Sequence ; Epistasis, Genetic ; Genes, Reporter ; Genome, Fungal ; Green Fluorescent Proteins/metabolism ; Nucleotide Motifs/genetics ; Protein Biosynthesis ; Proteome/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Reproducibility of Results ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Imprinted genes in clinical exome sequencing: Review of 538 cases and exploration of mouse-human conservation in the identification of novel human disease loci.
Autorzy :
Bhoj EJ; Division of Human Genetics, Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Electronic address: .
Rajabi F; Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Fegan 4, Boston, MA, 02115, USA. Electronic address: .
Baker SW; Division of Genomics Diagnosis, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Electronic address: .
Santani A; Division of Genomics Diagnosis, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address: .
Tan WH; Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Fegan 4, Boston, MA, 02115, USA. Electronic address: .
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Źródło :
European journal of medical genetics [Eur J Med Genet] 2020 Jun; Vol. 63 (6), pp. 103903. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Conserved Sequence*
Exome*
Genetic Loci*
Genomic Imprinting*
Genetic Diseases, Inborn/*genetics
Animals ; Databases, Genetic ; Humans ; Mice ; Mutation ; Whole Genome Sequencing/methods
Czasopismo naukowe
Tytuł :
Homeologs of Brassica SOC1, a central regulator of flowering time, are differentially regulated due to partitioning of evolutionarily conserved transcription factor binding sites in promoters.
Autorzy :
Sri T; Department of Biotechnology, TERI School of Advanced Studies, 10, Institutional Area, Vasant Kunj, New Delhi 110070, India.
Gupta B; Department of Biotechnology, TERI School of Advanced Studies, 10, Institutional Area, Vasant Kunj, New Delhi 110070, India.
Tyagi S; Department of Biotechnology, TERI School of Advanced Studies, 10, Institutional Area, Vasant Kunj, New Delhi 110070, India.
Singh A; Department of Biotechnology, TERI School of Advanced Studies, 10, Institutional Area, Vasant Kunj, New Delhi 110070, India. Electronic address: .
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Źródło :
Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2020 Jun; Vol. 147, pp. 106777. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conserved Sequence*/genetics
Evolution, Molecular*
Gene Expression Regulation, Plant*
Sequence Homology, Nucleic Acid*
Brassica/*genetics
Flowers/*genetics
Plant Proteins/*genetics
Transcription Factors/*metabolism
Base Sequence ; Binding Sites ; Brassica/metabolism ; DNA Copy Number Variations/genetics ; Genes, Reporter ; Phylogeny ; Polyploidy ; Promoter Regions, Genetic ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Enhancement in affinity of Aspergillus niger JMU-TS528 α-L-rhamnosidase (r-Rha1) by semiconservative site-directed mutagenesis of (α/α) 6 catalytic domain.
Autorzy :
Li L; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, China.
Gong J; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Li W; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Wu Z; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Jiang Z; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, China. Electronic address: .
Ni H; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, China.
Li Q; College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, China.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 May 15; Vol. 151, pp. 845-854. Date of Electronic Publication: 2020 Feb 15.
Typ publikacji :
Journal Article
MeSH Terms :
Catalytic Domain*/genetics
Conserved Sequence*
Aspergillus niger/*enzymology
Glycoside Hydrolases/*chemistry
Aspergillus niger/genetics ; Binding Sites ; Enzyme Activation ; Gene Expression ; Glycoside Hydrolases/genetics ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Self-analysis of repeat proteins reveals evolutionarily conserved patterns.
Autorzy :
Merski M; Structural Biology Group, Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, Warsaw, Poland. .
Młynarczyk K; Structural Biology Group, Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, Warsaw, Poland.
Ludwiczak J; Laboratory of Structural Bioinformatics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.; Laboratory of Bioinformatics, Nencki Institute of Experimental Biology, Warsaw, Poland.
Skrzeczkowski J; Structural Biology Group, Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, Warsaw, Poland.
Dunin-Horkawicz S; Laboratory of Structural Bioinformatics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Górna MW; Structural Biology Group, Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, Warsaw, Poland. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 May 07; Vol. 21 (1), pp. 179. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Conserved Sequence*
Evolution, Molecular*
Repetitive Sequences, Amino Acid*
Proteins/*chemistry
Amino Acid Sequence ; Databases, Protein ; Mutation/genetics
Czasopismo naukowe
Tytuł :
Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.
Autorzy :
Parker BW; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.
Gogl G; Institute of Organic Chemistry, Research Center for Natural Sciences, Magyar Tudósok körútja, 1117 Budapest, Hungary.; Equipe Labellisee Ligue 2015, Department of Integrated Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, 1 rue Laurent Fries, BP 10142, F-67404 Illkirch, France.
Bálint M; Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, 7624 Pécs, Hungary.
Hetényi C; Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, 7624 Pécs, Hungary.
Reményi A; Institute of Organic Chemistry, Research Center for Natural Sciences, Magyar Tudósok körútja, 1117 Budapest, Hungary.
Weiss EL; Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 May 05; Vol. 59 (17), pp. 1688-1700. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Conserved Sequence*
Intracellular Signaling Peptides and Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Amino Acid Sequence ; Animals ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Models, Molecular ; Nerve Tissue Proteins/chemistry ; Protein Binding ; Protein Conformation ; Protein-Serine-Threonine Kinases/chemistry ; Saccharomyces cerevisiae Proteins/chemistry ; Substrate Specificity
Czasopismo naukowe
Tytuł :
From transglutaminases (TGs) to arylamine N-acetyltransferases (NATs): Insight into the role of a spatially conserved aromatic amino acid position in the active site of these two families of enzymes.
Autorzy :
Xu X; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Zhang W; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France.
Berthelet J; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France.
Liu R; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France.
Michail C; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France.
Chaffotte AF; Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, 75015, Paris, France.
Dupret JM; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France.
Rodrigues-Lima F; Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Apr 30; Vol. 525 (2), pp. 308-312. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Sequence*
Conserved Sequence*
Arylamine N-Acetyltransferase/*chemistry
Transglutaminases/*chemistry
Amino Acids, Aromatic ; Animals ; Biocatalysis ; Catalytic Domain ; Humans ; Transglutaminases/genetics
Czasopismo naukowe
Tytuł :
Evolutionary relationships between the transcriptional repressors of the polyhydroxyalkanoate reserve storage system in prokaryotes: Conserved but phylogenetically heterogeneous.
Autorzy :
Kutralam-Muniasamy G; Department of Biotechnology and Bioengineering, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico.
Pérez-Guevara F; Department of Biotechnology and Bioengineering, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico; Nanoscience & Nanotechnology Program, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico. Electronic address: .
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Źródło :
Gene [Gene] 2020 Apr 20; Vol. 735, pp. 144397. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Conserved Sequence*
Evolution, Molecular*
Archaeal Proteins/*genetics
Bacterial Proteins/*genetics
Plant Lectins/*genetics
Polyhydroxyalkanoates/*biosynthesis
Transcription Factors/*genetics
Archaeal Proteins/chemistry ; Archaeal Proteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Phylogeny ; Plant Lectins/metabolism ; Polyhydroxyalkanoates/genetics ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Probing biased activation of mu-opioid receptor by the biased agonist PZM21 using all atom molecular dynamics simulation.
Autorzy :
Liao S; Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, USA.
Tan K; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, USA; Department of Chemistry, Xiamen University, Xiamen, Fujian 361005, China.
Floyd C; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, USA.
Bong D; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, USA.
Pino MJ Jr; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, USA.
Wu C; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119026. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Receptors, Opioid, mu/*agonists
Thiophenes/*pharmacology
Urea/*analogs & derivatives
Allosteric Regulation ; Animals ; Aspartic Acid/chemistry ; Cluster Analysis ; Conserved Sequence ; Crystallization ; Humans ; Ligands ; Mice ; Morphine/pharmacology ; Principal Component Analysis ; Protein Conformation ; Receptors, Opioid, mu/chemistry ; Receptors, Opioid, mu/metabolism ; Signal Transduction ; Structural Homology, Protein ; Thiophenes/chemistry ; Tyrosine/chemistry ; Urea/chemistry ; Urea/pharmacology ; Water/chemistry
Czasopismo naukowe
Tytuł :
Recognition of plausible therapeutic agents to combat COVID-19: An omics data based combined approach.
Autorzy :
Hossain MU; Bioinformatics Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka 1349, Bangladesh.
Bhattacharjee A; Bioinformatics Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka 1349, Bangladesh; Department of Biochemistry and Microbiology, North South University, Bashundhara, Dhaka 1229, Bangladesh.
Emon MTH; Department of Biotechnology and Genetic Engineering, Life Science Faculty, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh.
Chowdhury ZM; Department of Biochemistry and Microbiology, North South University, Bashundhara, Dhaka 1229, Bangladesh.
Mosaib MG; Department of Biochemistry and Molecular Biology, Faculty of Health & Medical Sciences, Gono Bishwabidyaloy, Ashulia, Savar, Dhaka 1344, Bangladesh.
Mourin M; Department of Biochemistry and Microbiology, North South University, Bashundhara, Dhaka 1229, Bangladesh; Department of Microbiology, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.
Das KC; Molecular Biotechnology Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka 1349, Bangladesh.
Keya CA; Department of Biochemistry and Microbiology, North South University, Bashundhara, Dhaka 1229, Bangladesh.
Salimullah M; Molecular Biotechnology Division, National Institute of Biotechnology, Ganakbari, Ashulia, Savar, Dhaka 1349, Bangladesh. Electronic address: .
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Źródło :
Gene [Gene] 2021 Mar 01; Vol. 771, pp. 145368. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Computational Biology/*methods
Gene Expression Profiling/*methods
SARS-CoV-2/*genetics
Whole Genome Sequencing/*methods
Antiviral Agents/therapeutic use ; COVID-19/virology ; Computer Simulation ; Conserved Sequence ; Coronavirus M Proteins/genetics ; Drug Design ; Female ; Gene Expression Regulation, Viral/drug effects ; Humans ; Interferons/pharmacology ; Middle Aged ; Prospective Studies ; RNA-Dependent RNA Polymerase/genetics ; SARS-CoV-2/classification ; Sequence Analysis, RNA ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe
Tytuł :
The atypical protein arginine methyltrasferase of Entamoeba histolytica (EhPRMTA) is involved in cell proliferation, heat shock response and in vitro virulence.
Autorzy :
Medina-Gómez C; Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México, Mexico.
Bolaños J; Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México, Mexico.
Borbolla-Vázquez J; Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México, Mexico.
Munguía-Robledo S; Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México, Mexico.
Orozco E; Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México, Mexico.
Rodríguez MA; Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México, Mexico. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Mar; Vol. 222, pp. 108077. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Entamoeba histolytica/*enzymology
Entamoeba histolytica/*pathogenicity
Protein-Arginine N-Methyltransferases/*metabolism
Amino Acid Sequence ; Cell Movement ; Cell Proliferation/physiology ; Conserved Sequence ; Entamoeba histolytica/cytology ; Entamoeba histolytica/metabolism ; Erythrocytes/metabolism ; Gene Expression Regulation, Enzymologic ; Gene Knockdown Techniques ; Heat-Shock Response/physiology ; Phagocytosis ; Protein Processing, Post-Translational/physiology ; Protein-Arginine N-Methyltransferases/classification ; Protein-Arginine N-Methyltransferases/genetics ; Virulence
Czasopismo naukowe

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