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Wyświetlanie 1-8 z 8
Tytuł :
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Nekorchuk M; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Lee MYH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Piantadosi A; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jan 21; Vol. 184 (2), pp. 460-475.e21. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Macaca mulatta*
Anti-Inflammatory Agents/*administration & dosage
Azetidines/*administration & dosage
COVID-19/*drug therapy
COVID-19/*immunology
Neutrophil Infiltration/*drug effects
Purines/*administration & dosage
Pyrazoles/*administration & dosage
Sulfonamides/*administration & dosage
Animals ; COVID-19/physiopathology ; Cell Death/drug effects ; Cell Degranulation/drug effects ; Disease Models, Animal ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/immunology ; Janus Kinases/antagonists & inhibitors ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Lymphocyte Activation/drug effects ; Macrophages, Alveolar/immunology ; SARS-CoV-2/physiology ; Severity of Illness Index ; T-Lymphocytes/immunology ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity.
Autorzy :
Nyamugenda E; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Griffin H; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Russell S; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Cooney KA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Kowalczyk NS; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Islam I; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Phelan KD; Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Baldini G; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Electronic address: .
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Źródło :
IScience [iScience] 2020 May 22; Vol. 23 (5), pp. 101114. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.
Autorzy :
Ioannidis NM; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA.
Rothstein JH; Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Pejaver V; Department of Computer Science and Informatics, Indiana University, Bloomington, IN 47405, USA.
Middha S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
McDonnell SK; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Baheti S; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Musolf A; Computational and Statistical Genomics Branch, National Human Genome Research Institute, Baltimore, MD 21224, USA.
Li Q; Computational and Statistical Genomics Branch, National Human Genome Research Institute, Baltimore, MD 21224, USA.
Holzinger E; Computational and Statistical Genomics Branch, National Human Genome Research Institute, Baltimore, MD 21224, USA.
Karyadi D; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Cannon-Albright LA; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Teerlink CC; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Stanford JL; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Isaacs WB; Brady Urological Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Xu J; NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA.
Cooney KA; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA; Departments of Internal Medicine and Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Lange EM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Schleutker J; Department of Medical Biochemistry and Genetics, University of Turku, Turku 20014, Finland; Department of Medical Genetics, Tyks Microbiology and Genetics, Turku University Hospital, Turku 20520, Finland.
Carpten JD; Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Powell IJ; Department of Urology, Wayne State University, Detroit, MI 48201, USA.
Cussenot O; Centre de Recherche sur les Pathologies Prostatiques et Urologiques, Universite Paris, Paris, 75013, France.
Cancel-Tassin G; Centre de Recherche sur les Pathologies Prostatiques et Urologiques, Universite Paris, Paris, 75013, France.
Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, VIC 3010, Australia.
MacInnis RJ; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, VIC 3010, Australia.
Maier C; Institute of Human Genetics, University Hospital of Ulm, Ulm 89075, Germany; Department of Urology, University Hospital of Ulm, Ulm 89075, Germany.
Hsieh CL; Department of Urology, University of Southern California, Los Angeles, CA 90033, USA.
Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden.
Catalona WJ; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Foulkes WD; Departments of Oncology and Human Genetics, Montreal General Hospital, Montreal, QC H3G 1A4, Canada.
Mandal D; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Eeles RA; Division of Genetics and Epidemiology, Institute of Cancer Research, London SM2 5NG, UK.
Kote-Jarai Z; Division of Genetics and Epidemiology, Institute of Cancer Research, London SM2 5NG, UK.
Bustamante CD; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
Schaid DJ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Hastie T; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Stanford University, Stanford, CA 94305, USA.
Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Bailey-Wilson JE; Computational and Statistical Genomics Branch, National Human Genome Research Institute, Baltimore, MD 21224, USA.
Radivojac P; Department of Computer Science and Informatics, Indiana University, Bloomington, IN 47405, USA.
Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Whittemore AS; Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
Sieh W; Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2016 Oct 06; Vol. 99 (4), pp. 877-885. Date of Electronic Publication: 2016 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Software*
Disease/*genetics
Mutation, Missense/*genetics
Area Under Curve ; DNA Mutational Analysis ; Exome/genetics ; Gene Frequency ; Humans ; ROC Curve
Czasopismo naukowe
Tytuł :
Integrative clinical genomics of advanced prostate cancer.
Autorzy :
Robinson D; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Wu YM; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Schultz N; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Lonigro RJ; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mosquera JM; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; New York Presbyterian Hospital, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Montgomery B; Computational Biology Program, Public Health Sciences Division and Basic Science Division, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109, USA; Department of Medicine and VAPSHCS, University of Washington, Seattle, WA 98109, USA.
Taplin ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Pritchard CC; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Attard G; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Beltran H; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; New York Presbyterian Hospital, New York, NY 10021, USA; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Abida W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Bradley RK; Computational Biology Program, Public Health Sciences Division and Basic Science Division, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109, USA.
Vinson J; Prostate Cancer Clinical Trials Consortium, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cao X; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Vats P; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Kunju LP; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Hussain M; Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Feng FY; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Tomlins SA; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Cooney KA; Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Smith DC; Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Brennan C; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Siddiqui J; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mehra R; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Chen Y; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Rathkopf DE; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Morris MJ; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Solomon SB; Interventional Radiology, Department of Radiology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Durack JC; Interventional Radiology, Department of Radiology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Reuter VE; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Gopalan A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Gao J; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Loda M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA.
Lis RT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Bowden M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA.
Balk SP; Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Gaviola G; Department of Musculoskeletal Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Sougnez C; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Gupta M; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Yu EY; Department of Medicine and VAPSHCS, University of Washington, Seattle, WA 98109, USA.
Mostaghel EA; Computational Biology Program, Public Health Sciences Division and Basic Science Division, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109, USA; Department of Medicine and VAPSHCS, University of Washington, Seattle, WA 98109, USA.
Cheng HH; Computational Biology Program, Public Health Sciences Division and Basic Science Division, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109, USA; Department of Medicine and VAPSHCS, University of Washington, Seattle, WA 98109, USA.
Mulcahy H; Department of Radiology, University of Washington, Seattle, WA 98109, USA.
True LD; Department of Pathology, University of Washington Medical Center, Seattle, WA 98109, USA.
Plymate SR; Department of Medicine and VAPSHCS, University of Washington, Seattle, WA 98109, USA.
Dvinge H; Computational Biology Program, Public Health Sciences Division and Basic Science Division, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109, USA.
Ferraldeschi R; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Flohr P; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Miranda S; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Zafeiriou Z; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Tunariu N; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Mateo J; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Perez-Lopez R; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Demichelis F; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Laboratory of Computational Oncology, CIBIO, Centre for Integrative Biology, University of Trento, 38123 Mattarello TN, Italy.
Robinson BD; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; New York Presbyterian Hospital, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Schiffman M; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Division of Interventional Radiology, Department of Radiology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Nanus DM; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; New York Presbyterian Hospital, New York, NY 10021, USA; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Tagawa ST; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; New York Presbyterian Hospital, New York, NY 10021, USA; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Sigaras A; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA; Department of Physiology & Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA.
Eng KW; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA; Department of Physiology & Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA.
Elemento O; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA.
Sboner A; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Heath EI; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
Scher HI; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Pienta KJ; The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Kantoff P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
de Bono JS; Cancer Biomarkers Team, Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK; Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust, London SM2 5NG, UK.
Rubin MA; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; Institute for Precision Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA; New York Presbyterian Hospital, New York, NY 10021, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Nelson PS; Department of Medicine and VAPSHCS, University of Washington, Seattle, WA 98109, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Meyer Cancer, Weill Medical College of Cornell University, New York, NY 10021, USA.
Garraway LA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Sawyers CL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
Chinnaiyan AM; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: .
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Źródło :
Cell [Cell] 2015 May 21; Vol. 161 (5), pp. 1215-1228.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Profiling/*methods
Prostatic Neoplasms, Castration-Resistant/*genetics
Prostatic Neoplasms, Castration-Resistant/*pathology
Cohort Studies ; Humans ; Male ; Mutation ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology ; Prostatic Neoplasms, Castration-Resistant/drug therapy
Czasopismo naukowe
Tytuł :
Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.
Autorzy :
Wang L; Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA.
Liu R
Li W
Chen C
Katoh H
Chen GY
McNally B
Lin L
Zhou P
Zuo T
Cooney KA
Liu Y
Zheng P
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Źródło :
Cancer cell [Cancer Cell] 2009 Oct 06; Vol. 16 (4), pp. 336-46.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Chromosomes, Human, X*
Gene Expression Regulation, Neoplastic*
Gene Silencing*
Mutation*
Forkhead Transcription Factors/*genetics
Prostatic Neoplasms/*genetics
Animals ; Cells, Cultured ; Forkhead Transcription Factors/deficiency ; Forkhead Transcription Factors/metabolism ; Gene Expression Profiling ; Humans ; Male ; Mice ; Mice, Knockout ; Prostatic Hyperplasia/genetics ; Prostatic Intraepithelial Neoplasia/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Proto-Oncogene Proteins c-myc/genetics ; RNA Interference ; Time Factors ; Transcription, Genetic ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics.
Autorzy :
Xu J; Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Dimitrov L
Chang BL
Adams TS
Turner AR
Meyers DA
Eeles RA
Easton DF
Foulkes WD
Simard J
Giles GG
Hopper JL
Mahle L
Moller P
Bishop T
Evans C
Edwards S
Meitz J
Bullock S
Hope Q
Hsieh CL
Halpern J
Balise RN
Oakley-Girvan I
Whittemore AS
Ewing CM
Gielzak M
Isaacs SD
Walsh PC
Wiley KE
Isaacs WB
Thibodeau SN
McDonnell SK
Cunningham JM
Zarfas KE
Hebbring S
Schaid DJ
Friedrichsen DM
Deutsch K
Kolb S
Badzioch M
Jarvik GP
Janer M
Hood L
Ostrander EA
Stanford JL
Lange EM
Beebe-Dimmer JL
Mohai CE
Cooney KA
Ikonen T
Baffoe-Bonnie A
Fredriksson H
Matikainen MP
Tammela TLj
Bailey-Wilson J
Schleutker J
Maier C
Herkommer K
Hoegel JJ
Vogel W
Paiss T
Wiklund F
Emanuelsson M
Stenman E
Jonsson BA
Gronberg H
Camp NJ
Farnham J
Cannon-Albright LA
Seminara D
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Corporate Authors :
ACTANE Consortium
Źródło :
American journal of human genetics [Am J Hum Genet] 2005 Aug; Vol. 77 (2), pp. 219-29. Date of Electronic Publication: 2005 Jun 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Genetic Linkage*
Genetic Predisposition to Disease*
Genome, Human*
Prostatic Neoplasms/*genetics
Aged ; Chromosome Mapping ; Family Health ; Genetic Markers ; Genotype ; Humans ; International Cooperation ; Lod Score ; Male ; Middle Aged ; Pedigree
Czasopismo naukowe
Tytuł :
Analysis of the prostate cancer-susceptibility locus HPC20 in 172 families affected by prostate cancer.
Autorzy :
Bock CH; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Cunningham JM
McDonnell SK
Schaid DJ
Peterson BJ
Pavlic RJ
Schroeder JJ
Klein J
French AJ
Marks A
Thibodeau SN
Lange EM
Cooney KA
Pokaż więcej
Źródło :
American journal of human genetics [Am J Hum Genet] 2001 Mar; Vol. 68 (3), pp. 795-801. Date of Electronic Publication: 2001 Feb 06.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Chromosomes, Human, Pair 20*
Polymorphism, Genetic*
Genetic Predisposition to Disease/*genetics
Prostatic Neoplasms/*genetics
African Continental Ancestry Group/genetics ; Aged ; Chromosome Mapping ; European Continental Ancestry Group ; Genetic Markers ; Genotype ; Humans ; Lod Score ; Male ; Middle Aged ; Prostatic Neoplasms/epidemiology ; United States
Czasopismo naukowe
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