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Tytuł :
Searching for germline mutations in the RUNX1 gene among Polish patients with acute myeloid leukemia.
Autorzy :
Bąk A; Department of Clinical Genetics, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Skonieczka K; Department of Clinical Genetics, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Jaśkowiec A; Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University, Wrocław, Poland.
Junkiert-Czarnecka A; Department of Clinical Genetics, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Heise M; Department of Clinical Genetics, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Pilarska-Deltow M; Department of Clinical Genetics, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Potoczek S; Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University, Wrocław, Poland.
Czyżewska M; Department of Hematology, Municipal Hospital, Toruń, Poland.
Haus O; Department of Clinical Genetics, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2021 Jul; Vol. 62 (7), pp. 1749-1755. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Germ-Line Mutation*
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/genetics
Humans ; Poland/epidemiology
Czasopismo naukowe
Tytuł :
RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks.
Autorzy :
Kellaway SG; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Keane P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Kennett E; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Bonifer C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
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Źródło :
Haematologica [Haematologica] 2021 Jun 01; Vol. 106 (6), pp. 1569-1580. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Leukemia, Myeloid, Acute*/genetics
Cell Cycle/genetics ; Gene Regulatory Networks ; Humans ; MDS1 and EVI1 Complex Locus Protein/genetics ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease.
Autorzy :
Bertran L; Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain.
Pastor A; Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain.
Portillo-Carrasquer M; Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain.
Binetti J; Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain.
Aguilar C; Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain.
Martínez S; Servei Anatomia Patològica, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain.
Vives M; Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, URV, IISPV, Avinguda Doctor Josep Laporte, 2, 43204 Reus, Spain.
Sabench F; Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, URV, IISPV, Avinguda Doctor Josep Laporte, 2, 43204 Reus, Spain.
Porras JA; Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain.
Riesco D; Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain.
Del Castillo D; Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, URV, IISPV, Avinguda Doctor Josep Laporte, 2, 43204 Reus, Spain.
Richart C; Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain.; Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain.
Auguet T; Grup de Recerca GEMMAIR (AGAUR)-Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain.; Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 15; Vol. 22 (10). Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Core Binding Factor Alpha 2 Subunit/*genetics
Non-alcoholic Fatty Liver Disease/*genetics
Obesity, Morbid/*genetics
Adult ; Core Binding Factor Alpha 2 Subunit/metabolism ; Female ; Humans ; Jejunum/physiology ; Lipid Metabolism/genetics ; Liver/pathology ; Liver/physiology ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity, Morbid/pathology ; RNA, Messenger ; Toll-Like Receptor 9/genetics ; Toll-Like Receptors/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
[The Roles of RUNX1 in the Proliferation and Osteogenic and Adipogenic Differentiation of Dental Pulp Stem Cells].
Autorzy :
Cui YJ; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Guo DM; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Sun JX; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Yang YY; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Xie J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Zhang DM; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2021 May; Vol. 52 (3), pp. 416-422.
Typ publikacji :
Journal Article
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Osteogenesis*
Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Dental Pulp ; Stem Cells
Czasopismo naukowe
Tytuł :
MiR-18a Aggravates Intracranial Hemorrhage by Regulating RUNX1-Occludin/ZO-1 Axis to Increase BBB Permeability.
Autorzy :
Ren S; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Wu G; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. Electronic address: .
Huang Y; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Wang L; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Li Y; Guizhou Medical University, Guiyang 550025, China.
Zhang Y; Guizhou Medical University, Guiyang 550025, China; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Aug; Vol. 30 (8), pp. 105878. Date of Electronic Publication: 2021 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Capillary Permeability*
Blood-Brain Barrier/*metabolism
Core Binding Factor Alpha 2 Subunit/*metabolism
Intracranial Hemorrhages/*metabolism
MicroRNAs/*metabolism
Occludin/*metabolism
Zonula Occludens-1 Protein/*metabolism
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Blood-Brain Barrier/pathology ; Cells, Cultured ; Coculture Techniques ; Core Binding Factor Alpha 2 Subunit/genetics ; Disease Models, Animal ; Electric Impedance ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Intracranial Hemorrhages/genetics ; Intracranial Hemorrhages/pathology ; Male ; MicroRNAs/genetics ; Occludin/genetics ; Rats, Sprague-Dawley ; Signal Transduction ; Zonula Occludens-1 Protein/genetics
Czasopismo naukowe
Tytuł :
RUNX1 promotes MAPK signaling to increase tumor progression and metastasis via OPN in head and neck cancer.
Autorzy :
Liu K; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Hu H; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Jiang H; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhang H; Department of Otolaryngology Head and Neck Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Gong S; Department of Otolaryngology Head and Neck Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wei D; Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, Shandong, China.
Yu Z; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2021 Apr 17; Vol. 42 (3), pp. 414-422.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Core Binding Factor Alpha 2 Subunit/*metabolism
Head and Neck Neoplasms/*genetics
MAP Kinase Signaling System/*genetics
Osteopontin/*genetics
Squamous Cell Carcinoma of Head and Neck/*genetics
Animals ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Mice ; Middle Aged ; Promoter Regions, Genetic/genetics ; Squamous Cell Carcinoma of Head and Neck/diagnosis ; Squamous Cell Carcinoma of Head and Neck/secondary ; Squamous Cell Carcinoma of Head and Neck/surgery ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
AML1-ETO inhibits acute myeloid leukemia immune escape by CD48.
Autorzy :
Wang Z; Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
Guan W; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
Wang M; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
Chen J; Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.
Zhang L; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
Xiao Y; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
Wang L; Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.
Li Y; Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.
Yu L; Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.; Department of Hematology, Chinese PLA General Hospital, Beijing, China.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2021 Apr; Vol. 62 (4), pp. 937-943. Date of Electronic Publication: 2020 Nov 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Leukemia, Myeloid, Acute*/genetics
Chromosomes, Human, Pair 21 ; Chromosomes, Human, Pair 8 ; Humans ; Oncogene Proteins, Fusion/genetics ; RUNX1 Translocation Partner 1 Protein/genetics ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation.
Autorzy :
Davis AG; Moores Cancer Center.; Department of Biological Sciences.
Einstein JM; Department of Cellular and Molecular Medicine.; Stem Cell Program, and.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA.
Zheng D; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ.
Jayne ND; Moores Cancer Center.; Department of Biological Sciences.
Fu XD; Department of Cellular and Molecular Medicine.
Tian B; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ.; Program in Gene Expression and Regulation, Center for Systems and Computational Biology, Wistar Institute, Philadelphia, PA; and.
Yeo GW; Department of Cellular and Molecular Medicine.; Stem Cell Program, and.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA.
Zhang DE; Moores Cancer Center.; Department of Biological Sciences.; Department of Pathology, University of California, San Diego, La Jolla, CA.
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Źródło :
Blood advances [Blood Adv] 2021 Mar 09; Vol. 5 (5), pp. 1310-1323.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Clustered Regularly Interspaced Short Palindromic Repeats*
Core Binding Factor Alpha 2 Subunit*/genetics
Hematopoiesis/genetics ; Protein Isoforms/genetics ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Autorzy :
Muskens IS; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Li S; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Jackson T; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Elliot N; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Hansen HM; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Myint SS; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Pandey P; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Schraw JM; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA.
Roy R; Computational Biology and Informatics, University of California San Francisco, San Francisco, CA, USA.
Anguiano J; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Goudevenou K; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Siegmund KD; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Lupo PJ; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA.
de Bruijn MFTR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Walsh KM; Department of Neurosurgery, Duke University, Durham, NC, USA.; Department of Pediatrics, Duke University, Durham, NC, USA.
Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Ma X; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Roy A; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Roberts I; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Wiemels JL; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
de Smith AJ; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. .; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 821. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Core Binding Factor Alpha 2 Subunit/*genetics
Down Syndrome/*genetics
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Proto-Oncogene Protein c-fli-1/*genetics
Case-Control Studies ; Core Binding Factor Alpha 2 Subunit/metabolism ; CpG Islands ; DNA Methylation ; Down Syndrome/metabolism ; Down Syndrome/pathology ; Female ; Fetus ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Genome, Human ; Genome-Wide Association Study ; Hematopoietic Stem Cells/pathology ; Humans ; Infant, Newborn ; Liver/metabolism ; Liver/pathology ; Male ; Promoter Regions, Genetic ; Proto-Oncogene Protein c-fli-1/metabolism
Czasopismo naukowe
Tytuł :
Definition of a small core transcriptional circuit regulated by AML1-ETO.
Autorzy :
Stengel KR; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: .
Ellis JD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Spielman CL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Bomber ML; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Hiebert SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 530-545.e5. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Core Binding Factor Alpha 2 Subunit/*metabolism
Hematopoietic Stem Cells/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Neoplastic Stem Cells/*metabolism
Oncogene Proteins, Fusion/*metabolism
RNA, Neoplasm/*biosynthesis
RUNX1 Translocation Partner 1 Protein/*metabolism
Acetylation ; Binding Sites ; Binding, Competitive ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Cell Self Renewal ; Core Binding Factor Alpha 2 Subunit/genetics ; Fetal Blood/cytology ; Gene Expression Regulation, Leukemic ; Gene Regulatory Networks ; HEK293 Cells ; Hematopoietic Stem Cells/pathology ; Histones/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Neoplastic Stem Cells/pathology ; Oncogene Proteins, Fusion/genetics ; Protein Binding ; Proteolysis ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; RNA, Neoplasm/genetics ; RUNX1 Translocation Partner 1 Protein/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Time Factors ; Transcriptome
Czasopismo naukowe
Tytuł :
The RUNX1/RUNX1T1 network: translating insights into therapeutic options.
Autorzy :
Swart LE; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Heidenreich O; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2021 Feb; Vol. 94, pp. 1-10. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Expression Regulation, Leukemic*
Core Binding Factor Alpha 2 Subunit/*genetics
Leukemia, Myeloid, Acute/*genetics
Oncogene Proteins, Fusion/*genetics
RUNX1 Translocation Partner 1 Protein/*genetics
Animals ; Cell Cycle ; Core Binding Factor Alpha 2 Subunit/metabolism ; Gene Regulatory Networks ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Oncogene Proteins, Fusion/metabolism ; Protein Interaction Maps ; RUNX1 Translocation Partner 1 Protein/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.
Autorzy :
Baars MJD; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Douma T; Center of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Simeonov DR; Diabetes Center, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Myers DR; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Kulhanek K; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Banerjee S; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Zwakenberg S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Baltissen MP; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Amini M; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
de Roock S; Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
van Wijk F; Center of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Vermeulen M; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Marson A; Diabetes Center, University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Roose JP; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Vercoulen Y; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Feb; Vol. 51 (2), pp. 471-482. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Autoimmunity/*genetics
Core Binding Factor Alpha 2 Subunit/*genetics
DNA-Binding Proteins/*genetics
Guanine Nucleotide Exchange Factors/*genetics
Transcription, Genetic/*genetics
Animals ; Autoimmunity/immunology ; CD4-Positive T-Lymphocytes/immunology ; CRISPR-Cas Systems/genetics ; CRISPR-Cas Systems/immunology ; Core Binding Factor Alpha 2 Subunit/immunology ; DNA-Binding Proteins/immunology ; Gene Expression Regulation/genetics ; Gene Expression Regulation/immunology ; Guanine Nucleotide Exchange Factors/immunology ; Histones/genetics ; Histones/immunology ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Transcription, Genetic/immunology
Czasopismo naukowe
Tytuł :
TNF-α signaling regulates RUNX1 function in endothelial cells.
Autorzy :
Whitmore HAB; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Amarnani D; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
O'Hare M; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Delgado-Tirado S; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Gonzalez-Buendia L; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
An M; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Pedron J; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Bushweller JH; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Arboleda-Velasquez JF; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Kim LA; Schepens Eye Research Institute of Massachusetts Eye and Ear Infirmary, Boston, MA, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21155. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Choroidal Neovascularization/*metabolism
Core Binding Factor Alpha 2 Subunit/*metabolism
Diabetic Retinopathy/*metabolism
Endothelial Cells/*metabolism
MAP Kinase Signaling System/*drug effects
Retinopathy of Prematurity/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
Wet Macular Degeneration/*metabolism
Animals ; Cells, Cultured ; Core Binding Factor Alpha 2 Subunit/antagonists & inhibitors ; Disease Models, Animal ; Endothelial Cells/drug effects ; Glucose/pharmacology ; Humans ; Mice ; Mice, Inbred C57BL ; Retina/cytology ; Retina/metabolism ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/pharmacology ; Up-Regulation/drug effects ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.
Autorzy :
Daifu T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Mikami M; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Hiramatsu H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Iwai A; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Umeda K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Noura M; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Kubota H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Masuda T; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Furuichi K; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Takasaki S; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Noguchi Y; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Morita K; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Bando T; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan.
Hirata M; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Kataoka TR; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Nakahata T; Drug Discovery Technology Development Office, Center for iPS Cell Research and Application (CiRA), Kyoto University, Sakyo-ku, Kyoto, Japan.
Kuwahara Y; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
Iehara T; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
Hosoi H; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan.
Adachi S; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Kamikubo Y; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2021 Feb; Vol. 68 (2), pp. e28789. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Alkylating/*therapeutic use
Chlorambucil/*therapeutic use
Core Binding Factor Alpha 2 Subunit/*antagonists & inhibitors
Rhabdoid Tumor/*drug therapy
Animals ; Cell Line, Tumor ; Chlorambucil/analogs & derivatives ; Core Binding Factor Alpha 2 Subunit/genetics ; Disease Models, Animal ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; RNA Interference ; RNA, Small Interfering/genetics ; SMARCB1 Protein/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development.
Autorzy :
Zhen T; Oncogenesis and Development Section, National Human Genome Research Institute, and.
Cao Y; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Ren G; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Zhao L; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
Hyde RK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE; and.
Lopez G; Oncogenesis and Development Section, National Human Genome Research Institute, and.
Feng D; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Alemu L; Oncogenesis and Development Section, National Human Genome Research Institute, and.
Zhao K; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Liu PP; Oncogenesis and Development Section, National Human Genome Research Institute, and.
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Źródło :
Blood [Blood] 2020 Nov 19; Vol. 136 (21), pp. 2373-2385.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Gene Expression Regulation, Leukemic*/drug effects
Transcriptional Activation*
Cell Transformation, Neoplastic/*genetics
Core Binding Factor Alpha 2 Subunit/*physiology
Leukemia, Experimental/*genetics
Myeloid Cells/*metabolism
Neoplasm Proteins/*physiology
Neoplastic Stem Cells/*metabolism
Oncogene Proteins, Fusion/*physiology
Animals ; Core Binding Factor Alpha 2 Subunit/deficiency ; Core Binding Factor Alpha 2 Subunit/genetics ; Gene Knock-In Techniques ; Humans ; Leukemia, Experimental/etiology ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/cytology ; Neoplastic Stem Cells/cytology ; Oncogene Proteins, Fusion/genetics ; Poly I-C/pharmacology ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; RNA, Neoplasm/biosynthesis ; RNA, Neoplasm/genetics ; RNA-Seq ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching.
Autorzy :
Shin B; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Hosokawa H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.; Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Romero-Wolf M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Zhou W; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Masuhara K; Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Tobin VR; School of Veterinary Medicine, University of California, Davis, CA 95616.
Levanon D; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76001, Israel.
Groner Y; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76001, Israel.
Rothenberg EV; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptome*
Cell Lineage/*immunology
Core Binding Factor Alpha 2 Subunit/*genetics
Core Binding Factor Alpha 3 Subunit/*genetics
Precursor Cells, T-Lymphoid/*immunology
T-Lymphocytes/*immunology
Animals ; Cell Differentiation ; Cell Lineage/genetics ; Core Binding Factor Alpha 2 Subunit/immunology ; Core Binding Factor Alpha 3 Subunit/immunology ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Interleukin-2 Receptor alpha Subunit/genetics ; Interleukin-2 Receptor alpha Subunit/immunology ; Male ; Mice ; Precursor Cells, T-Lymphoid/cytology ; Primary Cell Culture ; Repressor Proteins/genetics ; Repressor Proteins/immunology ; T-Lymphocytes/classification ; T-Lymphocytes/cytology ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/immunology
Czasopismo naukowe
Tytuł :
RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia.
Autorzy :
Grinev VV; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus. .
Barneh F; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
Ilyushonak IM; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus.
Nakjang S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Smink J; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
van Oort A; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands.
Clough R; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Seyani M; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
McNeill H; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Reza M; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Martinez-Soria N; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Ramanouskaya TV; Department of Genetics, Faculty of Biology, Belarusian State University, 220030, Minsk, Republic of Belarus.
Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Heidenreich O; Princess Maxima Center for Pediatric Oncology, 3584, CS, Utrecht, The Netherlands. .; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. .; Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 520. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Gene Expression Regulation, Leukemic*
Core Binding Factor Alpha 2 Subunit/*genetics
Leukemia, Myeloid/*genetics
Oncogene Proteins, Fusion/*genetics
RUNX1 Translocation Partner 1 Protein/*genetics
Acute Disease ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit/metabolism ; Gene Expression Profiling/methods ; Humans ; Leukemia, Myeloid/pathology ; Models, Genetic ; Oncogene Proteins, Fusion/metabolism ; RNA Interference ; RNA Isoforms/genetics ; RNA Isoforms/metabolism ; RUNX1 Translocation Partner 1 Protein/metabolism ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
[Clinical features and prognosis of ETV6-RUNX1-positive childhood B-precursor acute lymphocyte leukemia].
Autorzy :
Zheng YZ; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Pan LL; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Li J; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Chen ZS; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Hua XL; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Le SH; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Zheng H; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Chen C; Department of Pediatric Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Hu JD; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory, Fujian Medical University Union Hospital, Fuzhou 350001, China.
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Źródło :
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2021 Jan 14; Vol. 42 (1), pp. 45-51.
Typ publikacji :
Journal Article
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Lymphocytes*
Child ; China ; Disease-Free Survival ; Humans ; Oncogene Proteins, Fusion/genetics ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Accurate germline RUNX1 variant interpretation and its clinical significance.
Autorzy :
Feurstein S; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL.
Zhang L; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA; and.
DiNardo CD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
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Źródło :
Blood advances [Blood Adv] 2020 Dec 22; Vol. 4 (24), pp. 6199-6203.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Leukemia, Myeloid, Acute*/genetics
Germ Cells ; Germ-Line Mutation ; Humans
Czasopismo naukowe
Tytuł :
Machine learning derived genomics driven prognostication for acute myeloid leukemia with RUNX1-RUNX1T1 .
Autorzy :
Shaikh AF; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Kakirde C; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Dhamne C; Homi Bhabha National Institute (HBNI), Mumbai, India.; Pediatric Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Bhanshe P; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Joshi S; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Chaudhary S; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Chatterjee G; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Tembhare P; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute (HBNI), Mumbai, India.
Prasad M; Homi Bhabha National Institute (HBNI), Mumbai, India.; Pediatric Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Roy Moulik N; Homi Bhabha National Institute (HBNI), Mumbai, India.; Pediatric Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Gokarn A; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Bonda A; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Nayak L; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Punatkar S; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Jain H; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Bagal B; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Shetty D; Deparment of Cytogenetics, ACTREC, Tata Memorial Centre, Navi Mumbai, India.
Sengar M; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Narula G; Homi Bhabha National Institute (HBNI), Mumbai, India.; Pediatric Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Khattry N; Homi Bhabha National Institute (HBNI), Mumbai, India.; Adult Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Banavali S; Homi Bhabha National Institute (HBNI), Mumbai, India.; Pediatric Haematolymphoid Disease Management Group, Tata Memorial Centre, Mumbai, India.
Gujral S; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute (HBNI), Mumbai, India.
P G S; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute (HBNI), Mumbai, India.
Patkar N; Haematopathology Laboratory, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute (HBNI), Mumbai, India.
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Źródło :
Leukemia & lymphoma [Leuk Lymphoma] 2020 Dec; Vol. 61 (13), pp. 3154-3160. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Core Binding Factor Alpha 2 Subunit*/genetics
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/genetics
Genomics ; Humans ; Machine Learning ; Mutation ; RUNX1 Translocation Partner 1 Protein/genetics
Czasopismo naukowe

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