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Tytuł:
Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo.
Autorzy:
Hong M; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
He J; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li D; Central Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chu Y; Central Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pu J; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Tong Q; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Joshi HC; Department of Cell Biology, Emory University, Atlanta, GA, USA.
Tang S; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li S; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. shiwang_.
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Mar 20; Vol. 39 (1), pp. 52. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Core Binding Factor Alpha 2 Subunit/*genetics
Neuroblastoma/*genetics
Animals ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Movement/physiology ; Core Binding Factor Alpha 2 Subunit/biosynthesis ; Core Binding Factor Alpha 2 Subunit/metabolism ; Disease Progression ; Female ; Heterografts ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Neuroblastoma/blood supply ; Neuroblastoma/metabolism ; Neuroblastoma/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Morphological characteristics, cytogenetic profile, and outcome of RUNX1-RUNX1T1-positive acute myeloid leukemia: Experience of an Indian tertiary care center.
Autorzy:
Gupta R; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Yadav S; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Parashar Y; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Rahman K; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Singh MK; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Chandra D; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Gupta A; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
Nityanand S; Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Uttar Pradesh, Lucknow, India.
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Źródło:
International journal of laboratory hematology [Int J Lab Hematol] 2020 Feb; Vol. 42 (1), pp. 37-45. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji:
Journal Article
MeSH Terms:
Chromosomes, Human, Pair 21*/genetics
Chromosomes, Human, Pair 21*/metabolism
Chromosomes, Human, Pair 8*/genetics
Chromosomes, Human, Pair 8*/metabolism
Core Binding Factor Alpha 2 Subunit*/blood
Core Binding Factor Alpha 2 Subunit*/genetics
Leukemia, Myeloid, Acute*/blood
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/mortality
Sarcoma, Myeloid*/blood
Sarcoma, Myeloid*/drug therapy
Sarcoma, Myeloid*/genetics
Sarcoma, Myeloid*/mortality
Translocation, Genetic*
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Adolescent ; Adult ; Aged ; Asparaginase/administration & dosage ; Child ; Child, Preschool ; Daunorubicin/administration & dosage ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Prednisone/administration & dosage ; RUNX1 Translocation Partner 1 Protein/blood ; RUNX1 Translocation Partner 1 Protein/genetics ; Retrospective Studies ; Survival Rate ; Vincristine/administration & dosage
SCR Protocol:
PVDA protocol
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ETV6 / RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia.
Autorzy:
Montaño A; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.
Ordoñez JL; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.; Dept of Biochemistry and Molecular Biology, University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain.
Alonso-Pérez V; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.
Hernández-Sánchez J; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.
Santos S; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.
González T; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.; Department of Hematology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain.
Benito R; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.
García-Tuñón I; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.
Hernández-Rivas JM; IBSAL, IBMCC, Cancer Research Center, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain.; Department of Hematology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain.; Department of Medicine, Universidad de Salamanca and CIBERONC, 37007 Salamanca, Spain.
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Źródło:
Cells [Cells] 2020 Jan 15; Vol. 9 (1). Date of Electronic Publication: 2020 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Core Binding Factor Alpha 2 Subunit/*metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism
Proto-Oncogene Proteins c-ets/*metabolism
Repressor Proteins/*metabolism
CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Cell Proliferation ; Core Binding Factor Alpha 2 Subunit/deficiency ; Core Binding Factor Alpha 2 Subunit/genetics ; Gene Editing ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Proto-Oncogene Proteins c-ets/deficiency ; Proto-Oncogene Proteins c-ets/genetics ; Repressor Proteins/deficiency ; Repressor Proteins/genetics ; Tumor Cells, Cultured ; ETS Translocation Variant 6 Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Evidence for a role of RUNX1 as recombinase cofactor for TCRβ rearrangements and pathological deletions in ETV6-RUNX1 ALL.
Autorzy:
Seitz V; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.; HS Diagnomics GmbH, Berlin, Germany.
Kleo K; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Dröge A; HS Diagnomics GmbH, Berlin, Germany.
Schaper S; HS Diagnomics GmbH, Berlin, Germany.
Elezkurtaj S; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Bedjaoui N; University of Paris, Institute Necker-Enfants Malades (INEM), INSERM U1151, Laboratoire d'Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
Dimitrova L; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Sommerfeld A; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Berg E; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
von der Wall E; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Müller U; Heinrich-Pette-Institute, Leibniz-Institute for Experimental Virology, Hamburg, Germany.
Joosten M; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Lenze D; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany.
Heimesaat MM; Charité University Medicine Berlin, Institute of Microbiology, Infectious Diseases and Immunology, Berlin, Germany.
Baldus C; University Medical Center Schleswig-Holstein, Department of Internal Medicine II, Kiel, Germany.
Zinser C; Precigen Bioinformatics Germany GmbH, Munich, Germany.
Cieslak A; University of Paris, Institute Necker-Enfants Malades (INEM), INSERM U1151, Laboratoire d'Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
Macintyre E; University of Paris, Institute Necker-Enfants Malades (INEM), INSERM U1151, Laboratoire d'Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
Stocking C; University Medical Center Eppendorf, Department of Stem Cell Transplantation, Hamburg, Germany.
Hennig S; HS Diagnomics GmbH, Berlin, Germany.
Hummel M; Charité University Medicine Berlin, Institute of Pathology, Berlin, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 22; Vol. 10 (1), pp. 10024. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Deletion*
Core Binding Factor Alpha 2 Subunit/*physiology
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Proto-Oncogene Proteins c-ets/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Repressor Proteins/*genetics
Animals ; B-Lymphocytes ; Core Binding Factor Alpha 2 Subunit/genetics ; Lymphocyte Count ; Mice, Knockout ; T-Lymphocytes ; Thymus Gland/pathology ; ETS Translocation Variant 6 Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RUNX1 Is Regulated by Androgen Receptor to Promote Cancer Stem Markers and Chemotherapy Resistance in Triple Negative Breast Cancer.
Autorzy:
Fernández NB; Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina.
Sosa SM; Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina.
Roberts JT; Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
Recouvreux MS; Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Rocha-Viegas L; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina.; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina-Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina.
Christenson JL; Department of Pathology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Spoelstra NS; Department of Pathology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Couto FL; Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.
Raimondi AR; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina.; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina-Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina.
Richer JK; Department of Pathology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Rubinstein N; Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Buenos Aires C1425FQB, Argentina.
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Źródło:
Cells [Cells] 2023 Jan 29; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/pathology
Humans ; Cell Line, Tumor ; Core Binding Factor Alpha 2 Subunit/genetics ; Neoplasm Recurrence, Local ; Receptors, Androgen/metabolism ; Female
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An inherited variant of transcription factor RUNX1 related to thrombocytopenia with predisposition to acute myeloid leukaemia.
Autorzy:
Tian Y; Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Jia SX; Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Shi J; Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Fang MY; Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
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Źródło:
International journal of laboratory hematology [Int J Lab Hematol] 2019 Dec; Vol. 41 (6), pp. e128-e129. Date of Electronic Publication: 2019 Apr 29.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Core Binding Factor Alpha 2 Subunit*/genetics
Core Binding Factor Alpha 2 Subunit*/metabolism
Genetic Predisposition to Disease*
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Thrombocytopenia*/genetics
Thrombocytopenia*/metabolism
Thrombocytopenia*/pathology
Adult ; Humans ; Male
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Familial platelet disorder due to germline exonic deletions in RUNX1 : a diagnostic challenge with distinct alterations of the transcript isoform equilibrium.
Autorzy:
Engvall M; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Karlsson Y; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Kuchinskaya E; Department of Clinical Pathology and Clinical Genetics, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Jörnegren Å; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.
Mathot L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Pandzic T; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Palle J; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Ljungström V; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Cavelier L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Hellström Lindberg E; Department of Medicine, Division of Hematology, Huddinge, Karolinska University Hospital, Stockholm, Sweden.; Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Cammenga J; Department of Hematology, Linköping University Hospital, Linköping, Sweden.; Department of Molecular Medicine and Virology (MMV), Division of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Baliakas P; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2022 Oct; Vol. 63 (10), pp. 2311-2320. Date of Electronic Publication: 2022 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Platelet Disorders*/complications
Blood Platelet Disorders*/diagnosis
Blood Platelet Disorders*/genetics
Leukemia, Myeloid, Acute*/genetics
Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor Alpha 2 Subunit/metabolism ; Exons ; Germ Cells/metabolism ; Humans ; Protein Isoforms/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR.
Autorzy:
Elbezanti W; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Lin A; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Schirling A; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Jackson A; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Marshall M; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Duyne RV; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.
Maldarelli F; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Sardo L; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.; Currently at Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA 19486, USA.
Klase Z; Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.; Substance Use Disorder Institute, University of the Sciences, Philadelphia, PA 19104, USA.
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Źródło:
Viruses [Viruses] 2020 Feb 09; Vol. 12 (2). Date of Electronic Publication: 2020 Feb 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Integration*
Benzodiazepines/*pharmacology
Chromatin/*genetics
Core Binding Factor Alpha 2 Subunit/*metabolism
HIV Long Terminal Repeat/*genetics
Transcription, Genetic/*drug effects
Chromatin Immunoprecipitation ; Core Binding Factor Alpha 2 Subunit/antagonists & inhibitors ; Gene Expression Regulation ; HIV-1 ; Humans ; Leukocytes, Mononuclear/virology ; STAT5 Transcription Factor/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Leukemic lineage switch in a t(8;22)(p11.2;q11.2)/ BCR-FGFR1 -rearranged myeloid/lymphoid neoplasm with RUNX1 mutation - diagnostic pitfalls and clinical management including FGFR1 inhibitor pemigatinib.
Autorzy:
Manur R; Department of Pathology and Laboratory Medicine, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, PA, USA.
Sung PJ; Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Loren AW; Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Ritchie EK; Department of Medicine, Leukemia Program, Weill Cornell Medicine, New York, NY, USA.
Frank D; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Bagg A; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Geyer JT; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Bogusz AM; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2020 Feb; Vol. 61 (2), pp. 450-454. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Core Binding Factor Alpha 2 Subunit*/genetics
Leukemia, Myeloid/*drug therapy
Leukemia, Myeloid/*genetics
Morpholines/*therapeutic use
Pyrimidines/*therapeutic use
Pyrroles/*therapeutic use
Gene Rearrangement ; Humans ; Male ; Middle Aged ; Mutation ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Translocation, Genetic
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model.
Autorzy:
Tijchon E; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Yi G; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Mandoli A; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Smits JGA; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Ferrari F; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Heuts BMH; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Wijnen F; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Kim B; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Janssen-Megens EM; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
Schuringa JJ; Department of Hematology, University Medical Centre Groningen, Groningen, The Netherlands.
Martens JHA; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.
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Źródło:
PloS one [PLoS One] 2019 Dec 23; Vol. 14 (12), pp. e0226435. Date of Electronic Publication: 2019 Dec 23 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcriptome*/genetics
Cell Differentiation/*genetics
Cell Transformation, Neoplastic/*genetics
Core Binding Factor Alpha 2 Subunit/*physiology
Granulocytes/*physiology
Induced Pluripotent Stem Cells/*physiology
Oncogene Proteins, Fusion/*physiology
RUNX1 Translocation Partner 1 Protein/*physiology
Cell Proliferation/genetics ; Cells, Cultured ; Core Binding Factor Alpha 2 Subunit/genetics ; Granulocytes/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukopoiesis/genetics ; Monocytes/physiology ; Myelopoiesis/genetics ; Oncogene Proteins, Fusion/genetics ; Oncogenes/physiology ; RUNX1 Translocation Partner 1 Protein/genetics ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric ETV6-RUNX1 B-Acute Lymphoblastic Leukemia Patients.
Autorzy:
Serafin V; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.; Laboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Porcù E; Laboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Cortese G; Department of Statistical Sciences, University of Padova, 35121 Padova, Italy.
Mariotto E; Laboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Veltri G; Laboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Bresolin S; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.; Laboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Basso G; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Accordi B; Istituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.; Laboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 07; Vol. 20 (24). Date of Electronic Publication: 2019 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Core Binding Factor Alpha 2 Subunit/*metabolism
Drug Resistance, Neoplasm/*drug effects
Neoplasm Recurrence, Local/*drug therapy
Oncogene Proteins, Fusion/*metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Syk Kinase/*antagonists & inhibitors
Aminopyridines ; Cell Proliferation/drug effects ; Child ; Core Binding Factor Alpha 2 Subunit/genetics ; Cyclohexylamines/pharmacology ; Humans ; Indazoles/pharmacology ; Morpholines ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Oncogene Proteins, Fusion/genetics ; Oxazines/pharmacology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Pyrazines/pharmacology ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.
Autorzy:
Bera R; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Chiu MC; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Huang YJ; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Lin TH; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Kuo MC; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Shih LY; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. .; College of Medicine, Chang Gung University, Taoyuan, Taiwan. .; Division of Hematology-Oncology, Chang Gung Memorial Hospital, 199, Tung-Hwa North Road, Taipei, Taiwan, 10590. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2019 Oct 22; Vol. 12 (1), pp. 104. Date of Electronic Publication: 2019 Oct 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Core Binding Factor Alpha 2 Subunit/*metabolism
Leukemia, Myelomonocytic, Chronic/*genetics
Repressor Proteins/*metabolism
Animals ; Bone Marrow Transplantation ; Cell Line ; Cell Proliferation/drug effects ; Cells, Cultured ; Core Binding Factor Alpha 2 Subunit/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred C57BL ; Mutation ; Neoplasms, Experimental ; Protein Array Analysis ; Repressor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer.
Autorzy:
Li Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Lai Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
He C; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Fang Y; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Yan Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Zhang Y; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Wang X; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Gu C; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Wang Y; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Ye L; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Han L; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Lin X; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Chen J; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Cai J; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China.
Li A; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China. .
Liu S; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, Guangdong, People's Republic of China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Aug 01; Vol. 38 (1), pp. 334. Date of Electronic Publication: 2019 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Wnt Signaling Pathway*
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*pathology
Core Binding Factor Alpha 2 Subunit/*metabolism
Animals ; Binding Sites ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Chromatin Immunoprecipitation Sequencing ; Core Binding Factor Alpha 2 Subunit/genetics ; Disease Models, Animal ; Gene Knockdown Techniques ; Heterografts ; Humans ; Mice ; Models, Biological ; Neoplasm Metastasis ; Promoter Regions, Genetic ; Protein Binding ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
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Tytuł:
Co-expression of AML1-ETO and PML-RARa following treatment of de novo acute myeloid leukemia with AML1-ETO.
Autorzy:
Zhang S; a The First Clinical Medical College, Lanzhou University , Lanzhou , Gansu , China.
Zhou W; b Respiratory medicine department , Beijing Geriatric Hospital , Beijing , China.
Li Y; c Department of Hematology , Shanxi Provincial People's Hospital , Xian , Shanxi , China.
Yu S; d People's Hospital of Jingyuan County, Jingyuan , Baiyin , Gansu , China.
Xue M; a The First Clinical Medical College, Lanzhou University , Lanzhou , Gansu , China.
Qiao Y; a The First Clinical Medical College, Lanzhou University , Lanzhou , Gansu , China.
Jian J; a The First Clinical Medical College, Lanzhou University , Lanzhou , Gansu , China.
Liu B; a The First Clinical Medical College, Lanzhou University , Lanzhou , Gansu , China.; e Department of Hematology , The First Affiliated Hospital, Lanzhou University , Lanzhou , Gansu , China.
Wang D; f Department of Anatomy and Histology , Lanzhou University, School of Basic Medical Sciences , Lanzhou , China.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2019 May; Vol. 60 (5), pp. 1316-1319. Date of Electronic Publication: 2018 Oct 17.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Biomarkers, Tumor*
Gene Expression Regulation, Leukemic*
Core Binding Factor Alpha 2 Subunit/*genetics
Leukemia, Myeloid, Acute/*genetics
Oncogene Proteins, Fusion/*genetics
RUNX1 Translocation Partner 1 Protein/*genetics
Abnormal Karyotype ; Adolescent ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Core Binding Factor Alpha 2 Subunit/metabolism ; Humans ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Male ; Oncogene Proteins, Fusion/metabolism ; RUNX1 Translocation Partner 1 Protein/metabolism ; Translocation, Genetic
Raport
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Tytuł:
Nuclear Proteomics of Induced Leukemia Cell Differentiation.
Autorzy:
Novikova S; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Tolstova T; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Kurbatov L; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Farafonova T; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Tikhonova O; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Soloveva N; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Rusanov A; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Archakov A; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Zgoda V; Laboratory of Systems Biology, Institute of Biomedical Chemistry, 119121 Moscow, Russia.
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Źródło:
Cells [Cells] 2022 Oct 14; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukemia, Promyelocytic, Acute*/genetics
Leukemia, Promyelocytic, Acute*/metabolism
Leukemia, Promyelocytic, Acute*/pathology
Nuclear Proteins*/metabolism
Proteome*/metabolism
Granulocytes*/metabolism
Granulocytes*/pathology
Cell Nucleus*/metabolism
Humans ; Caspase 3/metabolism ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Chromosomal Proteins, Non-Histone/metabolism ; Core Binding Factor Alpha 2 Subunit/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Proteomics ; Tretinoin/pharmacology ; Tretinoin/metabolism ; Tumor Suppressor Protein p53/genetics ; HL-60 Cells
Czasopismo naukowe
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Tytuł:
Normal and Aberrant TALE-Class Homeobox Gene Activities in Pro-B-Cells and B-Cell Precursor Acute Lymphoblastic Leukemia.
Autorzy:
Nagel S; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ, German Collection of Microorganisms and Cell Cultures, 38124 Braunschweig, Germany.
Meyer C; Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ, German Collection of Microorganisms and Cell Cultures, 38124 Braunschweig, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 06; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/pathology
Core Binding Factor Alpha 2 Subunit/genetics ; Genes, Homeobox/genetics ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Myeloid Ecotropic Viral Integration Site 1 Protein/genetics ; Precursor Cells, B-Lymphoid/pathology ; RNA, Small Interfering
Czasopismo naukowe
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Tytuł:
Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Autorzy:
Hennawi M; Department of Pathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL 33612, USA.
Pakasticali N; Department of Pathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL 33612, USA.
Tashkandi H; Department of Pathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL 33612, USA.
Hussaini M; Department of Pathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL 33612, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 24; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 24.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia, Myeloid, Acute*/genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Acute Disease ; Core Binding Factor Alpha 2 Subunit/genetics ; Female ; Genomics ; Humans ; Male ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Decreased GZMB , NRP1 , ITPR1 , and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients.
Autorzy:
Giri PS; C. G. Bhakta Institute of Biotechnology, Faculty of Science, Uka Tarsadia University, Bardoli, Surat, 394 350 Gujarat, India.
Bharti AH; Independent Researcher, Vyara, Gujarat, India.
Dwivedi M; C. G. Bhakta Institute of Biotechnology, Faculty of Science, Uka Tarsadia University, Bardoli, Surat, 394 350 Gujarat, India.
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Źródło:
Journal of immunology research [J Immunol Res] 2022 Sep 15; Vol. 2022, pp. 3426717. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Serpins*/genetics
Serpins*/metabolism
Vitiligo*/genetics
Vitiligo*/metabolism
Calcium/metabolism ; Core Binding Factor Alpha 2 Subunit/metabolism ; Granzymes/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Neuropilin-1 ; STAT5 Transcription Factor/metabolism ; T-Lymphocytes, Regulatory
Czasopismo naukowe
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Tytuł:
A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.
Autorzy:
Hattori EY; Department of Neurosurgery, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Masuda T; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Mineharu Y; Department of Neurosurgery, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Mikami M; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.; Department of Pediatrics, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Terada Y; Department of Neurosurgery, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Matsui Y; Department of Neurosurgery, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Kubota H; Department of Pediatrics, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Matsuo H; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Hirata M; Department of Diagnostic Pathology, Kyoto University Hospital; Kyoto City, Kyoto, 606-8507, Japan.
Kataoka TR; Department of Diagnostic Pathology, Kyoto University Hospital; Kyoto City, Kyoto, 606-8507, Japan.
Nakahata T; Drug Discovery Technology Development Office, Center for iPS Cell Research and Application (CiRA), Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Ikeda S; Department of Chemistry, Graduate School of Science, Kyoto University; Kyoto City, Kyoto, 606-8502, Japan.
Miyamoto S; Department of Neurosurgery, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan.
Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University; Kyoto City, Kyoto, 606-8502, Japan. .
Arakawa Y; Department of Neurosurgery, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan. .
Kamikubo Y; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University; Kyoto City, Kyoto, 606-8507, Japan. .
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Źródło:
Communications biology [Commun Biol] 2022 Sep 09; Vol. 5 (1), pp. 939. Date of Electronic Publication: 2022 Sep 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms*/genetics
Glioblastoma*/genetics
Animals ; Apoptosis/genetics ; Core Binding Factor Alpha 2 Subunit ; DNA Helicases ; Mice ; Oncogenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes.
Autorzy:
Ogawa E; Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Edamitsu T; Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Ohmori H; Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Kohu K; Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Kurokawa M; Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Kiyonari H; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Satake M; Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Okuyama R; Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 02; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Keratin-1*/genetics
Keratin-10*/genetics
Core Binding Factor Alpha 2 Subunit/*metabolism
Core Binding Factor Alpha 3 Subunit/*metabolism
Animals ; Cell Differentiation ; Keratinocytes/metabolism ; Keratins/genetics ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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