CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells.
Autorzy:
Hammad R; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Freiburg iPS Core Facility, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; PhD Program, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany. Alzubi J; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Rhiel M; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Chmielewski KO; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; PhD Program, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany. Mosti L; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Rositzka J; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Heugel M; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Lawrenz J; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Pennucci V; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Gläser B; Institute of Human Genetics, Medical Center-University of Freiburg, 79106 Freiburg, Germany. Fischer J; Institute of Human Genetics, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. Schambach A; Institute for Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH Center for Regenerative and Translational Medicine, Hannover Medical School, 30625 Hannover, Germany. Moritz T; Institute for Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH Center for Regenerative and Translational Medicine, Hannover Medical School, 30625 Hannover, Germany. Lachmann N; REBIRTH Center for Regenerative and Translational Medicine, Hannover Medical School, 30625 Hannover, Germany.; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease, German Center for Lung Research, Hannover Medical School, 30625 Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625 Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625 Hannover, Germany. CornuTI; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. Mussolino C; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. Schäfer R; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Freiburg iPS Core Facility, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy.
Autorzy:
Dibas A; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Ph.D. Program, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany. Rhiel M; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Patel VB; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership between DKFZ and Medical Center-University of Freiburg, 79106 Freiburg, Germany. CornuTI; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. Alzubi J; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany. Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, 79106 Freiburg, Germany.; Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
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Źródło:
Cells [Cells] 2023 Nov 06; Vol. 12 (21). Date of Electronic Publication: 2023 Nov 06.
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