SARS-CoV-2 Vaccine-Induced T-Cell Response after Three Doses in People Living with HIV on Antiretroviral Therapy Compared to Seronegative Controls (CTN 328 COVAXHIV Study).
Autorzy:
Alexandrova Y; Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada.; Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Yero A; Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada. Mboumba Bouassa RS; Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada.; Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Comeau E; Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada. Samarani S; Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada. Hull M; British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. CrawleyAM; Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Coronavirus Variants Rapid Response Network-Biobank, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation (CI3), University of Ottawa, Ottawa, ON K1H 8M5, Canada. Langlois MA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation (CI3), University of Ottawa, Ottawa, ON K1H 8M5, Canada. Angel JB; Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation (CI3), University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Department of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Cooper CL; Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.; Department of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Needham J; CIHR Canadian HIV Trials Network and Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada. Lee T; CIHR Canadian HIV Trials Network and Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada. Singer J; CIHR Canadian HIV Trials Network and Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada. Anis AH; CIHR Canadian HIV Trials Network and Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada. Costiniuk CT; Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Department of Medicine, Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Jenabian MA; Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada.
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Źródło:
Viruses [Viruses] 2023 Feb 19; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 19.
In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism.
Autorzy:
Gobeil Odai K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. O'Dwyer C; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. Steenbergen R; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada. Shaw TA; Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada. Renner TM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. Ghorbani P; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. Rezaaifar M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. Han S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. Langlois MA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada. CrawleyAM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada.; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.; Department of Medicine, Division of Infectious Diseases, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.; Department of Biology, Faculty of Science, Carleton University, Ottawa, ON K1S 5B6, Canada. Russell RS; Immunology and Infectious Diseases, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada. Pezacki JP; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada.; Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada. Tyrrell DL; Department of Medical Microbiology and Immunology and Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada. Fullerton MD; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; University of Ottawa Centre for Infection, Immunity and Inflammation and Centre for Catalysis Research and Innovation, Ottawa, ON K1H 8M5, Canada.
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Źródło:
Viruses [Viruses] 2020 Jan 16; Vol. 12 (1). Date of Electronic Publication: 2020 Jan 16.
Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8 T-Cell Dysfunction.
Autorzy:
Ahmed F; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. .; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. . Ibrahim A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. .; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. . Cooper CL; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. .; Department of Medicine, Division of Infectious Diseases, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada. .; Public Health and Preventative Medicine, School of Epidemiology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1G 5Z3, Canada. . Kumar A; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. .; Department of Pathology, The Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. . CrawleyAM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. .; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. .; Department of Medicine, Division of Infectious Diseases, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada. .; Department of Biology, Faculty of Science, Carleton University, Ottawa, ON K1S 5B6, Canada. .
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Źródło:
Cells [Cells] 2019 Apr 25; Vol. 8 (4). Date of Electronic Publication: 2019 Apr 25.
Hepatitis C virus core protein reduces CD8 T-cell proliferation, perforin production and degranulation but increases STAT5 activation.
Autorzy:
Khan ST; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Chronic Diseases Programme, Ottawa Hospital Research Institute, Ottawa, ON, Canada. Karges W; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Chronic Diseases Programme, Ottawa Hospital Research Institute, Ottawa, ON, Canada. Cooper CL; School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, ON, Canada.; Division of Infectious Diseases, The Ottawa Hospital, Ottawa, ON, Canada.; Clinical Epidemiology Programme, Ottawa Hospital Research Institute, Ottawa, ON, Canada. CrawleyAM; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Chronic Diseases Programme, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biology, Carleton University, Ottawa, ON, Canada.
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Źródło:
Immunology [Immunology] 2018 May; Vol. 154 (1), pp. 156-165. Date of Electronic Publication: 2018 Jan 25.
Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques.
Autorzy:
Steele AK; Center for Infectious Disease Research, Seattle, WA, United States of America.; Collegiate Peaks Science Writing, Denver, CO, United States of America. Carrasco-Medina L; The Ottawa Hospital-General Campus, Division of Infectious Diseases, Ottawa, ON, Canada. Sodora DL; Center for Infectious Disease Research, Seattle, WA, United States of America. CrawleyAM; The Ottawa Hospital Research Institute, Chronic Disease Program, Ottawa, ON, Canada.; University of Ottawa, Dept. Biochem., Microbiol., and Immunol., Ottawa, ON, Canada.; Carleton University, Dept. Biol., Ottawa, ON, Canada.
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Źródło:
PloS one [PLoS One] 2017 Dec 19; Vol. 12 (12), pp. e0188427. Date of Electronic Publication: 2017 Dec 19 (Print Publication: 2017).
Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection.
Autorzy:
Burke Schinkel SC; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Carrasco-Medina L; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Cooper CL; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Division of Infectious Diseases, Ottawa Hospital-General Campus, Ottawa, Ontario, Canada. CrawleyAM; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Biology, Carleton University, Ottawa, Ontario, Canada.
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Źródło:
PloS one [PLoS One] 2016 Jun 17; Vol. 11 (6), pp. e0157055. Date of Electronic Publication: 2016 Jun 17 (Print Publication: 2016).
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