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Tytuł:
Investigations of the migraine-provoking effect of levcromakalim in patients with migraine with aura.
Autorzy:
Thomsen AV; Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Al-Karagholi MA; Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hougaard A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Ostrowski SR; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.
Hansen TF; Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Novo Nordisk Foundation Center for Protein Research, Brunak Lab, Copenhagen University Hospital, Copenhagen, Denmark.
Ashina M; Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Danish Knowledge Center on Headache Disorders, Glostrup, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2024 Mar; Vol. 44 (3), pp. 3331024241237247.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Migraine with Aura*
Migraine Disorders*/drug therapy
Epilepsy*
Adult ; Humans ; Cromakalim ; Cross-Over Studies ; Headache ; Double-Blind Method
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial.
Autorzy:
Raffaelli B; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Neurology, Charité Universitätsmedizin Berlin, corporate member of Freie Universitä Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Clinician Scientist Program, Berlin Institute of Health at Charité (BIH), Berlin, Germany.
Do TP; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Chaudhry BA; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Amin FM; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Brain and Spinal Cord Injury, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Ashina H; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Brain and Spinal Cord Injury, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Snellman J; Novartis Pharma AG, Basel, Switzerland.
Maio-Twofoot T; Novartis Pharma AG, Basel, Switzerland.
Ashina M; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2024 Jan; Vol. 44 (1), pp. 3331024231222916.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
KATP Channels*
Migraine Disorders*/chemically induced
Adult ; Humans ; Receptors, Calcitonin Gene-Related Peptide ; Cromakalim ; Cross-Over Studies ; Antibodies, Monoclonal ; Adenosine Triphosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache.
Autorzy:
Al-Khazali HM; Harvard Medical School, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christensen RH; Harvard Medical School, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dodick DW; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Chaudhry BA; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Burstein R; Harvard Medical School, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Ashina H; Harvard Medical School, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Brain and Spinal Cord Injury, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2023 Nov; Vol. 43 (11), pp. 3331024231210930.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Post-Traumatic Headache*/drug therapy
Post-Traumatic Headache*/etiology
Migraine Disorders*/drug therapy
Tension-Type Headache*
Hypersensitivity*
Humans ; Cromakalim/adverse effects ; KATP Channels ; Headache ; Double-Blind Method ; Adenosine Triphosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mechanisms for the α-Adrenoceptor-Mediated Positive Inotropy in Mouse Ventricular Myocardium: Enhancing Effect of Action Potential Prolongation.
Autorzy:
Hamaguchi S; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
Morinou I; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
Shiseki Y; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
Mikami A; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
Seki M; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
Namekata I; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
Tanaka H; Department of Pharmacology, Faculty of Pharmacological Science, Toho University, Chiba 274-8510, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 15; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Myocardial Contraction*/physiology
Myocardium*
Mice ; Animals ; Action Potentials ; Cromakalim/pharmacology ; Phenylephrine/pharmacology ; Receptors, Adrenergic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits.
Autorzy:
Roy Chowdhury U; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Kudgus RA; Department of Oncology Research, Mayo Clinic, Rochester, MN, United States of America.
Rinkoski TA; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Holman BH; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Bahler CK; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Hann CR; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Reid JM; Department of Oncology Research, Mayo Clinic, Rochester, MN, United States of America.
Dosa PI; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, United States of America.
Fautsch MP; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Apr 16; Vol. 15 (4), pp. e0231841. Date of Electronic Publication: 2020 Apr 16 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cromakalim/*pharmacokinetics
Cromakalim/*pharmacology
Prodrugs/*pharmacokinetics
Prodrugs/*pharmacology
Administration, Intravenous ; Administration, Topical ; Animals ; Aqueous Humor/drug effects ; Aqueous Humor/metabolism ; Chromatography, Liquid ; Cornea/cytology ; Cornea/drug effects ; Cromakalim/administration & dosage ; Cromakalim/blood ; Eye/cytology ; Eye/drug effects ; Eye/metabolism ; Female ; Mass Spectrometry ; Prodrugs/therapeutic use ; Rabbits ; Vitreous Body/drug effects ; Vitreous Body/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential.
Autorzy:
Clement A; Glostrup Research Institute, Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Nordstjernevej 42, Glostrup, 2600 Copenhagen, Denmark.
Guo S; Glostrup Research Institute, Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Nordstjernevej 42, Glostrup, 2600 Copenhagen, Denmark.; Department of Odontology, Panum Institute, Faculty of Health, University of Copenhagen, 2300 Copenhagen, Denmark.
Jansen-Olesen I; Glostrup Research Institute, Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Nordstjernevej 42, Glostrup, 2600 Copenhagen, Denmark.
Christensen SL; Glostrup Research Institute, Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Nordstjernevej 42, Glostrup, 2600 Copenhagen, Denmark.
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Źródło:
Cells [Cells] 2022 Aug 04; Vol. 11 (15). Date of Electronic Publication: 2022 Aug 04.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
KATP Channels*
Migraine Disorders*/drug therapy
Adenosine Triphosphate/therapeutic use ; Cromakalim/pharmacology ; Cromakalim/therapeutic use ; Headache ; Humans ; Vasodilator Agents/pharmacology ; Vasodilator Agents/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models.
Autorzy:
Christensen SL; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Rasmussen RH; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Cour S; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Ernstsen C; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Hansen TF; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark.
Kogelman LJ; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Lauritzen SP; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Guzaite G; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Styrishave B; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Janfelt C; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Christensen ST; Department of Biology, Section of Cell Biology and Physiology, University of Copenhagen, Denmark.
Aziz Q; The Heart Centre, 4617Queen Mary University of London, William Harvey Research Institute, Queen Mary University of London, UK.
Tinker A; The Heart Centre, 4617Queen Mary University of London, William Harvey Research Institute, Queen Mary University of London, UK.
Jansen-Olesen I; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Olesen J; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Kristensen DM; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2022 Feb; Vol. 42 (2), pp. 93-107. Date of Electronic Publication: 2021 Nov 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
KATP Channels*/genetics
KATP Channels*/metabolism
Migraine Disorders*
Adenosine Triphosphate ; Animals ; Cromakalim/adverse effects ; Disease Models, Animal ; Humans ; Mice ; Mice, Knockout ; Muscle, Smooth/metabolism ; RNA, Messenger
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine.
Autorzy:
Christensen SL; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Rasmussen RH; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Ernstsen C; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
La Cour S; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
David A; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Chaker J; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Haanes KA; Department of Clinical Experimental Research, 70590Rigshospitalet Glostrup, Rigshospitalet Glostrup, Denmark.
Christensen ST; Department of Biology, Section of Cell Biology and Physiology, University of Copenhagen, Denmark.
Olesen J; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.
Kristensen DM; Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.; Department of Biology, Section of Cell Biology and Physiology, University of Copenhagen, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2021 Dec; Vol. 41 (14), pp. 1413-1426. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcitonin Gene-Related Peptide*
Migraine Disorders*
Animals ; Cilostazol/toxicity ; Cromakalim ; Humans ; Mice ; Mice, Knockout ; Trigeminal Ganglion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of K ATP channel blocker glibenclamide on levcromakalim-induced headache.
Autorzy:
Al-Karagholi MA; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Ghanizada H; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Kokoti L; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Paulsen JS; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Hansen JM; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.; Danish Headache Knowledge Center, Rigshospitalet Glostrup, Glostrup, Denmark.
Ashina M; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.; Danish Headache Knowledge Center, Rigshospitalet Glostrup, Glostrup, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2020 Sep; Vol. 40 (10), pp. 1045-1054. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Analgesics/*pharmacology
Cromakalim/*adverse effects
Glyburide/*pharmacology
Headache/*chemically induced
Vasodilator Agents/*adverse effects
Adult ; Cross-Over Studies ; Double-Blind Method ; Female ; Healthy Volunteers ; Humans ; Male ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems.
Autorzy:
Roy Chowdhury U; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Bahler CK; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Holman BH; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
Dosa PI; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, United States of America.
Fautsch MP; Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Nov 04; Vol. 10 (11), pp. e0141783. Date of Electronic Publication: 2015 Nov 04 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Cromakalim/*pharmacology
Intraocular Pressure/*drug effects
KATP Channels/*agonists
Administration, Topical ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cells, Cultured ; Cromakalim/therapeutic use ; Drug Therapy, Combination ; Eye/cytology ; Eye/pathology ; Female ; Glaucoma/drug therapy ; Humans ; KATP Channels/metabolism ; Latanoprost ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Prostaglandins F, Synthetic/pharmacology ; Prostaglandins F, Synthetic/therapeutic use ; Tissue Donors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lipofundin MCT/LCT Inhibits Levcromakalim-Induced Vasodilation by Inhibiting Endothelial Nitric Oxide Release.
Autorzy:
Lee SH; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.
Kang D; Department of Physiology, Gyeongsang National University School of Medicine, Jinju-si 52727, Korea.
Ok SH; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, 11 Samjeongja-ro, Seongsan-gu, Changwon-si 51427, Korea.; Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju-si, 52727, Korea.
Kim JY; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.
Bae SI; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.
Hwang Y; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.
Park KE; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.
Kim JW; Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.
Sohn JT; Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Hospital, 15 Jinju-daero 816 Beon-gil, Jinju-si 52727, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju-si, 52727, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 04; Vol. 21 (5). Date of Electronic Publication: 2020 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Fatty Acids/*chemistry
NG-Nitroarginine Methyl Ester/*pharmacology
Nitric Oxide Synthase Type III/*metabolism
Phospholipids/*pharmacology
Sorbitol/*pharmacology
Vasodilation/*drug effects
Animals ; Aorta/metabolism ; Cromakalim ; Cyclic GMP/metabolism ; Drug Combinations ; Emulsions ; Endothelial Cells/metabolism ; Male ; Membrane Potentials ; Phosphorylation ; Potassium Channels/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anticonvulsant effect of melatonin through ATP-sensitive channels in mice.
Autorzy:
Mohammadi F; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Shakiba S; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehrzadi S; Razi Drug Research Center, Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran, 1449614535, Iran.
Afshari K; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Rahimnia AH; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Dehpour AR; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło:
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2020 Feb; Vol. 34 (1), pp. 148-155. Date of Electronic Publication: 2019 Jul 01.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants/*pharmacology
KATP Channels/*drug effects
Melatonin/*pharmacology
Seizures/*drug therapy
Animals ; Anticonvulsants/administration & dosage ; Cromakalim/pharmacology ; Diazoxide/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Glyburide/pharmacology ; Injections, Intraperitoneal ; KATP Channels/metabolism ; Male ; Melatonin/administration & dosage ; Mice ; Pentylenetetrazole ; Seizures/physiopathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects.
Autorzy:
Al-Karagholi MA; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Ghanizada H; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Hansen JM; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Aghazadeh S; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Skovgaard LT; Department of Biostatistics, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
Olesen J; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.; Glostrup Research Park, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Ashina M; Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2019 Dec; Vol. 39 (14), pp. 1789-1797. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Cromakalim/*administration & dosage
KATP Channels/*metabolism
Nociception/*drug effects
Vasodilation/*drug effects
Vasodilator Agents/*administration & dosage
Adolescent ; Adult ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Injections, Intradermal ; Injections, Intramuscular ; KATP Channels/agonists ; Male ; Nociception/physiology ; Pilot Projects ; Regional Blood Flow/drug effects ; Regional Blood Flow/physiology ; Vasodilation/physiology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp.
Autorzy:
Small HY; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.
McNeilly S; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.
Mary S; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.
Sheikh AM; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.
Delles C; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland. .
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Źródło:
Scientific reports [Sci Rep] 2019 May 03; Vol. 9 (1), pp. 6897. Date of Electronic Publication: 2019 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sex Characteristics*
Adipose Tissue/*pathology
Hypertension/*pathology
Hypertension/*physiopathology
Mesenteric Arteries/*physiopathology
Resistin/*metabolism
Adipose Tissue/metabolism ; Animals ; Cromakalim/metabolism ; Female ; Gene Expression Regulation ; Hypertension/metabolism ; Male ; Rats ; Rats, Inbred SHR
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice.
Autorzy:
Ostadhadi S; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Moradi A; Department of Periodontics, School of Dentistry, Alborz University of Medical Sciences, Alborz, Iran.
Zolfaghari S; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nikoui V; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Dehpour AR; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło:
Acta medica Iranica [Acta Med Iran] 2018 Jan; Vol. 56 (1), pp. 14-20.
Typ publikacji:
Journal Article
MeSH Terms:
Anticonvulsants/*administration & dosage
Carbamates/*poisoning
Cromakalim/*administration & dosage
Organophosphate Poisoning/*complications
Seizures/*prevention & control
Animals ; Dichlorvos/administration & dosage ; Dose-Response Relationship, Drug ; Glyburide/administration & dosage ; Male ; Mice ; Physostigmine/administration & dosage ; Potassium Channels/drug effects ; Seizures/chemically induced
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release.
Autorzy:
Almabrouk TAM; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Pharmacology, School of Medicine, University of Zawia, Zawia, Libya.
Ugusman AB; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Katwan OJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Biochemistry, College of Medicine, University of Diyala, Baqubah, Iraq.
Salt IP; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Kennedy S; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 Oct; Vol. 174 (20), pp. 3398-3410. Date of Electronic Publication: 2016 Oct 23.
Typ publikacji:
Journal Article
MeSH Terms:
AMP-Activated Protein Kinases/*physiology
Adipose Tissue/*physiology
Aorta, Thoracic/*physiology
Vasoconstriction/*physiology
AMP-Activated Protein Kinases/genetics ; Adiponectin/metabolism ; Adiponectin/physiology ; Animals ; Aorta, Thoracic/drug effects ; Cells, Cultured ; Cromakalim/pharmacology ; Female ; Male ; Mice, Knockout ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Rats, Inbred WKY ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.
Autorzy:
Egginton S; School of Biomedical Sciences, University of Leeds, Leeds, UK. .
Hussain A; Science Department, Denefield School, Reading, UK.; Centre for Cardiovascular Sciences, Medical School, University of Birmingham, Birmingham, UK.
Hall-Jones J; Centre for Cardiovascular Sciences, Medical School, University of Birmingham, Birmingham, UK.
Chaudhry B; Centre for Cardiovascular Sciences, Medical School, University of Birmingham, Birmingham, UK.
Syeda F; Centre for Cardiovascular Sciences, Medical School, University of Birmingham, Birmingham, UK.
Glen KE; Centre for Biological Engineering, Loughborough University, Loughborough, UK.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2016 Nov; Vol. 218 (3), pp. 153-166. Date of Electronic Publication: 2016 Jul 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stress, Mechanical*
Muscle, Skeletal/*physiology
Neovascularization, Physiologic/*physiology
Vasodilator Agents/*pharmacology
Angiogenesis Inducing Agents/pharmacology ; Animals ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Cromakalim/pharmacology ; Cyclooxygenase Inhibitors/pharmacology ; Enzyme Inhibitors/pharmacology ; Ethanol/pharmacology ; Heart Rate/drug effects ; Heart Rate/physiology ; Indomethacin/pharmacology ; Male ; Mice ; Muscle, Skeletal/drug effects ; Neovascularization, Physiologic/drug effects ; Nitric Oxide Synthase/antagonists & inhibitors ; Prazosin/pharmacology ; Verapamil/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Conducted dilatation to ATP and K in rat skeletal muscle arterioles.
Autorzy:
Dora KA; Department of Pharmacology, University of Oxford, Oxford, UK.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2017 Jan; Vol. 219 (1), pp. 202-218. Date of Electronic Publication: 2016 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine Triphosphate/*pharmacology
Arterioles/*drug effects
Potassium Chloride/*pharmacology
Vasoconstriction/*drug effects
Vasoconstrictor Agents/*pharmacology
Vasodilation/*drug effects
Acetylcholine/pharmacology ; Animals ; Arterioles/physiology ; Cromakalim/pharmacology ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Rats ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes.
Autorzy:
Limprasutr V; Department of Veterinary Physiology, Faculty of Veterinary Science, Chulalongkorn University, Thailand.
Saengklub N; Department of Physiology, Faculty of Pharmacy, Mahidol University, Thailand.
Meedech P; Department of Veterinary Physiology, Faculty of Veterinary Science, Chulalongkorn University, Thailand.
Kijtawornrat A; Department of Veterinary Physiology, Faculty of Veterinary Science, Chulalongkorn University, Thailand.; Research clusters: Research Study and Testing of Drug's Effect Related to Cardiovascular System in Laboratory Animals, Chulalongkorn University, Thailand.
Hamlin RL; QTest Labs, LLC. USA.
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Źródło:
The Journal of toxicological sciences [J Toxicol Sci] 2017; Vol. 42 (5), pp. 579-587.
Typ publikacji:
Journal Article
MeSH Terms:
Electrocardiography*
Systole*
Ventricular Pressure*
Arrhythmias, Cardiac/*physiopathology
Long QT Syndrome/*physiopathology
Anesthesia ; Animals ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/diagnosis ; Benzopyrans ; Biomarkers ; Biomarkers, Pharmacological ; Cromakalim ; Disease Models, Animal ; Isoflurane ; Long QT Syndrome/chemically induced ; Phenethylamines ; Pinacidil ; Quinidine ; Rabbits ; Risk ; Sulfonamides ; Torsades de Pointes/diagnosis
SCR Disease Name:
Short Qt Syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 501

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