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Wyszukujesz frazę ""Cryoelectron Microscopy"" wg kryterium: Temat


Tytuł :
Cryo-EM structure of the full-length Lon protease from Thermus thermophilus.
Autorzy :
Coscia F; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Löwe J; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
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Źródło :
FEBS letters [FEBS Lett] 2021 Nov; Vol. 595 (21), pp. 2691-2700. Date of Electronic Publication: 2021 Oct 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Protease La*
Thermus thermophilus*
Proteolysis
Czasopismo naukowe
Tytuł :
Structural basis of human transcription-DNA repair coupling.
Autorzy :
Kokic G; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Wagner FR; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Chernev A; Max Planck Institute for Biophysical Chemistry, Bioanalytical Mass Spectrometry, Göttingen, Germany.
Urlaub H; Max Planck Institute for Biophysical Chemistry, Bioanalytical Mass Spectrometry, Göttingen, Germany.; University Medical Center Göttingen, Institute of Clinical Chemistry, Bioanalytics Group, Göttingen, Germany.
Cramer P; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. .
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Źródło :
Nature [Nature] 2021 Oct; Vol. 598 (7880), pp. 368-372. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
DNA Repair*
Transcription, Genetic*
Multiprotein Complexes/*chemistry
Multiprotein Complexes/*ultrastructure
RNA Polymerase II/*chemistry
RNA Polymerase II/*ultrastructure
Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Carrier Proteins/ultrastructure ; DNA Helicases/chemistry ; DNA Helicases/metabolism ; DNA Helicases/ultrastructure ; DNA Repair Enzymes/chemistry ; DNA Repair Enzymes/metabolism ; DNA Repair Enzymes/ultrastructure ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/ultrastructure ; Humans ; Models, Molecular ; Multiprotein Complexes/metabolism ; Poly-ADP-Ribose Binding Proteins/chemistry ; Poly-ADP-Ribose Binding Proteins/metabolism ; Poly-ADP-Ribose Binding Proteins/ultrastructure ; RNA Polymerase II/metabolism ; Transcription Elongation, Genetic ; Transcription Factor TFIIH/chemistry ; Transcription Factor TFIIH/metabolism ; Transcription Factor TFIIH/ultrastructure ; Transcription Factors/chemistry ; Transcription Factors/metabolism ; Transcription Factors/ultrastructure ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/ultrastructure ; Ubiquitination
Czasopismo naukowe
Tytuł :
Structure-based classification of tauopathies.
Autorzy :
Shi Y; MRC Laboratory of Molecular Biology, Cambridge, UK.
Zhang W; MRC Laboratory of Molecular Biology, Cambridge, UK.
Yang Y; MRC Laboratory of Molecular Biology, Cambridge, UK.
Murzin AG; MRC Laboratory of Molecular Biology, Cambridge, UK.
Falcon B; MRC Laboratory of Molecular Biology, Cambridge, UK.
Kotecha A; Thermo Fisher Scientific, Eindhoven, The Netherlands.
van Beers M; Thermo Fisher Scientific, Eindhoven, The Netherlands.
Tarutani A; Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kametani F; Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Garringer HJ; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Vidal R; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Hallinan GI; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Lashley T; Department of Neurodegenerative Disease and Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Saito Y; Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Murayama S; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, University of Osaka, Osaka, Japan.
Yoshida M; Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.
Tanaka H; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Robinson AC; Clinical Sciences Building, University of Manchester, Salford Royal Foundation Trust, Salford, UK.
Mann DMA; Clinical Sciences Building, University of Manchester, Salford Royal Foundation Trust, Salford, UK.
Kovacs GG; Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Revesz T; Department of Neurodegenerative Disease and Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Hasegawa M; Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Goedert M; MRC Laboratory of Molecular Biology, Cambridge, UK. .
Scheres SHW; MRC Laboratory of Molecular Biology, Cambridge, UK. .
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Źródło :
Nature [Nature] 2021 Oct; Vol. 598 (7880), pp. 359-363. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Protein Folding*
Tauopathies/*classification
tau Proteins/*chemistry
tau Proteins/*ultrastructure
Aged ; Aged, 80 and over ; Amino Acid Sequence ; Dementia/genetics ; Denmark ; Female ; Humans ; Introns/genetics ; Male ; Middle Aged ; Models, Molecular ; Mutation ; Protein Isoforms/chemistry ; Protein Isoforms/ultrastructure ; Supranuclear Palsy, Progressive ; Tauopathies/pathology ; United Kingdom
Czasopismo naukowe
Tytuł :
Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones.
Autorzy :
Sato S; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Takizawa Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Hoshikawa F; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Dacher M; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Tanaka H; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Tachiwana H; Division of Cancer Biology, The Cancer Institute of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Kujirai T; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Iikura Y; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Ho CH; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Adachi N; Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801, Japan.
Patwal I; Center for Chromosome Biology, Biochemistry, School of Natural Sciences, National University of Ireland Galway, H91 TK33, Ireland.
Flaus A; Center for Chromosome Biology, Biochemistry, School of Natural Sciences, National University of Ireland Galway, H91 TK33, Ireland.
Kurumizaka H; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Sep 07; Vol. 49 (15), pp. 8934-8946.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Giardia lamblia/*ultrastructure
Histones/*genetics
Nucleosomes/*ultrastructure
Amino Acid Sequence/genetics ; Chromatin/genetics ; Chromatin/ultrastructure ; Giardia lamblia/genetics ; Histones/ultrastructure ; Humans ; Molecular Structure ; Nucleosomes/genetics
Czasopismo naukowe
Tytuł :
Gaia Pigino: Inside the cell.
Autorzy :
Morgado-Palacin L
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Sep 06; Vol. 220 (9). Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Biography; Historical Article; Journal Article; Portrait
MeSH Terms :
Cilia/*ultrastructure
Cryoelectron Microscopy/*history
Kidney/*ultrastructure
Lung/*ultrastructure
Academies and Institutes/history ; Animals ; Chlorophyta/metabolism ; Chlorophyta/ultrastructure ; Cilia/metabolism ; Cryoelectron Microscopy/methods ; Flagella/metabolism ; Flagella/ultrastructure ; History, 20th Century ; History, 21st Century ; Humans ; Italy ; Kidney/metabolism ; Lung/metabolism
Personal Name as Subject :
Pigino G
Czasopismo naukowe
Tytuł :
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
Autorzy :
Cao Q; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Boyer DR; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
Sawaya MR; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
Abskharon R; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
Saelices L; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA.
Nguyen BA; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.; Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA.
Lu J; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
Murray KA; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
Kandeel F; Department of Translational Research & Cellular Therapeutics, City of Hope, Duarte, CA, USA.
Eisenberg DS; Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Sep; Vol. 28 (9), pp. 724-730. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cryoelectron Microscopy*
Amyloid/*chemistry
Islet Amyloid Polypeptide/*chemistry
Amino Acid Sequence ; Amyloid/isolation & purification ; Congo Red ; Diabetes Mellitus, Type 2/metabolism ; Genotype ; Humans ; Islet Amyloid Polypeptide/genetics ; Islets of Langerhans/chemistry ; Models, Molecular ; Polymerase Chain Reaction ; Protein Aggregates ; Protein Conformation ; Recombinant Proteins/chemistry ; Sequence Analysis, DNA ; Staining and Labeling
Czasopismo naukowe
Tytuł :
A flexible framework for multi-particle refinement in cryo-electron tomography.
Autorzy :
Burt A; Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
Gaifas L; Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
Dendooven T; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Gutsche I; Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
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Źródło :
PLoS biology [PLoS Biol] 2021 Aug 26; Vol. 19 (8), pp. e3001319. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021).
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Electron Microscope Tomography*
Software*
Image Processing, Computer-Assisted/*methods
Escherichia coli ; Metadata
Czasopismo naukowe
Tytuł :
Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
Autorzy :
Barski MS; Imperial College London, St. Mary's Hospital, Department of Infectious Disease, Section of Virology, Norfolk Place, London, UK.; International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences, Warsaw, Poland.
Vanzo T; Imperial College London, St. Mary's Hospital, Department of Infectious Disease, Section of Virology, Norfolk Place, London, UK.; Department CIBIO, University of Trento, Povo-Trento, Italy.
Zhao XZ; Chemical Biology Laboratory, Centre for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Smith SJ; Retroviral Replication Laboratory, Centre for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Ballandras-Colas A; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.
Cronin NB; LonCEM Facility, The Francis Crick Institute, London, UK.
Pye VE; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.
Hughes SH; Retroviral Replication Laboratory, Centre for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Burke TR Jr; Chemical Biology Laboratory, Centre for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Cherepanov P; Imperial College London, St. Mary's Hospital, Department of Infectious Disease, Section of Virology, Norfolk Place, London, UK.; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.
Maertens GN; Imperial College London, St. Mary's Hospital, Department of Infectious Disease, Section of Virology, Norfolk Place, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 17; Vol. 12 (1), pp. 4996. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
HTLV-I Infections/*drug therapy
Human T-lymphotropic virus 1/*drug effects
Amides ; Catalytic Domain ; Deltaretrovirus ; Drug Resistance, Viral/drug effects ; HIV Integrase/drug effects ; HIV-1 ; Heterocyclic Compounds, 3-Ring ; Human T-lymphotropic virus 1/genetics ; Humans ; Naphthyridines/pharmacology ; Piperazines ; Pyridones ; Recombinant Proteins
Czasopismo naukowe
Tytuł :
Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold.
Autorzy :
Wu J; Department of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen, Switzerland.
Blum TB; Department of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen, Switzerland.
Farrell DP; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
DiMaio F; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
Abrahams JP; Department of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen, Switzerland.; Biozentrum, University of Basel, 4058, Basel, Switzerland.
Luo J; Department of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen, Switzerland.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 16; Vol. 60 (34), pp. 18680-18687. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Alzheimer Disease/*diagnosis
Amyloid beta-Peptides/*analysis
Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM.
Autorzy :
Dargel C; Physical and Biophysical Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.
Gräbitz-Bräuer F; Physical and Biophysical Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.
Geisler R; Physical and Biophysical Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.
Fandrich P; Physical and Biophysical Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.
Hannappel Y; Physical and Biophysical Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.
Porcar L; Institut Laue-Langevin, 71 Avenue des Martyrs CS 20156, CEDEX 9, 38042 Grenoble, France.
Hellweg T; Physical and Biophysical Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 16; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Cryoelectron Microscopy*
Scattering, Small Angle*
Glycyrrhizic Acid/*chemistry
Phosphatidylglycerols/*chemistry
Neutron Diffraction ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin.
Autorzy :
Zhao Y; Biophysics Graduate Program, Stanford University, Stanford, CA, USA.
Schmid MF; Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Frydman J; Biophysics Graduate Program, Stanford University, Stanford, CA, USA.; Department of Biology, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; CZ Biohub, San Francisco, CA, USA.
Chiu W; Biophysics Graduate Program, Stanford University, Stanford, CA, USA. .; Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Menlo Park, CA, USA. .; Department of Bioengineering, James Clark Center, Stanford University, Stanford, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 06; Vol. 12 (1), pp. 4754. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cryoelectron Microscopy*
Adenosine Triphosphate/*metabolism
Group II Chaperonins/*chemistry
Group II Chaperonins/*metabolism
Chaperonins/metabolism ; Hydrolysis ; Methanococcus/metabolism ; Models, Molecular ; Protein Conformation ; Protein Folding ; Protein Subunits/metabolism
Czasopismo naukowe
Tytuł :
Structural basis of ketamine action on human NMDA receptors.
Autorzy :
Zhang Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Ye F; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Zhang T; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Lv S; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhou L; University of Chinese Academy of Sciences, Beijing, China.; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Du D; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Lin H; Criminal Investigation Technology Department, The Third Research Institute of Ministry of Public Security, Shanghai, China.
Guo F; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Luo C; University of Chinese Academy of Sciences, Beijing, China. .; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. .
Zhu S; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China. .
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Źródło :
Nature [Nature] 2021 Aug; Vol. 596 (7871), pp. 301-305. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Ketamine/*chemistry
Ketamine/*pharmacology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*ultrastructure
Antidepressive Agents/chemistry ; Antidepressive Agents/metabolism ; Antidepressive Agents/pharmacology ; Asparagine/chemistry ; Asparagine/metabolism ; Binding Sites ; Glutamic Acid/chemistry ; Glutamic Acid/metabolism ; Glutamic Acid/pharmacology ; Glycine/chemistry ; Glycine/metabolism ; Glycine/pharmacology ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Ketamine/metabolism ; Leucine/chemistry ; Leucine/metabolism ; Molecular Dynamics Simulation ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/ultrastructure ; Receptors, N-Methyl-D-Aspartate/chemistry ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
Cryo-EM to visualize the structural organization of viruses.
Autorzy :
de Oliveira GA; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil. Electronic address: .
Silva JL; Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
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Źródło :
Current opinion in virology [Curr Opin Virol] 2021 Aug; Vol. 49, pp. 86-91. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cryoelectron Microscopy*
Viruses/*ultrastructure
Biological Evolution ; COVID-19/virology ; Humans ; SARS-CoV-2/chemistry ; SARS-CoV-2/physiology ; SARS-CoV-2/ultrastructure ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Viral Proteins/ultrastructure ; Virus Physiological Phenomena ; Viruses/chemistry ; Viruses/classification
Czasopismo naukowe
Tytuł :
Prospecting for natural products by genome mining and microcrystal electron diffraction.
Autorzy :
Kim LJ; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Ohashi M; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Zhang Z; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Tan D; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Asay M; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Cascio D; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.; UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA, USA.
Rodriguez JA; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.; UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA, USA.
Tang Y; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. .; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. .
Nelson HM; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Aug; Vol. 17 (8), pp. 872-877. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cryoelectron Microscopy*
Biological Products/*chemistry
Models, Molecular ; Molecular Conformation
Czasopismo naukowe
Tytuł :
Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
Autorzy :
Gao S; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Yao X; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Yan N; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. .
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Źródło :
Nature [Nature] 2021 Aug; Vol. 596 (7870), pp. 143-147. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cryoelectron Microscopy*
Analgesics, Non-Narcotic/*pharmacology
Calcium Channel Blockers/*pharmacology
Calcium Channels, N-Type/*chemistry
Calcium Channels, N-Type/*metabolism
omega-Conotoxins/*pharmacology
Calcium Channels, N-Type/ultrastructure ; Humans ; Models, Molecular ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphatidylinositol 4,5-Diphosphate/pharmacology ; Protein Conformation/drug effects ; Protein Stability/drug effects
Czasopismo naukowe
Tytuł :
Challenges in sample preparation and structure determination of amyloids by cryo-EM.
Autorzy :
Zielinski M; Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany.
Röder C; Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Schröder GF; Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany; Physics Department, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Aug; Vol. 297 (2), pp. 100938. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Amyloid*
Analytic Sample Preparation Methods*
Cryoelectron Microscopy*
Image Processing, Computer-Assisted
Czasopismo naukowe
Tytuł :
User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy.
Autorzy :
Kumar A; Molecular Biophysics Unit, Indian Institute of Science.
P S; Molecular Biophysics Unit, Indian Institute of Science.
Gulati S; Gatan Inc.
Dutta S; Molecular Biophysics Unit, Indian Institute of Science; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Jul 29 (173). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
COVID-19*
Cryoelectron Microscopy*/methods
Image Processing, Computer-Assisted*
Software*
Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Czasopismo naukowe
Tytuł :
Cryo-EM structure of human Wntless in complex with Wnt3a.
Autorzy :
Zhong Q; Fudan University, Shanghai, China.; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Zhao Y; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Ye F; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Xiao Z; Fudan University, Shanghai, China.; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Huang G; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Xu M; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Zhang Y; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Zhan X; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Sun K; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Wang Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Cheng S; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Feng S; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Mass Spectrometry Core Facility, The Biomedical Research Core Facility, Center for Research Equipment and Facilities, Westlake University, Hangzhou, Zhejiang, China.
Zhao X; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Mass Spectrometry Core Facility, The Biomedical Research Core Facility, Center for Research Equipment and Facilities, Westlake University, Hangzhou, Zhejiang, China.
Zhang J; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Lu P; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Xu W; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhou Q; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. .; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. .; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. .
Ma D; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. .; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. .; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 27; Vol. 12 (1), pp. 4541. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Receptors, G-Protein-Coupled/*ultrastructure
Wnt3A Protein/*ultrastructure
Frizzled Receptors/metabolism ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Models, Molecular ; Protein Conformation ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/metabolism ; Wnt3A Protein/chemistry ; Wnt3A Protein/metabolism
Czasopismo naukowe
Tytuł :
Routine sub-2.5 Å cryo-EM structure determination of GPCRs.
Autorzy :
Danev R; Graduate School of Medicine, University of Tokyo, Tokyo, Japan. .
Belousoff M; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Liang YL; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.; Confo Therapeutics, Ghent (Zwijnaarde), Belgium.
Zhang X; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Eisenstein F; Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
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Źródło :
Nature communications [Nat Commun] 2021 Jul 15; Vol. 12 (1), pp. 4333. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Molecular*
Cryoelectron Microscopy/*methods
Receptors, G-Protein-Coupled/*chemistry
Cryoelectron Microscopy/instrumentation ; Gold ; Image Processing, Computer-Assisted
Czasopismo naukowe

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