Temat: "Crystallography, X-Ray" - OpacWWW

Skocz do pozycji: 21.

Tytuł:: A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1.
Autorzy:: Das D; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.; Accelero Biostructures, Inc., San Carlos, CA 94070, USA.
Duncton MAJ; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.
Georgiadis TM; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.
Pellicena P; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.
Clark J; Mitchell Cancer Institute and Department of Pharmacology, University of South Alabama, Mobile, AL 36604, USA.
Sobol RW; Mitchell Cancer Institute and Department of Pharmacology, University of South Alabama, Mobile, AL 36604, USA.; Department of Pathology & Laboratory Medicine, Warrant Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.
Georgiadis MM; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
King-Underwood J; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.
Jobes DV; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.; Mid-Atlantic BioTherapeutics, Inc., Doylestown, PA 18902, USA.
Chang C; Department of BioSciences, Rice University, Houston, TX 77251, USA.
Gao Y; Department of BioSciences, Rice University, Houston, TX 77251, USA.
Deacon AM; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.; Accelero Biostructures, Inc., San Carlos, CA 94070, USA.
Wilson DM 3rd; XPose Therapeutics, Inc., San Carlos, CA 94070, USA.; Biomedical Research Institute, Hasselt University, 3500 Diepenbeek, Belgium.; Belgium & Boost Scientific, 3550 Heusden-Zolder, Belgium.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 23; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:: Journal Article
MeSH Terms:: DNA-Directed DNA Polymerase*/metabolism
Drug Discovery*
Binding Sites ; Endonucleases/metabolism ; Crystallography, X-Ray ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 22.

Tytuł:: Growing Crystals for X-ray Free-Electron Laser Structural Studies of Biomolecules and Their Complexes.
Autorzy:: Nanev CN; Rostislaw Kaischew Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Saridakis E; Institute of Nanoscience and Nanotechnology, National Centre for Scientific Research 'Demokritos', Ag. Paraskevi, 15310 Athens, Greece.
Chayen NE; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, UK.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 15; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:: Journal Article
MeSH Terms:: Electrons*
Synchrotrons*
X-Rays ; Crystallography, X-Ray ; Proteins ; Lasers

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 23.

Tytuł:: Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Autorzy:: Boby ML; Pharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.; Program in Chemical Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Program in Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Fearon D; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Ferla M; Oxford Biomedical Research Centre, National Institute for Health Research, University of Oxford, Oxford, UK.
Filep M; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel.
Koekemoer L; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Robinson MC; PostEra Inc., Cambridge, MA 02142, USA.
Chodera JD; Program in Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Lee AA; PostEra Inc., Cambridge, MA 02142, USA.
London N; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel.
von Delft A; Oxford Biomedical Research Centre, National Institute for Health Research, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
von Delft F; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa.
Achdout H; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Aimon A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Alonzi DS; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.
Arbon R; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Aschenbrenner JC; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Balcomb BH; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Bar-David E; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Barr H; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel.
Ben-Shmuel A; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Bennett J; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; University of Oxford, Nuffield Department of Medicine, Target Discovery Institute, Oxford, OX3 7FZ, UK.
Bilenko VA; Enamine Ltd, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.
Borden B; .
Boulet P; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.
Bowman GR; University of Pennsylvania, Departments of Biochemistry and Biophysics and Bioengineering, Philadelphia, PA 19083, USA.
Brewitz L; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.
Brun J; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.
Bvnbs S; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.
Calmiano M; UCB, Slough, SL1 3WE, UK.
Carbery A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; University of Oxford, Department of Statistics, Oxford OX1 3LB, UK.
Carney DW; Takeda Development Center Americas, Inc., San Diego, CA 92121, USA.
Cattermole E; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.
Chang E; Takeda Development Center Americas, Inc., San Diego, CA 92121, USA.
Chernyshenko E; Enamine Ltd, Kyiv, 02094, Ukraine.
Clyde A; Argonne National Lab, Lemont, IL 60439, USA.
Coffland JE; Cauldron Development Oy, Helsinki, 00140, Finland.
Cohen G; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel.
Cole JC; Cambridge Crystallographic Data Centre, Cambridge, CB2 1EZ, UK.
Contini A; University of Milan, Department of General and Organic Chemistry, Milan, 20133, Italy.
Cox L; Life Compass Consulting Ltd, Macclesfield, SK10 5UE, UK.
Croll TI; The University of Cambridge, Cambridge Institute for Medical Research, Department of Haematology, Cambridge CB2 0XY, UK.; Present address: Altos Labs, BioML group, Great Abington, CB21 6GP.
Cvitkovic M; PostEra Inc., Cambridge, MA, 02142, USA.
De Jonghe S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Dias A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Donckers K; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Dotson DL; Datryllic LLC, Phoenix AZ, 85003, USA.
Douangamath A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Duberstein S; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel.
Dudgeon T; Informatics Matters Ltd, Bicester, OX26 6JU, UK.
Dunnett LE; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Eastman P; Stanford University, Department of Chemistry, Stanford, CA 94305, USA.
Erez N; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Eyermann CJ; Northeastern University, Department of Chemistry and Chemical Biology, Boston MA 02115, USA.
Fairhead M; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.
Fate G; Thames Pharma Partners LLC, Mystic, CT 06355, USA.
Fedorov O; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; University of Oxford, Nuffield Department of Medicine, Target Discovery Institute, Oxford, OX3 7FZ, UK.
Fernandes RS; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.
Ferrins L; Northeastern University, Department of Chemistry and Chemical Biology, Boston MA 02115, USA.
Foster R; University of Leeds, School of Chemistry, Leeds, LS2 9JT, UK.
Foster H; University of Leeds, School of Chemistry, Leeds, LS2 9JT, UK.; Present address: Exscientia, Oxford Science Park, Oxford, OX4 4GE, UK.
Fraisse L; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.
Gabizon R; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel.
García-Sastre A; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Medicine, Division of Infectious Diseases, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Pathology, Molecular and Cell-Based Medicine, New York, NY 10029, USA.
Gawriljuk VO; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.; Present address: University of Groningen, Groningen Research Institute of Pharmacy, Department of Drug Design, Groningen, 9700 AV, Netherlands.
Gehrtz P; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel.; Present address: Merck Healthcare KGaA, Darmstadt, 64293, Germany.
Gileadi C; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.
Giroud C; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; University of Oxford, Nuffield Department of Medicine, Target Discovery Institute, Oxford, OX3 7FZ, UK.
Glass WG; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Present address: Exscientia, Oxford Science Park, Oxford, OX4 4GE, UK.
Glen RC; University of Cambridge, Department of Chemistry, Cambridge, CB2 1EW, UK.
Glinert I; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Godoy AS; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.
Gorichko M; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.
Gorrie-Stone T; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Griffen EJ; MedChemica Ltd, Macclesfield, Cheshire. SK11 6PU UK.
Haneef A; Illinois Institute of Technology, Department of Biology, Chicago IL 60616 USA.
Hassell Hart S; University of Sussex, Department of Chemistry, School of Life Sciences, Brighton, East Sussex, BN1 9QJ, UK.
Heer J; Syngene International Limited, Headington, Oxford, OX3 7BZ, UK.
Henry M; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Hill M; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; Present address: Sir William Dunn School of Pathology, Oxford. OX1 3RE, UK.
Horrell S; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Huang QYJ; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA.
Huliak VD; Enamine Ltd, Kyiv, 02094, Ukraine.
Hurley MFD; Temple University, Department of Chemistry, Philadelphia, PA 19122, USA.
Israely T; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Jajack A; PostEra Inc., Cambridge, MA, 02142, USA.
Jansen J; RWTH Aachen University, Institute of Experimental Medicine and Systems Biology, Aachen, 52074, Germany.
Jnoff E; UCB, Chemin du Foriest, 1420 Braine-l'Alleud, Belgium.
Jochmans D; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
John T; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.; Present address: AMSilk, Neuried, 82061, Germany.
Kaminow B; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA.
Kang L; Illinois Institute of Technology, Department of Applied Mathematics, Chicago IL 60616 USA.
Kantsadi AL; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; University of Thessaly, Department of Biochemistry and Biotechnology, Larissa, 415 00, Greece.
Kenny PW; Berwick-on-Sea, North Coast Road, Blanchisseuse, Saint George, Trinidad and Tobago.
Kiappes JL; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; Present address: University College of London, Department of Chemistry, London WC1H 0AJ, UK.
Kinakh SO; Enamine Ltd, Kyiv, 02094, Ukraine.
Kovar B; M2M solutions s.r.o. Žilina, 010 01, Slovakia.
Krojer T; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; MAX IV Laboratory, Fotongatan 2, 224 84 Lund, Sweden.
La VNT; Illinois Institute of Technology, Department of Biology, Chicago IL 60616 USA.
Laghnimi-Hahn S; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.
Lefker BA; Thames Pharma Partners LLC, Mystic, CT 06355, USA.
Levy H; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Lithgo RM; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Logvinenko IG; Enamine Ltd, Kyiv, 02094, Ukraine.
Lukacik P; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Macdonald HB; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Present address: Charm Therapeutics, London, N1C 4AG, UK.
MacLean EM; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.
Makower LL; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.
Malla TR; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.
Marples PG; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Matviiuk T; Enamine Ltd, Kyiv, 02094, Ukraine.
McCorkindale W; Present address: Charm Therapeutics, London, N1C 4AG, UK.; University of Cambridge, Cavendish Laboratory, Cambridge, CB3 0HE UK.
McGovern BL; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA.
Melamed S; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Melnykov KP; Enamine Ltd, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.
Michurin O; Enamine Ltd, Kyiv, 02094, Ukraine.
Miesen P; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands.
Mikolajek H; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Milne BF; University of Aberdeen, Department of Chemistry, Old Aberdeen, AB24 3UE Scotland, UK.; University of Coimbra, CFisUC, Department of Physics, Coimbra, 3004-516, Portugal.
Minh D; Illinois Institute of Technology, Department of Chemistry, Chicago IL 60616 USA.
Morris A; PostEra Inc., Cambridge, MA, 02142, USA.
Morris GM; University of Oxford, Department of Statistics, Oxford OX1 3LB, UK.
Morwitzer MJ; University of Nebraska Medical Centre, Dept of Pathology and Microbiology, Omaha, NE 68198-5900, USA.
Moustakas D; Relay Therapeutics, Cambridge, MA 02139, USA.
Mowbray CE; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.
Nakamura AM; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.; Present address: Instituto Butantan, Sao Paulo, 05503-900, Brazil.
Neto JB; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Neyts J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Nguyen L; PostEra Inc., Cambridge, MA, 02142, USA.
Noske GD; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.
Oleinikovas V; UCB, Slough, SL1 3WE, UK.; Present address: Monte Rosa Therapeutics, Basel, CH 4057, Switzerland.
Oliva G; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.
Overheul GJ; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands.
Owen CD; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Pai R; PostEra Inc., Cambridge, MA, 02142, USA.
Pan J; PostEra Inc., Cambridge, MA, 02142, USA.
Paran N; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Payne AM; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA.
Perry B; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.; Present address: Medicxi, Geneva, 1204, Switzerland.
Pingle M; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.
Pinjari J; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.; Present address: Sun Pharma Advanced Research Company (SPARC), Baroda, India.
Politi B; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Powell A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Pšenák V; M2M solutions s.r.o. Žilina, 010 01, Slovakia.
Pulido I; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Puni R; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Rangel VL; University of São Paulo, Ribeirão Preto School of Pharmaceutical Sciences, Ribeirão Preto - SP/CEP 14040-903, Brazil.; Present address: Evotec (UK) Ltd, Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK.
Reddi RN; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel.
Rees P; Compass Bussiness Partners Ltd, Southcliffe, Bucks, SL9 0PD, UK.
Reid SP; University of Nebraska Medical Centre, Dept of Pathology and Microbiology, Omaha, NE 68198-5900, USA.
Reid L; MedChemica Ltd, Macclesfield, Cheshire. SK11 6PU UK.
Resnick E; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel.
Ripka EG; PostEra Inc., Cambridge, MA, 02142, USA.
Robinson RP; Thames Pharma Partners LLC, Mystic, CT 06355, USA.
Rodriguez-Guerra J; Charité - Universitätsmedizin Berlin, In silico Toxicology and Structural Bioinformatics, Berlin, 10117, Germany.
Rosales R; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA.
Rufa DA; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA.
Saar K; University of Cambridge, Cavendish Laboratory, Cambridge, CB3 0HE UK.
Saikatendu KS; Takeda Development Center Americas, Inc., San Diego, CA 92121, USA.
Salah E; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.
Schaller D; Charité - Universitätsmedizin Berlin, In silico Toxicology and Structural Bioinformatics, Berlin, 10117, Germany.
Scheen J; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Schiffer CA; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA.
Schofield CJ; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.
Shafeev M; Enamine Ltd, Kyiv, 02094, Ukraine.
Shaikh A; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.
Shaqra AM; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA.
Shi J; UCB, Chemin du Foriest, 1420 Braine-l'Alleud, Belgium.; Present address: Eli Lilly and Company, San Diego, CA 92121, USA.
Shurrush K; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel.
Singh S; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Sittner A; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Sjö P; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.
Skyner R; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Smalley A; UCB, Slough, SL1 3WE, UK.
Smeets B; Radboud University Medical Center, Department of pathology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands.
Smilova MD; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.
Solmesky LJ; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel.
Spencer J; University of Sussex, Department of Chemistry, School of Life Sciences, Brighton, East Sussex, BN1 9QJ, UK.
Strain-Damerell C; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Swamy V; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.; Present address: TCG Life Sciences, Pune, India.
Tamir H; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Taylor JC; University of Oxford, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, Oxford OX3 7BN, UK.
Tennant RE; Lhasa Limited, Leeds, LS11 5PS, UK.
Thompson W; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Thompson A; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; Present address: Walter and Eliza Hall Institute, Parkville 3052, Victoria, Australia.
Tomásio S; Collaborative Drug Discovery, Cambridge, CB2 1GE, UK.
Tomlinson CWE; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Tsurupa IS; Enamine Ltd, Kyiv, 02094, Ukraine.
Tumber A; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.
Vakonakis I; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; Present address: Lonza Biologics, Lonza Ltd, Lonzastrasse, CH-3930 Visp, Switzerland.
van Rij RP; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands.
Vangeel L; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Varghese FS; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands.; Present address: uniQure Biopharma, Amsterdam, 1105 BP, Netherlands.
Vaschetto M; Collaborative Drug Discovery, Cambridge, CB2 1GE, UK.
Vitner EB; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Voelz V; Temple University, Department of Chemistry, Philadelphia, PA 19122, USA.
Volkamer A; Charité - Universitätsmedizin Berlin, In silico Toxicology and Structural Bioinformatics, Berlin, 10117, Germany.; Present address: Saarland University, Data Driven Drug Design, Campus - E2.1, 66123 Saarbrücken, Germany.
Walsh MA; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Ward W; Walter Ward Consultancy and Training, Derbyshire, SK22 4AA, UK.
Weatherall C; Collaborative Drug Discovery, Burlingame, CA 94010, USA.
Weiss S; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
White KM; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA.
Wild CF; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK.
Witt KD; University of Oxford, Nuffield Department of Medicine, Pandemic Sciences Institute, Oxford, Oxon, OX3 7DQ, UK.
Wittmann M; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Wright N; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.
Yahalom-Ronen Y; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel.
Yilmaz NK; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA.
Zaidmann D; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel.
Zhang I; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.
Zidane H; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel.
Zitzmann N; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.
Zvornicanin SN; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA.; Pokaż więcej
Corporate Authors:: COVID Moonshot Consortium‡
Źródło:: Science (New York, N.Y.) [Science] 2023 Nov 10; Vol. 382 (6671), pp. eabo7201. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:: Journal Article
MeSH Terms:: Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
SARS-CoV-2*
Drug Discovery*
Coronavirus Protease Inhibitors*/chemical synthesis
Coronavirus Protease Inhibitors*/chemistry
Coronavirus Protease Inhibitors*/pharmacology
COVID-19 Drug Treatment*
Humans ; Molecular Docking Simulation ; Structure-Activity Relationship ; Crystallography, X-Ray

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Skocz do pozycji: 24.

Tytuł:: Synthesis, X-ray crystallography and antimicrobial activity of 2-cyanoguanidinophenytoin.
Autorzy:: Mabied AF; X-Ray Crystallography Lab., Solid State Physics Department, National Research Centre, Dokki, 12622, Giza, Egypt. .
Moustafa AH; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt. amr_.; Faculty of Science, King Salman International University, Ras Sudr, Sinai, 46612, Egypt. amr_.
Abdelhamid AA; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.
Tiama TM; Department of Basic Sciences, October High Institute of Engineering & Technology - OHI, 6th of October City, Giza, Egypt.
Amer AA; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19510. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mannich Bases*/chemistry
Anti-Infective Agents*
Crystallography, X-Ray ; Morpholines

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Skocz do pozycji: 25.

Tytuł:: The centre cannot hold.
Autorzy:: Mar A; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.; Pokaż więcej
Źródło:: Acta crystallographica. Section C, Structural chemistry [Acta Crystallogr C Struct Chem] 2022 Oct 01; Vol. 78 (Pt 10), pp. 515-516. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:: Journal Article
MeSH Terms:: Crystallography, X-Ray*
Hydrogen Bonding

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Skocz do pozycji: 26.

Tytuł:: Variations on a theme: crystal forms of the amino-acid transporter MhsT.
Autorzy:: Neumann C; Center for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000 Aarhus, Denmark.
Focht D; Center for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000 Aarhus, Denmark.
Trampari S; Center for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000 Aarhus, Denmark.
Lyons JA; Center for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000 Aarhus, Denmark.
Nissen P; Center for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, DK-8000 Aarhus, Denmark.; Pokaż więcej
Źródło:: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2022 Aug 01; Vol. 78 (Pt 8), pp. 297-305. Date of Electronic Publication: 2022 Jul 26.
Typ publikacji:: Journal Article
MeSH Terms:: Crystallography, X-Ray*

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Skocz do pozycji: 27.

Tytuł:: Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Autorzy:: Lelyveld VS; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Fang Z; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Szostak JW; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Oct 27; Vol. 382 (6669), pp. 423-429. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:: Journal Article
MeSH Terms:: Calcium*/chemistry
DNA*/biosynthesis
DNA-Directed DNA Polymerase*/chemistry
Coenzymes*/chemistry
Geobacillus stearothermophilus*/enzymology
Bacterial Proteins*/chemistry
Nucleotides/chemistry ; Enzyme Activation ; Crystallography, X-Ray ; Protein Conformation ; Biocatalysis

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Skocz do pozycji: 28.

Tytuł:: Scattering of Attosecond Laser Pulses on a DNA Molecule during Its Nicking and Bending.
Autorzy:: Makarov D; Department of Fundamental and Applied Physics, Northern (Arctic) Federal University, Nab. Severnoi Dviny 17, 163002 Arkhangelsk, Russia.
Kharlamova A; Department of Fundamental and Applied Physics, Northern (Arctic) Federal University, Nab. Severnoi Dviny 17, 163002 Arkhangelsk, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 25; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:: Journal Article
MeSH Terms:: Light*
Lasers*
X-Ray Diffraction ; Crystallography, X-Ray ; DNA

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Skocz do pozycji: 29.

Tytuł:: Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics.
Autorzy:: Boulos I; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Jabbour J; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Khoury S; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Mikhael N; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Tishkova V; CNRS, CINaM (Centre Interdisciplinaire de Nanosciences de Marseille), Campus de Luminy, Case 913, Aix-Marseille University, CEDEX 09, F-13288 Marseille, France.
Candoni N; CNRS, CINaM (Centre Interdisciplinaire de Nanosciences de Marseille), Campus de Luminy, Case 913, Aix-Marseille University, CEDEX 09, F-13288 Marseille, France.
Ghadieh HE; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Veesler S; CNRS, CINaM (Centre Interdisciplinaire de Nanosciences de Marseille), Campus de Luminy, Case 913, Aix-Marseille University, CEDEX 09, F-13288 Marseille, France.
Bassim Y; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Azar S; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
Harb F; Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Oct 19; Vol. 28 (20). Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Membrane Proteins*/chemistry
Artificial Intelligence*
Humans ; Cryoelectron Microscopy/methods ; Microscopy, Electron ; Crystallography, X-Ray

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Skocz do pozycji: 30.

Tytuł:: Structure of a ribonucleotide reductase R2 protein radical.
Autorzy:: Lebrette H; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.; Laboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, CNRS, Université Toulouse III, Toulouse, France.
Srinivas V; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
John J; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Aurelius O; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.; MAX IV Laboratory, Lund University, Lund, Sweden.
Kumar R; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Lundin D; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Brewster AS; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Bhowmick A; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Sirohiwal A; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Kim IS; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Gul S; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Pham C; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Sutherlin KD; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Simon P; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Butryn A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Aller P; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Orville AM; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Fuller FD; LCLS, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Alonso-Mori R; LCLS, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Batyuk A; LCLS, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Sauter NK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yachandra VK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yano J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Kaila VRI; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Sjöberg BM; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Kern J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Roos K; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Högbom M; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Oct 06; Vol. 382 (6666), pp. 109-113. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:: Journal Article
MeSH Terms:: Ribonucleotide Reductases*/chemistry
Entomoplasmataceae*/enzymology
Bacterial Proteins*/chemistry
Electron Transport ; Protons ; Crystallography, X-Ray/methods ; Catalytic Domain
SCR Organism:: Mesoplasma florum

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Skocz do pozycji: 31.

Tytuł:: The Triterpenoids from Munronia pinnata and Their Anti-Proliferative Effects.
Autorzy:: Yang X; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Liu P; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.; School of Pharmacy, Guilin Medical University, No. 1 Zhiyuan Road, Guilin 541199, China.
Wei Y; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Song J; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Yan X; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Jiang X; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Li J; Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Li X; Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.
Li D; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.; Engineering Research Center of Innovative Traditional Chinese, Zhuang and Yao Materia Medica, Ministry of Education, Guangxi University of Chinese Medicine, No. 13 Wuhe Road, Nanning 530200, China.
Lu F; Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85 Yanshan Road, Guilin 541006, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Sep 28; Vol. 28 (19). Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:: Journal Article
MeSH Terms:: Protons*
Triterpenes*/pharmacology
Triterpenes*/chemistry
Humans ; Cell Line, Tumor ; Crystallography, X-Ray ; HCT116 Cells ; Molecular Structure

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Skocz do pozycji: 32.

Tytuł:: Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Autorzy:: Song J; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Gooding AR; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Hemphill WO; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Love BD; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.
Robertson A; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Yao L; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
Zon LI; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
North TE; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.
Kasinath V; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
Cech TR; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Sep 22; Vol. 381 (6664), pp. 1331-1337. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:: Journal Article
MeSH Terms:: Polycomb Repressive Complex 2*/chemistry
Polycomb Repressive Complex 2*/genetics
RNA Precursors*
RNA, Long Noncoding*/chemistry
RNA, Long Noncoding*/genetics
G-Quadruplexes*
Animals ; Cryoelectron Microscopy ; Histones/genetics ; Zebrafish/genetics ; Zebrafish/growth & development ; Gain of Function Mutation ; Promoter Regions, Genetic ; Protein Binding ; Enhancer of Zeste Homolog 2 Protein/chemistry ; Enhancer of Zeste Homolog 2 Protein/genetics ; Crystallography, X-Ray ; Protein Conformation ; Protein Multimerization

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Skocz do pozycji: 33.

Tytuł:: A Benchmark Study of Protein-Fragment Complex Structure Calculations with N MR .
Autorzy:: Torres F; Institute of Molecular Physical Science, Swiss Federal Institute of Technology, ETH-Hönggerberg, 8093 Zurich, Switzerland.
Stadler G; Institute of Molecular Physical Science, Swiss Federal Institute of Technology, ETH-Hönggerberg, 8093 Zurich, Switzerland.
Kwiatkowski W; Institute of Molecular Physical Science, Swiss Federal Institute of Technology, ETH-Hönggerberg, 8093 Zurich, Switzerland.
Orts J; Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 20; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:: Journal Article
MeSH Terms:: Benchmarking*
Magnetic Resonance Imaging*
Chemistry, Pharmaceutical ; Crystallography, X-Ray ; Gene Library

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Skocz do pozycji: 34.

Tytuł:: Structural Motifs in Aryl Organogermanium Ge-O Derivatives for Material Design.
Autorzy:: Zaitsev KV; Chemistry Department, M.V. Lomonosov Moscow State University, Leninskye Gory 1, 3, Moscow 119991, Russia.
Makarov IS; A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Pr. 29, Moscow 119991, Russia.
Oprunenko YF; Chemistry Department, M.V. Lomonosov Moscow State University, Leninskye Gory 1, 3, Moscow 119991, Russia.
Tafeenko VA; Chemistry Department, M.V. Lomonosov Moscow State University, Leninskye Gory 1, 3, Moscow 119991, Russia.
Lermontova EK; N.S. Kurnakov General and Inorganic Chemistry Institute, Russian Academy of Sciences, Leninskii Pr. 31, Moscow 119991, Russia.
Churakov AV; N.S. Kurnakov General and Inorganic Chemistry Institute, Russian Academy of Sciences, Leninskii Pr. 31, Moscow 119991, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 01; Vol. 24 (17). Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:: Journal Article
MeSH Terms:: Oxygen*
Crystallography, X-Ray ; Hydrolysis

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Skocz do pozycji: 35.

Tytuł:: X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA.
Autorzy:: Zhu N; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Mealka M; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Mitchel S; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Milani C; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Acuña LM; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Rogers E; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Lahana AN; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.
Huxford T; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1030, USA.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Aug 26; Vol. 13 (9). Date of Electronic Publication: 2023 Aug 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Interleukin-6*
NF-kappa B*
NF-kappa B p50 Subunit*/chemistry
NF-kappa B p50 Subunit*/physiology
Humans ; Crystallography, X-Ray ; DNA ; Lipocalin-2 ; X-Rays

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Skocz do pozycji: 36.

Tytuł:: Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Autorzy:: Liu CP; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yu Z; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Xiong J; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Hu J; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Song A; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Ding D; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yu C; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310024, China.
Yang N; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of Tianjin, Nankai University, Tianjin 300353, China.
Wang M; Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
Yu J; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Hou P; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zeng K; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Li Z; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang Z; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zhang X; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Li W; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang Z; Institute for Cancer Genetics, Department of Pediatrics and Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Zhu B; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; New Cornerstone Science Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Li G; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Xu RM; National Laboratory of Biomacromolecules and Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310024, China.; School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Aug 25; Vol. 381 (6660), pp. eadd8673. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:: Journal Article
MeSH Terms:: Chromatin Assembly Factor-1*/chemistry
Histones*/chemistry
Nucleosomes*
Humans ; Chromatin ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Protein Domains

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Skocz do pozycji: 37.

Tytuł:: A Novel Fluorescence Probe Based on Azamonardine for Detecting and Imaging Cysteine in Cells and Zebrafish with High Selectivity and Sensitivity.
Autorzy:: Zhao Y; Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou 121001, China.; Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou 121001, China.
Wang T; Faculty of Life Sciences and Technology, Kunming University of Science and Technology, Kunming 650500, China.; College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China.
Abdulkhaleq AMA; College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China.
Zuo Z; Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou 121001, China.; Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou 121001, China.
Peng Y; College of Basic Science, Jinzhou Medical University, Jinzhou 121001, China.
Zhou X; College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Aug 25; Vol. 28 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:: Journal Article
MeSH Terms:: Zebrafish*
Cysteine*
Animals ; Fluorescent Dyes ; Chromatography, High Pressure Liquid ; Crystallography, X-Ray ; Glutathione

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Skocz do pozycji: 38.

Tytuł:: Structures of the Insecticidal Toxin Complex Subunit XptA2 Highlight Roles for Flexible Domains.
Autorzy:: Martin CL; Department of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Chester DW; Department of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Radka CD; Department of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
Pan L; Department of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Yang Z; Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Hart RC; Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Binshtein EM; Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Wang Z; Biochemistry & Molecular Pharmacology, Cryo-Electron Microscopy and Tomography Core, Baylor College of Medicine, Houston, TX 77030, USA.
Nagy L; Department of Mathematics, Engineering & Physical Sciences, Jefferson State Community College, Jefferson Campus, Birmingham, AL 35215, USA.
DeLucas LJ; Predictive Oncology Inc., 200 Riverhills Business Park, Suite 250, Birmingham, AL 35242, USA.
Aller SG; Department of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 25; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:: Journal Article
MeSH Terms:: Insecticides*
Toxins, Biological*
Bandages ; Biological Transport ; Crystallography, X-Ray ; Protein Folding

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Skocz do pozycji: 39.

Tytuł:: C-H Groups as Donors in Hydrogen Bonds: A Historical Overview and Occurrence in Proteins and Nucleic Acids.
Autorzy:: Derewenda ZS; Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, VA 22903-2628, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 24; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Nucleic Acids*
Hydrogen Bonding ; Chemistry, Physical ; Crystallography, X-Ray ; Static Electricity

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Skocz do pozycji: 40.

Tytuł:: Design of stimulus-responsive two-state hinge proteins.
Autorzy:: Praetorius F; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Leung PJY; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA.
Tessmer MH; Department of Chemistry, University of Washington, Seattle, WA, USA.
Broerman A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Chemical Engineering, University of Washington, Seattle, WA, USA.
Demakis C; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA.
Dishman AF; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.; Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI, USA.
Pillai A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Idris A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Juergens D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA.
Dauparas J; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Li X; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Levine PM; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Lamb M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Ballard RK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Gerben SR; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Nguyen H; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Kang A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Sankaran B; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Bera AK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.
Volkman BF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
Nivala J; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.
Stoll S; Department of Chemistry, University of Washington, Seattle, WA, USA.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Aug 18; Vol. 381 (6659), pp. 754-760. Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Engineering*/methods
Crystallography, X-Ray ; Ligands ; Protein Conformation

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