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Wyświetlanie 1-9 z 9
Tytuł :
4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers.
Autorzy :
Woroniecka KI; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Duke University School of Medicine, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Rhodin KE; Duke University School of Medicine, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Dechant C; Duke University School of Medicine, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Cui X; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Chongsathidkiet P; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Wilkinson D; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Waibl-Polania J; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.
Sanchez-Perez L; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Fecci PE; Department of Pathology, Duke University Medical Center, Durham, North Carolina. .; Duke University School of Medicine, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Mar 15; Vol. 26 (6), pp. 1349-1358. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*therapy
CD8-Positive T-Lymphocytes/*immunology
Glioblastoma/*therapy
Glioma/*therapy
Lymphocytes, Tumor-Infiltrating/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Tumor Necrosis Factor Receptor Superfamily, Member 9/*agonists
Animals ; Brain Neoplasms/immunology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Glioblastoma/immunology ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Glioma/immunology ; Glioma/metabolism ; Glioma/pathology ; Humans ; Leukocytes, Mononuclear/immunology ; Mice ; Mice, Inbred C57BL ; Survival Rate ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.
Autorzy :
Liu Y; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.; Department of Chemistry, Duke University, Durham, NC 27708, USA.; Fitzpatrick Institute of Photonics, Duke University, Durham, NC 27708, USA.
Chongsathidkiet P; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Crawford BM; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.; Fitzpatrick Institute of Photonics, Duke University, Durham, NC 27708, USA.
Odion R; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.; Fitzpatrick Institute of Photonics, Duke University, Durham, NC 27708, USA.
Dechant CA; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
Kemeny HR; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
Cui X; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
Maccarini PF; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.; Fitzpatrick Institute of Photonics, Duke University, Durham, NC 27708, USA.
Lascola CD; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Fecci PE; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.; Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
Vo-Dinh T; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.; Department of Chemistry, Duke University, Durham, NC 27708, USA.; Fitzpatrick Institute of Photonics, Duke University, Durham, NC 27708, USA.; Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
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Źródło :
Immunotherapy [Immunotherapy] 2019 Oct; Vol. 11 (15), pp. 1293-1302. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glioblastoma*
Metal Nanoparticles*
Hyperthermia, Induced/*methods
Immunotherapy/*methods
Neoplasms, Experimental/*therapy
Phototherapy/*methods
Animals ; Brain Neoplasms ; Gold ; Immunologic Memory ; Laser Therapy/methods ; Mice ; Mice, Inbred C57BL ; Nanotechnology/methods
Czasopismo naukowe
Tytuł :
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.
Autorzy :
Woroniecka K; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Chongsathidkiet P; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Rhodin K; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Kemeny H; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Dechant C; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Farber SH; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Elsamadicy AA; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Cui X; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Koyama S; Department of Medical Oncology and Cancer Vaccine Center, Dana Farber Cancer Institute, Boston, Massachusetts.
Jackson C; Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland.
Hansen LJ; Department of Pharmacology and Molecular Cancer Biology, Duke University, Durham, North Carolina.
Johanns TM; Division of Medical Oncology, Department of Medicine, Washington University, St. Louis, Missouri.
Sanchez-Perez L; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Chandramohan V; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Yu YA; Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Bigner DD; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Giles A; Neuro-oncology Division, National Institutes of Health, Bethesda, Maryland.
Healy P; Department of Biostatistics, Duke University, Durham, North Carolina.
Dranoff G; Department of Medical Oncology and Cancer Vaccine Center, Dana Farber Cancer Institute, Boston, Massachusetts.
Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham, North Carolina.
Dunn GP; Department of Neurological Surgery, Center for Human Immunology and Immunotherapy Programs, Washington University, St. Louis, Missouri.
Fecci PE; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. .; Department of Pathology, Duke University Medical Center, Durham, North Carolina.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Sep 01; Vol. 24 (17), pp. 4175-4186. Date of Electronic Publication: 2018 Feb 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glioblastoma/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*immunology
T-Lymphocytes/*immunology
Adult ; Aged ; Aged, 80 and over ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic/immunology ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Interferon-gamma/genetics ; Interleukin-2/genetics ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Mice ; Middle Aged ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes/pathology ; Tumor Microenvironment/immunology ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.
Autorzy :
Chongsathidkiet P; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Jackson C; Department of Neurosurgery, The John Hopkins University School of Medicine, Baltimore, MD, USA.
Koyama S; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan.
Loebel F; Department of Neurosurgery, Charité Medical University, Berlin, Germany.
Cui X; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Farber SH; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Woroniecka K; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Elsamadicy AA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Dechant CA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Kemeny HR; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Sanchez-Perez L; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Cheema TA; Unum Therapeutics, Cambridge, MA, USA.
Souders NC; Dana-Farber Cancer Institute, Boston, MA, USA.
Herndon JE; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
Coumans JV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Everitt JI; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Nahed BV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sampson JH; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Gunn MD; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Immunology, Duke University Medical Center, Durham, NC, USA.; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dranoff G; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
Curry WT; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Fecci PE; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA. .; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA. .; Department of Pathology, Duke University Medical Center, Durham, NC, USA. .
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Źródło :
Nature medicine [Nat Med] 2018 Sep; Vol. 24 (9), pp. 1459-1468. Date of Electronic Publication: 2018 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Marrow/*immunology
Brain Neoplasms/*immunology
Glioblastoma/*immunology
T-Lymphocytes/*immunology
Animals ; Brain Neoplasms/pathology ; Endocytosis ; Glioblastoma/pathology ; Humans ; Lymphoid Tissue/pathology ; Lymphopenia/immunology ; Lysophospholipids/metabolism ; Mice, Inbred C57BL ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Spleen/pathology
Czasopismo naukowe
Tytuł :
Flow Cytometric Identification of Tumor-Infiltrating Lymphocytes from Glioblastoma.
Autorzy :
Woroniecka K; Department of Pathology, Duke University Graduate School, Durham, NC, USA.; Duke University School of Medicine, Durham, NC, USA.
Chongsathidkiet P; Department of Pathology, Duke University Graduate School, Durham, NC, USA.
Elsamadicy A; Duke University School of Medicine, Durham, NC, USA.
Farber H; Duke University School of Medicine, Durham, NC, USA.
Cui X; Duke University School of Medicine, Durham, NC, USA.
Fecci PE; Department of Pathology, Duke University Graduate School, Durham, NC, USA. .; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA. .; Preston Robert Tisch Brain Tumor Center at Duke University, Durham, NC, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1741, pp. 221-226.
Typ publikacji :
Journal Article
MeSH Terms :
Flow Cytometry*/methods
Immunophenotyping*/methods
Glioblastoma/*metabolism
Glioblastoma/*pathology
Lymphocytes, Tumor-Infiltrating/*metabolism
Lymphocytes, Tumor-Infiltrating/*pathology
Animals ; Biomarkers ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cytokines/metabolism ; Humans ; Immunohistochemistry ; Mice
Czasopismo naukowe
Tytuł :
Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care.
Autorzy :
Riccione K; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University; Department of Biomedical Engineering, Duke University.
Suryadevara CM; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University; Department of Pathology, Duke University.
Snyder D; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University.
Cui X; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University.
Sampson JH; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University; Department of Biomedical Engineering, Duke University; Department of Pathology, Duke University.
Sanchez-Perez L; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2015 Feb 16 (96). Date of Electronic Publication: 2015 Feb 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media
MeSH Terms :
Brain Neoplasms/*therapy
Glioblastoma/*therapy
Immunotherapy, Adoptive/*methods
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes/*immunology
Animals ; Brain Neoplasms/immunology ; ErbB Receptors/genetics ; ErbB Receptors/immunology ; Female ; Genetic Vectors ; Glioblastoma/immunology ; Mice ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell/genetics ; Standard of Care
Czasopismo naukowe
    Wyświetlanie 1-9 z 9

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