Autor: "Cui J" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: A phase Ib study evaluating the safety and efficacy of IBI310 plus sintilimab in patients with advanced non-small-cell lung cancer who have progressed after anti-PD-1/L1 therapy.
Autorzy:: Zhao Y; The First Hospital of Jilin University, Changchun, China.
Chen X; The First Hospital of Jilin University, Changchun, China.
Yao J; The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Long J; Chongqing University Affiliated Cancer Hospital, Chongqing, China.
Mao Y; Affiliated Hospital of Jiangnan University, Wuxi, China.
Wu D; The First Hospital of Jilin University, Changchun, China.
Zang A; Affiliated Hospital of Hebei University, Baoding, China.
Zhao J; Beijing Cancer Hospital, Beijing, China.
Liu Z; The First Hospital of Jilin University, Changchun, China.
Meng R; Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Chen Y; Innovent Biologics, Inc., Suzhou, China.
Luo Y; Innovent Biologics, Inc., Suzhou, China.
Guo Q; Innovent Biologics, Inc., Suzhou, China.
Li L; Innovent Biologics, Inc., Suzhou, China.
Cui J; The First Hospital of Jilin University, Changchun, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2024 Feb; Vol. 13 (3), pp. e6855. Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:: Clinical Trial, Phase I; Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms:: Antineoplastic Agents*
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Humans ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized/adverse effects

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Skocz do pozycji: 2.

Tytuł:: Synthesis and Antineoplastic Activity of a Dimer, Spiroindolinone Pyrrolidinecarboxamide.
Autorzy:: Cui J; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China.; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, 9 DongDan Santiao, Beijing 100730, China.
Wang Y; Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Li X; Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Xiao F; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China.; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, 9 DongDan Santiao, Beijing 100730, China.
Ren H; Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou 318000, China.
Wu M; Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 May 05; Vol. 28 (9). Date of Electronic Publication: 2023 May 05.
Typ publikacji:: Journal Article
MeSH Terms:: Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Antineoplastic Agents*/pharmacology
Humans ; Animals ; Mice ; Proto-Oncogene Proteins c-mdm2/metabolism ; Apoptosis ; Cell Proliferation ; Cell Line, Tumor

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Skocz do pozycji: 3.

Tytuł:: Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8) 2 , in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).
Autorzy:: Chong TC; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Wong ILK; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Cui J; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.; School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Law MC; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Zhu X; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Hu X; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Kan JWY; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Yan CSW; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.
Chan TH; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.; Department of Chemistry, McGill University, Montreal, QC H3A 2K6, Canada.
Chow LMC; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 31; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
ATP Binding Cassette Transporter, Subfamily G, Member 2*/antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Animals ; Humans ; Mice ; ATP-Binding Cassette Transporters/metabolism ; Cell Line, Tumor ; Drug Resistance, Multiple ; Mice, Nude ; Neoplasm Proteins/metabolism ; Neoplasms/drug therapy ; Topotecan/pharmacology ; Flavonoids/pharmacology ; Triazoles/pharmacology

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Skocz do pozycji: 4.

Tytuł:: Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3.
Autorzy:: Qi X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Li M; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhang XM; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Dai XF; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Cui J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Li DH; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Gu QQ; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Lv ZH; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Li J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 May 14; Vol. 25 (10). Date of Electronic Publication: 2020 May 14.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
G1 Phase Cell Cycle Checkpoints/*drug effects
STAT3 Transcription Factor/*genetics
A549 Cells ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation ; HCT116 Cells ; HT29 Cells ; Humans ; Inhibitory Concentration 50 ; Interleukin-6/genetics ; Interleukin-6/metabolism ; K562 Cells ; MCF-7 Cells ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Trichothecenes/pharmacology

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Skocz do pozycji: 5.

Tytuł:: A New Strategy for Identifying Mechanisms of Drug-drug Interaction Using Transcriptome Analysis: Compound Kushen Injection as a Proof of Principle.
Autorzy:: Shen H; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Qu Z; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Harata-Lee Y; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Cui J; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Aung TN; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Wang W; Zhendong Research Institute, Shanxi-Zhendong Pharmaceutical Co Ltd, Beijing, China.
Kortschak RD; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Adelson DL; Zhendong Australia - China Centre for Molecular Chinese Medicine, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Nov 04; Vol. 9 (1), pp. 15889. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*chemistry
Drugs, Chinese Herbal/*chemistry
Antineoplastic Agents/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cluster Analysis ; Down-Regulation/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Interactions/genetics ; Drugs, Chinese Herbal/pharmacology ; Fluorouracil/chemistry ; Fluorouracil/pharmacology ; Gene Expression Profiling/methods ; Humans ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Phenotype ; Up-Regulation/drug effects

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Skocz do pozycji: 6.

Tytuł:: Synthesis and Anticancer Activity Evaluation of Hydrolyzed Derivatives of Panaxnotoginseng Saponins.
Autorzy:: Xu L; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. .; College of Pharmacy, Yanbian University, Yanji 133000, China. .
Xiao S; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. .
Yuan W; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. .
Cui J; College of Pharmacy, Yanbian University, Yanji 133000, China. .
Su G; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. .
Zhao Y; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. .; Key Laboratory of Structure-based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2018 Nov 19; Vol. 23 (11). Date of Electronic Publication: 2018 Nov 19.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Panax notoginseng*/chemistry
Saponins*/chemistry
Saponins*/pharmacology
Neoplasms/*drug therapy
Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Plant Extracts/chemistry ; Plant Extracts/pharmacology

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Skocz do pozycji: 7.

Tytuł:: Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells.
Autorzy:: Man S; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Zhang L; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Cui J; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Yang L; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Ma L; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Gao W; Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2018 Aug; Vol. 51 (4), pp. e12458. Date of Electronic Publication: 2018 Apr 02.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/drug effects
Antineoplastic Agents/*pharmacology
Curcumin/*pharmacology
Diosgenin/*analogs & derivatives
Saponins/*pharmacology
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Curcumin/chemistry ; Diosgenin/chemistry ; Diosgenin/pharmacology ; Drug Synergism ; Fas Ligand Protein/genetics ; Fas Ligand Protein/metabolism ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Insulin-Like Growth Factor Binding Protein 1/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Tumor Necrosis Factor/genetics ; Receptors, Tumor Necrosis Factor/metabolism ; Saponins/chemistry ; Signal Transduction/drug effects

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Skocz do pozycji: 8.

Tytuł:: Reversal of P-glycoprotein-mediated multidrug resistance and pharmacokinetics study in rats by WYX-5.
Autorzy:: Wang Y; a Center for Drug Evaluation, CFDA, Beijing, PR China.; b Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Cui J; b Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Dai Y; b Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Wu Y; b Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Huang W; b Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.; c Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, PR China.
Qian H; b Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.; c Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing, PR China.
Ge L; d School of Pharmacy, China Pharmaceutical University, Nanjing, PR China.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2017 May; Vol. 95 (5), pp. 580-585. Date of Electronic Publication: 2016 Dec 22.
Typ publikacji:: Journal Article
MeSH Terms:: ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
Antineoplastic Agents/*pharmacokinetics
Antineoplastic Agents/*pharmacology
Drug Resistance, Multiple/*drug effects
Isoquinolines/*pharmacokinetics
Isoquinolines/*pharmacology
Triazoles/*pharmacokinetics
Triazoles/*pharmacology
Animals ; Doxorubicin/metabolism ; Doxorubicin/pharmacology ; Drug Interactions ; Humans ; K562 Cells ; Male ; Rats ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 9.

Tytuł:: Vitamin K4 inhibits the proliferation and induces apoptosis of U2OS osteosarcoma cells via mitochondrial dysfunction.
Autorzy:: Di W; Department of Pain Treatment, Binzhou Medical University Affiliated Hospital, Binzhou, Shandong 256600, P.R. China.
Khan M; College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116041, P.R. China.
Gao Y; Department of Pain Treatment, Binzhou Medical University Affiliated Hospital, Binzhou, Shandong 256600, P.R. China.
Cui J; Department of Pain Treatment, Binzhou Medical University Affiliated Hospital, Binzhou, Shandong 256600, P.R. China.
Wang D; Department of Pain Treatment, Binzhou Medical University Affiliated Hospital, Binzhou, Shandong 256600, P.R. China.
Qu M; Department of Pain Treatment, Binzhou Medical University Affiliated Hospital, Binzhou, Shandong 256600, P.R. China.
Feng L; Department of Pain Treatment, Binzhou Medical University Affiliated Hospital, Binzhou, Shandong 256600, P.R. China.
Maryam A; College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116041, P.R. China.
Gao H; Department of Pathology, Jilin University Bethune Second Hospital, Changchun, Jilin 130041, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2017 Jan; Vol. 15 (1), pp. 277-284. Date of Electronic Publication: 2016 Dec 07.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bone Neoplasms/*drug therapy
Mitochondria/*drug effects
Osteosarcoma/*drug therapy
Vitamin K/*pharmacology
Vitamins/*pharmacology
Bone Neoplasms/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/pathology ; Mitochondria/physiology ; Osteosarcoma/pathology

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Skocz do pozycji: 10.

Tytuł:: Antitumor potential of a synthetic interferon-alpha/PLGF-2 positive charge peptide hybrid molecule in pancreatic cancer cells.
Autorzy:: Yin H; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.; Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA 94304, USA.
Chen N; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.; Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA 94304, USA.
Guo R; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.; Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA 94304, USA.
Wang H; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.; Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA 94304, USA.
Li W; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.
Wang G; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.
Cui J; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.
Jin H; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.
Hu JF; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, China.; Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA 94304, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2015 Nov 20; Vol. 5, pp. 16975. Date of Electronic Publication: 2015 Nov 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Interferon-alpha/*pharmacology
Peptides/*pharmacology
Recombinant Fusion Proteins/*pharmacology
Antineoplastic Agents/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/genetics ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Interferon-alpha/chemistry ; Interferon-alpha/genetics ; Models, Molecular ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Peptides/chemistry ; Peptides/genetics ; Placenta Growth Factor ; Pregnancy Proteins/chemistry ; Pregnancy Proteins/genetics ; Protein Conformation ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Gemcitabine